Validation and Characterization of Compounds Modulating Neuroinflammation and Amyloid Beta Uptake in Microglial Cells

Growing evidence has implicated a critical role for microglia in mediating Alzheimer’s disease (AD) pathogenesis, making them a promising target for AD therapeutics. Impaired microglial phagocytosis results in accumulation of amyloid beta (Aβ), leading to neuroinflammation, which is the primary driver of neurodegeneration. Through an unbiased high-throughput screen of a ...

October 25, 2023

Ana Griciuc, Luisa Quinti

Rudy Tanzi Joins Francis Collins, Director of the National Institutes of Health, Eric Lander of the Broad Institute and Others to Explore Genetic Testing on NOVA

Last week, Cure Alzheimer’s Fund Research Consortium chairman Rudy Tanzi was featured on NOVA in a segment concerning genetic testing. The special followed several cases of people affected by genetic testing, showing both its benefits and challenges. NOVA only briefly touched on Alzheimer’s disease, but provided a comprehensive explanation of ...

April 4, 2012

Ride to Freedom VI

Year 6 of the Ride to Freedom, otherwise known as “RTF VI: Adding Another Thumb,” brings with it another chance to ride with good friends and donate to a good cause. This year, contributions are being made to the Cure Alzheimer’s Fund, a non-profit organization dedicated to funding research with ...

January 4, 2017

Understanding Human Brain Resilience to Alzheimer’s Pathology

2023 Not everyone who harbors classic Alzheimer’s lesions in the brain (e.g., plaques and tangles) develops clinical symptoms of the disease. This study was designed to understand the mechanisms involved in such natural human brain resilience, as they may hold key clues for the design of novel cognitive-sparing therapies in the ...

October 15, 2018

Teresa Gomez-Isla

Symposium Questions and Answers 2017

Answers to questions received during the Cure Alzheimer’s Fund Research Symposium held on October 18, 2017, in Boston, MA.

February 19, 2018

Letter from the Chairs

From our 2011 Annual Report.   Dear Friends, On behalf of the Board of Directors and the Research Consortium, we want to thank all the donors, researchers and academic institutional partners supporting Cure Alzheimer’s Fund research for your help in making 2011 such a successful science year. Guided by leading scientists in the ...

December 5, 2012

Study of Reactive Astrocytes-Derived Oxidative Stress and Proinflammation Leading to Neurodegenerative Microglial Activation in Alzheimer’s Disease

2019 As the recent failures of clinical trials in Alzheimer’s disease have raised questions as to the amyloid hypothesis validity, the “neuroinflammation hypothesis” begins to gain attention to explain AD pathogenesis. The interactions among the innate immune system—astrocytes and microglia—elevate inflammatory impact on AD pathogenesis; however, the mechanisms involved remain poorly ...

December 24, 2018

Hansang Cho

The Controversy Regarding Altered Images In An Alzheimer’s Disease Research Paper

In the weeks prior to the date of this writing, Dr. Lesné of the University of Minnesota was accused of using digital images, intentionally altered, to show false results in papers published in scientific journals over many years. Most notable is a paper published in 2006 in the highly prominent ...

August 3, 2022

Cure Alzheimer’s Fund Applauds the Obama Administration’s NAPA Plan to Fight Alzheimer’s Disease

National Alzheimer’s Project Act (NAPA) Mirrors Cure Alzheimer’s Fund Approach Washington, D.C.—Secretary of Health and Human Services Kathleen Sebelius announced today key implementation steps of the Obama administration’s National Alzheimer’s Project Act (NAPA), including the investment of $100 million toward combating Alzheimer’s disease and the ambitious goal of having effective treatments ...

May 15, 2012

Alzheimer’s and Diabetes: Finding the Common Origin

Answers to webinar questions have been posted below. We will continue to post additional answers as we receive them. On April 4, 2012,  Cure Alzheimer’s Fund Research Consortium member Sam Gandy, M.D., Ph.D., and David Shenk, author of the national bestseller, The Forgetting, presented a webinar about the linkage between Alzheimer’s ...

April 4, 2012