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Found 997 posts for " The role of APOE in microglia regulation in neurodegeneration ."

The Role of APOE in Microglia Regulation in Neurodegeneration

Microglia, the primary immune cells and the sensor of the brain’s health, play a pivotal role in the maintenance of brain homeostasis, but lose their functions during the course of aging and neurodegenerative diseases. There is a gap in our knowledge about how microglial function is maintained in a healthy ...

July 25, 2017

Oleg Butovsky

REMOVING ASTROCYTIC APOE4 MAY BE BENEFICIAL FOR LATE-STAGE ALZHEIMER’S DISEASE

Tauopathies, neurodegenerative disorders characterized by the presence of tau protein in the brain, are more likely to emerge in individuals harboring the APOE4 gene. Compared to other APOE variants, the expression of APOE4 significantly increases neuronal loss, decreases brain volume, and increases glial inflammatory signals. In the absence of APOE, ...

December 7, 2021

APOE Consortium: Toward Developing High-Density Lipoprotein Enriched in Apolipoprotein E as a Potential Biomarker and Therapeutic Targeting Vascular Contributions to Alzheimer’s Disease

2021 A major genetic risk factor for sporadic Alzheimer’s disease (AD) is a gene called apolipoprotein E (APOE), which codes for the APOE protein. The version of the APOE gene that confers higher AD risk makes the protein APOE4, while the normal version makes APOE3, and the protective version makes APOE2. Exactly how the different versions of ...

July 25, 2017

Cheryl Wellington

A RARE VARIANT OF APOE3 REDUCES RISK OF DEVELOPING AD

The rare APOE3-Jacksonville (APOE3-Jac) variant, named after the city in which it was discovered, significantly lowers a person’s risk for developing AD. The function of the APOE protein is to bind and transport lipids, including cholesterol, and mediate fat metabolism. The APOE3-Jac variant has a mutation in its lipid-binding region ...

October 7, 2022

APOE Consortium: Role of APOE Isoforms in Immune Responses in a Model of Tauopathy

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD). APOE4 increases risk and APOE2 decreases risk. The Holtzman lab found that in addition to the effect of APOE on amyloid beta, APOE exacerbates tau pathology and tau-mediated brain damage. Tau-dependent neurodegeneration is accompanied by ...

November 16, 2022

David Holtzman

APOE4 NEGATIVELY IMPACTS CEREBROVASCULAR FUNCTION

Although the three variants of the APOE gene (APOE2, APOE3, and APOE4) differ only by a single letter (nucleotide), the three variants have vastly different impacts on the brain. For example, APOE4, the main Alzheimer’s disease susceptibility gene, is also known to negatively impact cerebrovascular function. How and why APOE4 ...

December 7, 2021