Development of Tau Microdialysis as a Method to Study Tau Metabolism, Pathophysiology and Response to Treatment

Funding year(s): 
2009
Funding to date: 
$100,000

The hypothesis of this proposal is that a method can be developed to measure tau levels in the extracellular space of the brain (interstitial fluid–ISF) and that assessment of ISF tau in both normal mice as well as a variety of animal models that develop AD pathology will provide new insights into tau metabolism and the relationship between Aβ and tau in AD. If this method development is successful, it has a chance to tell us more about the pathophysiology of AD as well as a provide a novel way to screen for new AD treatments.

Researchers

Headshot photo
David Michael Holtzman, MD

The Andrew B. and Gretchen P. Jones Professor of Neurology and head of the Department of Neurology, Washington University, St. Louis
Charlotte and Paul Hagemann Professor of Neurology and Molecular Biology and Pharmacology
Associate Director of the Alzheimer's Disease Research Center
Member of the Hope Center for Neurological Disorders