Charlotte & Paul Hagemann Professor of Neurology and Co-Director, Center On Biological Rhythms And Sleep (COBRAS), Washington University School of Medicine in St. Louis
Dr. Musiek is currently the Charlotte & Paul Hagemann Professor of Neurology and Co-Director of the Center On Biological Rhythms And Sleep (COBRAS) at Washington University School of Medicine in St. Louis. He received his M.D. and Ph.D. from Vanderbilt University, and completed neurology residency at University of Pennsylvania before moving to Washington University for fellowship training in dementia, under the mentorship of Drs. John Morris and David Holtzman. He subsequently started his own lab at Washington University.
Clinically, Dr. Musiek is a neurologist with a specialty in memory disorders and dementia, and a member of the Knight Alzheimer’s Disease Research Center. His lab research focuses on circadian rhythms and clock gene function in the regulation of brain redox signaling and neurodegeneration, particularly in Alzheimer’s Disease. His work employs mouse and cellular models, and examines the role of circadian clock genes in neuronal homeostasis, the consequences of circadian dysfunction in models of neurodegenerative diseases, and the effect of age-related neurodegenerative disease (such as Alzheimer’s Disease) on circadian systems. The goal of these lines of inquiry is to identify novel neuroprotective strategies based on the endogenous circadian system and its regulation of brain susceptibility to neurodegenerative insults. Dr. Musiek is an investigator in several clinical studies through the Knight Alzheimer’s Disease Research Center at Washington University, and also conducts clinically-oriented research examining circadian rhythms in humans and how they relate to biomarkers of Alzheimer’s Disease pathology.