Neuroimmune Consortium: Examining the Impact of Peripherally Derived Human Macrophages in Alzheimer’s Disease Pathogenesis

Inflammation contributes to the development and progression of virtually every human disease. While the brain is considered immune privileged, a growing body of evidence has shown that peripheral inflammation can influence the development of many neurological disorders, including Parkinson’s disease, multiple sclerosis, frontotemporal dementia, and Alzheimer’s disease (AD). Yet the ...

January 11, 2024

Mathew Blurton-Jones

Neuroimmune Consortium: Examining the Role of Human Microglia in the Transition Between Parenchymal and Vascular Amyloid Beta Pathology

2022 Genetic and neuropathological studies have strongly implicated microglia in the development and progression of Alzheimer’s disease (AD). Yet precisely how AD risk genes alter microglial function to impact amyloid beta pathology remains unclear. One popular hypothesis is that microglial risk genes reduce amyloid beta clearance from the brain by impairing ...

December 18, 2020

Mathew Blurton-Jones

Alzheimer’s Disease Making Headlines

Research Update There has been a spate of announcements about promising drug therapies, “new” genes and environmental factors affecting Alzheimer’s disease (AD) in the news lately. These are likely to increase as the media becomes more sensitized to the looming disaster that Alzheimer’s presents to the world. We thought it would ...

August 20, 2009

‘Cancer Protein’ Linked to Alzheimer’s

In a significant discovery, a group of proteins long associated with cancer research has been shown to have an important link to Alzheimer’s disease. Among other implications, this advance could fast-track Alzheimer’s drug development, as there are already relevant therapies in active cancer trials.  The protein family, protein kinase C, also known as ...

April 21, 2015

Does Gum Disease Lead to Alzheimer’s Disease?

There has been a great deal of news surrounding the research implicating gum disease in contributing to Alzheimer’s disease and dementia. It is through the lens of the antimicrobial approach to treating Alzheimer’s disease that the latest study suggesting that periodontal bacteria can play a role in Alzheimer’s disease should be ...

March 15, 2019

Alzstream™ Webinar: From Genes to Therapies

On Feb. 6, we visited the site of the Cure Alzheimer’s Fund Research Consortium’s annual meeting to hear the latest progress from our Genes to Therapies™ Steering Committee. This webinar is moderated by David Shenk, author of “The Forgetting,” and features each of the researchers on the G2T Steering Committee. Learn ...

February 6, 2015

LOVE DEEPLY WEEP FREELY

Lisa Husted founded her company to provide comfort to those whose hearts are full of emotion and to grant them permission to cry in happy times and difficult times. The original design of the REMEMBRANCE handkerchief depicts two grey doves nestled among forget-me-nots, amidst a background of tiny blue dots. ...

October 30, 2020

Understanding Human Brain Resilience to Alzheimer’s Pathology

2023 Not everyone who harbors classic Alzheimer’s lesions in the brain (e.g., plaques and tangles) develops clinical symptoms of the disease. This study was designed to understand the mechanisms involved in such natural human brain resilience, as they may hold key clues for the design of novel cognitive-sparing therapies in the ...

October 15, 2018

Teresa Gomez-Isla

Genetic Targets to Block Tau Propagation: Test Knockdown of Heparan Sulfate Proteoglycan Genes In Vivo

2019 Neuritic plaques surround amyloid deposits and are made up of swollen, dystrophic neural processes that contain aggregated phosphorylated tau. Neurofibrillary tangles are made up of phosphorylated tau that has abnormally been aggregated in Alzheimer’s disease. Tau normally is microtubule adaptor protein involved in the highways of neurons that allow for ...

January 11, 2016

Marc Diamond

Tanzi Testifies Before Senate on Latest Progress of Fast-Track Effort to Map Genes for Alzheimer’s

Washington, May 14, 2008 – Mapping the sequence of the genes susceptible to Alzheimer’s disease provides a novel avenue for potential treatment while also improving the ability to predict risk for Alzheimer’s early in life, Dr. Rudolph Tanzi, chairman of the Cure Alzheimer’s Fund Research Consortium, told the Senate Special ...

May 14, 2008