Investigation of Certain Properties of Mitochondria Membranes Related to AD

Funding year(s): 
2008
Funding to date: 
$200,000

While the mechanism of Aβ cytotoxicity remains contentious, evidence is accumulating that membrane permiabilization plays a key role in the pathological activity of the peptide. This study will focus on role of Aβ oligomerization in the Aβ-mediated disruption of lipid bilayers.

Researchers

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Robert Moir, Ph.D.

Assistant Professor in Neurology, Harvard Medical School

Assistant Professor in Neurology, MGH Neurology Research

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Rudy Tanzi, Ph.D.

Dr. Rudolph Tanzi serves as Chair of the Cure Alzheimer’s Fund Research Consortium. He is also the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University and Director of the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH).