Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers resulting from our research grants. The researchers we have funded have published nearly 200 papers, which have been cited over 10,300 times. The work reflected in these papers has helped us to better understand Alzheimer’s and find ways to intervene that may lead to slowing or reversing the disease. We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate them for the important work they are doing. We also are grateful to our donors, who have made this work possible. Without your support and generosity, these papers and the forward momentum they represent would not exist.

2017

Tal Nuriel, Sergio L. Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y. Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S. Gross, S. Abid Hussaini, Herman Moreno, Scott A. Small, Karen E. Duff, Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology, Nature Communications, 8, 13 Nov 2017
Jean-Vianney Haure-Mirande, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, William L. Klein, Charles Glabe, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Minghui Wang, Bin Zhang, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich, Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology, Acta Neuropathologica, 134(5), Nov 2017, 769-788
Na Zhao, Chia-Chen Liu, Alexandra J. Van Ingelgom, Yuka A. Martens, Cynthia Linares, Joshua A. Knight, Meghan M. Painter, Patrick M. Sullivan, Guojun Bu, Apolipoprotein E4 Impairs Neuronal Insulin Signaling, Neuron, 96(1), 27 Sep 2017, 115-129
Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy, CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5, 27 Oct 2017, 77
Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, David M. Holtzman, TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy, Proceedings of the National Academy of Sciences of the United States of America, 114(43), 24 Oct 2017, 11524–11529
Amine Meliani, Florence Boisgerault, Zachary Fitzpatrick, Solenne Marmier, Christian Leborgne, Fanny Collaud, Marcelo Simon Sola, Severine Charles, Giuseppe Ronzitti, Alban Vignaud, Laetitia van Wittenberghe, Beatrice Marolleau, Fabienne Jouen, Sisareuth Tan, Olivier Boyer, Olivier Christophe, Alain R. Brisson, Casey A. Maguire, Federico Mingozzi, Enhanced liver gene transfer and evasion of preexisting humoral immunity with exosome-enveloped AAV vectors, Blood Advances, 1(23), 24 Oct 2017, 2019-2031
Christina D. Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y. Nguyen, Allison Wing, Emily L. Goldberg, Yun-Hee Youm, Chester W. Brown, John Elsworth, Matthew S. Rodeheffer, Joachim L. Schultze, Vishwa Deep Dixit, Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing, Nature, 550(7674), 5 Oct 2017, 119-123
Jordan J.S. VerPlank, Alfred L. Goldberg, Regulating protein breakdown through proteasome phosphorylation, Biochemical Journal, 474(19), 1 Oct 2017, 3355-3371
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass, An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function, EMBO Molecular Medicine, 9(10), Oct 2017, 1356-1365
Petra Füger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M. Wegenast-Braun, Jonas J. Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras, Mathias Jucker, Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging, Nature Neuroscience, 20(10), Oct 2017, 1371-1376
John S. Lazo, Kelley E. McQueeney, Elizabeth R. Sharlow, New Approaches to Difficult Drug Targets: The Phosphatase Story, SLAS DISCOVERY, 22(9), Oct 2017, 1071-1083
George S.Bloom, John S.Lazo, Andrés Norambuena, Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis, Neuropharmacology, 29 Sep 2017
Kanchana Padmanabhan, Katie Shpanskaya, Gonzalo Bello, P. Murali Doraiswamy, Nagiza F. Samatova, Toward Personalized Network Biomarkers in Alzheimer's Disease: Computing Individualized Genomic and Protein Crosstalk Maps, Frontiers in Aging Neuroscience, 26 Sep 2017
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T. Smith, Lingzhi Zhao, Wenjie Luo, Richard M. Tsai, Salvatore Spina, Lea T. Grinberg, Julio C. Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M. Sullivan, Caroline Baufeld, Michael W. Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L. Del-Aguila, John C. Morris, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Anne M. Fagan, Bruce L. Miller, Adam L. Boxer, William W. Seeley, Oleg Butovsky, Ben A. Barres, Steven M. Paul, David M. Holtzman, ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy, Nature, 20 Sep 2017
Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O’Loughlin, Yang Xu, Zain Fanek, David J. Greco, Scott T. Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D. Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L. Heppner, Vladimir Litvak, David M. Holtzman, Hans Lassmann, Howard L. Weiner, Jordi Ochando, Christian Haass, Oleg Butovsky, The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases, Immunity, 47(3), 19 Sep 2017, 566-581
Daniel G. Abernathy, Woo Kyung Kim, Matthew J. McCoy, Allison M. Lake, Rebecca Ouwenga, Seong Won Lee, Xiaoyun Xing, Daofeng Li, Hyung Joo Lee, Robert O. Heuckeroth, Joseph D. Dougherty, Ting Wang, Andrew S. Yoo, MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts, Cell Stem Cell, 21(3), 7 Sep 2017, 332-348
Myles R. Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W. Musch, Xunuo Shen, Bana Jabri, Eugene B. Change, Rudolph E. Tanzi, Sangram Sisodia, Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(Delta E9) murine model of Alzheimer's disease, Scientific Reports, 7, 5 Sep 2017
Hyung Jin Ahn, Zu-Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland, Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease, Current Opinion In Hematology, 24(5), 1 Sep 2017, 427-431
Kanchana Padmanabhan, Kelly Nudelman, Steve Harenberg, Gonzalo Bello, Dongwha Sohn, Katie Shpanskaya, Priyanka Tiwari Dikshit, Pallavi S. Yerramsetty, Rudolph E. Tanzi, Andrew J. Saykin, Jeffrey R. Petrella, P. Murali Doraiswamy, Nagiza F. Samatova, Alzheimer’s Disease Neuroimaging Initiative, Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer's Disease: A New Computational Approach, Processes, 5(3), Sep 2017, 47
Norelle C. Wildburger, Thomas J. Esparza, Richard D. LeDuc, Ryan T. Fellers, Paul M. Thomas, Nigel J. Cairns, Neil L. Kelleher, Randall J. Bateman, David L. Brody, Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain, Scientific Reports, 7, 25 Aug 2017
David L. Brody, Hao Jiang, Norelle Wildburger, Thomas J. Esparza, Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer's disease, Alzheimers Research & Therapy, 9(1), 17 Aug 2017, 62
Tyler K. Ulland, Wilbur M. Song, 7, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna, TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease, Cell, 170(4), 10 Aug 2017, 649–663
Vitaliy Ovod, Kara N. Ramsey, Kwasi G. Mawuenyega, Jim G. Bollinger, Terry Hicks, Theresa Schneider, Melissa Sullivan, Katrina Paumier, David M. Holtzman, John C. Morris, Tammie Benzinger, Anne M. Fagan, Bruce W. Patterson, Randall J. Bateman, Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis, Alzheimers & Dementia, 13(8), Aug 2017, 841-849
Dragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, P. Murali Doraiswamy, Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease, Scientific Reports, 7, 28 Jul 2017
Feng Liang, Yu Wan, Diane Schaak, Joseph Ward, Xunuo Shen, Rudolph E. Tanzi, Can Zhang, Qimin Quan, Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's diseaserelated oligomers by curcumin, Scientific Reports, 7, 18 Jul 2017
Jing Zhao, Mary D. Davis, Yuka A. Martens, Mitsuru Shinohara, Neill R. Graff-Radford, Steven G. Younkin, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu, APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics, 26(14), 15 Jul 2017, 2690-2700
Lies Schoonaert, Laura Rue, Bart Roucourt, Mieke Timmers, Susan Little, Lucia Chavez-Gutierrez, Maarten Dewilde, Peter Joyce, Adam Curnock, Peter Weber, Jurgen Haustraete, Gholamreza Hassanzadeh-Ghassabeh, Bart De Strooper, Ludo Van den Bosch, Philip Van Damme, Robin Lemmens, Wim Robberecht, Identification and characterization of Nanobodies targeting the EphA4 receptor, Journal Of Biological Chemistry, 292(27), 7 Jul 2017, 11452-11465
Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez‐Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass, The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, Embo Journal, 36(13), 3 Jul 2017, 1837-1853
Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman, Rudolph E. Tanzi, Pharmacological and Toxicological Properties of the Potent Oral gamma-Secretase Modulator BPN-15606, Journal Of Pharmacology And Experimental Therapeutics, 362(1), Jul 2017, 31-44
Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu, Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies, Journal Of Lipid Research, 58(7), Jul 2017, 1267-1281
Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Chen, TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers In Aging Neuroscience, 9, 21 Jun 2017, 204
Hyoung Tae Kim, Alfred L. Goldberg, The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis, Journal Of Biological Chemistry, 292(23), 9 Jun 2017, 9830-9839
Sarah K. Kaufman, Talitha L. Thomas, Kelly Del Tredici, Heiko Braak, Marc I. Diamond, Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue, Acta Neuropathologica Communications, 5, 7 Jun 2017, 41
Evan P. Lebois, Jason P. Schroeder, Thomas J. Esparza, Thomas M. Bridges, Craig W. Lindsley, P. Jeffrey Conn, David L. Brody, J. Scott Daniels, Allan I. Levey, Disease-Modifying Effects of M-1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model, Acs Chemical Neuroscience, 8(6), Jun 2017, 1177-1187
Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S. Boyden, Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell, 169(6), 1 Jun 2017, 1029-1041
Galen Andrew Collins, Alfred L. Goldberg, The Logic of the 26S Proteasome, Cell, 169(5), 18 May 2017, 792-806
Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass, TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports, 8 May 2017
Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland, Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice, Blood, 129(18), 4 May 2017, 2547-2556
Justin T. Rogers, Chia-Chen Liu, Na Zhao, Jian Wang, Travis Putzke, Longyu Yang, Mitsuru Shinohara, John D. Fryer, Takahisa Kanekiyo, Guojun Bu, Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging, 53, May 2017, 112-121
Jason D. Ulrich, Tyler K. Ulland, Marco Colonna, and David M. Holtzman, Elucidating the Role of TREM2 in Alzheimer’s Disease, Neuron, 94, 19 Apr 2017, 237-248
Paul Temkin, Wade Morishita, Debanjan Goswami, Kristin Arendt, Lu Chen, Robert Malenka, The Retromer Supports AMPA Receptor Trafficking During LTP, Neuron, 94(1), 5 Apr 2017, 74–82
Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph E. Tanzi, Marco Colonna, Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 13(4), Apr 2017, 381–387
L Ashley Watson, Li-Huei Tsai, In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology, 43, April 2017, 48-55
Bevan S. Main, Myles R. Minter, Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, 11, 23 Mar 2017, 151
Heide Loehlein Fier, Dmitry Prokopenko, Julian Hecker, Michael H. Cho, Edwin K. Silverman, Scott T. Weiss, Rudolph E. Tanzi, Christoph Lange, On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology, 41(4), 20 Mar 2017, 332–340
Jerrah K. Holth, Thomas E. Mahan, Grace O. Robinson, Andreia Rocha, David M. Holtzman, Altered sleep and EEG power in the P301S Tau transgenic mouse model, Ann Clin Transl Neurol, 4(3), 15 Feb 2017, 180-190
William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos, Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage, PNAS, 114(6), 7 Feb 2017, 1389–1394
Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S. Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W. Mandell, George S. Bloom, mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease, Alzheimer's & Dementia, 13(2), Feb 2017, 152-167
Randolph M. Nesse, Caleb E. Finch, and Charles L. Nunn, Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?, Evol Med Public Health, 2017(1), 24 Jan 2017, 39-46
Dylan Kwart, Dominik Paquet, Shaun Teo and Marc Tessier-Lavigne, Precise and efficient scarless genome editing in stem cells using CORRECT, Nature Protocols, 12, 19 Jan 2017, 329–354