Cure Alzheimer’s Fund created the preceding categories in order to better define our goals and focus research dollars where they are most likely to find a cure as fast as possible. However, we remain open to supporting rigorous investigations of intriguing ideas and theories outside these categories—from unexpected sources or disciplines or the emergence of new knowledge—when our Scientific Advisory Board and Research Consortium believe compelling scientific data justifies doing so. The Individual Projects category is designed to accommodate any project we choose to fund outside our core areas; some will prove to be so important that they justify the establishment of a new area. Neuroscience, epigenetics, proteomics, machine learning: Alzheimer’s disease research involves some of the most dynamic and least-conquered areas of science, and we are committed to remaining flexible and responsive as we pursue a cure.
Pathway Cross-talks Associated with Sex and Risk for Alzheimer’s Disease
Some recent findings suggest that women with mild cognitive impairment may progress to Alzheimer’s disease (AD) at faster rates than men. However, the biological basis of the sex differences in AD still is debated and warrants a more detailed examination. We propose to use novel “big data” computational methodologies to discover how cross-talk between biological pathways may be linked to sex differences and cognitive decline in people at risk for Alzheimer’s.