SUMMARY After declaring aducanumab a failure, new data from Biogen’s clinical trial suggests the drug may help slow cognitive decline in some patients. In the EMERGE trial for aducanumab, patients receiving the highest dose saw 23% less cognitive decline on the Clinical Dementia Rating-Sum of Boxes test in comparison to patients receiving ...
October 30, 2019
The Four Known Alzheimer’s Genes Over the past several decades, it has become increasingly clear that inheritance plays a major role in Alzheimer’s disease. The roughly 25,000 genes in the human genome are comprised of deoxyribonucleic acid (DNA) packaged into 24 different chromosomes, 1-22, X and Y. A gene’s job is ...
April 18, 2011
Cure Alzheimer’s Fund’s Dr. Rudy Tanzi’s submitted answers to Senator Hillary Rodham Clinton’s questions from the May 14, 2008, Senate Special Committee on Aging “The Future of Alzheimer’s: Breakthroughs and Challenges” Questions How can we best identify those at risk for Alzheimer’s Disease? Are there effective new drugs coming out anytime soon? How critical ...
June 8, 2008
2023 Not everyone who harbors classic Alzheimer’s lesions in the brain (e.g., plaques and tangles) develops clinical symptoms of the disease. This study was designed to understand the mechanisms involved in such natural human brain resilience, as they may hold key clues for the design of novel cognitive-sparing therapies in the ...
October 15, 2018
Microglia are the brain’s immune cells and express multiple Alzheimer’s disease (AD) risk genes. Understanding the impact of these risk genes on microglia is essential to identify how disease is initiated and progresses. Recently, it has been shown that peripheral inflammation is a major component of AD pathogenesis, but we ...
February 1, 2024
Norma Jean (Patton) Demorest, age 82, died peacefully at the Atria Del Sol memory care home in Mission Viejo, California on Monday, September 4th, 2017. The cause was complications associated with late stage Alzheimer’s disease. Born January 10, 1935, in Wellston Ohio, to Theora Grace Wood and Joseph Patton, she graduated ...
September 24, 2017
January 19, 2018
Vaccination against amyloid is a promising approach for the development of Alzheimer’s disease (AD) therapeutics. Approximately half of the investigational new therapeutics in human clinical trials for AD are active or passive immunotherapeutics. Active vaccination involves the injection of an antigen and relies on the production of antibodies in the vaccinated ...
October 13, 2009
Answers to webinar questions have been posted below. We will continue to post additional answers as we receive them. On April 4, 2012, Cure Alzheimer’s Fund Research Consortium member Sam Gandy, M.D., Ph.D., and David Shenk, author of the national bestseller, The Forgetting, presented a webinar about the linkage between Alzheimer’s ...
April 4, 2012
We collected your questions about Alzheimer’s from our fall symposium and social media and presented them to Dr. Rudy Tanzi, chairman of our Research Consortium. Watch the videos below! Q&A with Dr. Rudy Tanzi: Alzheimer’s & Genetics Video of Q&A with Dr. Rudy Tanzi: Alzheimer's & Genetics Part 1: Alzheimer’s and ...
April 17, 2014
