Modulation of Abeta Deposition by Cell-Specific Mechanisms
Researchers:
Funding year(s):
2010 - 2011
Funding to date:
$100,000
This project will employ a genetic strategy that allows for spatial-, temporal-, and cell-specific excision of a mutant PS transgene in order to examine cell autonomous versus non-cell-autonomous mechanisms of Aß deposition. Researchers have strong preliminary studies to validate that the cre excision strategy works efficiently in mice and have the requisite cellular, biochemical and molecular tools to carry out the proposed studies. If specific cell types in the brain are shown to have an impact on Aß deposition, investigations will expand to identify the cellular factor(s) responsible for the observed effects with the notion that strategies aimed at modulating the function of these molecules will be therapeutically efficacious in patients with AD.
