Neurobiological Basis of Cognitive Impairment in African Americans: Deep Phenotyping of Older African Americans at Risk of Dementia—The Dementia (in) African American Population Phenotyping (for) Potential Elevated Risk (DAAPPER) Study

2018, 2022

This proposal will leverage activities of the Michigan Alzheimer’s Disease Center to explore the neurobiological basis of dementia in African Americans, an understudied population about which we still lack fundamental knowledge regarding biomarkers of cognitive impairment. Through these studies, we hope to determine whether vascular compromise and increased amyloid and/or tau deposition have unique or synergistic effects on cognition. This information may be crucial in designing new pharmacological and nonpharmacological interventions, and in providing important information about targeted enrollment for such interventions.

Benjamin M. Hampstead, Ph.D., ABPP/CN Biomarkers/Diagnostics/Studies of Risk & Resilience Bruno Giordani, Ph.D. Foundational Henry Paulson

Related Content:

Utility of Blood-Based Markers for Predicting Amyloid-Related Imaging Abnormalities and Their Course in Mild Cognitive Impairment and Alzheimer’s Disease Subjects Undergoing Routine Clinical Treatment with Amyloid-Directed Antibodies P. Murali Doraiswamy 2024-01-12 Characterization of the Longitudinal Trajectories of the Synaptic Blood Marker Beta-Synuclein during Alzheimer’s Disease Pathogenesis and Improvement of the Measurement Procedure Patrick Oeckl Markus Otto 2023-09-19 Precision Medicine Prediction Model for Alzheimer’s Disease Using Cooperative Learning Approaches for Multi-Omic Data Christoph Lange 2023-05-02 Adding Genomics and Methylomics to Personalized Disease Prediction for Alzheimer’s Disease (EPIC4AD) Lars Bertram Christina M. Lill 2023-02-28 Identification and Validation of Plasma-Based Lipid Biomarkers for Early Alzheimer’s Disease in the Unique, Primarily Hispanic, South Texas Population Xianlin Han Bernard Fongang Juan Pablo Palavicini Tiffany F. Kautz 2023-02-23 Cerebrospinal Fluid Neuroinflammatory Signature in Alzheimer´s Disease and Related Proteopathies Mathias Jucker Stefan Lichtenthaler Stephan Kaeser 2022-11-22 Neuronal Subtype-Specific Modeling of Alzheimer’s Disease by Direct Neuronal Reprogramming of Patient Fibroblasts Andrew S. Yoo 2022-02-17 Targeted Recruitment of Underrepresented Americans for Brain Donation Registration Brain Donor Project 2022-02-10