Alzheimer’s disease pathogenesis: insights from molecular and cellular biolgoy studies of oligomeric A beta and Tau species

January 30, 2024

William C. Mobley

Non-canonical soluble amyloid beta aggregates and plaque buffering: controversies and future direction for target discovery in Alzheier’s disease.

January 30, 2024

David L. Brody, Norelle Wildburger, Ph.D.

Tau pathology spreads in S19 tau transgenic mice following locus coeruleus (LC) injections of synthestic tau fibrils is determined by the LC’s afferent and efferent connections

January 30, 2024

John Q. Trojanowski, Virginia Lee

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function

January 30, 2024

Li-Huei Tsai

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

January 30, 2024

Li Gan, Li-Huei Tsai, Subhash Sinha

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia

January 17, 2024

Casey Cook, Leonard Petrucelli

Activated Human Astrocyte-Derived Extracellular Vesicles Modulate Neuronal Uptake, Differentiation and Firing

January 30, 2024

Tsuneya Ikezu

Robert Moore

Robert Leonard 80, a longtime Cambridge resident and businessman, passed away on July 29th after a long illness. He was the loving husband of 59 years to Lynn Hirsh Moore and beloved father of three sons: Jeffrey (Lisa) Moore of Austin, Texas, Jonathan (Elizabeth) Moore of Chelmsford, Massachusetts, and Steven ...

August 20, 2018

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

January 30, 2024

Tsuneya Ikezu

Gene Expression Throughout Development of Pathology in APPKI Mice; Effects of Human Tau and Aging

2019 Recent advances in technology have allowed the development of improved animal models for Alzheimer’s disease. This has required optimization of protein levels for the factors that influence progression of the disease, which has been done by replacing mouse proteins with humanized amyloid precursor protein that include disease-causing mutations and normal ...

August 9, 2018

Frances Edwards, John Hardy