Murali Doraiswamy, M.D.

Professor of Translational Neuroscience

Director of the Neurocognitive Disorders Program in the Department of Psychiatry at Duke University Medical Center

Dr. Murali Doraiswamy is a Professor of Translational Neuroscience as well as Director of the Neurocognitive Disorders Program in the Department of Psychiatry at Duke University Medical Center. He also serves on the Executive Committee of the Duke Institute for Brain Sciences and as a Senior Fellow at the Duke Center for the Study of Aging. Dr. Doraiswamy directs a leading clinical trials unit which has been involved in the development of many of the leading products used today to treat cognitive and neuropsychiatric conditions. He is also widely recognized for his work in the study of imaging biomarkers (such as MRI volumetrics, amyloid PET and functional MRI). Dr. Doraiswamy is a Fellow of the Royal College of Physicians (London), a Fellow of the American Neurological Association and a member of the World Economic Forum's Global Agenda Council on Brain research. He also serves as an adviser to leading government agencies, biotech and health companies, and patient advocacy groups. Dr. Doraiswamy is a brain health adviser for Men's Health magazine and serves as an Alzheimer’s advisor for AARP. He is co-author of a popular book, The Alzheimer's Action Plan.

Funded Research

Project Description Researchers Funding
Pathway Cross-talks Associated with Sex and Risk for Alzheimer’s Disease

Some recent findings suggest that women with mild cognitive impairment may progress to Alzheimer’s disease (AD) at faster rates than men. However, the biological basis of the sex differences in AD still is debated and warrants a more detailed examination. We propose to use novel “big data” computational methodologies to discover how cross-talk between biological pathways may be linked to sex differences and cognitive decline in people at risk for Alzheimer’s.

2016
$151,655

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Joshua G Hunsberger, PhD, Mahendra Rao, MD, Joanne Kurtzberg, MD, Jeff W M Bulte, PhD, Anthony Atala, MD, Frank M LaFerla, PhD, Henry T Greely, JD, Akira Sawa,MD, Sam Gandy, MD, Lon S Schneider, MD, P Murali Doraiswamy, MBBS, Accelerating stem cell trials for Alzheimer's disease, The Lancet Neurology, 15(2), February 2016, 219–230
Joshua G Hunsberger, Ph.D., Mahendra Rao, M.D., Joanne Kurtzberg, M.D., Jeff W. M. Bulte, Ph.D., Anthony Atala, M.D., Frank M. LaFerla, Ph.D., Henry T. Greely, J.D., Akira Sawa, M.D., Sam Gandy, M.D., Lon S. Schneider, M.D., P. Murali Doraiswamy, M.B.B.S., Accelerating stem cell trials for Alzheimer's disease, The Lancet Neurology, 15 December 2015