We continue to broaden our understanding of Alzheimer’s disease by funding research into the underlying causes and mechanisms of the disease. Projects in the Pathological Pathways and Systems category aim to elucidate the mechanisms by which the known pathologies of Alzheimer’s disease, such as Abeta accumulation, tau tangle propagation, and inflammation, arise and progress-whether or not expression of a specific gene (or genes) has yet been identified as a root cause.