Alzheimer's Causes & Risk Factors

Sleep Regulation Protein a Promising Target for Preventing Alzheimer's

New research by David Holtzman, M.D. at the Washington University School of Medicine points to a sleep regulation protein in the brain as a possible target for Alzheimer's disease treatment or prevention. The protein, called orexin, plays a role in rousing the brain from sleep. 

The State of Alzheimer's Research, 2014

Rudy Tanzi, Ph.D. - The Current State of Alzheimer's Research, 2014

Dr. Rudy Tanzi, chairman of the Cure Alzheimer's Fund Research Consortium, presents on the current state of Alzheimer's research. Dr. Tanzi focuses on the importance of the recent "Alzheimer's in a Dish" study.

This footage was recorded at our event Celebrating 10 Years of Leading Research: 10th Anniversary and Symposium.

Your Alzheimer’s Questions Answered: Q&A with Rudy Tanzi

We collected your questions about Alzheimer's from our fall symposium and social media and presented them to Dr. Rudy Tanzi, chairman of our Research Consortium. Watch the videos below!

Q&A with Dr. Rudy Tanzi: Alzheimer’s and the Body

Q&A with Dr. Rudy Tanzi: Alzheimer's & the Body

Brain health is closely intertwined with the health of the rest of the body. In this video, Rudy Tanzi, Ph.D., answers your questions about how things like sleep, exercise levels, and cardiovascular health can relate to Alzheimer's disease.

Q&A with Dr. Rudy Tanzi: Alzheimer’s Risk and Prevention

Q&A with Dr. Rudy Tanzi: Alzheimer's Risk & Prevention

Rudy Tanzi, Ph.D., answers your questions about which factors in one's lifestyle can raise or lower risk for Alzheimer's.

Missed Part 1 of the Q&A? Click here to watch Alzheimer's and Genetics.

Circadian Clock Proteins a Potential Therapeutic Target for Alzheimer’s

Brain aging is associated with lower production of circadian clock proteins, which synchronize biological processes to light and dark cycles. In Alzheimer’s and other neurodegenerative diseases, circadian dysfunction is commonly observed.

Alzheimer's Proteins Found In Cerebrospinal Fluid of Older Patients Post Surgery

BOSTON – New research examining levels of the hallmark proteins linked to Alzheimer's disease found in patients suffering from post-operative cognitive changes (POCC) may lead to safer surgery care and better post-operative outcomes for senior adults.

Exposure to Air Pollution May Increase Risk of Alzheimer’s Disease

The study, led by Cure Alzheimer’s Research Consortium member Sam Gandy, M.D., Ph.D., of the Icahn School of Medicine at Mount Sinai, examined how elements in air pollution such as nickel nanoparticles affect the levels of certain peptides in the brain that are found to be at heightened levels in patients suffering from Alzheimer’s Disease.

“We don’t yet completely understand why the peptides accumulate, but we do know the genes responding to the peptides play an important role in developing Alzheimer’s,” said Gandy.

Traumatic Brain Injury Linked to Alzheimer's and Other Neurodegenerative Diseases

Traumatic Brain Injury (TBI) can lead to neurodegenerative syndromes that include Alzheimer's Disease (AD) and Chronic Traumatic Encephalopathy (CTE).

The April issue of Nature Reviews Neurology is devoted to Traumatic Brain Injury (TBI) and Chronic Traumatic Encephalopathy (CTE). Cure Alzheimer’s Fund research consortium member, Sam Gandy, M.D., Ph.D., of the Icahn School of Medicine at Mount Sinai is senior author of the lead review and overview.

Featured Researcher: Giuseppina Tesco, M.D., Ph.D.

Meet Dr. Giuseppina Tesco, Cure Alzheimer’s Funded researcher, and assistant professor of neuroscience, Alzheimer’s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine.

Early Days