Background Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and a burgeoning unmet medical need that will only worsen as the average lifespan continues to increase. The prevalence of AD increases with every decade after the age of 60 and ~ 20% of the population can ...
August 20, 2009
2019 Alzheimer’s disease is a huge health problem that imposes a severe social and economic burden; in the absence of an effective disease-modifying treatment, it is projected to become a dominant source of health care expenditures over the next several decades. Unfortunately, existing treatments are palliative, providing only temporary symptomatic benefit. ...
August 9, 2018
Dr. Junmin Peng is a Member (Professor) in the Departments of Structural Biology and Developmental Neurobiology at St. Jude Children’s Research Hospital in Memphis, Tennessee, USA. He obtained his Ph.D. in Biochemistry at the University of Iowa and then received postdoctoral training in Neurobiology and Proteomics as a Jane Coffin ...
February 29, 2024
Genome-wide association meta-analysis studies (GWAS) have identified more than 200 genes in strong correlation with Alzheimer’s disease (AD), most of which are expressed in brain immune cells (microglia). However, the intrinsic role of AD risk genes in the regulation of microglia phenotype and functions is unknown. We recently reported that ...
January 12, 2024
Alzheimer’s disease (AD), the most common form of late-onset dementia in the elderly, poses an existential threat to our health care system in modern society. It is characterized by the accumulation of pathological amyloid beta plaques and neurofibrillary tangles. There is compelling evidence showing that tau pathology, rather than amyloid ...
February 11, 2022
Alzheimer’s disease is the most common form of dementia, affecting over 5 million people in the United States alone; it is the sixth-leading cause of death and is expected to cost the nation over $200 billion in 2013, with costs projected to exceed $1 trillion by 2050. Currently, there is no ...
July 17, 2014
The promise of personalized medicine includes understanding sex differences in health and disease. It has been well documented that women have a higher risk of developing Alzheimer’s disease compared with men, but this is not simply because women on average live to older age than men. This proposal capitalizes on ...
December 10, 2020
Increasing evidence suggests that Alzheimer’s disease (AD) is not restricted to the aggregated proteins (amyloid and tau), but strongly proposes that immunological mechanisms have a key role in the pathogenesis. The study of the neuroinflammation surrounding this hypothesis is leading to novel findings that genes for brain resident immune cell ...
February 17, 2022
Yesterday, we posted about a new study showing that more than 35 million people worldwide are living with Alzheimer’s Disease and other forms of dementia. Cure Alzheimer’s Fund’s Rudy Tanzi, who is recognized as a leading expert on Alzheimer’s Disease, was interviewed by Boston’s NECN TV about the report and its ...
September 22, 2009
This study draws on a unique community-based longitudinal cohort of 378 subjects who span the range of impairment between normal aging and mild Alzheimer’s disease (AD). This research focuses on two key steps to find AD genes and to understand their impact. Investigate the relationship of amyloid deposition to memory impairment ...
February 11, 2011
