Machine learning is the study of algorithms and mathematical models that scientists rely on to progressively improve their performance on a specific task; these algorithms have the potential to provide a computational framework for predicting who will get Alzheimer’s disease. The ability to identify those patients with memory impairment who are ...
December 13, 2018
Julia Grimes passed away peacefully at the age of 75 on November 8, 2020. She was born on August 27, 1945, to Cleetis Raburn and Ernie Mae (Stovall) Raburn in the Centerville community near Mantachie. She grew up as the youngest of their six daughters, who all performed gospel music ...
November 10, 2020
Although the three variants of the APOE gene (APOE2, APOE3, and APOE4) differ only by a single letter (nucleotide), the three variants have vastly different impacts on the brain. For example, APOE4, the main Alzheimer’s disease susceptibility gene, is also known to negatively impact cerebrovascular function. How and why APOE4 ...
December 7, 2021
2024 Alzheimer’s disease (AD) is a major public health threat, a common neurodegenerative disorder, and the primary cause of dementia. The etiology of AD has not been completely elucidated, and there has yet to yield an effective therapy that can prevent, stop, or reverse cognitive deficits associated with AD. Epigenetics refers ...
March 21, 2023
Tauopathies, neurodegenerative disorders characterized by the presence of tau protein in the brain, are more likely to emerge in individuals harboring the APOE4 gene. Compared to other APOE variants, the expression of APOE4 significantly increases neuronal loss, decreases brain volume, and increases glial inflammatory signals. In the absence of APOE, ...
December 7, 2021
Part I. Disease-Modifying Drugs Targeting A-beta By Dr. Rudolph Tanzi, Massachusetts General Hospital Recent developments regarding drugs aimed at treating and preventing Alzheimer’s disease (AD) by targeting the neurotoxic peptide Abeta. This article, the first in a series of pieces reviewing promising new AD drugs in development, focuses on novel therapies based on ...
August 20, 2009
2018 Apolipoprotein E (APOE), the most important genetic predisposition factor for Alzheimer’s disease, seems to have direct effects on the formation of amyloid plaques but also many other plaque-independent effects on different types of brain cells, including on neurons. The precise mechanisms of these effects are not known. We have developed ...
July 25, 2017
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October 1, 2017
Taking advantage of recent research progress, we propose to carry out a compound screen to find potential drugs to treat Alzheimer’s disease (AD). The screen will use a revolutionary 3-D stem cell model, recently developed by Drs. Rudy Tanzi and Doo Yeon Kim at Massachusetts General Hospital, which for the ...
September 30, 2015
2022 For its Ground Hog Day Marathon in 2022, Bald Move again chose to raise funds for CureAlz. Together with their community, they raised $20,020 for vital research into Alzheimer’s disease. 2020 Together with the Bald Move community, we raised just raised over $15,700 in cash donations, plus easily another $1000 in subs ...
February 8, 2021
