Funding the World's Most Import Research / Annual Report 2015

Our Research Is Making a Difference

Cure Alzheimer’s Fund has a focused plan to end Alzheimer’s disease, and we make significant strides towards that goal each year. Our research has contributed to a more thorough understanding of how Alzheimer’s pathology progresses from the earliest to latest stages of the disease, including the identification of key genes and the functions of these genes. 


Alzheimer’s Disease Model

This model of Alzheimer’s disease allows us to identify three basic strategies for intervention in the process:

  1. An early-stage intervention inhibiting the production of the Abeta protein (the primary component of plaques characteristic of Alzheimer’s disease) and/or clearing it from the brain after it forms.
  2. An early- to mid-stage intervention that would inhibit the formation of tau tangles (proteins abundant in the central nervous system that have become defective and twisted into microscopic strands) and protect neurons from undue stress.
  3. A late-stage intervention that would fight inflammation and thus slow down or even stop the disease process.


Research Roadmap 

By addressing Alzheimer’s at its origins and finding the major causes of the disease, we are accelerating developments that may lead to effective therapies. The projects we fund are based on this research roadmap, which we believe to be the quickest way to a cure.


9 Areas of Research Focus

The four roadmap categories focus our funding and have helped us make significant progress in our understanding of the disease. This growing understanding has allowed us to further delineate our roadmap into the following areas of focus:



By funding the most promising research in each of these categories, we will build an in-depth and multifaceted picture of Alzheimer’s disease. Approaching the disease from these perspectives will allow convergence on the ultimate goal—a cure.

Go to to learn more about where we are focusing our research.