2018 Annual Appeal

We are closer.

For nearly 15 years, we have been relentlessly focused on funding the world’s best researchers working to understand this disease with the goal of finding a cure. The support you have provided – over $75 million from 41,000 donors since the founding of Cure Alzheimer’s Fund – has allowed 128 researchers worldwide to change and shorten the path to discoveries that will lead to effective therapies.

In a recent interview, Dr. Rudy Tanzi stated, “The group of researchers who receive grants from Cure Alzheimer’s Fund is singular in quality and research productivity and I am proud to work with each and every one of these scientists.”

We have you to thank for your generosity and enthusiastic support of these fine scientists and their work. Thank you for making it all possible.

2018 has been an exceptional year. The work you have funded has resulted in significant discoveries, moving us ever closer to effective therapies. Listed below are just a few of these game-changers:

  • Drs. Rudy Tanzi and Hansang Cho released the next generation of Alzheimer’s in a Dish that provides for the replication of all of the currently known elements of the disease pathology—amyloid plaque bundles, tau tangles and inflammation, as well as the microglia and astrocytes. This tool provides for expanded studies into how the disease develops, as well as on the impact of FDA-approved drugs for other diseases to test for their efficacy with Alzheimer’s. Alzheimer’s in a Dish is available to all scientists worldwide.
  • Dr. Karen Duff recently released findings of the phenomenon in the brain where some cells become diseased while other like cells do not.
  • Dr. Berislav Zlokovic has proposed a new model of Alzheimer’s disease biomarkers that links vascular changes in the brain to neurodegeneration.
  • Drs. Rudy Tanzi and Se Hoon Choi have demonstrated that exercise is beneficial to the brain and cognition.
  • Dr. Li-Huei Tsai used CRISPR-Cas9 technology to convert the single greatest risk factor for Alzheimer’s disease, the APOE4 gene variant, to the normal APOE3.

And for 2018, we were honored to receive the designation as one of the 10 Best Medical Research Organizations in the country by Charity Navigator.

With your help, by the end of 2019, we will have distributed $100 million to leading fundamental research. We continue to focus on bold ideas, collaboration among the funded scientists, accountability, and transparency. We remain committed to our mission to fund research with the greatest probability of preventing, slowing, or reversing Alzheimer’s disease. And, we are getting closer to a cure.

We are not there yet. Worldwide, 50 million people are afflicted with Alzheimer’s disease. Your continued support will help us end this disease. Our Board of Directors leverages your gift by paying for all of the overhead expenses of the fund, so that 100% of your donation goes directly to the researchers and their labs.

We’re in this together. Thank you.


Tim Armour
President and CEO

Read more details about the work of our Consortia