Cure Alzheimer's Fund Cure Alzheimer's Fund

Casey A. Maguire, Ph.D.

Casey A. Maguire obtained his B.S. from the University of Maine in 2000, and his Ph.D. from the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry in 2006. He was a postdoctoral fellow at Massachusetts General Hospital from 2006-2010. He was next an Instructor from 2010-2013. Currently, he is an Assistant Professor of Neurology at Harvard Medical School with laboratory space at the MGH. His labatory is focused on the development of effective gene delivery vehicles for in vivo gene therapy of various genetic diseases including Alzheimer’s disease. The current focus of the Maguire lab is the development of a unique hybrid gene delivery system called vexosomes. Vexosomes are endogenously enveloped adeno-associated virus (AAV) vectors. The envelope is derived from extracellular vesicles (EVs) which are natural lipid based nanoparticles released by cells. We have showns that EVs have several properties which enhance AAV-mediated gene delivery.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Extracellular Vesicle-Based Targeting of CD33-Mediated Pathology for Alzheimer’s Disease Therapy 2015 to 2016

$300,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Amine Meliani, Florence Boisgerault, Zachary Fitzpatrick, Solenne Marmier, Christian Leborgne, Fanny Collaud, Marcelo Simon Sola, Severine Charles, Giuseppe Ronzitti, Alban Vignaud, Laetitia van Wittenberghe, Beatrice Marolleau, Fabienne Jouen, Sisareuth Tan, Olivier Boyer, Olivier Christophe, Alain R. Brisson, Casey A. Maguire, Federico Mingozzi Enhanced liver gene transfer and evasion of preexisting humoral immunity with exosome-enveloped AAV vectors, Blood Advances, 1(23), 24 Oct 2017, 2019-2031, Read More

Back to Our Researchers