Year 2 aims: Diseases that affect learning and memory are of fundamental biological importance and are among the most challenging biomedical problems of our time. We recently demonstrated that compounds that inhibit amyloid precursor protein (APP) dimerization and enhance APP phosphorylation reduce the levels of Abeta, the peptide responsible for the ...
September 29, 2015
Paola Bovolenta is a Research Professor and Chair of the Program “Homeostasis of Tissue and Organs” at the Center for Molecular Biology Severo Ochoa, CSIC-UAM, Madrid, Spain. She obtained her Ph.D. degree at the New York University, School of Medicine, NY, and worked as a postdoctoral fellow at Columbia University, ...
October 22, 2020
2021 Alzheimer’s disease (AD) is the leading cause of dementia, with apolipoprotein E (APOE) being the strongest genetic risk factor. Our project, part of the APOE Consortium, is to define how the APOE2 gene and two other APOE genetic variants—Christchurch (APOE-Ch) and Jacksonville (APOE-Jac)—protect against AD-like outcomes such as amyloid beta ...
April 13, 2020
In our earlier proposal, we tested the hypothesis that the composition of the intestinal microbiome might play a key role in modulating neuroinflammation that, in turn, influences Abeta deposition. We have demonstrated that long-term treatment with an antibiotic (ABX) cocktail does not alter total bacterial abundance in either the cecum ...
July 5, 2016
2021 A major genetic risk factor for sporadic Alzheimer’s disease (AD) is a gene called apolipoprotein E (APOE), which codes for the APOE protein. The version of the APOE gene that confers higher AD risk makes the protein APOE4, while the normal version makes APOE3, and the protective version makes APOE2. Exactly how the different versions of ...
July 25, 2017
Axonal spheroids (dystrophic neurites) associated with amyloid plaques are a significant hallmark of Alzheimer’s disease (AD). Our research has revealed that a single amyloid plaque can induce the development of spheroids in numerous adjacent axons. Using special imaging techniques, we’ve observed that these enlarged spheroids disrupt the flow of electrical ...
June 13, 2024
Eng H. Lo received a BS in engineering at Yale, a PhD in biophysics from UC Berkeley, and completed a neuroscience fellowship at Stanford. In 1991, Dr. Lo joined the Massachusetts General Hospital where he is currently Professor of Radiology and Neuroscience at Harvard. His research interests include neuroprotection and ...
December 7, 2018
Thank you for registering for our ZOOM presentation with Dr. Ron Petersen on August 26th at 5:00 pm EST. To register, please complete the information box below. Once you have registered, you will receive an email with all of the access information and login credentials needed to join the event. ...
July 24, 2020
In a 2014 interview with The New York Times, Dr. Murali Doraiswamy of Duke University went on the record stating that “the lack of a viable model for Alzheimer’s disease has been the Achilles’ heel of the field.” This quote was featured in an article discussing the breakthrough research from ...
October 6, 2019
Myelin, the protective insulation surrounding nerves that enables efficient neural transmission in the brain, is vital for brain function and dysregulated in Alzheimer’s disease (AD). However, the role of myelin and oligodendroglia, the cells that produce myelin, in the onset and progression of AD remains incompletely understood. Sleep and circadian ...
December 8, 2023
