Selected Publications

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Zhongcong Xie, MD, PhD,∗ Sayre McAuliffe,∗ Celeste A. Swain,∗ Sarah A. P. Ward,∗ Catherine A. Crosby,∗ Hui Zheng,† Janet Sherman,‡ Yuanlin Dong,∗ Yiying Zhang,∗ Neelakantan Sunder,§ Dennis Burke,¶ Kevin Washicosky,|| Rudolph E. Tanzi,|| and Edward R. Marcantonio∗∗ , "Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change" , Annals of Surgery , Ann Surg 2013;00 , 5/10/2013 , 1-6
BV Hooli1, ZM Kovacs-Vajna2, K Mullin1, MA Blumenthal1, M Mattheisen3, C Zhang1, C Lange4, G Mohapatra5, L Bertram6 and RE Tanzi1 , "Rare autosomal copy number variations in early-onset familial Alzheimer’s disease" , Molecular Psychology , 6/11/2013
Wagner SL, Tanzi RE, Mobley WC, Galasko D , "Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease" , Arch Neurol. , July 16, 2012
Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z , "The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β" , Neurobiology of Aging , 33(7) , July 2012 , 1364-78
B.V. Hooli, PhD, G. Mohapatra, PhD, M. Mattheisen, MD, A.R. Parrado, PhD, J.T. Roehr, MS, Y. Shen, PhD, J.F. Gusella, PhD, R. Moir, PhD, A.J. Saunders, PhD, C. Lange, PhD, R.E. Tanzi, PhD and L. Bertram, MD , "Role of common and rare APP DNA sequence variants in Alzheimer disease" , Neurology 78 , 78/16 , April 17, 2012 , 1250-1257
Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE , "RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing" , Transl Neurodegener. , 1:8 , Mar 22, 2012
Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L , "Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene database" , PLoS Genet. , 8(3) , March 2012 , e1002548
Yiying Zhang MD, MS1, Zhipeng Xu MD, PhD1, Hui Wang MD1,2, Yuanlin Dong MD, MS1, Hai Ning Shi PhD, DVM3, Deborah J. Culley MD4, Gregory Crosby MD4, Edward R. Marcantonio MD5, Rudolph E. Tanzi PhD.6, Zhongcong Xie MD, PhD1,* , "Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory" , Annals of Neurology , Volume 71, Issue 5 , February 24, 2012 , 687–698
Sungho Wona, Qing Luc, Lars Bertram, Rudolph E. Tanzi, Christoph Lange , "On the Meta-Analysis of Genome-Wide Association Studies: A Robust and Efficient Approach to Combine Population and Family-Based Studies" , Human Heredity , 73 , January 18, 2012 , 35-46
Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M , "Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking" , Mol Cell Biol. , 31(11) , June 2011 , 2326–2340
A. Li, C. Zhou, J. Moore, P. Zhang, T.-H. Tsai, H.-C. Lee, D.M. Romano, M.L. McKee, D.A. Schoenfeld, M.J. Serra,3 K. Raygor, H.F. Cantiello, J.G. Fujimoto, and R.E. Tanzi , "Changes in the Expression of the Alzheimer’s Disease- Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction" , NIHPA Author Manuscripts , 8/3 , May 1, 2011 , 313-322
Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KMA, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Nertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M , "Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation" , Traffic , 12(3) , Mar 12, 2011 , 330-48
Brit-Maren M. Schjeide, BS; Cathrin Schnack, PhD; Jean-Charles Lambert, PhD; Christina M. Lill, MD; Julia Kirchheiner, MD, PhD; Hayrettin Tumani, MD; Markus Otto, MD; Rudolph E. Tanzi, PhD; Hans Lehrach, PhD; Philippe Amouyel, PhD; Christine A. F. von Arnim, MD; Lars Bertram, MD , "The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels" , Arch Gen Psychiatry , 68(2) , February 7, 2011 , 207-213
Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ , "Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice" , Journal of Cerebral Blood Flow & Metabolism , 31 , January 2011 , 351–61
Bertram L, Lill CM, Tanzi RE , "The Genetics of Alzheimer Disease: Back to the Future" , Neuron , 68(2) , Oct 21, 2010 , 270-81
Zhang C, Browne A, Child D, Tanzi RE , "Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein" , The Journal of Biological Chemistry , 285(37) , Sep 10, 2010 , 28472-80
Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE , "Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome" , PLoS ONE , 5(5) , May 20, 2010
Zhang C, Browne A, Child D, DiVito JR, Stevenson JA, Tanzi RE , "Loss-of-Function of ATXN1 Increases Amyloid-Beta Levels by Potentiating Beta-Secretase Processing of APP" , Journal of Biological Chemistry , 285(12) , Mar 19, 2010 , 8515-26
Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, delMonte F. , "Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy" , Circulation: Journal of the American Heart Association , 121(10) , Mar 16, 2010 , 1216-26
Zhang C, Browne A, Kim DY, Tanzi RE , "Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secretase Amyloid-Beta Protein Precursor Generated by Beta-Secretase Cleavage" , Current Alzheimer Research , 7(1) , February 2010 , 21-6
Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M , "CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid" , Neuroscience Letters , Volume 469, Issue 2 , Jan 22 2010 , 265-267
Won S, Bertram L, Becker D, Tanzi RE, Lange C. , "Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family - Based Association Tests" , Statistics in Biosciences , 1(2) , Nov 2009 , 125-143
Bertram, L, Tanzi RE , "Genome-wide association studies in Alzheimer's disease" , Human Molecular Genetics , Vol 18, Review Issue 2 , Oct 15, 2009
Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE. , "Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity." , Human Molecular Genetics , Vol 18 , Oct 15, 2009
Hooli BV, Tanzi RE , "A current view of Alzheimer's disease" , F1000 Biology Rep. , 1 , July 8, 2009 , 54