Murali Doraiswamy, M.D.

Professor of Translational Neuroscience

Director of the Neurocognitive Disorders Program in the Department of Psychiatry at Duke University Medical Center

Dr. Murali Doraiswamy is a Professor of Translational Neuroscience as well as Director of the Neurocognitive Disorders Program in the Department of Psychiatry at Duke University Medical Center. He also serves on the Executive Committee of the Duke Institute for Brain Sciences and as a Senior Fellow at the Duke Center for the Study of Aging. Dr. Doraiswamy directs a leading clinical trials unit which has been involved in the development of many of the leading products used today to treat cognitive and neuropsychiatric conditions. He is also widely recognized for his work in the study of imaging biomarkers (such as MRI volumetrics, amyloid PET and functional MRI). Dr. Doraiswamy is a Fellow of the Royal College of Physicians (London), a Fellow of the American Neurological Association and a member of the World Economic Forum's Global Agenda Council on Brain Research. He also serves as an advisor to leading government agencies, biotech and health companies, and patient advocacy groups. Dr. Doraiswamy is a brain health advisor for Men's Health magazine and serves as an Alzheimer’s advisor for AARP. He is co-author of a popular book, The Alzheimer's Action Plan.

Funded Research

Project Description Researchers Funding
Pathway Cross-talks Associated with Sex and Risk for Alzheimer’s Disease

Although women may constitute some 60 percent of all cases of Alzheimer’s disease (AD) in the United States, we still don’t understand the reasons why. We are using data from a large national biomarker study called the Alzheimer’s Disease Neuroimaging Initiative to study this issue more systematically. Their initial results suggest that among people with mild cognitive impairment, women may decline at faster rates than men. In addition, their preliminary results also suggest that the presence of amyloid beta and tangle pathology in the brain may have a bigger effect in women than in men.

2016 to 2017

$303,931

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Dragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, P. Murali Doraiswamy, Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease, Scientific Reports, 7, 28 Jul 2017
Joshua G Hunsberger, PhD, Mahendra Rao, MD, Joanne Kurtzberg, MD, Jeff W M Bulte, PhD, Anthony Atala, MD, Frank M LaFerla, PhD, Henry T Greely, JD, Akira Sawa,MD, Sam Gandy, MD, Lon S Schneider, MD, P Murali Doraiswamy, MBBS, Accelerating stem cell trials for Alzheimer's disease, The Lancet Neurology, 15(2), February 2016, 219–230
Joshua G Hunsberger, Ph.D., Mahendra Rao, M.D., Joanne Kurtzberg, M.D., Jeff W. M. Bulte, Ph.D., Anthony Atala, M.D., Frank M. LaFerla, Ph.D., Henry T. Greely, J.D., Akira Sawa, M.D., Sam Gandy, M.D., Lon S. Schneider, M.D., P. Murali Doraiswamy, M.B.B.S., Accelerating stem cell trials for Alzheimer's disease, The Lancet Neurology, 15 December 2015