Cure Alzheimer's Fund Cure Alzheimer's Fund

Since our inception in 2004, our steadfast focus has been providing research grants to the worlds’ leading scientists researching Alzheimer’s disease. We are honored to work with scientists who are passionate in their pursuit to rid our world of this debilitating disease.

Many of the funded projects have resulted in significant breakthroughs in developing a better understanding of Alzheimer’s disease and getting closer to a cure.


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Title Researchers Date
The Role of Astrocyte-Secreted Insulin-like Growth Factor Binding Protein 2 (IGFBP2) in the Progression of Alzheimer’s Disease Nicola Allen 2024-04-09
Specificity of T Cell Responses in Autosomal Dominant Alzheimer’s Disease (ADAD) Naresha Saligrama 2024-03-19
Neuroimmune Consortium: Astrocyte Inflammatory Contributions to Alzheimer’s Disease Shane Liddelow 2024-03-18
Cellular Vulnerability to Pathological Tau Protein Accumulation in Alzheimer’s Disease Mathieu Bourdenx Karen Duff 2024-03-18
Preclinical Analysis of Synaptogyrin-3 Oligonucleotides to Target Tauopathy Patrik Verstreken 2024-03-18
Tau and Amyloid Beta are Innate Immune Antimicrobial Peptides in the Brain William Eimer 2024-02-29
Decipher the Astrocyte Cell-Surface Proteome in Alzheimer’s Disease Hui Zheng Junmin Peng 2024-02-28
Elucidating the Therapeutic Potential of the Endo-Lysosome Pathway for Alzheimer’s Disease Jessica Young 2024-02-28
T-Cell Modulation of Microglia to Treat Alzheimer’s Disease Howard L. Weiner 2024-02-28
Investigating the Association Between Clonal Hematopoiesis and Alzheimer’s Disease Cameron McAlpine 2024-02-28
Multiomic and Functional Characterization of sTREM2 Modifiers Carlos Cruchaga 2024-02-28
Systematic Assessment of Tandem Repeats in Alzheimer’s Disease (STaR-AD) Lars Bertram Valerija Dobricic 2024-02-28
General Scientific Support Wilma Wasco 2024-02-06
Defining a Role for the MS4A Genes in Alzheimer’s Disease Sandeep Robert Datta 2024-02-01
Neuroimmune Consortium: Impact of AD Polygenic Risk Score on Microglial Response to Peripheral Inflammation Martine Therrien 2024-02-01
ADAM10 Cleavage of Amyloid Precursor Protein: Physiological Function in the Brain and Therapeutic Potential for Alzheimer’s Disease Jaehong Suh, Ph.D. 2024-02-01
Interpreting Alzheimer’s Disease-Associated Genetic Variation at Enhancer Regions Andreas R. Pfenning 2024-02-01
Moving the Cure Alzheimer’s Fund Genome Project Beyond Simple Associations: Integrating Functional Information, Fine-Mapping and Causal Inference Approaches into the Family-Based Analysis of the Cure Alzheimer’s Fund Whole-Genome Sequencing (WGS) Family Study Christoph Lange 2024-02-01
Do Classical Complement Activation and the Route of Administration of Anti-Amyloid Antibodies Contribute to Vascular Side Effects Known as Amyloid-Related Imaging Abnormalities? Cynthia A. Lemere 2024-02-01
Exploring Novel Drug Candidates for Alzheimer’s Disease Through Integrative Pathway Analysis and Validation in 3D Cellular Models Doo Yeon Kim Luisa Quinti 2024-02-01
Development of Small Molecule Inhibitors of Cholesterol 25-hydroxylase Anil Cashikar Bahaa Elgendy 2024-02-01
Characterization and Validation of Two Recently Created Sheep Models of Alzheimer’s Disease in Preparation for Use as a Preclinical Pharmaceutical Testing Model Russell G. Snell Natasha McKean 2024-01-31
A New Model of Microglia Genetic Perturbation in Vivo to Screen All Risk Factors Associated with Alzheimer’s Disease Oleg Butovsky Vijay K. Kuchroo 2024-01-12
Investigating the Role of Tau Protein in Neuronal Senescence Miranda Orr 2024-01-12
Deciphering and Restoring Computational Setpoints in Alzheimer’s Disease Through Sleep-Enhanced Network Homeostasis Keith Hengen 2024-01-12
Utility of Blood-Based Markers for Predicting Amyloid-Related Imaging Abnormalities and Their Course in Mild Cognitive Impairment and Alzheimer’s Disease Subjects Undergoing Routine Clinical Treatment with Amyloid-Directed Antibodies P. Murali Doraiswamy 2024-01-12
Understanding the Dynamic Lipid-Immunometabolome of Protective and Risk Alzheimer’s Microglia Rik van der Kant 2024-01-12
Neuroimmune Consortium: Mechanisms Mediating Microglia Sensing of Peripheral Inflammation Christopher K. Glass 2024-01-11
Neuroimmune Consortium: Effects of Peripheral Inflammation on Myeloid Cell Function in Alzheimer’s Disease Beth Stevens 2024-01-11
Extracellular ATP is a Key Factor in Promoting Alzheimer’s Disease Neuroinflammation Paola Pizzo Francesco Di Virgilio 2024-01-11
Neuroimmune Consortium: Examining the Impact of Peripherally Derived Human Macrophages in Alzheimer’s Disease Pathogenesis Mathew Blurton-Jones 2024-01-11
Investigating MEF2C Transcription Factor as a Therapeutic Target to Reprogram Pathological Microglial States in Alzheimer’s Disease Alison Goate Edoardo Marcora 2024-01-11
Morphological, Electrophysiological and Transcriptional Characterization of Single Neurons from Resilient and Susceptible Models of Human Alzheimer’s Disease Catherine Kaczorowski Shannon Moore 2024-01-10
Neuronal Mechanisms Driving Synapse Loss in Alzheimer’s Disease Martin Kampmann 2024-01-10
A Multimodality Study on the Lipid Molecular Basis of Obesity and Its Roles in Regulating Alzheimer’s Pathogenesis for Developing Potential Targeted Interventions Stephen T.C. Wong 2024-01-10
Role of Checkpoint Molecules TIM-3 and LAG-3 in Microglial Function in Alzheimer’s Disease Vijay K. Kuchroo 2023-12-21
To Elucidate the Role of Memory T Cells as a Determinant of Age-Related Inflammation in Alzheimer’s Disease Susan M. Kaech 2023-12-21
Neuroproteasomes Mechanistically Connect APOE Isoforms to Endogenous Tau Aggregation Kapil V. Ramachandran 2023-12-21
APP Gene Dose-Mediated Dysregulation of the Endolysosomal Network Acts to Compromise Synaptic Structure and Function Leading to Alzheimer’s Disease in Down Syndrome William C. Mobley 2023-12-21
The Role of Interferon-Induced Transmembrane Protein 3 (IFITM3) and Gamma-Secretase in Microglia Yueming Li 2023-12-21
Neuroinflammation at the Choroid Plexus in Alzheimer’s Disease Maria Lehtinen Liisa Myllykangas 2023-12-21
Investigating Lysosomal Mechanisms of Risk and Resilience in Alzheimer’s Disease Joel Blanchard 2023-12-09
Multiomics Characterization of Tau Pathology Onset and Its Relationship with Amyloid in the Human Hippocampus Inma Cobos 2023-12-09
Restore Meningeal Lymphatic Drainage to Alleviate White Matter Damage and Cerebral Amyloid Angiopathy in a Model of Alzheimer’s Disease Sandro Da Mesquita 2023-12-09
Circadian Desynchrony, Glial Dysfunction and Alzheimer’s Disease Pathogenesis Erik S. Musiek 2023-12-09
Contribution of Skull Bone Marrow-Derived Cells to Alzheimer’s Disease Jonathan Kipnis 2023-12-08
Oligodendroglial Dynamics and Myelination in Alzheimer’s Disease Erin M. Gibson 2023-12-08
Identifying Mediators of Tau-Mediated Neuronal Necroptosis Using an Innovative In Vivo CRISPR Screen Bart De Strooper Sriram Balusu 2023-12-08
Scaling the Divide in Alzheimer’s Disease: An Integrated Molecular, Cellular and Network-Level Study Marc Aurel Busche Samuel Harris 2023-12-08
Mechanisms of Astrocyte-Derived Lipid Toxicity in Alzheimer’s Disease Shane Liddelow 2023-12-08
Noncoding Translation Feedback Loop in Alzheimer’s Disease Xuebing Wu 2023-12-08
Growth, Characterization and Distribution of a Neurodegenerative Disease-Focused Fibroblast/iPS Cell Bank to Support Molecular Models of Patient-Specific Variation with Validation in Matched Donated Brain Tissues Derek H. Oakley 2023-12-08
Microbiome Consortium: Interaction of the Microbiome with Astrocytes and Amyloid Pathology Robert Vassar 2023-11-02
Microbiome Consortium: Microbial Profiling of Human Brain and Gut Microbiomes in Alzheimer’s Disease Rudy Tanzi Nanda Kumar Navalpur Shanmugam 2023-11-02
Microbiome Consortium: Temporal Relationships Between Gut Dysbiosis, Brain Amyloid Beta Metabolism and Microglia Cell Activation Following Antibiotic Treatment Sangram S. Sisodia 2023-11-02
Microbiome Consortium: The Role of Gut Microbial Metabolism in Tau-Mediated Neurodegeneration David Holtzman 2023-11-02
Microbiome Consortium: Harnessing Diet-Microbe Interactions to Prevent Alzheimer’s Disease Pathogenesis Laura Cox 2023-11-02
Elucidating the Protective Effects of APOE2 in the Presence of APOE4 Gene Allele in Animal Models Na Zhao Yingxue Ren 2023-11-02
Role of Stabilization of MAMs and MAM-Associated Palmitoylated APP (MAM-palAPP) in Alzheimer’s Disease Raja Bhattacharyya 2023-11-02
Mitochondrial Alzheimer’s Risk Factors Control APOE Expression and Secretion Victor Faundez 2023-10-26
Targeting Neuroinflammation with Nasal Administration of Anti-CD3 Monoclonal Antibody to Treat Alzheimer’s Disease Rafael M. Rezende 2023-10-25
Multidisciplinary Phenotyping of a Novel Humanized LOAD Mouse Model Giuseppina Tesco 2023-10-25
Elucidating the Role of CLEC7A in Tau-Mediated Neurodegenerative Disease John R. Lukens 2023-10-25
Validation and Characterization of Compounds Modulating Neuroinflammation and Amyloid Beta Uptake in Microglial Cells Ana Griciuc Luisa Quinti 2023-10-25
Identification and Development of CD33 Inhibitors and Pre-RNA Splicing Modulators Subhash Sinha 2023-10-25
Dissecting Alzheimer’s Disease Phenotypes in Directly Reprogrammed Patient-Derived Neurons Andrew S. Yoo 2023-10-25
Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease Se Hoon Choi Christiane Wrann 2023-10-25
Tau-Induced Postsynaptic Dysfunction in Tauopathy Models Karin Hochrainer Costantino Iadecola 2023-09-19
Role of CD8+ T-Cell-Glial Interactions in Mediating Alzheimer’s Disease Pathogenesis Mehdi Jorfi Joseph Park Rudy Tanzi 2023-09-19
Characterization of the Longitudinal Trajectories of the Synaptic Blood Marker Beta-Synuclein during Alzheimer’s Disease Pathogenesis and Improvement of the Measurement Procedure Patrick Oeckl Markus Otto 2023-09-19
Endogenous Human Antibodies Associated with Alzheimer’s Disease Charles Glabe 2023-09-19
In Vivo Models for Golgi Fragmentation and the Molecular Pathogenesis of Alzheimer’s Disease Sam Gandy Yanzhuang Wang 2023-09-19
Functional Changes to Cerebrospinal Fluid Immune Cells Resulting from Bacillus Calmette-Guérin (BCG) Vaccination in Older Adults With and Without Alzheimer’s Disease Marc Weinberg Steven Arnold 2023-07-11
Role of Ras and Rab Interactor 3 (RIN3) and Bridging Integrator 1(BIN1) Interaction in the Neurons for Alzheimer’s Disease Development Raja Bhattacharyya 2023-07-10
Characterizing Gut Bacteriome-Mycobiome Synergy in Correlation to Amylin-Amyloid Beta Antimicrobial Synergy in Alzheimer’s Disease (AD) in AD Mouse Models Deepak Kumar Vijaya Kumar 2023-05-02
Decoding Microbial Products Modulating Alzheimer’s Disease—Toward Precision Postbiotics Treatment Eran Elinav 2023-05-02
CIRCUITS: Dissecting Microglial State Dynamics in Alzheimer’s Disease Li-Huei Tsai 2023-05-02
Brain Entry and Exit Consortium: A 3D In Vitro Neurovascular Human Brain Model With Meningeal Lymphatics for Elucidating Mechanisms Underlying Alzheimer’s Disease Se Hoon Choi 2023-05-02
Genomic Variant Calling and Data Management for the Cure Alzheimer’s Fund Alzheimer’s Genome Project™ Winston Hide 2023-05-02
Precision Medicine Prediction Model for Alzheimer’s Disease Using Cooperative Learning Approaches for Multi-Omic Data Christoph Lange 2023-05-02
Antiviral T Cell Infiltration to the Meninges and Brain Influences Neurodegeneration in Alzheimer’s Disease Jasmin Herz 2023-03-23
Characterization of CNS-Penetrant HDAC11-Selective Inhibitors in Alzheimer’s Disease Models Can (Martin) Zhang Changning Wang 2023-03-21
Genetic Ancestry-Specific Risk Estimation of Alzheimer’s Disease in the APOE Region Christoph Lange 2023-03-21
Effect of APOE Genotype in a Novel Rat Model of Cerebral Amyloid Angiopathy William Van Nostrand 2023-03-21
Analytical and Statistical Tools for Sequence Analysis for Alzheimer’s Disease Christoph Lange 2023-02-28
Adding Genomics and Methylomics to Personalized Disease Prediction for Alzheimer’s Disease (EPIC4AD) Lars Bertram Christina M. Lill 2023-02-28
Identification and Validation of Plasma-Based Lipid Biomarkers for Early Alzheimer’s Disease in the Unique, Primarily Hispanic, South Texas Population Xianlin Han Bernard Fongang Juan Pablo Palavicini Tiffany F. Kautz 2023-02-23
A Proposal to Evaluate the Effect of Bacillus Calmette-Guérin Vaccination on Alzheimer’s Disease Development Tamir Ben-Hur Herve Bercovier 2023-02-23
The Impact of Mutations in the Ligand-Binding Domain of CD33 on Alzheimer’s Disease Pathogenesis Ana Griciuc 2023-02-22
Structural Mimicry in Microbial and Antimicrobial Amyloids Connected to Neurodegenerative Diseases Meytal Landau 2023-01-20
Combined Hormone Therapy as a Novel Treatment for Alzheimer’s Disease in the Face of a Metabolic Challenge: Influence of Sex and Genotype Liisa Galea Annie Ciernia 2023-01-20
Alzheimer’s Disease Tau Consortium: Role of VCP/p97 in Tau Prion Replication Marc Diamond 2023-01-20
Alzheimer’s Disease Tau Consortium: The Role of Amyloid Beta-Induced Membrane Damage in Tau Pathology Katherine Sadleir Robert Vassar 2023-01-18
Alzheimer’s Disease Tau Consortium: How Do Soluble Tau Species Replicate Bradley T. Hyman 2023-01-18
Alzheimer’s Disease Tau Consortium: Impact of Tau Mutations and Amyloid Beta on Tau Post-Translational Modifications and Conformation Karen Duff 2023-01-18
RNA as a Determinant of Tau Seeding Marc Diamond 2023-01-12
Alzheimer’s Disease Tau Consortium: Deep Mass Spectrometry Profiling of Tau Aggregates in Alzheimer’s Disease and Other Tauopathies Henrik Zetterberg Gunnar Brinkmalm 2023-01-06
Genes to Therapies (G2T), Alzheimer’s Disease Drug Discovery & Development (AD4) and General Scientific Support Wilma Wasco 2023-01-06
Role of the Circulating Exerkine GPLD1 in Ameliorating Alzheimer’s Disease Pathology Saul Villeda 2023-01-06
Using Long-Read Sequencing to Investigate the MAPT Locus and Transcripts in Neurodegeneration John Hardy 2023-01-06
Alzheimer’s Disease Pathophysiology Alters the Level of Electrical and Chemical Synapse Coupling in the Network of GABAergic PV+ Interneurons Early in Disease Course Srdjan D. Antic Riqiang Yan 2023-01-05
Identifying the Sex-Specific Roles of the Gut Microbiome-Brain Axis in a Mouse Model of Amyloid Beta Amyloidosis Sangram S. Sisodia 2022-12-22
Dissecting the Modulatory Roles of Interleukin-17 Receptor D in Alzheimer’s Disease Jun Huh 2022-12-22
Toxic Effects of Extracellular Tau Oligomers on Neurons George S. Bloom 2022-12-22
APOE Consortium: Modulation of Selective Neuronal Vulnerability in Alzheimer’s Disease by Apolipoprotein E Jean-Pierre Roussarie 2022-12-22
Cerebrospinal Fluid Neuroinflammatory Signature in Alzheimer´s Disease and Related Proteopathies Mathias Jucker Stefan Lichtenthaler Stephan Kaeser 2022-11-22
Turning Up Mitophagy to Blunt Alzheimer’s Tau Pathologies Evandro F. Fang 2022-11-21
Prenatal Inflammation Effects on Blood-Brain Barrier Function and Alzheimer’s Disease-Related Pathologies Across the Lifespan Alexandre Bonnin 2022-11-21
Neuroimmune Consortium: Biomarker Tool Development Jacob Hooker 2022-11-16
Understanding How Human Brain Vascular Cells Mediate Genetic Risk for Alzheimer’s Disease Andrew Yang 2022-11-16
Microglial-Specific INPP5D Knockdown Modulates Behavior, Amyloidosis and Tauopathy in Alzheimer’s Mouse Models Sam Gandy Michelle E. Ehrlich 2022-11-16
Neuroimmune Connectome Perturbations in Alzheimer’s Disease Francisco J. Quintana 2022-11-16
APOE Consortium: Effect of Cholesteryl Ester Transfer Protein Activity on Amyloid and Cerebrovascular Pathologies in Animal Models of Alzheimer’s Disease Cheryl Wellington 2022-11-16
APOE Consortium: Role of APOE Isoforms in Immune Responses in a Model of Tauopathy David Holtzman 2022-11-16
APOE Consortium: APOE4-Mediated Dysfunction of CD8 T-Cell-Microglia Crosstalk in Alzheimer’s Disease Oleg Butovsky 2022-11-16
APOE Consortium: APOE Genotype-Specific Effects of Human Young Plasma on Cerebrovasculature and Alzheimer’s Disease Pathology Guojun Bu 2022-11-16
Neuroimmune Consortium: Assessing the Links Between the MS4A Risk Genes, Microglia and Alzheimer’s Disease Sandeep Robert Datta 2022-08-15
Temporal Relationships Between Gut Dysbiosis and Microglia Cell Activation Following Antibiotic Treatment Sangram S. Sisodia 2022-08-15
Evaluating TMEM106B Accumulation in Alzheimer’s Disease Leonard Petrucelli Casey Cook 2022-08-15
Exploring the Therapeutic Potential of Clusterin in a Preclinical Model of Alzheimer’s Disease Alban Gaultier 2022-07-19
Cellular Vulnerability to Aging in Alzheimer’s Disease Mathieu Bourdenx Karen Duff 2022-07-19
Contributions of IL-34 Signaling to Microglial Function and Alzheimer’s Pathology in Mice Staci Bilbo 2022-07-19
Targeting the Microbiome and Innate Immunity in Alzheimer’s Disease Howard L. Weiner Laura Cox 2022-06-23
Human Brain CD33 Ligand, Receptor Protein Tyrosine Phosphatase Zeta (RPTPζ)S3L, Limits Microglial Phagocytosis and Contributes to Alzheimer’s Disease Progression Ronald Schnaar Philip C. Wong 2022-06-23
Circadian Perturbations of the Vasculome and Microgliome in Alzheimer’s Disease Eng H. Lo 2022-06-23
ABCA7 Loss of Function in Aging and Alzheimer’s Disease Takahisa Kanekiyo 2022-06-23
Characterization of Tau Pathology Heterogeneity Across the Alzheimer’s Disease Spectrum Oskar Hansson Rik Ossenkoppele 2022-06-23
Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease Se Hoon Choi Christiane Wrann 2022-06-23
Stress and Neurovascular-Immune Networks in Alzheimer’s Disease Scott J. Russo Wolfram C. Poller 2022-05-11
Regional Variability of Pathology-Associated Properties of Tau in Posterior Cortical Atrophy Bradley T. Hyman John R. Dickson 2022-05-09
Brain Entry and Exit Consortium: Central Nervous System Fluid Homeostasis and Waste Clearance in Alzheimer’s Disease Characterized by MRI Helene Benveniste Allen Tannenbaum David Xianfeng Gu 2022-05-09
Brain Entry and Exit Consortium: Identifying the Blood-Brain Barrier Changes During Alzheimer’s Disease Richard Daneman 2022-05-05
Single Nucleus RNA Sequencing Analysis of ACE1 R1284Q Knock-in Mice Robert Vassar David M. Gate Leah Cuddy 2022-05-03
Brain Entry and Exit Consortium: Biochemical and Functional Analysis of Cerebrospinal Fluid and Lymph Following Changes in Brain Fluid Dynamics Laura Santambrogio 2022-05-03
Brain Entry and Exit Consortium: Crosstalk of Central Nervous System Barriers and Clearance Routes in Homeostasis and Alzheimer’s Disease Jonathan Kipnis 2022-05-03
Development of a Multicellular Brain Model to Study Brain-Vascular-Peripheral Immune Cells Crosstalk in Alzheimer’s Disease Mehdi Jorfi Joseph Park Rudy Tanzi 2022-02-17
CIRCUITS: Interpreting Alzheimer’s Disease-Associated Genetic Variation at Enhancer Regions Andreas R. Pfenning 2022-02-17
Cellular and Molecular Studies of Apolipoprotein E Regulation of Blood-Brain Barrier, Synaptic and Neuronal Functions and Protection Strategies in Mouse Models With and Without Alzheimer’s Pathology Berislav Zlokovic 2022-02-17
Elucidating the Role of Soluble Epoxide Hydrolase and Arachidonic Acid Metabolism in Neuroinflammation and Alzheimer’s Disease Hui Zheng 2022-02-17
Neuronal Subtype-Specific Modeling of Alzheimer’s Disease by Direct Neuronal Reprogramming of Patient Fibroblasts Andrew S. Yoo 2022-02-17
Alzheimer’s Disease Drug Discovery and Development Consortium: Blocking Synaptotoxicity in Alzheimer’s Three-Dimensional Models Weiming Xia 2022-02-17
Alzheimer’s Disease Drug Discovery and Development Consortium: Uncovering the Molecular Mechanism of Selected Drug Candidates Derived from Systematic Alzheimer’s Drug Repositioning Stephen T.C. Wong 2022-02-17
Genes to Therapies™ (G2T), Alzheimer’s Disease Drug Discovery & Development (AD4), ACTFAST and General Scientific Support Wilma Wasco 2022-02-17
Continuing Studies of the Effects of GSM 776890 Administration on Amyloid Species and Microgliosis in Older Alzheimer’s Model Mice Kevin Rynearson 2022-02-17
Targeting Tauopathies With Antisense Oligonucleotides to Synaptogyrin-3 Patrik Verstreken 2022-02-17
Neural Synaptic Circuit Changes During Alzheimer’s Disease Progression Huizhong W. Tao 2022-02-17
Stimulating Synaptic Proteasome Activity for the Treatment of Alzheimer’s Disease Hermann Steller 2022-02-15
Interrogating Levetiracetam’s Impact on Amyloid Pathology and Presynaptic Proteostasis in Knock-In Mouse Models with Humanized Amyloid Beta Jeffrey Savas 2022-02-15
Brain Entry and Exit Consortium: Lymphatics and Central Nervous System Fluid Homeostasis Laura Santambrogio 2022-02-15
Patient-Based Structural and Functional Biology of Tauopathies Leonard Petrucelli 2022-02-15
Extracellular ATP Is a Key Factor in Promoting Alzheimer’s Disease Neuroinflammation Paola Pizzo Francesco Di Virgilio 2022-02-15
Protection Against APOE4 With Longevity-Promoting Interventions Christian Pike Bérénice A. Benayoun Caleb Finch 2022-02-15
Immunotherapies Targeting the Microbiota to Prevent Cognitive Decline in Alzheimer’s Disease Gerald B. Pier Colette Cywes-Bentley Cynthia A. Lemere 2022-02-15
Functional Basis for Novel Protein Kinase C-eta K56R Mutation in Alzheimer’s Disease Alexandra C. Newton 2022-02-15
Investigating Bone Marrow Hematopoiesis as the Link Between Sleep Fragmentation and Vascular Inflammation in AD Cameron McAlpine Filip Swirski 2022-02-15
Role of Microglia in Degradation and Trimming of Alzheimer’s Amyloid Beta Frederick Maxfield 2022-02-15
Targeting a Master Innate Immune Adaptor Molecule in Alzheimer’s Disease John R. Lukens 2022-02-15
The Role of Astrocyte-Derived Toxic Lipids Mediating Degeneration in Alzheimer’s Disease Shane Liddelow 2022-02-15
The Role of Interferon-Induced Transmembrane Protein 3 (IFITM3) and Gamma-Secretase in Microglia Yueming Li 2022-02-15
Neuroinflammation Contributions to Alzheimer’s Disease: Role of the Choroid Plexus Maria Lehtinen Liisa Myllykangas 2022-02-15
Role of Checkpoint Molecule TIM-3 in Regulating Microglia in Alzheimer’s Disease Vijay K. Kuchroo 2022-02-14
Contribution of Skull Bone Marrow-Derived Cells to Alzheimer’s Disease Jonathan Kipnis 2022-02-14
Alzheimer’s Disease Drug Discovery and Development Consortium: High-Throughput Drug Screening for Alzheimer’s Disease Using Three-Dimensional Human Neural Culture Systems Doo Yeon Kim Luisa Quinti 2022-02-14
Apolipoprotein E and Immunometabolism in Alzheimer’s Disease Lance Johnson Josh Morganti Ramon Sun 2022-02-14
Targeting Microglial TSG101 for Synaptic Protection and Cognitive Enhancement in Alzheimer’s Disease Seiko Ikezu Tsuneya Ikezu 2022-02-14
Alzheimer’s Disease Drug Discovery and Development Consortium: Modulating CD33 Function and Neuroinflammation as a Therapeutic Approach for Alzheimer’s Disease Ana Griciuc 2022-02-14
CIRCUITS: A Unified Approach to Actionable Alzheimer’s Disease Signatures Winston Hide 2022-02-14
Signaling Function of TREM2 Cleavage Products, Which are Affected by Agonistic Antibodies to the Stalk Region Christian Haass Kai Schlepckow 2022-02-14
Revealing New Genes and Pathways at the Intersection of Lipotoxic and Genetic Risk for Alzheimer’s Disease Anna Greka Beth Stevens 2022-02-14
Understanding the Mechanism Underlying Vaccination for Alzheimer’s Disease Charles L. Greenblatt Benjamin Y. Klein Ofer N. Gofrit 2022-02-14
Systems Integration and Therapeutics Translation in Alzheimer’s Disease Alison Goate Edoardo Marcora 2022-02-14
T Cell Epigenetics in Alzheimer’s Disease David M. Gate 2022-02-14
Development of Human cGAS Inhibitors to treat Alzheimer’s Disease Li Gan Subhash Sinha 2022-02-11
Air Pollution and Alzheimer’s Disease Risk Interact With Premature Aging of Neural Stem Cells and Apolipoprotein E Alleles Caleb Finch Michael A. Bonaguidi 2022-02-11
Tau and Amyloid Beta are Innate Immune Antimicrobial Peptides in the Brain William Eimer 2022-02-11
Influence of Plaque Vicinity on Microglial and Astrocyte Gene Expression; Role of Human Tau and TREM2 Frances Edwards John Hardy 2022-02-11
Harnessing Meningeal Lymphatics and Immunity to Alleviate APOE4-Induced Brain Dysfunction Sandro Da Mesquita 2022-02-11
Understanding the Role of Natural Amyloid Beta-Specific B Cell Responses in Alzheimer’s Disease Progression Marco Colonna 2022-02-11
Targeted Recruitment of Underrepresented Americans for Brain Donation Registration Brain Donor Project 2022-02-10
Disentangling the Role of Intracranial Arteriosclerosis in Alzheimer’s Disease Daniel Bos Frank J. Wolters Geert Jan Biessels Julia Neitzel Meike Vernooij 2022-02-10
Establishing the Molecular and Cellular Mechanisms and Biomarkers of APOE4-Mediated Susceptibility to Tau-Related Cognitive Impairments Joel Blanchard 2022-02-10
Effects of Depalmitoylation and ACAT Inhibition on Axonal Amyloid Beta Generation Via MAM-Associated palAPP Raja Bhattacharyya Rudy Tanzi 2022-02-10
CIRCUITS: Characterizing Epigenetic Biomarkers of Human Cognitive Aging Lars Bertram 2022-02-10
Glymphatic-Lymphatic Coupling in Alzheimer’s Disease Helene Benveniste Allen Tannenbaum 2022-02-10
The Role of Astrocyte-Secreted Insulin-Like Growth Factor Binding Protein 2 (IGFBP2) in the Progression of Alzheimer’s Disease Nicola Allen 2022-02-10
Identifying Blood-Brain Barrier (BBB) Enhancers and Role of Neutrophils in a 3-D BBB Vascularized Model of Alzheimer’s Disease Roger D. Kamm Se Hoon Choi 2022-01-11
Consortium to Infer Regulatory Circuits and Uncover Innovative Therapeutic Strategies—Production Group Manolis Kellis Li-Huei Tsai 2021-02-23
A Transcriptional Rejuvenation Signature for Alzheimer’s Disease Tony Wyss-Coray 2021-01-29
Personalized Disease Prediction for Alzheimer’s Disease Using Proteome Profiling: The EPIC4AD Study Christina M. Lill Lars Bertram 2021-01-29
Gut Microbiota, Endothelial Dysfunction and Tau-Mediated Cognitive Impairment Giuseppe Faraco Costantino Iadecola 2021-01-29
Role of Secreted Protein Acidic and Rich in Cysteine (SPARC) in Immunometabolic Control of Age-Related Inflammation Vishwa Deep Dixit 2021-01-29
Mechanisms of Tau Propagation Across the Plasma Membrane Marc Diamond 2021-01-29
Understanding and Mimicking the Biological Effects of the Phospholipase C-gamma-2 P522R Variant That Protects Against Alzheimer’s Disease Rik van der Kant Philip Scheltens 2021-01-29
Identification of CD33 Antagonists Subhash Sinha 2021-01-05
Small Molecule Activators of PLC-gamma-2 as Novel Therapeutics for Alzheimer’s Disease Qisheng Zhang John Sondek Kenneth Pearce 2020-12-21
Investigating the Contribution of Astrocytic-Dependent Inflammation on Amyloid-Induced Tau Pathology Gilbert Gallardo 2020-12-21
Uncovering the Molecular Mechanism of Selected Drug Candidates Derived from Systematic Alzheimer’s Drug Repositioning Stephen T.C. Wong 2020-12-21
Proteomics of Alzheimer’s Disease Three-Dimensional Cultures Weiming Xia 2020-12-21
Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease George S. Bloom Elizabeth R. Sharlow John S. Lazo 2020-12-21
Neuroimmune Consortium: Examining the Role of Human Microglia in the Transition Between Parenchymal and Vascular Amyloid Beta Pathology Mathew Blurton-Jones 2020-12-18
Novel Entry Routes for Therapeutic Biologicals to the Brain Maarten Dewilde Bart De Strooper 2020-12-18
Characterizing Gut Microbiome Synergy With Emphasis on Mycobiome and Its Impact on Alzheimer’s Disease (AD) Pathology in AD Mouse Models Deepak Kumar Vijaya Kumar Nanda Kumar Navalpur Shanmugam Rudy Tanzi William Eimer 2020-12-18
High-Throughput Drug Screening for Alzheimer’s Disease Using Three-Dimensional Human Neural Culture Systems Doo Yeon Kim Luisa Quinti 2020-12-18
Modulating CD33 Function and Neuroinflammation as a Therapeutic Approach for Alzheimer’s Disease Ana Griciuc 2020-12-18
Neuroimmune Consortium: Understanding the Consequences of Noncoding Alzheimer’s Disease Risk Alleles on Microglia Function Beth Stevens 2020-12-15
Neuroimmune Consortium: Leveraging Enhancer Landscapes to Decode Alzheimer’s Disease Risk Alleles in Microglia Christopher K. Glass 2020-12-15
Effect of Gut Microbiome Dysbiosis on Neuroinflammation and Amyloid Beta Deposition: A Longitudinal Micro-PET Study in Alzheimer’s Transgenic Mice Sangram S. Sisodia 2020-12-15
Discovery and Development of Chemical Probes to Elucidate MS4A Protein Function Jacob Hooker 2020-12-15
Neuroimmune Consortium: Investigation of Alzheimer’s Disease Risk Alleles in Astrocytes—Focus on Cholesterol Transport and Microglia Interactions Shane Liddelow 2020-12-15
Sex Differences in Alzheimer’s Disease Progression: Framingham Heart Study P. Murali Doraiswamy 2020-12-10
Single Nucleus RNA Sequencing Analysis of ACE1 R1284Q Knockin Mice GENEWIZ Leah Cuddy Robert Vassar 2020-11-12
Sex Matters: Understanding the Influence of Sex and Apolipoprotein E (APOE) Genotype on Hippocampal Plasticity and Cognition Liisa Galea 2020-11-11
VGF-Derived Peptide Therapy for Alzheimer’s Disease: Studies of Mouse and Human TLQP-21 and its Receptor, C3aR1 Michelle E. Ehrlich Stephen R. Salton 2020-11-06
The NEDD4-1 and PKCa Connection in Alzheimer’s Disease Gentry Patrick 2020-11-05
Creation of a Fibroblast/iPS Cell Bank to Facilitate Peripheral/Brain Comparisons, and Allow Molecular Investigations into Molecular Mechanisms Underlying Differences in Disease Aggressiveness Bradley T. Hyman 2020-11-05
Investigating the Role of Tau Protein in Neuronal Senescence Induction and Maintenance Miranda Orr 2020-11-04
SFRP1 as a Therapeutic Target and Diagnostic/Prognostic Factor in Alzheimer’s Disease Paola Bovolenta Pilar Esteve 2020-11-04
Comprehensive Analyses of Chronic Efficacy Studies with GSM 776890 for Submission of the Pre-IND Brochure to the FDA Prior to Pre-IND Meeting and IND Filing for the SAD/MAD Phase I Safety/Toxicity and Ultimately for Phase II and Phase III Efficacy Clinical Trials to Support the NDA Steven L. Wagner 2020-08-04
Microbes and Alzheimer’s Disease: Metagenomics on Saliva, Cerebrospinal Fluid, Blood and Brain Nanda Kumar Navalpur Shanmugam Deepak Kumar Vijaya Kumar Rudy Tanzi William Eimer 2020-08-03
Regulation by Apolipoprotein E of Selective Neuronal Vulnerability to Alzheimer’s Disease Jean-Pierre Roussarie 2020-04-13
Counteracting Pathogenic Events in Alzheimer’s Disease with Peripheral or Central Apolipoprotein E Takahisa Kanekiyo 2020-04-13
APOE Consortium: Assessing the Added Diagnostic Value of Peripheral Apolipoprotein E Protein Levels in Current Blood-Based Biomarker Assays for Central Nervous System Amyloidosis Randall J. Bateman 2020-04-13
In Vivo Characterization of a Loss-of-Function GGA3 Rare Variant Associated with Alzheimer’s Disease Giuseppina Tesco 2020-03-24
Characterization of Alzheimer’s Disease Molecular Biomarker Profiles Throughout the Pathobiological Continuum Krista L. Moulder 2020-02-18
ABCA7 Loss of Function in Aging and Alzheimer’s Disease Takahisa Kanekiyo Guojun Bu 2020-02-18
Application of Machine Learning Methods in Alzheimer’s Disease Clinical Trials Ali Ezzati Richard Lipton 2020-02-18
Molecular Signatures of APOE-Mediated Blood-Brain Barrier Dysfunction Causing Neuronal and Synaptic Dysfunction Berislav Zlokovic 2020-01-09
An Innovative Study of the Pupil Light Reflex in Alzheimer’s Disease Shirley Wray 2020-01-09
Targeting the Microbiome and Microglia in Alzheimer’s Disease Howard L. Weiner Laura Cox 2020-01-09
Harnessing Big Data to Understand Alzheimer’s Disease Risk Brad A. Racette Alejandra Camacho-Soto Susan Searles Nielsen 2020-01-09
Tau and Amyloid Beta are Innate Immune Antimicrobial Peptides in the Brain William Eimer Deepak Kumar Vijaya Kumar Rudy Tanzi 2020-01-09
Alzheimer’s Genome Project™ Rudy Tanzi 2020-01-09
The Role of Clusterin in Tau Pathology John D. Fryer 2019-12-26
Evaluation of the Effect of Cell Type-Specific Deletion of ESCRT Genes on the Spread of Tau Pathology Tsuneya Ikezu 2019-12-24
Berg Brain Entry and Exit Consortium: Direct Migration of Myeloid Cells from the Skull Marrow to the Brain Through Anatomical Channels: Adding Fuel to the Fire in Alzheimer’s Disease Fanny Herisson 2019-12-17
Berg Brain Entry and Exit Consortium: Patch-Seq Analysis of the Choroid Plexus Epithelial Cell Barrier in Homeostasis and in Alzheimer’s Disease Fernanda Marques 2019-12-17
Berg Brain Entry and Exit Consortium: Crosstalk of Central Nervous System Barriers and Clearance Routes in Homeostasis and Alzheimer’s Disease Jonathan Kipnis 2019-12-17
Berg Brain Entry and Exit Consortium: Assessment of Antibody-Based Drug Trafficking Across the Blood-Brain Barrier Via Skull-Meninges Connections Ali Ertürk 2019-12-17
Berg Brain Entry and Exit Consortium: Identifying the Blood-Brain Barrier Changes During Alzheimer’s Disease Richard Daneman 2019-12-17
Berg Brain Entry and Exit Consortium: Human 3D Neurovascular Interaction and Meningeal Lymphatics Models with Application to Alzheimer’s Disease Se Hoon Choi Roger D. Kamm 2019-12-17
Alzheimer’s Risk is Higher in Women: Identification of Female-Specific Brain Bioenergetic Targets 2019-11-05
Patient-Based Structural and Functional Biology of Tauopathies Anthony Fitzpatrick Leonard Petrucelli 2019-11-04
Interpretation of Noncoding Risk Alleles for Alzheimer’s Disease Christopher K. Glass 2019-08-27
Assessing the Links Between the Ms4a Risk Genes, Microglia and Alzheimer’s Disease Sandeep Robert Datta 2019-08-27
Two Genes Appear to Act as On/Off Switches for Neuroinflammation and Alzheimer’s Disease Rudy Tanzi Ana Griciuc Marco Colonna 2019-07-12
Mechanisms for Alzheimer’s Disease-associated SORLA Mutations in Microglia and Neurons in AD Pathogenesis Huaxi Xu Timothy Huang 2019-06-11
Understanding Molecular Biomarker Changes in Alzheimer’s Disease Using Genetically Defined Mouse Models Mathias Jucker Stephan Kaeser 2019-06-11
The Role of MGnD-neurodegenerative Clec7a+ Microglia in an Alzheimer’s Disease Mouse Model Oleg Butovsky 2019-06-11
PEGASUS Clinical Study of AMX0035 in Alzheimer’s Disease Amylyx 2019-03-15
The Role of the Contact System in Alzheimer’s Disease Erin H. Norris Sidney Strickland 2019-01-10
The Development of DNA-Encoded Libraries to Discover Therapeutically Valuable Low Molecular Weight Compounds for Alzheimer’s Disease Marc Flajolet Subhash Sinha 2019-01-10
Amyloid Beta-Mediated Inhibition of Gamma-Secretase Activity Induces Alzheimer’s Disease-Relevant Cellular Phenotypes William C. Mobley Lucía Chávez-Gutiérrez 2019-01-10
The Neuroprotective Glial Barrier: A Multicellular Reaction with Therapeutic Potential in Alzheimer’s Disease Jaime Grutzendler 2019-01-10
Neurobiological Basis of Cognitive Impairment in African Americans: Deep Phenotyping of Older African Americans at Risk of Dementia—The Dementia (in) African American Population Phenotyping (for) Potential Elevated Risk (DAAPPER) Study Henry Paulson Benjamin M. Hampstead, Ph.D., ABPP/CN Bruno Giordani, Ph.D. 2019-01-10
Interleukin-3 in Alzheimer’s Disease Filip Swirski 2018-12-27
Senescent Cells and Alzheimer’s Disease Darren J. Baker 2018-12-27
Pharmacologically Protecting and Rescuing Synapses from Beta Amyloid by Raising Synaptic PSD-95 Roberto Malinow 2018-12-27
Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease Se Hoon Choi Christiane Wrann 2018-12-27
The Effect of Chronic Gamma-Secretase Modulation on the Prevention of Traumatic Brain Injury-Provoked and Alzheimer’s Disease-Relevant Biochemical, Pathological and Behavioral Alterations Steven L. Wagner Brian P. Head 2018-12-24
Human-Specific Evolution of CD33: Evolutionary Relationship to Ancient Host-Pathogen Interactions and Current Implications for Alzheimer’s Disease Ajit Varki Nissi Varki Pascal Gagneux 2018-12-24
The Role of Impaired Synaptic Vesicle Machinery Proteostasis in Alzheimer’s Disease Pathogenesis Jeffrey Savas 2018-12-24
Role of Microglial Matricellular Protein SPARC in Control of Inflammasome Activation Vishwa Deep Dixit 2018-12-24
Study of Reactive Astrocytes-Derived Oxidative Stress and Proinflammation Leading to Neurodegenerative Microglial Activation in Alzheimer’s Disease Hansang Cho 2018-12-24
Alzheimer’s Disease Pharmacomics in 3-D Weiming Xia 2018-12-20
Single-Cell Analysis of 3D Human Triculture Model of Alzheimer’s Disease: The Impact of AD-Associated Genetic Variants Joseph Park Rudy Tanzi 2018-12-20
Inhibiting CD33 Function and Modulating Microglial Activation State for Alzheimer’s Disease Therapy Ana Griciuc 2018-12-20
Identifying the Blood-Brain Barrier Changes During Alzheimer’s Disease Richard Daneman 2018-12-18
Reversal of Tau Pathology by an Adenosine A1 Receptor Antagonist Eva-Maria Mandelkow Anja Schneider Eckhard Mandelkow 2018-12-18
Dietary Salt, Tau Phosphorylation and Cognitive Impairment Giuseppe Faraco Costantino Iadecola 2018-12-18
Physiological Method for Early Detection of Synaptic Vulnerability in Alzheimer’s Disease Model Animals Riqiang Yan Srdjan D. Antic 2018-12-17
Effects of Cerebrovascular Insufficiency and Exercise on the Alzheimer’s Brain Eng H. Lo 2018-12-17
The Circadian Clock Modulates Neurodegeneration in Alzheimer’s Disease Via REV-ERBA (Year 1) Erik S. Musiek 2018-12-13
Central Clock Influence on Alzheimer’s Disease Pathogenesis Geraldine J. Kress 2018-12-13
Understanding Human Brain Resilience to Alzheimer’s Pathology Teresa Gomez-Isla 2018-10-15
Validation of Endogenous Human Antibodies That are Correlated With Avoiding Alzheimer’s Disease and Their Corresponding Antigens, for Immunotherapeutic Development Charles Glabe 2018-08-27
Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures Elizabeth R. Sharlow George S. Bloom John S. Lazo 2018-08-27
Mechanisms By Which the Gut Microbiome Influences Amyloid Deposition and Neuroinflammation in the APPswe/ PS1DE9 Mouse Model of Amyloid Beta Amyloidosis Sangram S. Sisodia 2018-08-27
Gut Microbiome-Mediated Shifts in Amyloid Beta Deposition in a Humanized Alzheimer’s Disease Mouse Model Deepak Kumar Vijaya Kumar 2018-08-27
VGF, a Novel Therapeutic Effector of Alzheimer’s Disease Pathogenesis and Progression Stephen R. Salton Michelle E. Ehrlich 2018-08-27
Amyloid Beta Kinetics and Enhancing the Diagnostic and Prognostic Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease Randall J. Bateman Norelle Wildburger, Ph.D. 2018-08-27
Exploring Sex Differences in AD Pathogenesis Using 3-D Human Non-Cell-Autonomous Models Doo Yeon Kim Daniel Irimia 2018-08-27
A Microfluidics-Based Human Brain Cell 3-D Culture System in Alzheimer’s Disease Hansang Cho 2018-08-27
Interactions Among TREM2, APOE and Sex Caleb Finch Christian Pike 2018-08-27
TREM2: Role in Modulating Amyloid Beta and Tau-Related Pathologies and Neurodegeneration David Holtzman Marco Colonna 2018-08-27
Investigating the Mechanism of APOE4-associated Neuronal Hyperactivity in the Entorhinal Cortex and its Effect on Tauopathy Propagation Karen Duff Tal Nuriel 2018-08-27
Uncovering the Molecular Mechanism of Selected Drug Candidates Derived from Systemic Alzheimer’s Drug Repositioning Stephen T.C. Wong 2018-08-27
Alzheimer’s Disease Stem Cell Drug Screening in 3-D Weiming Xia 2018-08-09
Compounds Modulating Microglial Uptake of Amyloid Beta and CD33-Targeted Immunotherapy for Alzheimer’s Disease Ana Griciuc Rudy Tanzi 2018-08-09
Evaluation of Blood-Brain Barrier (BBB) Penetration of Alzheimer’s Drug Targets, and Identification of BBB Integrity Enhancers Roger D. Kamm Se Hoon Choi 2018-08-09
Gene Expression Throughout Development of Pathology in APPKI Mice; Effects of Human Tau and Aging Frances Edwards John Hardy 2018-08-09
Novel Chemical Modulators for BACE1-Mediated Cleavage of Amyloid Beta Precursor Protein Tae-Wan Kim 2018-08-09
Cerebrovascular Dysfunction in AD: Targeting the Mechanisms of Vascular Activation Paula Grammas 2018-08-09
Biochemical Mapping of the GSM Binding Site of Novel Pyridazine-Derived Small Molecule Gamma-Secretase Modulators Steven L. Wagner Yueming Li 2018-08-09
Stimulating Proteasome Activity for the Treatment of Alzheimer’s Disease (Year 1) Hermann Steller 2018-08-09
Evaluation of Sleep-EEG in Transgenic Mice PsychoGenics 2018-08-09
Treating with Gamma-Secretase Modulators (GSMs) to Prevent Neurodegeneration in Mouse Models of Down Syndrome William C. Mobley 2018-08-09
Microglial TAM Receptors as Modulators of Alzheimer’s Pathology Greg Lemke 2018-08-09
Synapse Pruning by Astrocytes: A Potential New Target for Treating Alzheimer’s Disease Won-Suk Chung 2018-08-09
Targeting Reactive Astrocytes for Therapeutic Intervention in Alzheimer’s Disease Gilbert Gallardo 2018-08-09
Scientific Directions for the Exploration of Racial Disparities in Alzheimer’s Disease Krista L. Moulder 2018-07-24
Neurotoxic Reactive Astrocytes in Alzheimer’s Disease Shane Liddelow 2018-07-24
Imaging Microglial Homeostasis and Disruption: P2RY12 Radiotracer Development Jacob Hooker Michael Placzek 2018-07-24
Targeting Beneficial Innate Immunity in Alzheimer’s by Interleukin-1 Receptor-Associated Kinase M Deletion Jeannie Chen Karen Chang 2018-07-24
Role of Ataxin-1 in Regulating BACE1 Activity (Year 2) Jaehong Suh, Ph.D. 2018-07-24
Temporal Analysis of Infection in Alzheimer’s Disease Models Judith Steen 2018-07-24
Chronic Viral Neuroinfection Mediates Amyloid Beta Deposition in Transgenic Alzheimer’s Disease Mice Robert Moir 2018-06-22
Neuroimmune Molecular Imaging: Redefining the Landscape of Opportunities in Alzheimer’s Disease Jacob Hooker 2018-06-19
The Role of Neurexins in Alzheimer’s Disease (Year 2) Meng Chen Rudy Tanzi 2018-06-19
PICALM Gene Therapy and Drug Screening for Amyloid Beta Clearance (Year 3) Berislav Zlokovic 2018-06-19
Microglial Heterogeneity and Transcriptional State Changes in Alzheimer’s Disease Beth Stevens 2018-06-19
Stable Isotope Labeling and Quantitative Mass Spectrometry Imaging of Alzheimer’s Disease Pathology in Human Brain Katherine Schwetye 2018-04-27
Inhibition of Tau Pathology in Human Neurons Benjamin Wolozin 2017-08-01
Understanding the Effect of APOE on Tau-Mediated Neurodegeneration David Holtzman 2017-07-25
Effects of Peripheral APOE on Central Nervous System Functions and AD Pathogenesis Guojun Bu 2017-07-25
The Role of APOE in Microglia Regulation in Neurodegeneration Oleg Butovsky 2017-07-25
APOE Consortium: Toward Developing High-Density Lipoprotein Enriched in Apolipoprotein E as a Potential Biomarker and Therapeutic Targeting Vascular Contributions to Alzheimer’s Disease Cheryl Wellington 2017-07-25
APOE Proteoforms in Human CNS and Validation of APOE Pharmacodynamic Translational Markers Randall J. Bateman 2017-07-25
Impact of APOE and Sex on Vulnerable Neuron-Specific Functional Network Paul Greengard 2017-07-25
Propagation of Tauopathy and Ubiquitin Proteasome System Dysfunction: Impact and Rescue with a UPS Activator Karen Duff Natura Myeku 2017-03-01
Role of ATXN1 in Regulating BACE1 Activity Jaehong Suh, Ph.D. 2017-01-26
CIRCUITS: Integrating Functional Maps to Discover MicroRNAs in Alzheimer’s Disease Winston Hide 2017-01-05
CIRCUITS: Impact of Genetic, Epigenetic and Cellular Variants on Alzheimer’s Disease Pathology Rudolf Jaenisch Joseph R. Ecker 2017-01-05
CIRCUITS: Identifying Novel Epigenetic Biomarkers of Human Cognitive Aging Lars Bertram 2017-01-05
CIRCUITS: Production Center for Reference and Variation Gene-Regulatory Maps Manolis Kellis Li-Huei Tsai 2017-01-05
CIRCUITS: Functional Analysis of Alzheimer’s Disease Risk Genes Using Human-Induced Pluripotent Stem Cells Li-Huei Tsai Manolis Kellis 2017-01-05
CIRCUITS: IPS Cells and the Human Brain Bradley T. Hyman 2017-01-05
Interpreting Alzheimer’s Disease-Associated Genetic Variation at Enhancer Regions Andreas R. Pfenning 2017-01-04
The APOE Mimetic Therapeutic Peptide CN-105 Attenuates AD Pathology and Improves Functional Outcomes in a Murine Model of Alzheimer’s Disease Daniel Laskowitz 2017-01-04
Intersection of Microglial Transcriptomes to Identify Key Alzheimer’s Pathways of Brain Phagocytes Sam Gandy 2017-01-04
Regulation of Microglial Lysosome Acidification Frederick Maxfield 2016-12-06
Identification of a Protective Human Immune Response for Alzheimer’s Disease Charles Glabe 2016-12-06
Characterization of Certain Human APOE Targeted Gene Replacement Mice David Holtzman Jason D. Ulrich 2016-10-28
Binding Site Characterization of a Novel Pyridazine-Derived Class of γ-Secretase Modulators Steven L. Wagner 2016-09-23
Search for Female-Specific Genetic Factors Contributing to Risk for Alzheimer’s Disease Rudy Tanzi 2016-09-07
Impact of Inflammasome Deactivation on Alzheimer’s Disease Vishwa Deep Dixit 2016-09-07
Nanobodies to Cross the Blood-Brain Barrier Bart De Strooper Maarten Dewilde 2016-09-01
SORLA Attenuates Abeta Toxicity Through Interactions With EphA4 Huaxi Xu 2016-08-17
Early Role of Microglia in Synapse Loss in Alzheimer’s Disease Beth Stevens 2016-07-15
The Role of Meningeal Lymphatics in Cleansing the Brain: Implications for Alzheimer’s Disease Jonathan Kipnis 2016-07-05
Will Restoration of Normal Glymphatic Function Slow Progression of Cognitive Decline and Amyloid Plaques in a Murine Alzheimer Model? Maiken Nedergaard 2016-07-05
Therapeutic Modulation of TREM2 Activity Christian Haass 2016-07-05
Mechanisms By Which the Gut Microbiome Influences Amyloid Deposition and Neuroinflammation in Mouse Models of Alzheimer’s Disease Sangram S. Sisodia 2016-07-05
Investigating the Mechanism of Entorhinal Cortex Hypermetabolism in APOE4 Targeted Replacement Mice Karen Duff Tal Nuriel 2016-05-12
Role of Neurexins in Alzheimer’s Disease Pathophysiology Rudy Tanzi 2016-05-04
Activation of the 26S Proteasome for the Treatment of Alzheimer’s Disease Alfred L. Goldberg 2016-04-28
Modeling DNA Methylation Changes in Alzheimer’s Disease Using Human-Induced Pluripotent Stem Cells Rudolf Jaenisch 2016-04-28
Modeling Alzheimer’s Disease in Specific Subtypes of Human Neurons Through Direct Neuronal Reprogramming of Patient Fibroblasts Andrew S. Yoo 2016-04-26
Alzheimer Disease-Associated Mutations in Protein Kinase C Alexandra C. Newton 2016-04-26
Pathway Cross-talks Associated with Sex and Risk for Alzheimer’s Disease P. Murali Doraiswamy 2016-04-26
Acceleration of FDA-Required GLP Gene Toxicity Studies with the GSM BPN-15606 Steven L. Wagner 2016-04-26
In Vitro and In Vivo Analysis of APP Variants Sangram S. Sisodia 2016-04-26
A Combination of Anti-Abeta and Growth Factor Therapy for AD Mark H. Tuszynski 2016-04-26
ABCA7 in Brain Homeostasis and Alzheimer’s Disease Guojun Bu Takahisa Kanekiyo 2016-02-29
The Role of PICALM Mutations in Alzheimer’s Disease Berislav Zlokovic Zhen Zhao 2016-01-12
Molecular and Cellular Mechanisms of ACE1 Variant in Alzheimer’s Disease Robert Vassar 2016-01-12
Studying the Functional Consequences of Alzheimer’s Disease Risk Variants in the CLU and ABCA7 Genes Using Both Human and Mouse Models Li-Huei Tsai 2016-01-12
Functional Characterization of GGA3 Mutations Associated with Alzheimer’s Disease Giuseppina Tesco 2016-01-11
Amyloid Beta Expression Protects the Brain from Herpes Simplex Virus Robert Moir 2016-01-11
Tau Missorting in AD—Causes and Consequences Eckhard Mandelkow Eva-Maria Mandelkow 2016-01-11
Extracellular Vesicle-Based Targeting of CD33-Mediated Pathology for Alzheimer’s Disease Therapy Casey A. Maguire 2016-01-11
Discovery of Chemical Compounds That Induce Degradation of APP Beta-CTF Victor Bustos 2016-01-11
Stem Cell Approach to Investigating the Phenomenon of Brain Insulin Resistance Sam Gandy 2016-01-11
Genetic Targets to Block Tau Propagation: Test Knockdown of Heparan Sulfate Proteoglycan Genes In Vivo Marc Diamond 2016-01-11
Evaluation of AMX0035, a Neuroprotecting and M1-Deactivating Therapeutic, in an Immunological Model of AD Amylyx 2016-01-11
The Biological Impact of TREM Locus Mutations in Alzheimer’s Disease Marco Colonna David Holtzman 2015-11-05
Targeting Beneficial Innate Immunity in Alzheimer’s by IRAK-M Deletion Terrence Town 2015-11-04
Role of the Gut Microbiome in AD Pathology and the Potential of Probiotic Therapeutic Strategies Deepak Kumar Vijaya Kumar Robert Moir 2015-11-03
TREM2 Function and Dysfunction in Alzheimer’s Disease Christian Haass 2015-10-29
Rejuvenation of Microglia in Brain Aging and Neurodegeneration Tony Wyss-Coray 2015-10-29
Systemic Inflammatory Networks in Alzheimer’s Disease Filip Swirski Matthias Nahrendorf 2015-10-29
3DDS: Alzheimer’s Disease Drug Discovery in 3-D Weiming Xia 2015-10-22
Regulation of RNA Translation by MAPT in Alzheimer’s Disease Benjamin Wolozin 2015-10-01
Use of High-Content Drug Screening and Systems Biology Modeling on a Novel 3-D Cell Model to Repurpose Known Drugs for Alzheimer’s Disease Stephen T.C. Wong 2015-09-30
A 3-D Human Neural Cell Culture System for Studying Neuron-Microglia Interaction in Alzheimer’s Disease Hansang Cho 2015-09-30
Development of Novel APP Dimerization Inhibitors That Lower Abeta Levels Carmela R. Abraham 2015-09-29
Role of Blood-Brain Barrier Function in Alzheimer’s Disease Pathogenesis Investigated Using a 3-D Microfluidic Platform Se Hoon Choi Roger D. Kamm 2015-09-29
Microglial Core/CD33 and Alzheimer’s Disease: From Biology to Therapy Ana Griciuc Rudy Tanzi 2015-09-29
3-D Neural Core/High-Throughput Drug Screening for Alzheimer’s Disease Using 3-D Human Neural Culture Systems Doo Yeon Kim 2015-09-29
Cell Cycle Re-entry in 3-D Human Neuron Cultures John S. Lazo George S. Bloom 2015-09-28
The Putative Role of Red Blood Cell CR1 Levels in Amyloid-Beta Clearance and Alzheimer’s Disease Pathogenesis Cynthia A. Lemere 2015-09-28
PICALM Gene Therapy and Drug Screening for Abeta Clearance Berislav Zlokovic Beverly L. Davidson 2015-09-28
Understanding Reactive Astrocytes and Their Roles in Alzheimer’s Disease Ben Barres 2015-09-28
Uncovering Determinants of Neuronal Vulnerability in Alzheimer’s Disease Paul Greengard 2015-09-24
BIN1 in Alzheimer’s Disease Neuropathology Gopal Thinakaran 2015-09-24
Lead Optimization and Lead Evolution of Potent SGSMs for the Treatment of Alzheimer’s Disease Steven L. Wagner Rudy Tanzi 2015-07-02
Analytical and Statistical Tools for Sequence Analysis for Alzheimer’s Disease Christoph Lange 2015-06-29
Optimization of Pharmacalogic Properties of Molecular Tweezers Gal Bitan 2015-06-25
The Role of Microbial Immune Responses in Alzheimer’s Disease Sangram S. Sisodia 2015-06-25
Long Abetas, Intraneuronal Amyloid and an Alternative Amyloid Hypothesis of Alzheimer’s Disease Charles Glabe 2015-06-25
The Role of the KIBRA Gene in Abeta Regulation of AMPAR Trafficking Richard L. Huganir 2015-06-25
Generation of Neural Progenitor Cells Overexpressing Alzheimer’s Disease Genes with Familial Mutations and Analysis of Pathological Changes of Alzheimer’s Cells in Vivo Doo Yeon Kim 2015-04-21
Identification of Functional Properties of Human Alzheimer’s Disease Cells That Affect Their Bilateral Interactions with Brain Environment Tamir Ben-Hur 2015-04-21
G2T Research Models and Materials Taconic Biosciences 2015-04-21
Genes to Therapies (G2T) Centralized Research Core Oversight Wilma Wasco 2015-04-21
Development of an APP-specific B-secretase inhibitor for Alzheimer’s disease therapy Lawrence Rajendran 2015-01-14
The Role of TREML2 in Alzheimer’s Disease Marco Colonna 2014-12-16
Elucidation of the Molecular Target of Potent γ-Secretase Modulators Steven L. Wagner 2014-12-03
Generation of iPS Cells and Neurons from Skin Fibroblasts from Subjects with Familial and Sporadic AD Sam Gandy Scott Noggle 2014-12-03
Air Pollution and APP processing Caleb Finch 2014-11-19
FXII System’s Effect on Alzheimer’s Disease Sidney Strickland 2014-11-19
Myeloperoxidase, Imaging and Treatment Target for Alzheimer’s Disease John Chen 2014-08-11
Orbitrap Fusion Tribrid Mass Spectrometer Randall J. Bateman 2014-08-07
High-Throughput Multiplex Real-Time PCR For CSF-Biomarker And MicroRNA Profiling In AD Lars Bertram 2014-08-04
Regulation of Tau Oligomerization by Interaction with TIA-­‐1, a Component of Stress Granules Benjamin Wolozin 2014-07-17
GABAergic inhibitory efficiency and adult neurogenesis in the hippocampus of aged Ts65Dn mice, a model of ‘Alzheimer’s disease in Down syndrome’, after chronic treatment with the monoacylglycerol lipase inhibitor JZL184 William C. Mobley 2014-07-17
Characterizing the role of LOAD-associated variants of DLGAP1 in AD Roberto Malinow 2014-07-17
The role of PICALM in vascular clearance of amyloid-B and neuronal injury Berislav Zlokovic 2014-07-17
Molecular mechanisms of synaptic plasticity in the hippocampus: A path to novel therapies Robert C. Malenka 2014-07-17
Patient-derived Reprogrammed Neurons as a Model to Study Neurodegenerative Diseases in a Dish Marc Tessier-Lavigne 2014-07-17
Discovery of Alzheimer’s Disease Blood Biomarkers Using Phage Display Technology Yueming Li 2014-01-27
The Root of Alzheimer’s Disease: Purification and Characterization of Amyloid-beta Oligomers from the Human Brain David L. Brody 2013-12-10
Vascular Regenerative Therapy for Alzheimer’s Disease Guojun Bu 2013-12-10
Characterization of the pathological significance of a novel type of vascular amyloid Charles Glabe 2013-12-09
Sleep and tauopathies: Effect of an anti-tau antibody David Holtzman 2013-12-09
Elucidation of the mechanism of action of Gamma Secretase Modulators Steven L. Wagner 2013-07-10
Effects of Inhibitors of Monoacylglycerol Lipase on Behavior and Synaptic Plasticity of Ts65Dn Mice, a Genetic Model of Down Syndrome William C. Mobley 2013-06-13
Stem Cell Consortium Doo Yeon Kim Kevin Eggan Marc Tessier-Lavigne Sam Gandy Scott Noggle Tamir Ben-Hur 2013-03-19
Potential for Host Cytotoxicity from Microbially-derived Abeta Oligomers Charles Glabe Rudy Tanzi 2013-02-06
Antibody Signature of Alzheimer’s Disease: Promise of an Early Diagnostic Test Lucas Restrepo 2013-01-31
Normalizing Abeta synaptic depression with drugs targeting PICK1 Roberto Malinow 2013-01-18
Investigations of the Mechanism of Action of TagretinR/Bexarotene on Amyloid Clearance in Transgenic Mouse Models Robert Vassar Sangram S. Sisodia 2012-12-12
Whole Genome Sequencing Rudy Tanzi 2012-12-12
The roles of Eps homology domain (EHD) proteins and synaptic activity in axon transport of the Alzheimer’s Beta-secretase BACE1 in the brain Robert Vassar 2012-12-06
BACE1 transcytosis in Alzheimer’s disease pathogenesis Gopal Thinakaran 2012-12-06
iPS-Derived and Trans-Differentiated Human Neurons as Models to Study Alzheimer’s Disease Marc Tessier-Lavigne 2012-12-06
The Putative Role of Red Blood Cell CR1 levels in Amyloid Beta Clearance and Alzheimer’s Disease Pathogenesis Cynthia A. Lemere 2012-12-06
The Role of PICALM in Vascular Clearance of Amyloid Beta Berislav Zlokovic 2012-12-05
Aβ Oligomers and the Pathogenic Spread of Tau Aggregation: Implications for Alzheimer’s Disease Mechanism and Treatment Dominic Walsh Dennis Selkoe 2012-03-20
General Anesthetics and Alzheimer’s Disease Zhongcong Xie 2012-03-20
Understand the Role of ADAM10 in the Pathogenesis of Alzheimer’s Disease After Head Trauma Giuseppina Tesco 2012-03-20
Optimization of Novel ACAT Inhibitors for Alzheimer’s Disease Dora M. Kovacs 2012-03-20
The Development of UDP Analogs for the Treatment of Alzheimer’s Disease Phil Haydon 2012-03-20
Metallomic Mapping of the Aging Brain in Trg2576 Transgenic Mouse Model Lee Goldstein 2012-03-20
Cellular and Animal Models of Amyloid Pathology in Early Alzheimer’s Disease Charles Glabe 2011-11-11
Structural and Functional Analysis of Novel Abeta and Tau Oligomers Using Conformation-Specific Monoclonal Antibodies George S. Bloom 2011-11-11
Selective Cell Vulnerability in Alzheimer’s Disease Paul Greengard 2011-11-11
Novel Soluble Gamma-Secretase Modulators for the Treatment of Alzheimer’s Disease Identification of the Molecular Target of Potent Gamma-Secretase Modulators Steven L. Wagner 2011-11-11
Mechanisms of Retinoid X Receptor-Mediated Abeta Clearance in Alzheimers’ Disease David Holtzman Gary Landreth 2011-11-11
Effect of Bexarotene on Abeta in APP Tg Mice Expressing ApoE3 and ApoE4 David Holtzman Gary Landreth 2011-11-11
Alzheimer Disease Models Based on Human Neural Progenitor Cells Doo Yeon Kim 2011-11-09
Exploring Adult Neurogenesis as a Therapeutic Target for Alzheimer’s Disease Se Hoon Choi 2011-11-09
Molecular Tweezers—Novel Inhibitors of Amyloidogenic Proteins and Promising Drug Candidates for Alzheimer’s Disease Gal Bitan 2011-11-09
Oligomer Collaborative Projects Charles Glabe David Holtzman Paul Greengard Rudy Tanzi Sam Gandy Sangram S. Sisodia Stephen Strittmatter Tae-Wan Kim Virginia Lee 2011-03-01
Design, Synthesis and Characterization of Novel and Potent Gamma Secretase Modulators: Physiochemical and Pharmacokinetic Properties Steven L. Wagner William C. Mobley 2011-02-12
ADAM10 and Dimebolin Sam Gandy 2011-02-12
Core Facility for Abeta Microdialysis Drug Discovery Platform David Holtzman 2011-02-12
Novel Soluable Gamma-Secretase Modulators Steven L. Wagner Rudy Tanzi 2011-02-12
Passive Tau Immunotherapy Virginia Lee 2011-02-12
Three Studies of ACAT Inhibitors as Potential Therapies for AD Dora M. Kovacs 2011-02-12
Curcumin Collaborative Project Rudy Tanzi William Klunk 2011-02-12
Peek and Treat Approach to Diagnosis, Treatment and Monitoring of AD Ananth Annapragada Jason Eriksen 2011-02-12
Support of Cerebrospinal Fluid Biomarker Study–ADNI John Q. Trojanowski Leslie M. Shaw 2011-02-12
TBI and Stroke Relationship to Alzheimer’s Disease Giuseppina Tesco 2011-02-12
Development of Tau Microdialysis as a Method to Study Tau Metabolism, Pathophysiology and Response to Treatment David Holtzman 2011-02-12
Understanding the Up-Regulation of Neuroserpin in the Alzheimer’s Brain and Isolating a Potential Therapeutic Inhibitor of its Action: Continued Nicholas Seeds 2011-02-12
Longitudinal Study of AD Genotypes Deborah Blacker 2011-02-11
Relating AD Brain Morphology to AD Genotype Bradley T. Hyman 2011-02-11
Identification of Agents that Inhibit the Generation and Neurotoxicity of Cross-linked B-amyloid Protein Species Rudy Tanzi Robert Moir 2011-02-11
Fine Mapping of Prioritized GWAS Results Lars Bertram 2011-02-11
Modulation of Abeta Assembly and Cytotoxicity by a Fragment of Myelin Basic Protein William Van Nostrand 2011-02-11
Molecular Mechanism Underlying Hippocampal Neurogenisis by Familial AD-linked Presenilin-1 Variants Sangram S. Sisodia 2011-02-11
Investigation of Certain Properties of Mitochondria Membranes Related to AD Rudy Tanzi Robert Moir 2011-02-11
Understanding the Cell Biology Underlying the Effects of Abeta on Synapse Roberto Malinow 2011-02-11
Defining the Effects of Physiological Synaptic Activity on Abeta Levels: Implications for AD David Holtzman 2011-02-11
miRNAs in AD Pathology Aleister J. Saunders 2011-02-11
Rescue of Synapses in AD Rodent Models Roberto Malinow 2011-02-11
Modulation of Abeta Deposition by Cell-Specific Mechanisms Sangram S. Sisodia 2011-02-11
NMDA Receptors Roberto Malinow 2011-02-11
Mouse Model for Non-Generic Alzheimer’s Disease Frank LaFerla 2011-02-11
Anti-APOE Antibodies David Holtzman 2011-02-11
Brain Structure, Abeta Metabolism and Behavior in Mice Deficient in Diabetes and Alzheimer’s Associated SorCS1 Sam Gandy 2011-02-11
Upkeep and Maintenance of the AlzGene Database Lars Bertram 2011-02-11
The Amylin Protein of Diabetes Mellitus is an Antimicrobial Peptide Robert Moir Rudy Tanzi 2011-02-11