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Sangram S. Sisodia, Ph.D.
Thomas A. Reynolds Sr. Family Professor of Neurosciences, University of Chicago
Director, Center for Molecular Neurobiology
Dr. Sisodia is a leading expert on the molecular and cell biology of Alzheimer's disease pathology. He has been at the forefront of learning how the familial Alzheimer's disease (FAD) genes, including the amyloid precursor protein and the presenilins, function normally, and contribute to Alzheimer's disease pathogenesis. Most recently, Dr. Sisodia's studies have shown that in mice, exercise has a remarkable ability to protect against Alzheimer's disease pathology by favorably changing gene activity in the brain.
Project Description Researchers Funding Investigations of the Mechanism of Action of TagretinR/Bexarotene on Amyloid Clearance in Transgenic Mouse Models
Recent studies from the laboratory of Dr. Gary Landreth (Cramer P. et. al (2012) Science 335) have demonstrated that Bexarotene (Targretin), a highly selective, blood-brain barrier-permeant, FDA-approved, RXR agonist for the treatment of cutaneous T-cell lymphoma, can rapidly reduce amyloid plaque burden and rescue behavioral deficits in transgenic mouse models of AD.Sangram S. Sisodia, Ph.D.Robert Vassar, Ph.D.
Modulation of Abeta Deposition by Cell-Specific Mechanisms
The goal of this project is to determine which types of cells and factors in the brain influence excess Abeta deposition in Alzheimer’s patients, using animal models of the disease.
Sangram S. Sisodia, Ph.D. 2010 - 2011
Molecular Mechanism Underlying Hippocampal Neurogenisis by Familial AD-linked Presenilin-1 Variants
The specific hypothesis behind the proposed research is that presenilin 1 regulates cell fate determination of adult neural progenitor cells by interfering with instructive intercellular signals prevailing within the neural progenitor cell niche, and that expression of the familial AD-linked presenilin 1adversely affects this process.
Sangram S. Sisodia, Ph.D. 2008
These published papers resulted from Cure Alzheimer’s Fund support."A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2" , The Journal of Neuroscience , 32(25) , June 20, 2012 , 8633-8648,"Heterogeneity of CNS myeloid cells and their roles in neurodegeneration" , Nat Neurosci. , 14(10) , 2011 Sept 27 , 1227-35,"Activation and Intrinsic γ-Secretase Activity of Presenilin 1" , Proc. Natl. Acad. Sci USA , 50 , Oct 15, 2010 , 21435–21440,"Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling" , The Journal of Neuroscience , 30(20) , May 19, 2010 , 6903-6915,"Amyloid beta from axons and dendrites reduces local spine number and plasticity" , Nature Neuroscience , 13(2) , Feb 2010 , 190-196,"Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF" , Mol Neurodegener , 4 , Dec 21, 2009 , 52,"Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides" , Angewandte Chemi International Edition , Volume 48 Issue 8 , February 9, 2009 , 1487–1489,"Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation" , Neuron , Volume 59, Issue 4 , August 28, 2008 , 568-580,"Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin)" , J Neurosci , (26) , 2007 , 7006-7010,