Takahisa Kanekiyo, M.D., Ph.D.

Assistant Professor of Neuroscience
Mayo Clinic Jacksonville

Takahisa Kanekiyo, M.D., Ph.D., is an Assistant Professor of Neuroscience at Mayo Clinic Jacksonville. Dr. Kanekiyo earned his M.D. and Ph.D. from Osaka University Graduate School of Medicine in Japan, and completed his postdoctoral training at the Washington University School of Medicine in St. Louis and Mayo Clinic Jacksonville. He has been studying the pathogenic pathways of age-related neurodegenerative diseases and neurovascular diseases. His current interest is to understand the roles of apolipoprotein E (apoE) and apoE receptors in Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA). He is also exploring AD pathogenesis using iPS cells from patients with the disease risk genes including APOE4 and ABCA7. Dr. Kanekiyo has received several awards including the New Investigator Research Grant from the Alzheimer’s Association and Scientist Development Grant from the American Heart Association.  

Funded Research

Project Description Researchers Funding
ABCA7 in Brain Homeostasis and Alzheimer's Disease

Genetic and environmental factors influence the risk of late-onset Alzheimer's disease; genetic studies have identified novel risk genes for the disease. ABCA7 is the gene encoding ATP-binding cassette sub-family A member 7; variants of ABCA7, which shares a homology with ABCA1, have shown a strong association with increased risk for late-onset Alzheimer’s disease. Importantly, loss-of-function variants in ABCA7 also have been demonstrated to significantly increase Alzheimer’s disease risk.

2015 to 2017

$400,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Jing Zhao, Mary D. Davis, Yuka A. Martens, Mitsuru Shinohara, Neill R. Graff-Radford, Steven G. Younkin, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu, APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics, 26(14), 15 Jul 2017, 2690-2700
Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu, Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies, Journal Of Lipid Research, 58(7), Jul 2017, 1267-1281
Justin T. Rogers, Chia-Chen Liu, Na Zhao, Jian Wang, Travis Putzke, Longyu Yang, Mitsuru Shinohara, John D. Fryer, Takahisa Kanekiyo, Guojun Bu, Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging, 53, May 2017, 112-121
Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M. Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D. Fryer, Michael L. Fitzgerald, Yasumasa Ohyagi, Steven G. Younkin, Guojun Bu, and Takahisa Kanekiyo, ABCA7 Deficiency Accelerates Amyloid- Generation and Alzheimer’s Neuronal Pathology, Neurobiology of Disease, 36(13), 30 Mar 2016, 3848–3859
Mitsuru Shinohara, Takahisa Kanekiyo, Longyu Yang, Duane Linthicum, Motoko Shinohara, Yuan Fu, Laura Price, Jessica L. Frisch-Daiello, Xianlin Han, John D. Fryer, Guojun Bu, APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations, Annals of Neurology, 79(5), 2 Mar 2016, 758-774
, Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T, Journal of Biological Chemistry, 290(22), May 2015, 14208-14217
Chia-Chen Liu, Jin Hu, Chih-Wei Tsai, Mei Yue, Heather L. Melrose, Takahisa Kanekiyo, and Guojun Bu, Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, The Journal of Neuroscience, 35(14), April 2015, 5851-5859