A paper published inĀ NeuronĀ by first author Ana Griciuc and Cure Alzheimerās Fundās Research Leadership Group members Rudy Tanzi and Marco Colonna has made important headway in answering an open problem in Alzheimerās research: how do two risk genes for Alzheimerās disease, CD33 and TREM2, interact to modulate pathology and memory? ...
July 12, 2019
The path from research discovery to drug development can be a long one. Current estimates target the time for an Alzheimerās drug to get to market at around 12 years. However, with new technological advances in such areas as genetics, we are optimistic that scientific opportunities have never been greater to ...
August 20, 2009
Year 6 of the Ride to Freedom, otherwise known as “RTF VI: Adding Another Thumb,” brings with it another chance to ride with good friends and donate to a good cause. This year, contributions are being made to the Cure Alzheimer’s Fund, a non-profit organization dedicated to funding research with ...
January 4, 2017
Below is the text from an article included on the Eureka blog which provides an overview of the need for a multi-pronged approach to stopping Alzheimer’s disease. The work of Dr.’s Rudy Tanzi and David Holtzman, and the late Stephen Wagner, of the Cure Alzheimer’s Fund Research Leadership Group, is ...
November 2, 2023
October 15, 2019
By John R. Cirrito, Ph.D., and David M. Holtzman, M.D.Microdialysis Core Facility, Department of Neurology, Hope Center for Neurological Diseases, Washington University, St. Louis, MO A major contributing factor in Alzheimerās disease is the elevation of a protein called amyloid-Ī², or AĪ². Since high levels of AĪ² play a role in ...
August 20, 2009
January 30, 2024
In just its first year of operation, Cure Alzheimerās Fundās ambitious new Genes to Therapiesā¢ (G2T) research program has bloomed far beyond expectations. āWeāre firing on all cylinders now,ā says Research Consortium Chair Dr. Rudy Tanzi. āItās exactly where we need to be headed to stop this disease.ā In 2015, Cure Alzheimerās ...
February 12, 2016
One America Charity Ride 3,200 Mile Update – April 25, 2017 WhenĀ I last reported, I was just recovering from bruised ribs in Louisville.Ā I am happy to report that I am now feeling much better in Confluence, PA.Ā On the home stretch now. Some of you have asked if there would be a ...
April 27, 2018
2020 Genetics and neuropathology of Alzheimerās disease clearly point to the importance for pathogenesis of decreased gamma-secretase-mediated processing of the amyloid precursor protein with consequent increased levels of long, aggregation-prone amyloid beta peptides. Recent research has provided evidence that the disease develops as a vicious cycle of impaired function of gamma-secretase, ...
January 10, 2019
