December 14, 2021
December 14, 2021
Alzheimer’s disease and Type II diabetes long have been observed to have a clinical connection, with patients with diabetes more than twice as likely as those without the disease to develop Alzheimer’s. But the precise nature of this connection has been a mystery until recently. Over the last few years, ...
March 6, 2012
Dr. Jonathan (Jony) Kipnis’s research group focuses on the complex interactions between the immune system and the central nervous system (CNS). The goal is to elucidate the cellular and molecular mechanisms underlying these interactions in neurodegenerative, neurodevelopmental, and mental disorders as well as in physiology (including healthy aging). Kipnis’s research team ...
May 24, 2017
Nasally administered anti-CD3 monoclonal antibody induces an anti-inflammatory immune response that attenuates neuroinflammation in the brain resident microglia and astrocytes. The mechanism of action of nasal anti-CD3 is associated with the induction of regulatory T cells (Tregs) in the cervical lymph node and the subsequent migration of these Tregs to ...
October 25, 2023
In healthy humans, the cerebrospinal fluid (CSF) is renewed approximately four times a day. In aging adults, impaired function of lymphatic vessels in the meninges can lead to accelerated accumulation of toxic amyloid beta protein in the brain. The meninges are made up of membranes that line the skull in ...
December 13, 2018
In healthy humans, the cerebrospinal fluid (CSF) is renewed approximately four times per day, and the skull is lined with membranes that protect the brain and spinal cord. More than 200 years ago, it was speculated that the brain was also protected by lymphatic vessels whose purpose is, among other ...
March 28, 2019
Despite evidence demonstrating that impairments in the clearance of toxic waste in the brain contribute to late-onset Alzheimer’s disease, the science of lymphatic system dysfunction and the systems regulating entry and exit through the blood-brain barrier has been largely overlooked in Alzheimer’s disease — until now. The Maxine and Richard ...
December 19, 2019
OLEG BUTOVSKY, Ph.D. Dr. Butovsky’s major scientific interest is to understand the biology of resident microglia and peripheral inflammatory monocytes in homeostasis and neurodegenerative conditions. During his Ph.D. studies at the Weizmann Institute of Science, he investigated the role of microglia in regulating the Aβ plaque deposition in Alzheimer’s models and ...
December 19, 2019
“The Central Nervous System (CNS) was historically considered as an immune privileged organ. Key factors contributing to immune privilege were considered to be the blood-brain barrier and the lack of lymphatic drainage of the CNS, which results in a physical disconnect with the immune system. Our lab has shattered the ...
October 7, 2022
October 31, 2022