Alzheimer’s disease is the most common form of dementia among older people. The blood-brain barrier is a highly selective permeable barrier that separates the brain from circulating blood. It is formed by brain endothelial cells and prevents harmful materials from the blood from entering the brain. The BBB also plays ...
December 17, 2019
Gary Hugh Johnson 1932 – 2017 His family has lost a loving father and grandfather, his community a respected businessman, and his friends a loyal confidant. After courageously living with Lewy Body Dementia for over nine years, Gary Johnson peacefully left this earth Monday, January 9, 2017. Gary Johnson was born in Shawnee ...
January 10, 2017
At the time of a clinical diagnosis of Alzheimer’s disease (AD), the underlying disease process already has evolved in the affected individuals for often more than a decade and led to irrecoverable brain damage. Without reliable predisease biomarkers, the development and successful application of effective treatment or preventive strategies thus is ...
January 29, 2021
Alzheimer’s disease (AD) is an age-related disease of the central nervous system. Its prevalence has become a major concern in both developed and developing countries. There are 5.4 million AD patients in the United States; 96% of them are age 65 and older, but no disease-modifying drug is available except ...
January 5, 2021
February 3, 2021
Patrik Verstreken obtained his degree in bio-engineering from the University of Brussels in 1998. He joined the Graduate school of Biomedical Sciences at Baylor College of Medicine and under the mentorship of Hugo Bellen, he obtained a Ph.D. in Developmental Biology in 2003. After postdoctoral training and with support of ...
June 7, 2021
Functional disruptions in Alzheimer’s disease (AD) have been well characterized. However, how AD affects the synaptic connectivity in neuronal networks leading to these functional disruptions has remained poorly understood. One major research direction in the principal investigator’s laboratory has been to investigate the synaptic mechanisms, in particular excitatory and inhibitory ...
February 17, 2022
October 31, 2022
2023 Alzheimer’s disease (AD) stands as an age-dependent chronic neurodegenerative condition marked by the accumulation of aberrant proteins in the brain (amyloid and tau), resulting in memory loss and cognitive decline. Notably, before the manifestation of detectable brain plaques and noticeable behavioral changes, there is an onset of dysfunctional neuronal activity. ...
January 5, 2023
This gene provides the instructions for making the presenilin 1 protein. Presenilin 1 is part of the gamma-secretase complex, which cuts other proteins into small pieces. The gamma-secretase complex is best known for cutting the amyloid precursor protein into smaller pieces. One of the resulting pieces is amyloid beta.
April 24, 2023
