Charles Glabe of the University of California, Irvine and our Research Consortium and George Bloom of the University of Virginia have added significantly to the growing evidence of the link between the proteins Abeta and tau in initiating Alzheimer’s disease. In a collaboration supported by Cure Alzheimer’s Fund, the two ...
May 4, 2012
Evidence is accumulating that vaccination against a variety of different pathogens can reduce the risk of Alzheimer’s disease (AD). The vaccines now include: the Bacillus Calmette-Guérin (BCG) vaccine, a 100-year-old anti-tuberculosis vaccine; the triple vaccine of childhood (DPT); anti-tetanus or anti-diphtheria vaccination alone; anti-influenza; anti-pneumonia; and possibly anti-shingles, currently “under review.” The ...
February 14, 2022
This research will attempt to understand the following central cell biological questions: What is the sub-cellular site where Aβ is secreted? Can the effects of Aβ secretion on synapses be blocked by drugs? Preliminary data show that overproduction of either axonal or dendritic Aβ reduces spine density and plasticity at dendrites close (~ ...
February 11, 2011
By John R. Cirrito, Ph.D., and David M. Holtzman, M.D.Microdialysis Core Facility, Department of Neurology, Hope Center for Neurological Diseases, Washington University, St. Louis, MO A major contributing factor in Alzheimer’s disease is the elevation of a protein called amyloid-β, or Aβ. Since high levels of Aβ play a role in ...
August 20, 2009
Traditionally, the search for a drug requires a large quantity of starting material, heavy screening costs, and a complex and costly infrastructure that allows for several hundred thousand compounds to be screened. This research proposal intends to use a revolutionary approach to generate 24 million drug-like compounds that have the ...
January 10, 2019
2019 This project recently established a more accurate and efficient model to identify fluorescent images generated by treating the Alzheimer’s in a Dish model with compounds that can clear accumulated phosphorylated tau. Meanwhile, 29 new candidate compounds recently going through clinical trials for various diseases were generated by in silico prediction ...
August 27, 2018
Alzheimer’s disease is the most common form of dementia.
September 24, 2017
2019 Alzheimer’s disease is a huge health problem that imposes a severe social and economic burden; in the absence of an effective disease-modifying treatment, it is projected to become a dominant source of health care expenditures over the next several decades. Unfortunately, existing treatments are palliative, providing only temporary symptomatic benefit. ...
August 9, 2018
Patricia Anne “Patty” Ciaschi, 80, died peacefully at home in Ithaca on July 15, 2022. She was born on December 2, 1941, to Albert E. II and Vivian Greene of Ithaca, NY. In addition to her parents, Patricia was pre-deceased by her parents-in-law Robert and Connie O’Neil; her sister Janet ...
September 1, 2022
The President states in the budget message for the National Institutes of Health that the proposed budget delivers on the “… Administration’s commitment to enhance investment in Alzheimer’s research” by adding approximately $80 million to the current year’s amount. This commitment which moves Alzheimer’s research from about 1.6% of the ...
April 11, 2013
