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Novel Therapies for Alzheimer’s Disease Based on Early Onset Genes

Supplemental Information for Senate Special Committee on Aging Hearing Introduction Alzheimerā€™s disease (AD), the most common form of dementia, was first described roughly one hundred years ago in Bavaria by Dr. Alois Alzheimer in his presentation of an early-onset (

August 20, 2009

Two Genes Appear to Act as On/Off Switches for Neuroinflammation and Alzheimer’s Disease

  A paper published inĀ NeuronĀ by first author Ana Griciuc and Cure Alzheimerā€™s Fundā€™s Research Leadership Group members Rudy Tanzi and Marco Colonna has made important headway in answering an open problem in Alzheimerā€™s research: how do two risk genes for Alzheimerā€™s disease, CD33 and TREM2, interact to modulate pathology and memory? ...

July 12, 2019

Ana Griciuc, Marco Colonna, Rudolph Tanzi

Groundbreaking Alzheimerā€™s Disease Blood Test Subject of Upcoming Webinar

Cure Alzheimerā€™s Fund will host Dr. David Holtzman for a live webinar on Thursday, May 27 at 5:30 PM.Ā  Diagnosing Alzheimerā€™s Disease: A Groundbreaking New Blood Test is free and open to the public. Registration is required. Dr. Holtzman is a co-inventor of a new blood test, PrecivityAD, designed to assist ...

May 20, 2021

The Search for New Ways to Treat Alzheimer’s Disease

By John R. Cirrito, Ph.D., and David M. Holtzman, M.D.Microdialysis Core Facility, Department of Neurology, Hope Center for Neurological Diseases, Washington University, St. Louis, MO A major contributing factor in Alzheimerā€™s disease is the elevation of a protein called amyloid-Ī², or AĪ². Since high levels of AĪ² play a role in ...

August 20, 2009

Letter from the Chairs

From our 2011 Annual Report. Ā  Dear Friends, On behalf of the Board of Directors and the Research Consortium, we want to thank all the donors, researchers and academic institutional partners supporting Cure Alzheimerā€™s Fund research for your help in making 2011 such a successful science year. Guided by leading scientists in the ...

December 5, 2012

Moving the Cure Alzheimerā€™s Fund Alzheimer’s Genome Projectā„¢ Beyond Simple Associations: Integrating Functional Information, Fine-Mapping and Causal Inference Approaches into the Family-Based Analysis of the Cure Alzheimerā€™s Fund Whole-Genome Sequencing (WGS) Family Study

We will develop and implement a set of analysis approaches that will enable us to move our whole-genome sequencing analysis approaches of the family data in the Cure Alzheimerā€™s Fund Alzheimerā€™s Genome Projectā„¢ beyond ā€œsimple association analysis,ā€ fostering a deeper understanding of the underlying genetic architecture of Alzheimerā€™s disease (AD). ...

February 1, 2024

Christoph Lange