December 13, 2018
December 13, 2018
By John R. Cirrito, Ph.D., and David M. Holtzman, M.D.Microdialysis Core Facility, Department of Neurology, Hope Center for Neurological Diseases, Washington University, St. Louis, MO A major contributing factor in Alzheimer’s disease is the elevation of a protein called amyloid-β, or Aβ. Since high levels of Aβ play a role in ...
August 20, 2009
Alzheimer’s disease (AD) involves a complex cascade of pathologies, yet current drug discovery initiatives are predominantly centered around reducing amyloid beta levels. Identifying effective targets across the broader AD pathological cascade remains challenging. In this proposal, we will combine unbiased integrated pathway analyses and validation in various three-dimensional (3D) human ...
February 1, 2024
The first family-based genome-wide association study in Alzheimer’s disease has identified the sites of four novel genes that may significantly influence risk for the most common late-onset form of the devastating neurological disorder. BOSTON – The first family-based genome-wide association study in Alzheimer’s disease has identified the sites of four novel ...
October 31, 2008
Chronic sleep deprivation in mice with Alzheimer’s disease-type changes makes Alzheimer’s brain plaques appear earlier and more often, researchers led by Cure Alzheimer’s Fund’s Dr. David M. Holtzman at Washington University School of Medicine in St. Louis reported in Science Express. The study was funded in part by Cure Alzheimer’s ...
December 10, 2009
One of the many challenges presented by Alzheimer’s disease is that different patients decline at very different rates. A recent study suggests differences in tau, the protein that makes up the neurofibrillary tangles in Alzheimer’s pathology, may help explain this observation between individuals. Among the authors are two members of ...
October 23, 2020
There has been a great deal of news surrounding the research implicating gum disease in contributing to Alzheimer’s disease and dementia. It is through the lens of the antimicrobial approach to treating Alzheimer’s disease that the latest study suggesting that periodontal bacteria can play a role in Alzheimer’s disease should be ...
March 15, 2019
In just its first year of operation, Cure Alzheimer’s Fund’s ambitious new Genes to Therapies™ (G2T) research program has bloomed far beyond expectations. “We’re firing on all cylinders now,” says Research Consortium Chair Dr. Rudy Tanzi. “It’s exactly where we need to be headed to stop this disease.” In 2015, Cure Alzheimer’s ...
February 12, 2016
To date, few studies have been conducted that examine racial differences in Alzheimer’s disease biomarkers despite the fact that African Americans may have more than 2-fold increased risk for Alzheimer’s dementia than their white counterparts. A study published on this week in JAMA Neurology by Dr. John Morris, Dr. Krista ...
March 14, 2019
It’s a Sunday morning and my wife and I are arguing about the previous night’s dinner party. “No one would let me talk,” Laurie says. “What do you mean? Of course they let you talk.” “No. They’re all just talking constantly and I never get a chance to say anything.” “But Laurie, that’s what ...
February 18, 2020