Christian Haass, Ph.D.

Biomedizinisches Centrum (BMC), Stoffwechselbiochemie, Ludwig-Maximilians Universität München & Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V. 

Dr. Haass graduated in Molecular Biology at the University of Heidelberg, Germany.  He was a postdoc and assistant professor of Neurology at the Harvard Medical School in the institute of Dr. Dennis Selkoe.  Since 1999 he is the head of the division of Biochemistry at the Ludwig-Maximilians University and since 2009 he is also the speaker of the German Center for Neurodegenerative Diseases (DZNE) in Munich.  Dr. Haass received a number of prestigious awards, among them, the Gottfried Wilhelm Leibniz-Award of the Deutsche Forschungsgemeinschaft, the Potamkin Award of the American Academy of Neurology, the Sheik Hamdan Award for Medical Sciences and most recently the ERC advanced grant.

Funded Research

Project Description Researchers Funding
Therapeutic Modulation of TREM2 Activity

There is strong evidence that inflammation occurs in different stages of Alzheimer’s disease (AD). Understanding this process can help us to design new therapeutic approaches. TREM2 is a protein directly related to the inflammation process that occurs in the brain of patients with AD. Mutations in this protein increase the risk to develop AD up to threefold. A fragment of this protein, namely soluble TREM2 (sTREM2), increases at very early stages of AD, and this increase occurs in parallel to an increase of biomarkers for neuronal cell death.

2016
$150,000
TREM2 Function and Dysfunction in Alzheimer's Disease

There is strong evidence that inflammation occurs in different stages of Alzheimer’s disease (AD), and understanding this process can help us to design new therapeutic approaches. TREM2 is a protein that is directly related to the inflammation process that occurs in the brain of patients with AD; mutations in this protein increase the risk to develop AD up to threefold. A fragment of this protein, namely soluble TREM2 (sTREM2), can be detected in biological fluids like the cerebrospinal fluid (CSF). The function of sTREM2 in health and disease currently is not known.

2015
$144,182

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez‐Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass, The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, Embo Journal, 36(13), 3 Jul 2017, 1837-1853
Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass, TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports, 8 May 2017
Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo, The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 6, 2017, 50-59
Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monté, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo, Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease, Alzheimer's & Dementia, 12(12), Dec 2016, 1259–1272
Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass, TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine, 8(9), 1 Sep 2016, 987-1113
Marc Suárez‐Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez‐Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass, sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers, EMBO Molecular Medicine, 8(3), March 2016, 173-303