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A new study by David Holtzman of Cure Alzheimer’s Fund’s Research Consortium published by the journal “Science Translational Medicine” brings sharp new focus on the direct relationship between the accumulation of A-beta in the brain and notorious sleep problems associated with Alzheimer's disease.
A study just published in the New England Journal of Medicine points to the value of conducting a new series of Alzheimer's prevention studies, suggests Cure Alzheimer's Consortium member Sam Gandy in an accompanying NEJM editorial. The study, led by Washington University's Randall J. Bateman, found that patients with a more genetic-oriented form of Alzheimer's experience a rise in beta-amyloid (Aβ) up to 25 years before symptoms begin -- and an increased level of tau protein up to 15 years before symptoms.
Cure Alzheimer’s Fund supported researcher, Tesco, publishes major paper on the link between Traumatic Brain Injury and Alzheimer’s.
Dr. Giuseppina Tesco of Tufts University School of Medicine has found that “a moderate-to-severe TBI, or head trauma, is one of the strongest environmental factors for Alzheimer’s disease.”
Genes are the specific DNA blueprints for life, and all genes play roles that are essential for health. But some can carry DNA variants that influence risk for disease, either by increasing or decreasing susceptibility. If a variation in a gene is very rare, it’s called a mutation. The mutation may cause disease, increase risk for a disease, protect against a disease, or have no impact on health at all.
Charles Glabe of the University of California, Irvine and our Research Consortium and George Bloom of the University of Virginia have added significantly to the growing evidence of the link between the proteins Abeta and tau in initiating Alzheimer’s disease. In a collaboration supported by Cure Alzheimer’s Fund, the two researchers and their colleagues identify a little-studied form of Abeta as a possible key to the ultimate destruction of nerve cells in the brain.
Coconut Oil: A Scientific Perspective
Cure Alzheimer’s Fund Research Consortium member David Holtzman’s latest paper has been published in the Journal of Neuroscience, addressing how Alzheimer’s plaques affect brain networks.
Dr. Gary Landreth and colleagues at Case Western Reserve published a paper online in Science Express yesterday that received much attention because of the rather stunning results it reports in stopping and even reversing “a broad range of Abeta-induced deficits."
Exercise and stimulation of the brain may help ward off Alzheimer's disease, according to Dr. Tanzi and Dr. Gandy, both Cure Alzheimer's Fund Research Consortium members who were recently quoted in an article in the AARP Bulletin.
TheVisualMD has announced a new health initiative on Alzheimer's disease, a project that is anchored by the creation of a digital e-booklet that helps non-researchers better understand Alzheimer's. Dr. Rudy Tanzi, chairman of Cure Alzheimer's Fund Research Consortium, was interviewed about the new initiative:
"There is a great degree of confusion in the general public about the causes of dementia, Alzheimer's disease and age-related memory problems. This comprehensive educational initiative will go a long way to demystify these issues."