At its core, Alzheimer’s is a disease that disrupts communications between neurons (nerve cells) in the brain, and ultimately kills those neurons. Cure Alzheimer’s Fund has committed to understanding this destructive process as a necessary component to stopping the disease. To that end, it has recruited four of the world’s top experts in the field: University of California, San Diego’s Roberto Malinow, Stanford’s Robert Malenka and Thomas Südhof, and Rick Huganir at Johns Hopkins.
We collected your questions about Alzheimer's from our fall symposium and social media and presented them to Dr. Rudy Tanzi, chairman of our Research Consortium. Watch the videos below!
Greg O’Brien is a reporter from Brewster, Mass. He is the former editor and publisher of the Cape Codder and an award-winning writer. O’Brien was diagnosed with early-onset Alzheimer's disease in 2010. The following is an excerpt from a speech he gave on March 13, 2014.
Over the past few years, our understanding of Alzheimer’s disease has increased immensely. We can now identify three distinct parts of the disease pathology: early-stage Abeta (amyloid) accumulation, mid-stage development of tau tangles, and late-stage inflammation.
Scientists on our Research Consortium are investigating all three of these points of intervention. On March 6, we talked to Drs. Steven Wagner, David Holtzman, and Rudy Tanzi about how their labs are working to stop Alzheimer’s in its early, middle, and late stages.
Bruce Yankner, M.D., Ph.D., led a recent study (not funded by Cure Alzheimer's Fund) on a protein called REST. His results suggest that this protein may protect neurons from damage such as oxidative stress and inflammation. The study also gives us clues as to why plaques and tangles, two well-known features of Alzheimer's pathology, may not always cause cognitive decline.
A new study published in the medical journal of the American Academy of Neurology reports that Alzheimer's may actually be the third leading cause of death - right behind heart disease and cancer.
Cure Alzheimer's Fund is gratified that President Obama has specifically highlighted Alzheimer's disease research to benefit from increased research funding included in the Administration's Fiscal Year 2015 budget proposal.
On Wednesday, February 26, 2014, a U.S. Senate subcommittee heard from several panelists on the state of research, funding and awareness for Alzheimer's disease and related dementias. The first panel was led by Dr. Francis Collins, director of the National Institutes of Health (NIH). In his talk, Dr. Collins describes much of the research being conducted by Cure Alzheimer’s Fund, which is focused on identifying both the causes of Alzheimer’s disease and identifying therapeutic targets for drug discovery to prevent cognitive decline.
In recent years, depictions of dementia on the stage and screen have become increasingly common. On February 20, 2014, Cure Alzheimer's Fund president and CEO Tim Armour appeared on WGBH News to discuss art and Alzheimer's disease. He was joined by WGBH arts editor Jared Bowen to talk about a recent play, "Absence", which tells the story of a woman living with dementia through her own eyes.
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