Funding the World's Most Import Research / Annual Report 2015

Funded Research

Cure Alzheimer’s Fund distributed $10 million to support 44 research projects across our focus areas, an all-time high that allowed us to fund even more of the most innovative research in 2015.

Genes to Therapies™ / Drug Screening

Finding mechanisms of actions by which Alzheimer’s genes affect risk and identifying targets for potential drug intervention
Project Researcher(s)
3-D Neural Core/High-Throughput Drug Screening for Alzheimer’s Disease Using 3-D Human Neural Culture Systems
3DDS: Alzheimer's Disease Drug Discovery in 3-D
A 3-D Human Neural Cell Culture System for Studying Neuron-Microglia Interaction in Alzheimer’s Disease
ABCA7 in Brain Homeostasis and Alzheimer's Disease
Alzheimer’s Genome Project™
BIN1 in Alzheimer’s Disease Neuropathology
Discovery of CK1 Activators for Inducing the Autophagic Degradation of APP Beta-CTF
Extracellular Vesicle-Based Targeting of CD33-Mediated Pathology for Alzheimer’s Disease Therapy
Functional Characterization of GGA3 Mutations Associated with Alzheimer’s Disease
G2T Research Models and Materials
Genes to Therapies (G2T) Centralized Research Core Oversight
Microglial Core/CD33 and Alzheimer’s Disease: From Biology to Therapy
Molecular and Cellular Mechanisms of ACE1 Variant in Alzheimer’s Disease
PICALM Gene Therapy and Drug Screening for Abeta Clearance
PKC Mutations and Alzheimer's Disease
Role of Blood-Brain Barrier Function in Alzheimer’s Disease Pathogenesis Investigated Using a 3-D Microfluidic Platform
Studying the Functional Consequences of Alzheimer’s Disease Risk Variants in the CLU and ABCA7 Genes Using Both Human and Mouse Models
The Biological Impact of TREM Locus Mutations in Alzheimer’s Disease
The Putative Role of Red Blood Cell CR1 Levels in Amyloid-Beta Clearance and Alzheimer’s Disease Pathogenesis
The Role of PICALM Mutations in Alzheimer’s Disease
The Role of the KIBRA Gene in Abeta Regulation of AMPAR Trafficking
TREM2 Function and Dysfunction in Alzheimer's Disease
Use of High-Content Drug Screening and Systems Biology Modeling on a Novel 3-D Cell Model to Repurpose Known Drugs for Alzheimer’s Disease

Identification and Early Detection

Improving our methods of detecting Alzheimer’s in its early stages, opening the doors for treatments that stop the disease before symptoms begin or progress
Project Researcher(s)
Discovery of Alzheimer’s Disease Blood Biomarkers Using Phage Display Technology

Innate Immunity

Understanding the role of the brain’s immune response — including inflammation — in the development and progression of Alzheimer’s disease
Project Researcher(s)
Abeta Expression Protects the Brain from Herpes Simplex Virus
Targeting Beneficial Innate Immunity in Alzheimer’s by IRAK-M Deletion

Stem Cell Models

Using stem cells to create highly accurate models of the Alzheimer’s brain in the lab, in order to observe disease pathology and test possible therapies
Project Researcher(s)
Stem Cell Approach to Investigating the Phenomenon of Brain Insulin Resistance

Whole Genome Sequencing and Epigenetics

Assessing the entire human genome, including intergenic DNA, for variants that influence risk for Alzheimer’s
Project Researcher(s)
Analytical and Statistical Tools for Sequence Analysis for Alzheimer's Disease