Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers that result from Cure Alzheimer’s Fund support.

Most of the papers grow out of the Alzheimer’s Genome Project™ (AGP), as that is where most of our investment has gone. The AGP has met its goal of identifying most of the remaining genes that affect risk or provide protection from Alzheimer’s disease in three years for about $3 million. Some 70 genes have been newly identified and now are available for follow up by Cure Alzheimer’s Fund-supported researchers and others.

The other papers represent innovative and in most cases collaborative investigations of more “translational” research–research enabled by the discovery of the first four genes that have been known to the field for some time. These papers point to ways for potentially faster development of therapies that affect the disease mechanism, not just the symptoms.

We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate all of them for the important work reflected in these papers. We also are grateful to all of those who literally made this work possible. Without those of you who have supported Cure Alzheimer’s Fund projects through your generosity, these papers and the momentum forward they represent would not exist.

 

2013

Zhang L, Zhang J, Yang L, Dong Y, Zhang Y, Xie Z , "Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells" , British Journal of Anaesthesia , April 19, 2013
Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S , "Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-β Peptide" , J Neurosci , 33(16) , April 17, 2013 , 7099-7107
Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy , "Traumatic Brain Injury (TBI) can lead to Neurodegenerative Syndromes that include Alzheimer Disease (AD) and Chronic Traumatic Encephalopathy (CTE)" , Nature Reviews Neurology , Volume 9, No 4 , April 2013 , 192-200
Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z , "Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment" , Anesthesiology , Jan 9, 2013

2012

Soong Ho Kim1, Elysse M Knight, Eric L Saunders, Azita K Cuevas, Marusia Popovech, Lung-Chi Chen, Sam Gandy , "Rapid doubling of Alzheimer’s amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution" , F1000Research , 1:70 , Dec 21, 2012
Arai H, Glabe C, Luecke H , "Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers" , Biochim Biophys Acta , 1820(12) , Dec 2012 , 1908-14
Aida Attar, Cristian Ripoli, Elisa Riccardi, Panchanan Maiti, Domenica D. Li Puma, Tingyu Liu, Jane Hayes, Mychica R. Jones, Kristin Lichti-Kaiser, Fusheng Yang, Greg D. Gale, Chi-hong Tseng, Miao Tan, Cui-Wei Xie, Jeffrey L. Straudinger, Frank-Gerrit Klarner, Thomas Schrader, Sally A. Frautschy, Claudio Grassi and Gal Bitan , "Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers " , Brain, A Journal of Neurology , doi:10.1093/brain/aws289 , November 26, 2012 , 3735-48
Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM , "Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis" , J Exp Med. , 209(12) , Nov 19, 2012 , 2149-56
Rachel F. Lane, Peter St George-Hyslop, Barbara L. Hempstead, Scott A. Small, Stephen M. Strittmatter, and Sam Gandy , "Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes" , The Journal of Neuroscience , 32(41) , October 10, 2012 , 14080 –14086
Jee Hoon Roh,1,2,3 Yafei Huang,1 Adam W. Bero,1,2,3 Tom Kasten,1 Floy R. Stewart,1,2,3 Randall J. Bateman,1,2,3 David M. Holtzman1,2,3,4* , "Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of Amyloid-b in Mice with Alzheimer’s Disease Pathology" , Science Translational Medicine Home , Vol. 4, Issue 150 , September 5, 2012
Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z , "Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons" , Curr Mol Med. , Sep 3, 2012
Lill CM, Bertram L , "Developing the ‘next generation’ of genetic association databases for complex diseases" , Hum. Mutat. , 33(9) , September 2012 , 1366–72
Lill CM, Liu T, Schjeide BM, Roehr JT, Akkad DA, Damotte V, Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes LA, Luessi F, Fernadez O, Izquierdo G, Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S, Faber H, Liebsch M, Meissner E, Chanvillard C, Touze E, Pico F, Corcia P; ANZgene Consortium, Dörner T, Steinhagen-Thiessen E, Baeckman L, Heekeren HR, Li SC, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Fontaine B, Vandenbroeck K, Matesanz F, Urcelay E, Bertram L, Zipp F , "Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects" , J Med Genet. , 49(9) , September 2012 , 558-62
Hiromi Arai, Charles Glabe, Hartmut Luecke , "Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers" , Biochimica et Biophysica Acta , Aug 24, 2012
Xie Z, Xu Z , "General anesthetics and β-amyloid protein" , Prog Neuropsychopharmacol Biol Psychiatry , Aug 14, 2012
Kendall R. Walker, Eugene L. Kang, Michael J. Whalen, Yong Shen, and Giuseppina Tesco , "Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1" , The Journal of Neuroscience , 32 (30) , July 25, 2012 , 10423–10437
Wagner SL, Tanzi RE, Mobley WC, Galasko D , "Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease" , Arch Neurol. , July 16, 2012
Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T , "Disrupted cortical function underlies behavior dysfunction due to social isolation" , J Clin Invest. , 122(7) , Jul 2, 2012 , 2690-701
Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen JT, Trikalinos TA , "Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining" , Genet Med. , 14(7) , July 2012 , 663-9
Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z , "The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β" , Neurobiology of Aging , 33(7) , July 2012 , 1364-78
Xulun Zhang1, Krassimira Garbett2, Karthikeyan Veeraraghavalu, Brian Wilburn, Reid Gilmore, Karoly Mirnics, and Sangram S. Sisodia , "A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2" , The Journal of Neuroscience , 32(25) , June 20, 2012 , 8633-8648
Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS , "Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies" , Proc Natl Acad Sci U S A , 109(22) , May 29, 2012 , 8534-9
Nussbaum, JM; Schilling, S; Cynis, H; Silva, A; Swanson, E; Wangsanut, T; Tayler, K; Wiltgen, B; Hatami, A; Ronicke, R; Reymann, K; Hutter-Paier, B; Alexandru, A; Jagla, W; Graubner, S; Glabe, CG; Demuth, HU; Bloom, GS , "Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β" , Nature , 485 , May 2, 2012 , 651-655
B.V. Hooli, PhD, G. Mohapatra, PhD, M. Mattheisen, MD, A.R. Parrado, PhD, J.T. Roehr, MS, Y. Shen, PhD, J.F. Gusella, PhD, R. Moir, PhD, A.J. Saunders, PhD, C. Lange, PhD, R.E. Tanzi, PhD and L. Bertram, MD , "Role of common and rare APP DNA sequence variants in Alzheimer disease" , Neurology 78 , 78/16 , April 17, 2012 , 1250-1257
Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC , "Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory" , J Biol Chem. , 287(16) , Apr 13, 2012 , 12879-85
Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM , "Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain" , J Neurosci. , 32(13) , Mar 28, 2012 , 4334-40
Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE , "RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing" , Transl Neurodegener. , 1:8 , Mar 22, 2012
Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L , "Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene database" , PLoS Genet. , 8(3) , March 2012 , e1002548
Yiying Zhang MD, MS1, Zhipeng Xu MD, PhD1, Hui Wang MD1,2, Yuanlin Dong MD, MS1, Hai Ning Shi PhD, DVM3, Deborah J. Culley MD4, Gregory Crosby MD4, Edward R. Marcantonio MD5, Rudolph E. Tanzi PhD.6, Zhongcong Xie MD, PhD1,* , "Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory" , Annals of Neurology , Volume 71, Issue 5 , February 24, 2012 , 687–698
Lill CM, Schjeide BM, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Bertram L, Zipp F , "Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample" , Neurogenetics , 13(1) , February 2012 , 83-6
Sungho Wona, Qing Luc, Lars Bertram, Rudolph E. Tanzi, Christoph Lange , "On the Meta-Analysis of Genome-Wide Association Studies: A Robust and Efficient Approach to Combine Population and Family-Based Studies" , Human Heredity , 73 , January 18, 2012 , 35-46
Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying Zhang, Zhongcong Xie , "Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation" , PLoS One , 7(6) , 2012
Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Özer E, Bertram L, von Einem B, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, von Arnim CA , "Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD" , Neurobiol Aging , 33(1) , January 2012 , 201.e9-201.e18

2011

Bertram L, Hampel H , "The role of genetics for biomarker development in neurodegeneration" , Prog Neurobiol. , 95(4) , December 2011 , 501-4
Lill CM, Bertram L , "Towards unveiling the genetics of neurodegenerative diseases" , Semin Neurol. , 31(5) , November 2011 , 531-41
Prinz M, Priller J, Sisodia SS, Ransohoff RM , "Heterogeneity of CNS myeloid cells and their roles in neurodegeneration" , Nat Neurosci. , 14(10) , 2011 Sept 27 , 1227-35
Haworth A, Bertram L, Carrera P, Elson JL, Braastad CD, Cox DW, Cruts M, den Dunnen JT, Farrer MJ, Fink JK, Hamed SA, Houlden H, Johnson DR, Nuytemans K, Palau F, Rayan DL, Robinson PN, Salas A, Schüle B, Sweeney MG, Woods MO, Amigo J, Cotton RG, Sobrido MJ , "Call for participation in the neurogenetics consortium within the Human Variome Project" , Neurogenetics , 12(3) , August 2011 , 169-73
Bertram, L , "Alzheimer’s genetics in the GWAS era: a continuing story of ‘replications and refutations’" , Curr Neurol Neurosci Rep. , 11(3) , June 2011 , 246-53
Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M , "Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking" , Mol Cell Biol. , 31(11) , June 2011 , 2326–2340
A. Li, C. Zhou, J. Moore, P. Zhang, T.-H. Tsai, H.-C. Lee, D.M. Romano, M.L. McKee, D.A. Schoenfeld, M.J. Serra,3 K. Raygor, H.F. Cantiello, J.G. Fujimoto, and R.E. Tanzi , "Changes in the Expression of the Alzheimer’s Disease- Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction" , NIHPA Author Manuscripts , 8/3 , May 1, 2011 , 313-322
Thomas Pfeiffer, Lars Bertram, John P. A. Ioannidis , "Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias " , Plos One , 6:3 , March 29, 2011
Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KMA, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Nertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M , "Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation" , Traffic , 12(3) , Mar 12, 2011 , 330-48
Jing L. Guo and Virginia M.-Y. Lee , "Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles" , The Journal of Biological Chemistry , 286/17 , March 3, 2011 , 15317-15331
Brit-Maren M. Schjeide, BS; Cathrin Schnack, PhD; Jean-Charles Lambert, PhD; Christina M. Lill, MD; Julia Kirchheiner, MD, PhD; Hayrettin Tumani, MD; Markus Otto, MD; Rudolph E. Tanzi, PhD; Hans Lehrach, PhD; Philippe Amouyel, PhD; Christine A. F. von Arnim, MD; Lars Bertram, MD , "The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels" , Arch Gen Psychiatry , 68(2) , February 7, 2011 , 207-213
Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ , "Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice" , Journal of Cerebral Blood Flow & Metabolism , 31 , January 2011 , 351–61

2010

Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL , "Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study" , Neurobiology of Disease , Volume 40, Issue 3 , Dec 2010 , 555-564
Bertram L, Lill CM, Tanzi RE , "The Genetics of Alzheimer Disease: Back to the Future" , Neuron , 68(2) , Oct 21, 2010 , 270-81
Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming Li , "Activation and Intrinsic γ-Secretase Activity of Presenilin 1" , Proc. Natl. Acad. Sci USA , 50 , Oct 15, 2010 , 21435–21440
Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S , "Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex" , The Journal of Neuroscience , 30(39) , Sep 29, 2010 , 13110-13115
Zhang C, Browne A, Child D, Tanzi RE , "Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein" , The Journal of Biological Chemistry , 285(37) , Sep 10, 2010 , 28472-80
Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM-Y, Trojanowski JQ, Grossman M , "Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia" , Neurology , 75(7) , Aug 17, 2010 , 595-602
Kessels HW, Nguyen LN, Nabavi S, Malinow R , "The prion protein as a receptor for beta-amyloid" , Nature , 466(7308) , Aug 12, 2010 , E3-E5
Huttunen HJ, Hutter-Paier B, Barren C, Peach C, Havas D, Duller S, Xia W, Frosch MP, Windisch M, Kovacs DM. , "The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice" , Journal of Neuropathology and Experimental Neurology , 69(8) , August 2010 , 777-88
Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME , "Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers" , Annals of Neurology , Volume 68, Issue 2 , August 2010
Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, Nace J, Lin BK, Khoury MJ, Ioannidis JP, Bagade S, Zheng X, Dubin RA, Bertram L, Velez Edwards DR, Menon R , "Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene)" , Public Health Genomics , 13(7-8) , May 20, 2010 , 514-23
Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE , "Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome" , PLoS ONE , 5(5) , May 20, 2010
Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS , "Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling" , The Journal of Neuroscience , 30(20) , May 19, 2010 , 6903-6915
Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Lauren J, Gimbel ZA, Strittmatter SM , "Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein" , The Journal of Neuroscience , 30(18) , May 5, 2010 , 6367-6374
Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ , "Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP" , The Journal of Neuroscience , 30(17) , Apr 28 2010 , 5948-5957
Zhang C, Browne A, Child D, DiVito JR, Stevenson JA, Tanzi RE , "Loss-of-Function of ATXN1 Increases Amyloid-Beta Levels by Potentiating Beta-Secretase Processing of APP" , Journal of Biological Chemistry , 285(12) , Mar 19, 2010 , 8515-26
Kim SH, Fraser PE, Westaway D, George-Hyslop PH, Ehrlich ME, Gandy S , "Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β42 from Isolated Intact Nerve Terminals" , The Journal of Neuroscience , 30(11) , Mar 17, 2010 , 3870-3875
Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, delMonte F. , "Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy" , Circulation: Journal of the American Heart Association , 121(10) , Mar 16, 2010 , 1216-26
Zeng C, Pan F, Jones LA, Lim MM, Griffin EA, Sheline YI, Mintun MA, Holtzman DM, Mach RH , "Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system" , Brain Research , Volume 1319 , Mar 10 2010 , 21-32
Zhang C, Browne A, Kim DY, Tanzi RE , "Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secretase Amyloid-Beta Protein Precursor Generated by Beta-Secretase Cleavage" , Current Alzheimer Research , 7(1) , February 2010 , 21-6
Wei W, Nguyen L, Kessels HW, Hagiwara H, Sisodia S, Malinow R , "Amyloid beta from axons and dendrites reduces local spine number and plasticity" , Nature Neuroscience , 13(2) , Feb 2010 , 190-196
Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA , "The COPD genetic association compendium: a comprehensive online database of COPD genetic associations" , Hum. Mol. Genet. , 10.1093/hmg/ddp519 , Feb 1, 2010
Sleegers K, Lambert J-C, Bertram L, Cruts M, Amouyel P, Broeckhoven CV , "The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects" , Trends in Genetics , Volume 26, Issue 2 , February 2010 , 84-93
Silva S, Alacoque X, Fourcade O, Samii K, Marque P, Woods R, Mazziotta J, Chollet F, Loubinoux I , "Wakefulness and loss of awareness: Brain and brainstem interaction in the vegetative state" , Neurology , 74(4) , Jan 26, 2010 , 313-20
Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M , "CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid" , Neuroscience Letters , Volume 469, Issue 2 , Jan 22 2010 , 265-267
Lublin AL, Gandy S , "Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer's Disease" , Mount Sinai Joural of Medicine , 77 , January 2010 , 43-9
Lill CM, Bertram L , "Online databases and systematic meta-analyses of genetically complex diseases" , Medizin Genet , 22 , 2010 , 235-241

2009

Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins R, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T , "Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction" , The Journal of Biological Chemistry , 284(52) , Dec 25, 2009 , 36024-33
Choi SH, Li Y, Parada LF, Sisodia SS , "Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF" , Mol Neurodegener , 4 , Dec 21, 2009 , 52
Steele JW, Kim HS, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PSG, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S , "Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo" , Molecular Neurodegeneration , 4:51 , Dec 17, 2009
Kaufer D, Gandy S. , "APOE ε4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics" , Neurology , 73(24) , Dec 15, 2009 , 2052-3
Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JSK , "CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease" , Neurology , 73(23) , December 8, 2009 , 1982-7
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM , "Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle" , Science , 326(5955) , Nov 13, 2009 , 1005-7
Zhang Y-w, Liu Shijie, Zhang X, Li W-B, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen S, Greengard P, Liao F-F, Li L, Xu H , "A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation" , Neuron , 64(3) , Nov 12, 2009 , 328-40
Won S, Bertram L, Becker D, Tanzi RE, Lange C. , "Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family - Based Association Tests" , Statistics in Biosciences , 1(2) , Nov 2009 , 125-143
Nygaard HB, Strittmatter SM , "Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers" , Archives of Neurology , 66(11) , Nov 2009 , 1325-8
Liao M-C, Ahmed M, Smith SO, Norstrand WEV , "Degradation of Amyloid β Protein by Purified Myelin Basic Protein" , The Journal of Biological Chemistry , 284(42) , October 16, 2009 , 28917-28925
Bertram, L, Tanzi RE , "Genome-wide association studies in Alzheimer's disease" , Human Molecular Genetics , Vol 18, Review Issue 2 , Oct 15, 2009
Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE. , "Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity." , Human Molecular Genetics , Vol 18 , Oct 15, 2009
Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee J-M , "Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice" , The Journal of Neuroscience , 29(34) , Aug 26 2009 , 10706-10714
Andreas Åslund, Christina J. Sigurdson, Therése Klingstedt, Stefan Grathwohl, Tristan Bolmont, Dara L. Dickstein, Eirik Glimsdal, Stefan Prokop, Mikael Lindgren, Peter Konradsson, David M. Holtzman, Patrick R. Hof, Frank L. Heppner, Samuel Gandy, Mathias Jucker, Adriano Aguzzi, Per Hammarström and K. Peter R. Nilsson , "Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses" , Chemical Biology , 4:8 , July 22, 2009 , 673-684
Hooli BV, Tanzi RE , "A current view of Alzheimer's disease" , F1000 Biology Rep. , 1 , July 8, 2009 , 54
Cao C, Cirrito JR, Lin X, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H , "Caffeine suppresses beta-amyloid levels in plasma and brain of Alzheimer's transgenic mice." , Journal of Alzheimer's disease , July 2009
Hoos MD, Ahmed M, Smith SO, Van Nostrand WE , "Myelin basic protein binds to and inhibits the fibrillar assembly of Aß42 in vitro" , Biochemistry , 48 , June 9, 2009 , 4720-4727
Bertram L , "Alzheimer's Disease Genetics: Current Status and Future Perspectives" , International Review of Neurobiology , Vol. 84 , 2009
Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z , "The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels" , Archives of Neurology , Vol. 66 No. 5 , May 2009
Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., and Glabe, C , "Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer" , J Biol Chem , 284 , February 13, 2009 , 4230-4237
Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, and Bertram L. , "Assessment of Alzheimer's disease case-control associations using family-based methods" , Neurogenetics , DOI 10.1007/s10048-008-1051-3, , Feb 10, 2009 , 568-580
Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF , "Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides" , Angewandte Chemi International Edition , Volume 48 Issue 8 , February 9, 2009 , 1487–1489
Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L , "GAB2 as an Alzheimer Disease Susceptibility Gene, Follow up of Genomewide Association Results" , Arch Neurol , 66 , Feb 2009 , 250 – 254

2008

Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE. , "No association between CALHM1 and Alzheimer's disease risk." , Cell , 135(6) , Dec 12 2008 , 993-4
Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE.  , "The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo." , Annals of Neurology , Volume 64 , Dec 2008
Cotton RG, Auerbach AD, Axton M, Barash CI, Berkovic SF, Brookes AJ, Burn J, Cutting G, den Dunnen JT, Flicek P, Freimer N, Greenblatt MS, Howard HJ, Katz M, Macrae FA, Maglott D, Möslein G, Povey S, Ramesar RS, Richards CS, Seminara D, Smith TD, Sobrido MJ, Solbakk JH, Tanzi RE, Tavtigian SV, Taylor GR, Utsunomiya J, Watson M , "The Human Variome Project" , Science. , 322(5903) , Nov 7 2008 , 861-2
Bertram L, Lange CL, Mullin K, Parkinson M, Hsiao M, Hogan MF,  Schjeide BMM, Hooli B, DeVito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. , "Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE" , Am. J. Hum. Genet. , 83 , November 2008 , 623-632
Glabe, CG , "Structural classification of toxic amyloid oligomers" , J Biol Chem , 283 , October 31, 2008 , 29639-29643
Kavvoura FK, McQueen MP, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JPA. , "Evaluation of the potential excess of statistically significant findings reported genetic association studies: application to Alzheimer's disease" , Am. J. Epidemiol. , October 15, 2008
Lagace D, Benavides D, Kansy J, Mapelli M, Greengard P, Bibb J, Eisch A , "Cdk5 is essential for adult hippocampal neurogenesis" , Proceedings of the National Academy of Science , Vol. 105 No. 47 , October 9, 2008 , 18567-18571
Bertram L, Tanzi RE , "Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses" , Nature Reviews Neurosci. , October 2008
Schaffer B, Bertram L, Miller L, Mullin K, Weintraub S, Johnson N, Bigio E, Mesulam M, Wiedau-Pazos M, Jackson G, Cummings J, Cantor R, Levey A, Tanzi RE, and Geschwind D , "Association of GSK3B with Alzheimer's Disease and Frontotemporal Dementia" , Arch. Neurol. , 65(10) , October 2008 , 1368-1374
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM , "Amyloid-beta dynamics correlate with neurological status in the injured human brain" , Science , 321(5893) , Aug 29, 2008 , 1221-4
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS , "Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation" , Neuron , Volume 59, Issue 4 , August 28, 2008 , 568-580
Brody DL, Holtzman DM , "Active and Passive Immunotherapy for Neurodegenerative Disorders" , Annu Rev Neurosci. , 31 , July 2008 , 175–193
Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z , "The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions." , J Biol Chem. , 2;283(18) , May 2, 2008 , 11866-75
Berman DE, Dall’Armi C, Voronov SV, McIntire LBJ, Zhang H, Moore AZ, Staniszewski A, Arancio O, Kim T, Di Paolo G. , "Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4, 5-bisphosphate metabolism." , Nature Neuroscience , May 2008
Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. , "Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine." , J Neurosci , 28 , April 23, 2008 , 4551-60
Cirrito JR, Kang J, Lee J, Stewart FR, Verges D, Silverio LM, Bu G, Mennerick S, Holtzman DM. , "Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo." , Neuron , 58(1) , April 10, 2008 , 42-51

2007

Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., et al , "Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers" , Mol Neurodegener , 2(18) , Sep 26, 2007 , 1-11
Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS , "Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin)" , J Neurosci , (26) , 2007 , 7006-7010
Tesco G, Koh YH, Kang E, Cameron A, Das S, Sena-Esteves M, Hiltunen, Yang S-H, Zhong Z, Shen Y, Simpkins J, Tanzi RE. , "Depletion of GGA3 stabilizes BACE and enhances β-secretase activity" , Neuron , 54(5) , 2007 , 721-37
Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM , "Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity" , Neurology , Vol. 75/no. 7 , June 2007 , 595-602
Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE , "Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer’s disease families." , Journal of Biological Chemistry , 282(11) , 2007 , 7825-32
Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE. , "The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation." , J. Neurosci. , 27 , 2007 , 1247-1254
McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. , "Exploring Candidate Gene Associations with Neuropsychological Performance." , Am J Med Genet B Neuropsychiatr Genet , 144(8) , 2007 , 987-91