What do the developing brain and the Alzheimerās brain have in common? Beth Stevens, Ph.D., a developmental neurologist, is investigating an important connection: the loss of synapses, where neurons connect with one another to transmit important signals. Stevens heads a lab in the F.M. Kirby Neurobiology Center at Childrenās Hospital in ...
October 3, 2016
Dr. Saul Villeda obtained his B.S. in Physiological Sciences from the University of California Los Angeles and his Ph.D. in Neuroscience from Stanford University. At Stanford, he investigated how systemic changes in aging blood contribute to age-related impairments in neural stem cell function and cognitive processes. Dr. Villeda went on ...
December 21, 2022
Genetics and other known factors indicating the risk of Alzheimer’s disease
September 24, 2017
2018 to 2019 Alzheimerās disease has become a major public health problemāand there is no cure for the disease. Previously, we have developed a novel three-dimensional human neural cell culture model of AD (Alzheimerās in a Dish), which recapitulates key pathological events in AD in human brain-like environment. In this ongoing ...
September 29, 2015
Dr. Steve Paul is Founder and Chair of the Board of Directors at Seaport Therapeutics. Dr. Paul previously served as the Chief Scientific Officer, President of Research and Development, and a member of the Board of Directors at Karuna Therapeutics. He also served as Chairman of the Board, President, and ...
January 5, 2017
Conor Michael OāBrienāa native Cape Codder, Nauset High School graduate, and graduate of Johnson & Wales University in Providence with a degree in sports events managementāpassed away Sunday from complications of a seizure. He was 33, the youngest of three siblings. Our hearts are broken, but we are at peace in ...
August 22, 2022
This idea for Puzzles to Remember came from then 13-year old Max Wallack. In caring for his great grandmother, he noticed that when his grandmother worked on certain jigsaw puzzles, the activity produced a positive, calming response. This special line of puzzles offers a simple activity with lifelong benefits such ...
October 30, 2020
We built an iterative scheme of āmodeling->screening->validationā through the collaboration within the AD4 consortium. More than 3,000 compounds were physically screened through automated imaging of the 3D Alzheimerās in a Dishā¢ assay developed by AD4 consortium collaborators, and nearly 30 compounds have shown an ability to significantly reduce the level ...
February 17, 2022
Amyloid-lowering strategies may be most effective if administered prior to the clinical presentation of Alzheimer’s disease.Ā By the time memory trouble brings patients to see a physician, there may well already be brain pathology and nerve cell damage. Supported by CAF funds, Sam Gandy of the CAF Research Consortium, in collaboration ...
September 26, 2011
We will complete the characterization of the protective effects of neural progenitor cell (NPC) transplantation in E200K mice. We will also examine the effect of NPC transplantation on the progression of AD in 5xFAD mice, and we will characterize various pathological features of disease, rate of neurodegeneration and behavioral tests. ...
April 21, 2015
