Eva-Maria Mandelkow, M.D., Ph.D.

Principal Investigator, German Center for Neurodegenerative Diseases (DZNE)

Eva-Maria Mandelkow studied medicine in Heidelberg and Hamburg, followed by a 3-year internship at university hospitals in Hamburg and Heidelberg, and then a doctoral dissertation at the Max Planck Institute for Medical Research, Heidelberg, with research on enzyme kinetics of the motor protein myosin. She then performed postdoctoral research at Brandeis University in Waltham, MA and at the Scripps Research Institute in La Jolla, CA. She joined the Max Planck Institute in Heidelberg as research scientist where she studied the self-assembly of microtubules by cryo-electron microscopy. After that she became Principal Investigator at the Max Planck Unit for Structural Molecular Biology at Deutsches Elektronen-Synchrotron (DESY), Hamburg. The current research interests of her group include the cell biology of tau protein and its role in Alzheimer's disease, with emphasis on cell models, transgenic mouse models, and development of therapeutic approaches. She is recipient of a 2007 Breuer Award, a 2010 Metlife Award and a 2011 Potamkin Award. In 2011, she moved to the German Center for Neurodegenerative Diseases in Bonn (DZNE) as a Principal Investigator. 

Funded Research

Project Description Researchers Funding
Tau Missorting in AD—Causes and Consequences

During the development of Alzheimer’s dementia, multiple changes occur in brain cells, making the search for and treatment of underlying causes difficult. Therefore, a key goal of Alzheimer’s disease (AD) research is to identify early changes occurring long before cognitive deficits become apparent. One such event is the so-called "missorting" of tau protein, which normally is found in the axons of neurons, but which in AD accumulates in the ''wrong'' compartments, the cell bodies and dendrites.

2015 to 2017

$322,500