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2025-02-21
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Mechanisms of astrocyte aging in reactivity and disease, Molecular Neurodegeneration |
Gildea, H. K., & Liddelow, S. A. |
2025-02-21
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2025-02-21
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2025-02-20
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2025-02-19
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2025-02-19
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2025-02-18
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2025-02-17
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2025-02-17
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2025-02-16
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2025-02-15
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Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia, Alzheimer's Research & Therapy |
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2025-02-13
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The neuroimmune connectome in health and disease, Nature Medicine |
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2025-02-12
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2025-02-12
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2025-02-05
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2025-02-05
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2025-01-31
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2025-01-28
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2025-01-24
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2025-01-22
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2025-01-18
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2025-01-16
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2025-01-15
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Evaluating plasma biomarkers NfL, GFAP, GDF15, and FGF21 as indicators of disease severity in Charcot–Marie Tooth patients, Frontiers in Neurology |
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2025-01-14
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2025-01-12
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2025-01-10
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2025-01-09
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2025-01-08
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2025-01-08
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2025-01-07
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Identify biological Alzheimer’s disease using a novel nucleic acid–linked protein immunoassay, Brain Communications |
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2025-01-07
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2025-01-07
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2025-01-06
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2025-01-06
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Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society, NeuroMolecular Medicine |
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2025-01-05
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2025-01-04
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2025-01-04
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2025-01-02
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2025-01-02
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2024-12-28
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Considering the interconnected nature of social identities in neuroimaging research, Nature Neuroscience |
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2024-12-24
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2024-12-24
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2024-03-19
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Towards Unveiling the Genetics of Neurodegenerative Diseases, Seminars in Neurology |
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2017-03-03
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2023-09-23
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2015-06-22
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2022-04-22
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2022-03-24
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2022-03-16
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Application of predictive models in boosting power of Alzheimer’s disease clinical trials: A post hoc analysis of phase 3 solanezumab trials, Alzheimer's & Dementia |
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2022-03-14
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Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain, Nature Neuroscience |
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2022-03-08
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2022-03-04
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2022-03-03
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The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner, Scientific Reports |
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2022-03-03
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2022-02-09
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2022-02-09
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Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature, Journal of Personalized Medicine |
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2022-01-24
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Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer’s disease, Alzheimer's & Dementia |
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2022-01-27
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Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix, STAR Protocols |
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2022-01-07
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A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data, Genes |
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2022-01-06
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2022-01-03
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Single-cell delineation of lineage and genetic identity in the mouse brain, Nature |
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2021-12-15
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Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology, Nature Aging |
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2021-12-10
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Predictive value of ATN biomarker profiles in estimating disease progression in Alzheimer’s disease dementia, Alzheimer's & Dementia |
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2021-11-17
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Leveraging machine learning predictive biomarkers to augment the statistical power of clinical trials with baseline magnetic resonance imaging, Brain Communications |
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2021-10-15
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Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?, Neuronal Signaling |
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2021-10-08
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Neurotoxic reactive astrocytes induce cell death via saturated lipids., Nature |
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2021-10-06
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2021-09-16
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2021-09-14
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Exercise hormone irisin is a critical regulator of cognitive function, Nature Metabolism |
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2021-08-20
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Neuroinflammatory astrocyte subtypes in the mouse brain, Nature Neuroscience |
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2021-08-19
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2021-08-16
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2021-07-21
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Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature |
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2021-07-14
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Nuclei isolation of multiple brain cell types for omics interrogation, Nature Protocols |
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2021-01-25
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2021-06-23
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2021-06-07
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2021-05-18
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2021-04-15
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2021-04-02
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The role of innate immune genes in Alzheimer’s disease, Current Opinion in Neurology |
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2021-04-01
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The AD tau core spontaneously self-assembles and recruits full-length tau to filaments, Cell Reports |
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The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration, Life |
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2021-03-02
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Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells-Implications for Cancer and Neurodegeneration, Life |
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Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs, Cell Stem Cell |
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2021-01-07
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Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates, Journal of Experimental Medicine |
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2020-12-07
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REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis, eLife |
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2020-12-01
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Advancing Computerized Cognitive Training for MCI and Alzheimer’s Disease in a Pandemic and Post-pandemic World, Frontiers in Psychiatry |
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2020-11-25
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Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings, Science Translational Medicine |
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2020-11-18
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An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse Models, Cells |
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2020-11-04
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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease, Nature Communications |
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2020-10-23
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Abeta-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice, Science Translational Medicine |
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2020-09-30
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2020-09-17
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2020-09-08
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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators, Bioorganic and Medicinal Chemistry |
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2020-09-01
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency, Nature |
Zhang, J., Velmeshev, D., Hashimoto, K., Huang, Y. H., Hofmann, J. W., Shi, X., Chen, J., Leidal, A. M., Dishart, J. G., Cahill, M. K., Kelley, K. W., Liddelow, S. A., … Huang, E. J. |
2020-08-31
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Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?, Trends in Immunology |
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2020-08-17
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2020-08-17
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Upregulation of Alzheimer’s Disease Amyloid-beta Protein Precursor in Astrocytes Both in vitro and in vivo, Journal of Alzheimer's Disease |
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2020-08-04
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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model, Nature Communications |
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2020-07-27
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2020-07-13
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Non-invasive red-light optogenetic control of Drosophila cardiac function, Communications Biology |
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2020-06-29
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Neurotoxic Reactive Astrocytes Drive Neuronal Death After Retinal Injury, Cell Reports |
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2020-06-23
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2020-06-22
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2020-04-18
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2020-04-17
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Crenshaw, E., Leung, B. P., Kwok, C. K., Sharoni, M., Olson, K., Sebastian, N. P., Ansaloni, S., Schweitzer-Stenner, R., Akins, M. R., Bevilacqua, P. C., & Saunders, A. J. |
2015-11-30
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Optogenetic pacing in Drosophila melanogaster, Science Advances |
Alex, A., Li, A., Tanzi, R. E., & Zhou, C. |
2015-10-09
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Alzheimer’s in 3D culture: Challenges and Perspectives, BioEssays |
D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., & Kim, D. Y. |
2015-10-01
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Massachusetts Alzheimer’s Disease Research Center: Progress and Challenges, Alzheimer's & Dementia |
Hyman, B. T., Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. T., Haass, C., Hudry, E., Jack, C. R., Jr, Johnson, K. A., Khachaturian, Z. S., Kim, D. Y., Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L., Young, A. B., Phelps, C. H., & McCaffrey, P.M. |
2015-10-01
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A circadian clock gene, cry, affects heart morphogenesis and function in Drosophila as revealed by optical coherence microscopy, PLoS One |
Alex, A., Li, A., Zeng, X., Tate, R. E., McKee, M. L., Capen, D. E., Zhang, Z., Tanzi, R. E., & Zhou, C. |
2015-09-08
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Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families, BMC Medical Genetics |
Park, S., Lee, S., Lee, Y., Herold, C., Hooli, B., Mullin, K., Park, T., Park, C., Bertram, L., Lange, C., Tanzi, R., & Won, S. |
2015-08-19
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A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols |
Kim, Y. H., Choi, S. H., D'Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K. J., Klee, J. B., Brüstle, O., Tanzi, R. E., & Kim, D. Y. |
2015-07-01
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Three dimensions of the amyloid hypothesis: time, space, and ‘wingmen’, Nature Neuroscience |
Musiek, E. S., & Holtzman, D. M. |
2015-06-01
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Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance, Nature Neuroscience |
Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., Owens, N. C., Rege, S. V., Si, G., Ahuja, A., Zhu, D., Miller, C. A., Schneider, J. A., Maeda, M., Maed |
2015-05-25
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Gamma-Secretase modulators reduce endogenous amyloid beta (42) levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal |
D'Avanzo, C., Sliwinski, C., Wagner, S. L., Tanzi, R. E., Kim, D. Y., & Kovacs, D. M. |
2015-04-22
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Sleep, circadian rhythms and the pathogenesis of Alzheimer Disease, Experimental and Molecular Medicine |
Musiek, E. S., Xiong, D. D., & Holtzman, D. M. |
2015-03-01
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A gamma secretase inhibitor, but not a gamma-secretase modulator, induced defects in BDNF Axonal trafficking and signaling: evidence for a role for APP, PLoS One |
Weissmiller, A. M., Natera-Naranjo, O., Reyna, S. M., Pearn, M. L., Zhao, X., Nguyen, P., Cheng, S., Goldstein, L. S., Tanzi, R. E., Wagner, S. L., Mobley, W. C., & Wu, C. |
2015-02-24
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A three-dimensional human neural cell culture model of Alzheimer’s disease, Nature |
Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J. B., Zhang, C., Wainger, B. J., Peitz, M., Kovacs, D. M., Woolf, C. J., Wagner, S. L., Tanzi, R. E., & Kim, D. Y. |
2014-10-12
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The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk, Neurology |
Hooli, B. V., Parrado, A. R., Mullin, K., Yip, W. K., Liu, T., Roehr, J. T., Qiao, D., Jessen, F., Peters, O., Becker, T., Ramirez, A., Lange, C., Bertram, L., & Tanzi, R. E. |
2014-10-07
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Cerebral vascular leak in a mouse model of amyloid neuropathology, Journal of Cerebral Blood Flow & Metabolism |
Tanifum, E. A., Starosolski, Z. A., Fowler, S. W., Jankowsky, J. L., & Annapragada, A. V. |
2014-10-01
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Age-dependent, non-cell autonomous deposition of amyloid from synthesis of beta-amyloid by cells other than excitatory neurons, Journal of Neuroscience |
Veeraraghavalu, K., Zhang, C., Zhang, X., Tanzi, R. E., & Sisodia, S. S. |
2014-03-05
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Soluble gamma-secretase modulators slectively inhibit the production of the 42 amino-acid amyloid beta peptide variant and augment the production of multiple carboxy-truncated amyloid beta species, Biochemistry |
Wagner, S. L., Zhang, C., Cheng, S., Nguyen, P., Zhang, X., Rynearson, K. D., Wang, R., Li, Y., Sisodia, S. S., Mobley, W. C., & Tanzi, R. E. |
2014-01-22
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Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Scientific Reports |
Xu, Z., Dong, Y., Wang, H., Culley, D. J., Marcantonio, E. R., Crosby, G., Tanzi, R. E., Zhang, Y., & Xie, Z. |
2014-01-20
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Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, Journal of Clinical Investigation |
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., Herzog, E. D., Hogenesch, J. B., Wozniak, D. F., Dikranian, K., Giasson, B. I., Weaver, D. R., Holtzman, D. M., & Fitzgerald, G. A. |
2013-12-02
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ADAM10 Missense Mutations Potentiate beta-amyloid accumulation by impairing pro-domain chaperone function, Neuron |
Suh, J., Choi, S. H., Romano, D. M., Gannon, M. A., Lesinski, A. N., Kim, D. Y., & Tanzi, R. E. |
2013-09-19
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Cerebrospinal fluid Abeta to Tau ratio and postoperative cognitive change, Annals of Surgery |
Xie, Z., McAuliffe, S., Swain, C. A., Ward, S. A., Crosby, C. A., Zheng, H., Sherman, J., Dong, Y., Zhang, Y., Sunder, N., Burke, D., Washicosky, K. J., Tanzi, R. E., & Marcantonio, E. R. |
2013-08-01
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Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychiatry |
Hooli, B. V., Kovacs-Vajna, Z. M., Mullin, K., Blumenthal, M. A., Mattheisen, M., Zhang, C., Lange, C., Mohapatra, G., Bertram, L., & Tanzi, R. E. |
2013-06-11
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Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta, Neuron |
Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. |
2013-05-22
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Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Human Molecular Genetics |
Li, A., Ahsen, O. O., Liu, J. J., Du, C., McKee, M. L., Yang, Y., Wasco, W., Newton-Cheh, C. H., O'Donnell, C. J., Fujimoto, J. G., Zhou, C., & Tanzi, R. E. |
2013-05-21
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Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells, Biochemsitry |
Viswanathan, J., Haapasalo, A., Kurkinen, K. M., Natunen, T., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., & Hiltunen, M. |
2013-05-10
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Origins of Alzheiemr’s disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid beta and tau involvement, Current Opinion in Neurology |
Musiek, E. S., & Holtzman, D. M. |
2012-12-01
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Intravenous delivery of targeted liposomes to amyloid-beta in APP/PSEN1 transgenic mice, PLoS One |
Tanifum, E. A., Dasgupta, I., Srivastava, M., Bhavane, R. C., Sun, L., Berridge, J., Pourgarzham, H., Kamath, R., Espinosa, G., Cook, S. C., Eriksen, J. L., & Annapragada, A. |
2012-10-31
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Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochimica et Biophysica Acta - General Subjects |
Arai, H., Glabe, C., & Luecke, H. |
2012-08-24
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Developing the “Next Generation: of genetic association databases for complex diseases, Human Mutation |
Lill, C. M., & Bertram, L. |
2012-07-12
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Chronic Traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model, Science Translational Medicine |
Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X. L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., Goletiani, C. J., Maglakelidze, G. M., Casey, N., Moncaster, J. A., Minaeva, O., Moir, R. D., … Tanzi, R. E., ... McKee, A. C. |
2012-05-16
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The levels of water-soluble and triton-soluble A beta are increased in Alzheimer’s disease brain, Brain Research |
McDonald, J. M., Cairns, N. J., Taylor-Reinwald, L., Holtzman, D., & Walsh, D. M. |
2012-04-23
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Role of common and rare APP DNA sequence variants in Alzheimer’s Disease, Neurology |
Hooli, B. V., Mohapatra, G., Mattheisen, M., Parrado, A. R., Roehr, J. T., Shen, Y., Gusella, J. F., Moir, R., Saunders, A. J., Lange, C., Tanzi, R. E., & Bertram, L. |
2012-04-17
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Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain, Journal of Neuroscience |
Bero, A. W., Bauer, A. Q., Stewart, F. R., White, B. R., Cirrito, J. R., Raichle, M. E., Culver, J. P., & Holtzman, D. M. |
2012-03-28
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The Zinc Dyshomeostasis Hypothesis of Alzheimer’s Disease, PLoS One |
Craddock, T. J., Tuszynski, J. A., Chopra, D., Casey, N., Goldstein, L. E., Hameroff, S. R., & Tanzi, R. E. |
2012-03-23
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ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models, Science |
Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., Brunden, K. R., Wilson, D. A., & Landreth, G. E. |
2012-03-23
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Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson’s Disease Genetics: the PDGene database, PLoS Genetics |
Lill, C. M., Roehr, J. T., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B. M., Schjeide, L. M., Meissner, E., … Tanzi, R. E., ... Bertram, L. |
2012-03-15
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Anesthetics isoflurane and desflurane directly affect mitochondrial function, learning, and memory, Annals of Neurology |
Zhang, Y., Xu, Z., Wang, H., Dong, Y., Shi, H. N., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. |
2012-02-24
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On the Meta-Analysis of Genome-Wide Association studies: a robust and efficient approach to combine population and family-based studies, Human Heredity |
Won, S., Lu, Q., Bertram, L., Tanzi, R. E., & Lange, C. |
2012-01-18
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Functional Links between A beta toxicity, Endocytic trafficking, and Alzheimer’s disease risk factors in yeast, Science |
Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., Han, H., Lindhagen-Persson, M., Reiman, E. M., Evans, D. A., Bennett, D. A., Olofsson, A., DeJager, P. L., Tanzi, R. E., Caldwell, K. A., Caldwell, G. A., … Lindquist, S. |
2011-12-02
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Characterization of a Drosophila Alzheimer’s disease model: pharmacoogical rescue of cognitive defects, PLoS One |
Chakraborty, R., Vepuri, V., Mhatre, S. D., Paddock, B. E., Miller, S., Michelson, S. J., Delvadia, R., Desai, A., Vinokur, M., Melicharek, D. J., Utreja, S., Khandelwal, P., Ansaloni, S., Goldstein, L. E., Moir, R. D., Lee, J. C., Tabb, L. P., Saunders, A. J., & Marenda, D. R. |
2011-06-06
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Changes in the expression of the Alzheimer’s disease-associated presenilin gene in Drosophila heart leads to cardiac dysfunction, Current Alzheimer Research |
Li, A., Zhou, C., Moore, J., Zhang, P., Tsai, T. H., Lee, H. C., Romano, D. M., McKee, M. L., Schoenfeld, D. A., Serra, M. J., Raygor, K., Cantiello, H. F., Fujimoto, J. G., & Tanzi, R. E. |
2011-05-01
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Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking, Molecular and Cellular Biology |
Sarajärvi, T., Tuusa, J. T., Haapasalo, A., Lackman, J. J., Sormunen, R., Helisalmi, S., Roehr, J. T., Parrado, A. R., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., Petäjä-Repo, U. E., & Hiltunen, M. |
2011-04-04
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The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzhiemer Disease risk and cerebrospinal fluid biomarker levels, Archives of General Psychiatry |
Schjeide, B. M., Schnack, C., Lambert, J. C., Lill, C. M., Kirchheiner, J., Tumani, H., Otto, M., Tanzi, R. E., Lehrach, H., Amouyel, P., von Arnim, C. A., & Bertram, L. |
2011-02-01
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Alzheimer’s disease-associated Ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation, Traffic |
Viswanathan, J., Haapasalo, A., Böttcher, C., Miettinen, R., Kurkinen, K. M., Lu, A., Thomas, A., Maynard, C. J., Romano, D., Hyman, B. T., Berezovska, O., Bertram, L., Soininen, H., Dantuma, N. P., Tanzi, R. E., & Hiltunen, M. |
2011-01-07
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The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1 beta, Neurobiology of Aging |
Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. |
2010-12-28
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The Genetics of Alzheimer’s disease: back to the future, Neuron |
Bertram, L., Lill, C. M., & Tanzi, R. E. |
2010-10-21
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Amyloid-beta Production Via Cleavage of Amyloid-beta Protein Precursor is Modulated by Cell Density, Journal of Alzheimer's Disease |
Zhang, C., Browne, A., Divito, J. R., Stevenson, J. A., Romano, D., Dong, Y., Xie, Z., & Tanzi, R. E. |
2010-10-01
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Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-beta metabolism: evidence for involvement of SorL1 and the Retromer Complex, Journal of Neuroscience |
Lane, R. F., Raines, S. M., Steele, J. W., Ehrlich, M. E., Lah, J. A., Small, S. A., Tanzi, R. E., Attie, A. D., & Gandy, S. |
2010-09-29
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Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein, Journal of Biological Chemistry |
Zhang, C., Browne, A., Child, D., & Tanzi, R. E. |
2010-09-10
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Alzheimer’s disease Amyloid-beta links lens and brain pathology in Down syndrome, PLoS One |
Moncaster, J. A., Pineda, R., Moir, R. D., Lu, S., Burton, M. A., Ghosh, J. G., Ericsson, M., Soscia, S. J., Mocofanescu, A., Folkerth, R. D., Robb, R. M., Kuszak, J. R., Clark, J. I., Tanzi, R. E., Hunter, D. G., & Goldstein, L. E. |
2010-05-20
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The Alzheimer’s Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide, PLoS One |
Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., & Moir, R. D. |
2010-03-03
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Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy, Circulation |
Gianni, D., Li, A., Tesco, G., McKay, K. M., Moore, J., Raygor, K., Rota, M., Gwathmey, J. K., Dec, G. W., Aretz, T., Leri, A., Semigran, M. J., Anversa, P., Macgillivray, T. E., Tanzi, R. E., & del Monte, F. |
2010-03-01
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Familial Alzhiemer’s Disease mutations in presenilin 1 do not alter levels of the secreted amyloid-protein precursor generated by beta-secretase cleavage, Current Alzheimer Research |
Zhang, C., Browne, A., Kim, D. Y., & Tanzi, R. E. |
2010-02-01
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Loss of Function of ATXN1 Increases Amyloid beta-Protein Levels by Potentiating beta-Secretase Processing of beta-Amyloid Precursor Protein, Journal of Biological Chemistry |
Zhang, C., Browne, A., Child, D., Divito, J. R., Stevenson, J. A., & Tanzi, R. E. |
2010-01-22
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CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid, Neuroscience Letters |
Giedraitis, V., Glaser, A., Sarajärvi, T., Brundin, R., Gunnarsson, M. D., Schjeide, B. M., Tanzi, R. E., Helisalmi, S., Pirttilä, T., Kilander, L., Lannfelt, L., Soininen, H., Bertram, L., Ingelsson, M., & Hiltunen, M. |
2010-01-22
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Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity, Human Molecular Genetics |
Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., Norton, D., Tesco, G., Elliott, K., Wagner, S. L., Moir, R. D., Becker, K. D., & Tanzi, R. E. |
2009-10-15
|
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Genome-wide association studies in Alzheimer’s Disease, Human Molecular Genetics |
Bertram, L., & Tanzi, R. E. |
2009-10-15
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GAB2 as an Alzheimer Disease Susceptibility Gene, Archives of Neurology |
Schjeide, B. M., Hooli, B., Parkinson, M., Hogan, M. F., DiVito, J., Mullin, K., Blacker, D., Tanzi, R. E., & Bertram, L. |
2009-02-01
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Assessment of Alzheimer’s disease case-control associations using family-based methods, Neurogenetics |
Schjeide, B. M., McQueen, M. B., Mullin, K., DiVito, J., Hogan, M. F., Parkinson, M., Hooli, B., Lange, C., Blacker, D., Tanzi, R. E., & Bertram, L. |
2009-02-01
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The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta protein level in vivo, Annals of Neurology |
Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. |
2008-11-11
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Genome-wide Association Analysis Reveals Putative Alzheimer’s Disease Susceptibility Loci in Addition to APOE, American Journal of Human Genetics |
Bertram, L., Lange, C., Mullin, K., Parkinson, M., Hsiao, M., Hogan, M. F., Schjeide, B. M., Hooli, B., Divito, J., Ionita, I., Jiang, H., Laird, N., Moscarillo, T., Ohlsen, K. L., Elliott, K., Wang, X., Hu-Lince, D., Ryder, M., Murphy, A., Wagner, S. L., Blacker, D., … Tanzi, R. E. |
2008-10-30
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Spatial memory is intact in aged rats after propofol anesthesia, Anesthesia & Analgesia |
Lee, I. H., Culley, D. J., Baxter, M. G., Xie, Z., Tanzi, R. E., & Crosby, G. |
2008-10-01
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Association of GSK3b with Alzheimer disease and frontotemporal dementia, Archives of Neurology |
Schaffer, B. A., Bertram, L., Miller, B. L., Mullin, K., Weintraub, S., Johnson, N., Bigio, E. H., Mesulam, M., Wiedau-Pazos, M., Jackson, G. R., Cummings, J. L., Cantor, R. M., Levey, A. I., Tanzi, R. E., & Geschwind, D. H. |
2008-10-01
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Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neuroscience |
Bertram, L., & Tanzi, R. E. |
2008-10-01
|
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Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies: Application to Alzheimer’s Disease, American Journal of Epidemiology |
Kavvoura, F. K., McQueen, M. B., Khoury, M. J., Tanzi, R. E., Bertram, L., & Ioannidis, J. P. |
2008-09-09
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