Proteomics of Alzheimer’s Disease Three-Dimensional Cultures

2020

The goal of this proposed project is to understand the composition of different proteins in a three-dimensional model of Alzheimer’s disease (AD) brain and the responses of these proteins to drugs that will be repurposed and tested for potential therapeutic use for AD. We will focus on specific groups of proteins involved in inflammation and their relationship to AD pathological proteins. The proposed research will provide critical information about potential AD therapeutics and their effectiveness in the model system.


Funding to Date

$172,500

Focus

Drug Discovery, Genes to Therapies™

Researchers

Weiming Xia, Ph.D.