Identifying the Blood-Brain Barrier Changes During Alzheimer’s Disease

2018

Alzheimer’s disease is the leading cause of dementia. It has been suggested recently that dysfunction of the blood vessels in the brain may be an important component of this disease; however, very little is known about how blood vessels in the brain change during Alzheimer’s disease and how this may contribute to the onset and progression of dementia. We aim to determine how the blood vessels in the brain change during Alzheimer’s and how these changes affect the brain. Our ultimate goal is to determine whether the blood vessels in the brain may be a potential therapeutic target to treat patients with Alzheimer’s disease.

 


Funding to Date

$172,500

Focus

Foundational Genetics, Pathological Pathways and Systems

Researchers

Richard Daneman, Ph.D.