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Zhongcong Xie, MD, Ph.D.
Mass General Hospital/Harvard
Funded in 2011 for work on "Surgery-induced Brain Inflammation Interacting With Genetic Mutation-Induced Elevated A-beta, Leading to Memory Impairment"
Project Description Researchers Funding General Anesthetics and Alzheimer’s Disease
The goal of this project is to test the hypothesis that desflurane is a safer anesthetic than isoflurane for AD patients in order to find safer anesthetics that won’t worsen AD symptoms.
Zhongcong Xie, MD, Ph.D. 2012
These published papers resulted from Cure Alzheimer’s Fund support."Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells" , British Journal of Anaesthesia , April 19, 2013,"Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment" , Anesthesiology , Jan 9, 2013,"Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons" , Curr Mol Med. , Sep 3, 2012,"General anesthetics and β-amyloid protein" , Prog Neuropsychopharmacol Biol Psychiatry , Aug 14, 2012,"The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β" , Neurobiology of Aging , 33(7) , July 2012 , 1364-78,"RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing" , Transl Neurodegener. , 1:8 , Mar 22, 2012,"Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory" , Annals of Neurology , Volume 71, Issue 5 , February 24, 2012 , 687–698,"Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation" , PLoS One , 7(6) , 2012,"The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo." , Annals of Neurology , Volume 64 , Dec 2008,"The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions." , J Biol Chem. , 2;283(18) , May 2, 2008 , 11866-75,