New evidence—funded by Cure Alzheimer’s Fund (CAF) and others—has emerged suggesting a strong connection between air pollution and Alzheimer’s disease. “These findings underscore the complexity of this disease,” says CAF President and CEO Tim Armour, “and emphasize the need for a comprehensive approach to stop it.” While Alzheimer’s researchers have theorized ...
June 27, 2016
Although the three variants of the APOE gene (APOE2, APOE3, and APOE4) differ only by a single letter (nucleotide), the three variants have vastly different impacts on the brain. For example, APOE4, the main Alzheimer’s disease susceptibility gene, is also known to negatively impact cerebrovascular function. How and why APOE4 ...
December 7, 2021
2018 Apolipoprotein E (APOE), the most important genetic predisposition factor for Alzheimer’s disease, seems to have direct effects on the formation of amyloid plaques but also many other plaque-independent effects on different types of brain cells, including on neurons. The precise mechanisms of these effects are not known. We have developed ...
July 25, 2017
January 1, 2018
Inflammation contributes to the development and progression of virtually every human disease. While the brain is considered immune privileged, a growing body of evidence has shown that peripheral inflammation can influence the development of many neurological disorders, including Parkinson’s disease, multiple sclerosis, frontotemporal dementia, and Alzheimer’s disease (AD). Yet the ...
January 11, 2024
January 30, 2024
Anne, Mom, Grammy, Gracie My mother died last February of Alzheimer’s Disease. I have been surprised at how hard it has been to lose her. I thought I was ready . . . she was, after all, declining. I was not ready. I thought that when she died I would feel ...
March 8, 2015
Washington — Uncovering the cure for Alzheimer’s disease at a rate never before possible and giving individuals a way to better understand their chances of facing Alzheimer’s are the outcomes of new advances in stem cell research from the Cure Alzheimer’s Fund (CAF) Stem Cell Research Consortium that use skin ...
March 21, 2013
There has been a great deal of news surrounding the research implicating gum disease in contributing to Alzheimer’s disease and dementia. It is through the lens of the antimicrobial approach to treating Alzheimer’s disease that the latest study suggesting that periodontal bacteria can play a role in Alzheimer’s disease should be ...
March 15, 2019
“The human race has one really effective weapon, and that is laughter.”—Mark Twain It’s easy often to feel sorry for oneself—the pity thing. There’s a bit of Eyore in all of us—the forever gloomy old gray donkey in A.A. Milne’s Winnie in Pooh and the Honey Tree: “I was so upset, I ...
April 11, 2024
