Instructor in Neurology, Harvard Medical School; Assistant in Neuroscience, Massachusetts General Hospital
Dr. Ana Griciuc received her M.Eng. in biotechnology from INSA-Lyon and M.Sc. in biochemistry from the Max Planck Institute of Neurobiology (Munich) in 2006. She then became a fellow of the European Union research training network “Marie Curie-Neurotrain” and received her Ph.D. degree in neurobiology from the Helmholtz Research Center Munich in 2010. Dr. Griciuc is the recipient of the 2011 Graduate Student Award in Environmental Health Research.
Dr. Griciuc began her post-doctoral research training in the laboratory of Dr. Rudolph Tanzi at the Massachusetts General Hospital (MGH) and Harvard Medical School in 2011. She has been exploring how CD33, an innate immunity-related gene, serves as a pathogenetic risk factor in Alzheimer’s disease (AD). Dr. Griciuc found that CD33 activity in microglia strongly impairs their ability to uptake and clear brain amyloid beta (Griciuc et al., Neuron, 2013). This study delineates a novel pathway for amyloid beta clearance in the aging brain and was selected as a featured article by Neuron.
Dr. Griciuc was appointed as instructor in neurology at Massachusetts General Hospital and Harvard Medical School in 2014. Her current research projects focus on investigating the function of CD33 and other innate immunity genes, and how mutations in these genes result in susceptibility to late-onset AD. Dr. Griciuc received several awards, including a two-year post-doctoral fellowship from the German Research Foundation, the Tosteson & Fund for Medical Discovery Fellowship from MGH/ECOR and the NIH Pathway to Independence Award (K99/R00).