These projects were made possible from Cure Alzheimer's Fund support.
|Optimization of Novel ACAT Inhibitors for Alzheimer’s Disease||
|Three Studies of ACAT Inhibitors as Potential Therapies for AD||
2004 to 2010
These published papers resulted from Cure Alzheimer’s Fund support.
Carla D’Avanzo, Christopher Sliwinski, Steven L. Wagner, Rudolph E. Tanzi, Doo Yeon Kim, and Dora M. Kovacs γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal, 29(8), 22 April 2015, 3335-3341, Read More
Raja Bhattacharyya, Cory Barren, Dora M. Kovacs Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts, The Journal of Neuroscience, 33(27), 3 July 2013, 11169-83, Read More, Download Paper
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels, FASEB J, 27(6), June 2013, 2458-67, Read More
Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Curr Mol Med., Sep 3, 2012, Read More
Huttunen HJ, Hutter-Paier B, Barren C, Peach C, Havas D, Duller S, Xia W, Frosch MP, Windisch M, Kovacs DM. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice, Journal of Neuropathology and Experimental Neurology, 69(8), August 2010, 777-88, Read More