News

Climbing for a Cure

Posted: Feb. 19, 2010

We first introduced you to Alan Arnette back in 2007 when he embarked upon an adventure he called “The Road Back to Mount Everest: Memories are Everything.” He spent the yearlong journey climbing 5 of the world’s highest mountains to raise money for Cure Alzheimer’s Fund -- and we couldn’t be more thankful!

But Alan isn’t done yet and this time his sights are set on an even bigger goal -- climbing the world’s biggest mountains to raise $1 million for Alzheimer’s research!

“The Seven Summits” is no small feat, but Alan is ready for the challenge. An experienced climber, Alan says this mission isn’t just about climbing, it’s about trying to find a cure for the disease that took the lives of his mother and 2 aunts -- and 100% of every dollar Alan raises will go directly to the research that will eventually cure this devastating disease!

So what exactly lies ahead for Alan? He will climb Mount Kilimanjaro (19,563 feet) this summer and then on to:

  • Denali, 20,320 feet, in Alaska
  • Elbrus, 18,481 feet, in Russia
  • Everest, 29,035 feet, in Nepal
  • Aconcagua, 22,841 feet, in Argentina
  • Vinson, 16,850 feet, in Antarctica
  • Mount Kosciuszko, 7,310 feet, and Carstensz Pyramid, 16,023 feet, on Irian Jaya, in Australia/Oceania

If you want to learn more about Alan and his quest to raise $1 million for Alzheimer’s research, visit him at www.alanarnette.com or check out the Loveland Reporter Herald’s recent piece on Alan!


Alzheimer’s costs to hit $2 trillion this decade

Posted: Feb. 17, 2010

From Cure Alzheimer's Fund President & CEO, Tim Armour:

I’ve been talking about the “cost of Alzheimer’s” for years, but we just released our new numbers and the statistics are shocking.

Over the next 10 years, we will spend $2 trillion on Alzheimer’s care.

Alzheimer’s costs the federal government over $100 billion per year, but as the baby boomer generation ages, the costs of health care are going to increase at an even faster pace. We can’t sustain this, Alzheimer’s alone will single-handedly bankrupt Medicare and Medicaid if we don’t act.

That’s why we must find a cure for Alzheimer’s now. We need the federal government to make a serious investment in research so our loved ones -- and our nation’s health care system -- will not suffer the consequences.

That is why I’m asking each and every one of you to sign our petition telling Congress to cure Alzheimer’s now.

http://salsa.wiredforchange.com/o/5850/t/5223/petition.jsp?petition_KEY=755

These numbers are truly alarming, reminding us that we must cure Alzheimer's now not only to address the obvious looming economic disaster, but also to bring real hope and relief to those already suffering from the disease. That’s why we founded the Cure Alzheimer's Fund. We have a roadmap to a cure -- we are the only ones -- we just need to fund it.

With a federal investment of $5 billion a year for the next decade, our country can capitalize on current research, including Cure Alzheimer’s Fund’s successful efforts to identify and characterize all the genes related to Alzheimer’s, bringing us that much closer to curing this devastating disease -- that’s a lot less than the $2 trillion price of inaction.

Another American gets Alzheimer’s every 70 seconds, yet our government spends very little on research. We need a long-term investment or our health care system -- and the American people -- will continue to suffer.

Lend your voice to our cause and help us cure Alzheimer’s once and for all.

As Number of Alzheimer’s Cases Increases, Federal Funding Continues to Decrease

Posted: Feb. 10, 2010

A Letter from Cure Alzheimer's Fund President & CEO, Tim Armour:

For 5 years now, we’ve been saying the same thing – with increased federal funding, we will find a cure for Alzheimer’s.

We have urged the federal government to make a national commitment to increase research funding and in the Senate’s recent appropriations bill, we are finally seeing the beginnings of such a commitment.

In light of the growing burden that Alzheimer's disease is placing on society, the Committee believes greater resources are clearly warranted. In particular, the Committee strongly urges the NIA (National Institute of Aging) to devote more funding to clinical studies, including studies of individuals who are genetically predisposed to develop early-onset Alzheimer's disease, and renewal of the Alzheimer Disease Neuroimaging Initiative, including biomarker development studies.

This is encouraging language from the Senate, but we need Washington to do more to stop this immense crisis. According to a startling new report released by the University of Rochester, federal funding for Alzheimer’s research is actively on a steady decline. This must be reversed.

That’s why I’m asking all of you to speak up and remind our members of Congress that we need to cure Alzheimer’s now.

Please click on the link below to send a message to your elected officials and tell them you support increased federal funding for Alzheimer’s research:

http://salsa.wiredforchange.com/o/5850/t/5153/campaign.jsp?campaign_KEY=3111

Did you know that in 2010, 17% of the combined Medicare and Medicaid expenses – a staggering $186 billion – will go to Alzheimer's care? And if we don’t invest in finding a cure today, the financial burden on our Medicare and Medicaid systems will only continue to increase.

What we do right now is critical. Let’s join together and cure this disease – not only because no one should face the prospect of losing a lifetime of memories, but, because the health of our entire health care system depends on it.

Thank you for everything you do,

Tim Armour

President & CEO, Cure Alzheimer’s Fund

Running 4 Answers

Posted: Feb. 1, 2010

By Carolyn Mastrangelo

The saddest part is that my story isn’t unique. Many who read this will have similar ones to tell. Noticing that my mom wasn’t quite right was a scary revelation. Realizing that it was happening at the age of 55 was terrifying. She is a wife, mother, daughter, sister, friend -- roles that she taught me how to do well. She was an avid reader and trivia buff. She was a registered nurse at a nursing home for 22 years, a job she enjoyed tremendously. She has lived in one now for 5 years. She is almost 66 years old.

Having lost my mother-in-law to breast cancer, I knew there were many ways to donate -- many ways to DO SOMETHING. As a runner, I found races that support breast cancer research. I looked for races to support my mom, but, for a disease that affects 35 million and continues to afflict another American every 70 seconds, I was shocked to find not one race benefitting Alzheimer’s.

The disease is devastating to watch; however there was nothing to do but watch.

As a personal trainer, I believe in change -- that things can be different than they are now. I decided to change the lack of races. I reached out to my friend and fellow fitness enthusiast, Barbara Geiger, and asked if she would be interested in helping me put something together. A race was born.

The name of the race started with Melissa Etheridge’s song in reference to breast cancer, “I Run For Life.” A song I love, we looked at the lyrics to spark some ideas and found the line, “running for answers.” The second we read that line, we knew we had found a name for our race.

We lack answers. They are lacking in the research and they are lacking in our daily lives. How often did I hope that the answer to the question, “Mom, do you know who I am?” would produce the right answer -- or even an answer.

Cure Alzheimer’s Fund is exactly the type of organization I was looking for. Their singular focus on research is what we need.

This experience is exciting. Daunting. Beyond rewarding. I’m not just watching my mom in a nursing home. We are doing something. It alone will not solve the problem, but it is a step in the right direction.

This race offers the opportunity for YOU to do something, too. Run. Walk. Donate. Sponsor.

Join us.

Carolyn is one of the race organizers of "Running 4 Answers," a 4-mile race and 1.5-mile walk to benefit Cure Alzheimer's Fund. For more information on "Running 4 Answers," visit http://www.running4answers.org

Martha Stewart on the “Silver Tsunami”

Posted: Jan. 28, 2010

Martha Stewart believes our nation is ill-equipped for the “silver tsunami” that is quickly approaching -- and we agree with her.

Stewart recently posted her views on the popular blog, The Huffington Post, calling the nation’s rise in the number of elderly citizens, America’s “other health crisis.”

Life expectancy rates in this country are at an all-time high and with advanced age comes the increased threat of Alzheimer’s. This disease will affect 115 million of our loved ones, family members and friends by 2050, but, if we fail to find a cure, the cost of treatment and care for Alzheimer's patients will be $2 trillion, potentially bankrupting the entire health care system.

We have a tremendous opportunity to end Alzheimer’s disease by 2020, so that our sons and daughters never face the tragic prospect of losing a lifetime of memories.

Stand with us and urge Congress to support increased funding for Alzheimer’s:
TELL CONGRESS: DON'T FORGET ALZHEIMER'S

We can all agree that Martha Stewart’s blog post touches on an increasingly important aspect of health care reform that we, as a nation, have not appropriately addressed. Just as Martha concludes her piece:

We're all in this together. Whether or not you care about older people, you will, if you're lucky, be one of them. It's not just a demographic. It's personal -- it's you, your parents, your aunts, uncles, friends and children. We need to do a better job caring for this population -- and supporting those who care for them.

Click here to read the article in its entirety:

A Better Way to Look for Diseases’ Genetic Roots

Posted: Jan. 26, 2010

If you haven’t checked out Nicholas Wade’s piece in today’s New York Times, you should. The prominent science writer has taken on the traditional method of gene hunting, claiming there may be a new, arguably more successful, way to look for diseases’ genetic roots -- the very research strategy conducted by the Cure Alzheimer’s Fund since our inception in 2004.

Having developed increasingly sophisticated approaches to Genome Wide Association Screens (GWAS) Cure Alzheimer’s Fund supported researchers have been arguing that the common method of gene hunting is flawed or at least insufficient -- that it is the common variants that may actually be pointing to the rare mutations responsible for diseases such as Alzheimer’s. It’s this research focus that has allowed us to develop our roadmap to a cure, something that has made us truly unique among other research organizations. A key paper on this topic titled, "Genome-wide association studies in Alzheimer’s disease" was published recently in the journal Human Molecular Genetics by Cure Alzheimer’s Fund supported researchers Lars Bertram and Rudy Tanzi.

Wade’s piece references Dr. David B. Goldstein, a Duke geneticist who believes that genome-wide association studies may have taken significant time and resources, but were vital to providing the science community with “next steps.”

Goldstein, like our very own Rudy Tanzi, believes that finding even a few rare variants could point to genes that make potential targets for drug makers, accelerating the developments of effective therapies.

It appears where the traditional method of gene hunting has failed to identify the right genes, the rare variants just might.

Click on the link below to read the full article:
http://www.nytimes.com/2010/01/26/science/26gene.html

CBS Poll: Nearly 50% of Americans Concerned about Alzheimer’s

Posted: Jan. 22, 2010

According to a recent CBS poll, nearly half of Americans are concerned they will one day suffer from Alzheimer’s disease -- a fear that will only continue to grow until we find a cure for this devastating disease.

As the baby boomers reach the age of retirement, we are seeing a rapid increase in Alzheimer’s. Over 5 million Americans currently suffer from this disease and that number is expected to rise to as many as 16 million by 2050.

But there is hope. The CBS poll claims that 54% of Americans expect a cure to be found in their lifetime and we know they’re right -- we can find a cure in the next 10 years.

By following our roadmap to a cure, we have continually funded research with the highest probability of slowing, stopping or reversing Alzheimer’s and 2010 will be no exception. In the coming months, our research consortium will explore some of the most critical questions that remain in Alzheimer’s pathology, embarking upon an aggressive research agenda that truly makes us unique.

Stay tuned this year as we continue to update you on all the exciting developments happening at Cure Alzheimer’s Fund!

Check out the CBS poll to learn more:

href="http://www.cbsnews.com/blogs/2010/01/12/politics/politicalhotsheet/entry6088901.shtml">http://www.cbsnews.com/blogs/2010/01/12/politics/politicalhotsheet/entry6088901.shtml

Support Cure Alzheimer’s Fund in the Inaugural “Running 4 Answers” 4-Mile Race!

Posted: Jan. 8, 2010

For far too many of us, Alzheimer’s is a cause that is deeply personal. One such woman is Carolyn Mastrangelo.

Carolyn’s mother has suffered from early onset Alzheimer’s for over 10 years. A personal trainer and avid runner, Carolyn wanted to incorporate her love of running and apply it to raising funds and awareness of this devastating disease. To do just that, she joined forces with her friend and fellow runner, Barbara Geiger, to create the inaugural “Running 4 Answers” 4-mile run to benefit Cure Alzheimer’s Fund!

Carolyn and Barbara picked the title “Running 4 Answers” because they understand all too well the devastating effects of Alzheimer’s and the growing need for answers. Every 70 seconds another American gets Alzheimer’s disease -- that’s 35 million people worldwide! We must find a cure, and soon.

Events like “Running 4 Answers” go a long way in helping us spread awareness and reach our goal of curing Alzheimer’s in the next 10 years! Thank you, Carolyn and Barbara!

Join us on April 10th as we participate in the “Running 4 Answers” race through beautiful Roseland and Essex Fells, NJ. If you would like to be a race sponsor, make a donation, become a volunteer or run in the inaugural race, visit www.running4answers.org!

 

Study Sheds More Light on Abeta’s Impact on Alzheimer's -- Research Funded in Part by Cure Alzheimer’s Fund

Posted: Jan. 4, 2010

A new study, funded in part by Cure Alzheimer’s Fund, is shedding more light on amyloid beta’s (Aβ) impact on Alzheimer’s disease.

If you regularly read our blog, you know that studies suggest that Aβ contributes to the early stages of Alzheimer’s (Aβ plays a key role in early synaptic failure which is commonly associated with memory dysfunction), but very little is known about Aβ's effect on the plasticity of dendritic spines.

 

The plasticity of dendritic spines is important because these spines provide memory storage and transmit signals across the brain, actions which require the ability to change and grow.

 

The study, led by Cure Alzheimer’s own Dr. Robert Malinow, found that Aβ affects structural and functional plasticity -- preventing synapses from growing bigger and stronger. In fact, if Aβ is over-produced, its destructive effects can affect thousands and thousands of synapses.

 

Malinow and his team discovered that a continuous release of Aβ is needed to prevent plasticity so even a short period of time without Aβ secretion is enough to allow plasticity to occur -- a positive sign if scientists learn how to stop the secretion of Aβ at synaptic sites.

 

Want to learn more about this study? Check out Science Daily for additional details:

 

http://www.sciencedaily.com/releases/2009/12/091228152352.htm

 

Study Sheds More Light on Abeta's Impact on Alzheimer's -- Research Funded in Part by Cure Alzheimer’s Fund

Posted: Jan. 4, 2010

A new study, funded in part by Cure Alzheimer’s Fund, is shedding more light on amyloid beta’s (Aβ) impact on Alzheimer’s disease.

If you regularly read our blog, you know that studies suggest that Aβ contributes to the early stages of Alzheimer’s (Aβ plays a key role in early synaptic failure which is commonly associated with memory dysfunction), but very little is known about Aβ's effect on the plasticity of dendritic spines.

 

The plasticity of dendritic spines is important because these spines provide memory storage and transmit signals across the brain, actions which require the ability to change and grow.

 

The study, led by Cure Alzheimer’s own Dr. Robert Malinow, found that Aβ affects structural and functional plasticity -- preventing synapses from growing bigger and stronger. In fact, if Aβ is over-produced, its destructive effects can affect thousands and thousands of synapses.

 

Malinow and his team discovered that a continuous release of Aβ is needed to prevent plasticity so even a short period of time without Aβ secretion is enough to allow plasticity to occur -- a positive sign if scientists learn how to stop the secretion of Aβ at synaptic sites.

 

Want to learn more about this study? Check out Science Daily for additional details:

 

http://www.sciencedaily.com/releases/2009/12/091228152352.htm