To celebrate the eleventh season of the medical drama Grey’s Anatomy, fans of the show are hoping to raise $11,000 for research towards a cure for Alzheimer’s. Previous seasons of the show have portrayed several characters with Alzheimer’s disease. Dr. Ellis Grey, a legendary surgeon (played by Kate Burton), is diagnosed with early-onset Alzheimer’s and ...
July 1, 2014
At the Pine Hill School in Sherborn, Mass., they don’t just teach reading, writing and arithmetic. They also teach the importance of making a difference in the world. At the end of the school year, each 5th grader participates in a project called “Citizenship in Action,” where students choose an ...
December 4, 2013
Neurons, highly organized brain cells, are characterized by specialized projections called dendrites and axons. The axon is the longest neuronal projection where proteins move like along a highway, in two different directions and at different speeds. Scientists demonstrated that in the brain of subjects affected by Alzheimer’s disease (AD), a disorder characterized by memory loss, this ...
January 11, 2016
This research will identify the critical sites of interaction between novel pyridazine-derived soluble gamma secretase modulators (SGSMs) and their molecular target, as well as provide valuable information toward fostering an improved understanding of the mechanism by which these therapeutically relevant small molecules affect the production of specific Abeta peptide variants ...
September 23, 2016
The work proposed in this application stems from dramatic advances in our understanding of reasons that nerve cells die in Alzheimer’s disease. This work derives from new insights into how our bodies respond to stress. We have discovered a group of proteins, termed RNA-binding proteins (RBPs), that bind directly to ...
August 1, 2017
Fil Swirski, Ph.D., is the Arthur and Janet C. Ross Professor of Medicine (Cardiology) and Professor of Diagnostic, Molecular and Interventional Radiology at the Icahn School of Medicine at Mount Sinai, as well as Director of the Cardiovascular Research Institute. He has secondary appointments at the Precision Immunology Institute and ...
August 2, 2016
Dr. Newton studies the molecular mechanisms underlying how cells process information in health and in disease. Cellular homeostasis depends on precise control of the balance between “go” and “stop” signals controlled by protein kinases and protein phosphatases, enzymes with opposing functions. Deregulation of this balance leads to pathophysiological states, driving ...
February 7, 2017
Joel Blanchard is an Assistant Professor of Neuroscience at the Icahn School of Medicine at Mt. Sinai in New York City. He is also an investigator in the Ronald Loeb Alzheimer’s Disease Center and the Black Family Stem Cell Institute. His research aims to understand how genetics, diet, and traumatic ...
January 3, 2022
2022 There have been numerous associations of the composition of the microbes in the gastrointestinal (GI) tract with the occurrence of Alzheimer’s disease (AD), but how these microbes lead to changes in the brain and the associated signs and symptoms of AD are poorly understood. We have proposed that small fragments of ...
February 15, 2022
Advanced age is the greatest risk factor for developing Alzheimer’s disease and related dementias. Disease processes begin decades prior to noticeable symptoms. Our work focuses on how brain cells change throughout the lifespan to identify early disease processes. This strategy led to the discovery of an abnormal type of brain ...
January 12, 2024
