Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Title Researchers Date
Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitvie impariment induced by isoflurane in aged mice, Anesthesiology Li, X. M., Su, F., Ji, M. H., Zhang, G. F., Qiu, L. L., Jia, M., Gao, J., Xie, Z., & Yang, J. J. 2014-07-01
Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3 beta activation in young mice, Anesthesiology Tao, G., Zhang, J., Zhang, L., Dong, Y., Yu, B., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. 2014-09-01
Anaesthetic Neurotoxicity and Neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, British Journal of Anaesthesia Jevtovic-Todorovic, V., Absalom, A. R., Blomgren, K., Brambrink, A., Crosby, G., Culley, D. J., Fiskum, G., Giffard, R. G., Herold, K. F., Loepke, A. W., Ma, D., Orser, B. A., Planel, E., Slikker, W., Jr, Soriano, S. G., Stratmann, G., Vutskits, L., Xie, Z., & Hemmings, H. C., Jr. 2013-08-01
Isoflurane induces endoplasmic reticulum stress and caspase actication through ryanodine receptors, British Journal of Anaesthesia Wang, H., Dong, Y., Zhang, J., Xu, Z., Wang, G., Swain, C. A., Zhang, Y., & Xie, Z. 2014-04-03
Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia Zhang, L., Zhang, J., Yang, L., Dong, Y., Zhang, Y., & Xie, Z. 2013-04-19
Neurotoxicity of General Anesthetics: an update, Current Pharmaceutical Design Vlisides, P., & Xie, Z. 2012-12-01
Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochorne mice levels between m neural progenitor cells and neurons, Frontiers in Cellular Neuroscience Zhang, Y., Pan, C., Wu, X., Dong, Y., Culley, D. J., Crosby, G., Li, T., & Xie, Z. 2014-01-30
Surgery plus anesthesia induces loss of attention in mice, Frontiers in Cellular Neuroscience Ren, Q., Peng, M., Dong, Y., Zhang, Y., Chen, M., Yin, N., Marcantonio, E. R., & Xie, Z. 2015-09-08
Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA recptor 2B in mice, Journal of Neuroscience Zhang, X., Xin, X., Dong, Y., Zhang, Y., Yu, B., Mao, J., & Xie, Z. 2013-11-06
Perioperative cognitive decline in aging population, MAYO Clinic Proceedings Terrando, N., Brzezinski, M., Degos, V., Eriksson, L. I., Kramer, J. H., Leung, J. M., Miller, B. L., Seeley, W. W., Vacas, S., Weiner, M. W., Yaffe, K., Young, W. L., Xie, Z., & Maze, M. 2011-09-01
Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95, Molecular Neurobiology Zhang, J., Dong, Y., Zhou, C., Zhang, Y., & Xie, Z. 2014-05-29
Vitamin C attenuates isoflurane-induced caspase-3 activation and cognitive impairment, Molecular Neurobiology Cheng, B., Zhang, Y., Wang, A., Dong, Y., & Xie, Z. 2014-11-04
Sleep disturbance induces neuroinflammation and impariment of learning and memory, Neurobiology of Disease Zhu, B., Dong, Y., Xu, Z., Gompf, H. S., Ward, S. A., Xue, Z., Miao, C., Zhang, Y., Chamberlin, N. L., & Xie, Z. 2012-12-01
Anesthetic isoflurante increases phosphorylated tau levels mediated by caspase activation and A beta generation, PLoS One Dong, Y., Wu, X., Xu, Z., Zhang, Y., & Xie, Z. 2012-06-20
General anesthetics and beta-amyloid protein, Progress in Neuro-Psychopharmacology & Biological Psychiatry Xie, Z., & Xu, Z. 2012-08-13
Anesthetics isoflurane and desflurane directly affect mitochondrial function, learning, and memory, Annals of Neurology Zhang, Y., Xu, Z., Wang, H., Dong, Y., Shi, H. N., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. 2023-01-19
Cerebrospinal fluid Abeta to Tau ratio and postoperative cognitive change, Annals of Surgery Xie, Z., McAuliffe, S., Swain, C. A., Ward, S. A., Crosby, C. A., Zheng, H., Sherman, J., Dong, Y., Zhang, Y., Sunder, N., Burke, D., Washicosky, K. J., Tanzi, R. E., & Marcantonio, E. R. 2013-08-01
Amyloid-beta Production Via Cleavage of Amyloid-beta Protein Precursor is Modulated by Cell Density, Journal of Alzheimer's Disease Zhang, C., Browne, A., Divito, J. R., Stevenson, J. A., Romano, D., Dong, Y., Xie, Z., & Tanzi, R. E. 2010-10-01
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1 beta, Neurobiology of Aging Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. 2010-12-28
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta protein level in vivo, Annals of Neurology Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. 2008-11-11
Hybrid PET/MRI Enables High-Spatial Resolution, Quantitative Imaging of Amyloid Plaques in an Alzheimer’s Disease Mouse Model, Scientific Reports Frost, G. R., Longo, V., Li, T., Jonas, L. A., Judenhofer, M., Cherry, S., Koutcher, J., Lekaye, C., Zanzonico, P., & Li, Y. M. 2020-06-25
γ-Secretase Inhibitors and Modulators: Mechanistic Insights Into the Function and Regulation of γ-Secretase, Seminars in Cell & Developmental Biology Nie, P., Vartak, A., & Li, Y. M. 2020-04-02
Evidence that the “Lid” domain of nicastrin is not essential for regulating secretase activity, Journal of Biological Chemistry Zhang, X., Sullivan, E., Scimeca, M., Wu, X., Li, Y. M., & Sisodia, S. S. 2016-02-17
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of gamma-secrtase using synthetic antibodies, Proceedings of the National Academy of Sciences of the United States of America Zhang, X., Hoey, R. J., Lin, G., Koide, A., Leung, B., Ahn, K., Dolios, G., Paduch, M., Ikeuchi, T., Wang, R., Li, Y. M., Koide, S., & Sisodia, S. S. 2012-05-14
Therapeutic TVs for Crossing Barriers in the Brain, Cell Zhao, Z., & Zlokovic, B. V. 2020-07-23
Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo, Frontiers in Aging Neuroscience Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. 2020-04-29
Endothelial Tip Cell Finds Its Way with Piezo1, Neuron Zhao, Z., & Zlokovic, B. V. 2020-10-14
Blood-Brain Barrier: From Physiology to Disease and Back, Physiological Reviews Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. 2019-01-01
Prion Protein Antagonists Rescue Alzheimer’s Amyloid-Beta Related Cognitive Deficits, Trends in Molecular Medicine Sagare, A. P., Sweeney, M. D., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. 2019-02-01
Can prehospital “plasma supplement” neutralize the systemic storm in severe trauma?, Cell Reports Medicine Zhao, Z., & Zlokovic, B. V. 2021-12-21
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier, Molecular Neurodegeneration Kisler, K., Sagare, A. P., Lazic, D., Bazzi, S., Lawson, E., Hsu, C. J., Wang, Y., Ramanathan, A., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. 2023-01-27
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism, Molecular Neurodegeneration Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. 2018-10-19
Inflammatory pain may induce cognitive impairment through an interlukin-6 dependent and postsynaptic density-95 associated mechanism, ​​Anesthesia & Analgesia Yang, L., Xin, X., Zhang, J., Zhang, L., Dong, Y., Zhang, Y., Mao, J., & Xie, Z. 2014-05-30
2-Deoxy-D-Glucose Enhances Anesthetic Effects in Mice, ​​Anesthesia & Analgesia Wang, H., Xu, Z., Wu, A., Dong, Y., Zhang, Y., Yue, Y., & Xie, Z. 2015-02-01
Propofol Enhances Hemoglobin-induced cytotoxicity in Neurons, ​​Anesthesia & Analgesia Yuan, J., Cui, G., Li, W., Zhang, X., Wang, X., Zheng, H., Zhang, J., Xiang, S., & Xie, Z. 2016-01-14
Glucose May Attenuate Isoflurane-Induced Caspase-3 Activation in H4 Human Neuroglioma Cells, ​​Anesthesia & Analgesia Sun, Y., Zhang, Y., Cheng, B., Dong, Y., Pan, C., Li, T., & Xie, Z. 2014-07-26
Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment, Anesthesiology Shen, X., Dong, Y., Xu, Z., Wang, H., Miao, C., Soriano, S. G., Sun, D., Baxter, M. G., Zhang, Y., & Xie, Z. 2013-03-01
Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice, Anesthesiology Zheng, H., Dong, Y., Xu, Z., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. 2013-03-01
Effects of Anesthetic Isoflurane and Desflurane on Human Cerebrospinal Fluid Aβ and τ Level, Anesthesiology Zhang, B., Tian, M., Zheng, H., Zhen, Y., Yue, Y., Li, T., Li, S., Marcantonio, E. R., & Xie, Z. 2013-07-01
Cancer prognosis: can anesthesia play a role?, Anesthesiology Xie Z. 2013-09-01
Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro., Biochemistry Hoos, M. D., Ahmed, M., Smith, S. O., & Van Nostrand, W. E. 2009-04-22
Fine mapping of the amyloid β-protein binding site on myelin basic protein, Biochemistry Kotarba, A. E., Aucoin, D., Hoos, M. D., Smith, S. O., & Van Nostrand, W. E. 2013-04-04
Mechanism of Nucleated conformational conversion of A beta 42, Biochemistry Fu, Z., Aucoin, D., Davis, J., Van Nostrand, W. E., & Smith, S. O. 2015-06-12
Degradation of amyloid beta protein by purified myelin basic protein, Journal of Biological Chemistry Liao, M. C., Ahmed, M., Smith, S. O., & Van Nostrand, W. E. 2009-08-19
N-terminal Domain of Myelin Basic Protein Inhibits Amyloid beta-Protein Fibril Assembly, Journal of Biological Chemistry Liao, M. C., Hoos, M. D., Aucoin, D., Ahmed, M., Davis, J., Smith, S. O., & Van Nostrand, W. E. 2010-08-31
Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils., Nature Structural & Molecular Biology Ahmed, M., Davis, J., Aucoin, D., Sato, T., Ahuja, S., Aimoto, S., Elliott, J. I., Van Nostrand, W. E., & Smith, S. O. 2010-04-11
Small molecule amyloid-beta protein precurosr processing modulators lower amyloid beta peptide levels via cKit signaling, Journal of Alzheimer's Disease Chen, C. D., Zeldich, E., Khodr, C., Camara, K., Tung, T. Y., Lauder, E. C., Mullen, P., Polanco, T. J., Liu, Y. Y., Zeldich, D., Xia, W., Van Nostrand, W. E., Brown, L. E., Porco, J. A., & Abraham, C. R. 2019-02-12
PanomiR: a systems biology framework for analysis of multi-pathway targeting by miRNAs, Briefings in Bioinformatics Naderi Yeganeh, P., Teo, Y. Y., Karagkouni, D., Pita-Juárez, Y., Morgan, S. L., Slack, F. J., Vlachos, I. S., & Hide, W. A. 2023-11-20
The relative resistance of children to sepsis mortality: from pathways to drug candidates, Molecular Systems Biology Joachim, R. B., Altschuler, G. M., Hutchinson, J. N., Wong, H. R., Hide, W. A., & Kobzik, L. 2018-05-01
Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment, Human Molecular Genetics Li, A., Hooli, B., Mullin, K., Tate, R. E., Bubnys, A., Kirchner, R., Chapman, B., Hofmann, O., Hide, W., & Tanzi, R. E. 2017-02-10
Central regulation of stress-evoked peripheral immune responses, Nature Reviews Neuroscience Chan, K. L., Poller, W. C., Swirski, F. K., & Russo, S. J. 2023-08-25
Glial control of synapse number in healthy and diseased brain, Frontiers in Cellular Neuroscience Lee, E., & Chung, W. S. 2019-02-13
γ-Secretase fanning the fire of innate immunity, Biochemical Society Transactions Liu, C., Nikain, C., & Li, Y. M. 2023-08-31
Turning the tide on Alzheimer’s disease: modulation of γ-secretase., Cell & Bioscience Luo, J. E., & Li, Y. M. (2022) 2022-01-04
γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors, Frontiers in Aging Neuroscience Wong, E., Frost, G. R., & Li, Y. M. 2020-12-02
Friend, Foe or Both? Immune Activity in Alzheimer’s Disease, Frontiers in Aging Neuroscience Frost, G. R., Jonas, L. A., & Li, Y. M. 2019-12-10
The role of astrocytes in amyloid production and Alzheimer’s disease, Open Biology Frost, G. R., & Li, Y. M. 2017-12-13
Functional insight into LOAD-associated microglial response genes, Open Biology Jonas, L. A., Jain, T., & Li, Y. M. 2022-01-26
Versatility of presenilin 1, Proceedings of the National Academy of Sciences of the United States of America Frost, G. R., Wong, E., & Li, Y. M. 2017-06-23
Recent developments of small molecule γ-secretase modulators for Alzheimer’s disease, RSC Medicinal Chemistry Mekala, S., Nelson, G., & Li, Y. M. 2020-08-27
Gamma-Secretase and its modulators: Twenty years and beyond, Neuroscience Letters Xia W. 2019-02-11
Three dimensional human neuro-spherod model of Alzheimer’s disease based on differentiated induced pluripotent stem cells, PLoS One Lee, H. K., Velazquez Sanchez, C., Chen, M., Morin, P. J., Wells, J. M., Hanlon, E. B., & Xia, W. 2016-09-29
Diagnosis of Alzheimer’s disease using laser-induced breakdown spectroscopy and machine learning, Spectrochimica Acta Part B: Atomic Spectroscopy Gaudiuso, R., Ewusi-Annan, E., Xia, W., & Melikechi, N. 2020-07-15
The Acyl-coenzyme A: cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid pathology in aged amyloid precursor protein transgenic mice, Journal of Neuropathology & Experimental Neurology Huttunen, H. J., Havas, D., Peach, C., Barren, C., Duller, S., Xia, W., Frosch, M. P., Hutter-Paier, B., Windisch, M., & Kovacs, D. M. 2010-08-01
Reticulon 1 and 3 are essential for axonal growth and synaptic maintenance associated with the intellectual development, Human Molecular Genetics Zhou, J., Shi, Q., Ge, Y. Y., He, W., Hu, X., Xia, W., & Yan, R. 2023-05-25
OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages, eBioMedicine Li, X., Wang, L., Cykowski, M., He, T., Liu, T., Chakranarayan, J., Rivera, A., Zhao, H., Powell, S., Xia, W., & Wong, S. T. C. 2020-01-10
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease, Nature Communications Kwak, S. S., Washicosky, K. J., Brand, E., von Maydell, D., Aronson, J., Kim, S., Capen, D. E., Cetinbas, M., Sadreyev, R., Ning, S., Bylykbashi, E., Xia, W., Wagner, S. L., Choi, S. H., Tanzi, R. E., & Kim, D. Y. 2020-03-13
Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer’s disease., Alzheimer's & Dementia Jun, G. R., You, Y., Zhu, C., Meng, G., Chung, J., Panitch, R., Hu, J., Xia, W., Alzheimer's Disease Genetics Consortium, Bennett, D. A., Foroud, T. M., Wang, L. S., Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Schellenberg, G. D., Au, R., Lunetta, K. L., Ikezu, T., Stein, T. D., … Farrer, L. A. 2022-02-09
Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids, Methods Muraoka, S., Lin, W., Chen, M., Hersh, S. W., Emili, A., Xia, W., & Ikezu, T. 2020-02-05
Proteomic and biological profiling of extracellular vesicles from Alzheimer’s disease human brain tissues, Alzheimer's & Dementia Muraoka, S., DeLeo, A. M., Sethi, M. K., Yukawa-Takamatsu, K., Yang, Z., Ko, J., Hogan, J. D., Ruan, Z., You, Y., Wang, Y., Medalla, M., Ikezu, S., Chen, M., Xia, W., Gorantla, S., Gendelman, H. E., Issadore, D., Zaia, J., & Ikezu, T. 2020-04-17
Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain, Annual Review of Neuroscience Fu, X. D., & Mobley, W. C. 2023-07-10
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders, Annual Review of Pharmacology and Toxicology Bartesaghi, R., Vicari, S., & Mobley, W. C. 2022-01-06
Local TrkB signaling: themes in development and neural plasticity, Cell and Tissue Research Johnstone, A., & Mobley, W. 2020-09-16
Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses, Frontiers in Neuroscience Chen, X. Q., & Mobley, W. C. 2019-05-07
Alzheimer’s disease pathogenesis: insights from molecular and cellular biolgoy studies of oligomeric A beta and Tau species, Frontiers in Neuroscience Chen, X. Q., & Mobley, W. C. 2019-06-21
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome, Neurobiology of Disease Kleschevnikov, A. M., Yu, J., Kim, J., Lysenko, L. V., Zeng, Z., Yu, Y. E., & Mobley, W. C. 2017-03-22
Down syndrome conitive phenotypes modeled in mice trisomic for all HAS 21 Homologues, PLoS One Belichenko, P. V., Kleschevnikov, A. M., Becker, A., Wagner, G. E., Lysenko, L. V., Yu, Y. E., & Mobley, W. C. 2015-07-31
Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis, Journal of Neuroscience Stupack, J., Xiong, X. P., Jiang, L. L., Zhang, T., Zhou, L., Campos, A., Ranscht, B., Mobley, W., Pasquale, E. B., Xu, H., & Huang, T. Y. 2020-06-29
Dementia in Down Syndrome, Lancet Neurology Ballard, C., Mobley, W., Hardy, J., Williams, G., & Corbett, A. 2016-04-11
Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease, Neurology Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Wuu, J., Mathis, C. A., Scheff, S. W., Mufson, E. J., & DeKosky, S. T. 2011-07-05
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia, Molecular Psychiatry Ledo, J. H., Liebmann, T., Zhang, R., Chang, J. C., Azevedo, E. P., Wong, E., Silva, H. M., Troyanskaya, O. G., Bustos, V., & Greengard, P. 2020-08-13
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles, Journal of Biological Chemistry Guo, J. L., & Lee, V. M. 2011-03-03
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice, Journal of Neuroscience Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M., & Holtzman, D. M. 2011-09-14
Tau pathology spreads in S19 tau transgenic mice following locus coeruleus (LC) injections of synthestic tau fibrils is determined by the LC’s afferent and efferent connections, Acta Neuropathologica Iba, M., McBride, J. D., Guo, J. L., Zhang, B., Trojanowski, J. Q., & Lee, V. M. 2015-07-07
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzhiemer’s like tauopathy, Journal of Neuroscience Iba, M., Guo, J. L., McBride, J. D., Zhang, B., Trojanowski, J. Q., & Lee, V. M. 2013-01-16
Aging induces an NLRP3 inflammasome-dependent expansion of adipose B cells that impair metabolic homeostasis, Cell Metabolism Camell, C. D., Günther, P., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y. H., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., Schultze, J., & Dixit, V. D. 2019-11-14
IL-33 causes thermogenic failure in aging by dysfunctional adipose ILC2, Cell Metabolism Goldberg, E. L., Shchukina, I., Youm, Y. H., Ryu, S., Tsusaka, T., Young, K. C., Camell, C. D., Dlugos, T., Artyomov, M. N., & Dixit, V. D. 2021-09-01
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging, Cell Metabolism Mihaylova, M. M., Chaix, A., Delibegovic, M., Ramsey, J. J., Bass, J., Melkani, G., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., Latimer, M. N., Mattison, J. A., Thalacker-Mercer, A. E., Dixit, V. D., Panda, S., & Lamming, D. W. 2023-06-30
Loss of Nucleobindin-2 causes insulin resistance in obesity without impacting satiety or adiposity, Cell Reports Ravussin, A., Youm, Y. H., Sander, J., Ryu, S., Nguyen, K., Varela, L., Shulman, G. I., Sidorov, S., Horvath, T. L., Schultze, J. L., & Dixit, V. D. 2018-07-31
Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice, eLife Ryu, S., Shchukina, I., Youm, Y. H., Qing, H., Hilliard, B., Dlugos, T., Zhang, X., Yasumoto, Y., Booth, C. J., Fernández-Hernando, C., Suárez, Y., Khanna, K., Horvath, T. L., Dietrich, M. O., Artyomov, M., Wang, A., & Dixit, V. D. 2021-06-21
Dietary Regulation of Immunity, Immunity Lee, A. H., & Dixit, V. D. 2020-09-15
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging, Immunity Ryu, S., Sidorov, S., Ravussin, E., Artyomov, M., Iwasaki, A., Wang, A., & Dixit, V. D. 2022-08-12
Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity, Journal of Clinical Investigation Ryu, S., Spadaro, O., Sidorov, S., Lee, A. H., Caprio, S., Morrison, C., Smith, S. R., Ravussin, E., Shchukina, I., Artyomov, M. N., Youm, Y. H., & Dixit, V. D. 2023-10-02
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing, Nature Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y. H., Brown, C. W., Elsworth, J., Rodeheffer, M. S., Schultze, J. L., & Dixit, V. D. 2017-09-27
Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome, Nature Aging Shchukina, I., Bagaitkar, J., Shpynov, O., … Dixit, V. D., … Artyomov, M. N. 2021-11-23
Caloric restriction in humans reveals immunometabolic regulators of health span, Science Spadaro, O., Youm, Y., Shchukina, I., Ryu, S., Sidorov, S., Ravussin, A., Nguyen, K., Aladyeva, E., Predeus, A. N., Smith, S. R., Ravussin, E., Galban, C., Artyomov, M. N., & Dixit, V. D. 2022-02-10
Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau, Journal of Alzheimer's Disease Chen, M., Song, H., Cui, J., Johnson, C. E., Hubler, G. K., DePalma, R. G., Gu, Z., & Xia, W. 2018-10-30
Proteomic Profiling of Plasma and Brain Tissue from Alzheimer’s Disease Patients Reveals Candidate Network of Plasma Biomarkers, Journal of Alzheimer's Disease Chen, M., & Xia, W. 2020-06-30
Multi-Focal Neuronal Ultrastructural Abnormalities and Synaptic Alterations in Mice after Low-Intensity Blast Exposure, Journal of Neurotrauma Konan, L. M., Song, H., Pentecost, G., Fogwe, D., Ndam, T., Cui, J., Johnson, C. E., Grant, D., White, T., Chen, M., Xia, W., Cernak, I., DePalma, R. G., & Gu, Z. 2019-03-13
Common Proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer’s patients, Journal of Proteomics Chen, M., Lee, H. K., Moo, L., Hanlon, E., Stein, T., & Xia, W. 2018-04-27
Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles, Aging and Disease Muraoka, S., Lin, W., Takamatsu-Yukawa, K., Hu, J., Ikezu, S., DeTure, M. A., Dickson, D. W., Emili, A., & Ikezu, T. 2021-09-01
Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons, Brain Ruan, Z., Pathak, D., Venkatesan Kalavai, S., Yoshii-Kitahara, A., Muraoka, S., Bhatt, N., Takamatsu-Yukawa, K., Hu, J., Wang, Y., Hersh, S., Ericsson, M., Gorantla, S., Gendelman, H. E., Kayed, R., Ikezu, S., Luebke, J. I., & Ikezu, T. 2020-11-27
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study, Cells Muraoka, S., Jedrychowski, M. P., Yanamandra, K., Ikezu, S., Gygi, S. P., & Ikezu, T. 2020-08-25
Proteomic Profiling of Extracellular Vesicles Isolated from Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy, Frontiers in Neuroscience Muraoka, S., Jedrychowski, M. P., Tatebe, H., DeLeo, A. M., Ikezu, S., Tokuda, T., Gygi, S. P., Stern, R. A., & Ikezu, T. 2019-10-09
Activated Human Astrocyte-Derived Extracellular Vesicles Modulate Neuronal Uptake, Differentiation and Firing, Journal of Extracellular Vesicles You, Y., Borgmann, K., Edara, V. V., Stacy, S., Ghorpade, A., & Ikezu, T. 2019-12-26
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models., Journal of Proteome Research Muraoka, S., Jedrychowski, M. P., Iwahara, N., Abdullah, M., Onos, K. D., Keezer, K. J., Hu, J., Ikezu, S., Howell, G. R., Gygi, S. P., & Ikezu, T. 2021-02-03
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A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data, Genes Hahn, G., Prokopenko, D., Lutz, S. M., Mullin, K., Tanzi, R. E., Cho, M. H., Silverman, E. K., Lange, C., & On The Behalf Of The Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium 2022-01-06
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The Impact of the Cellular Environment and Aging on Modeling Alzheimer’s Disease in 3D Cell Culture Models, Advanced Science Hebisch, M., Klostermeier, S., Wolf, K., Boccaccini, A. R., Wolf, S. E., Tanzi, R. E., & Kim, D. Y. 2023-01-15
Human Neurospheroid Arrays for in vitro studies of Alzheimer’s disease, Scientific Reports Jorfi, M., D'Avanzo, C., Tanzi, R. E., Kim, D. Y., & Irimia, D. 2018-02-05
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A 3D Human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience Park, J., Wetzel, I., Marriott, I., Dréau, D., D'Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. 2018-06-27
Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription, Cell Suh, J., Romano, D. M., Nitschke, L., Herrick, S. P., DiMarzio, B. A., Dzhala, V., Bae, J. S., Oram, M. K., Zheng, Y., Hooli, B., Mullin, K., Gennarino, V. A., Wasco, W., Schmahmann, J. D., Albers, M. W., Zoghbi, H. Y., & Tanzi, R. E. 2019-08-22
Lack of hepatic apoE does not influence early A beta deposition: observations from a new APOE knock-in model, Molecular Neurodegeneration Huynh, T. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., Ulrich, J. D., & Holtzman, D. M. 2019-10-17
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Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage, Journal of Experimental Medicine Rustenhoven, J., Pavlou, G., Storck, S. E., Dykstra, T., Du, S., Wan, Z., Quintero, D., Scallan, J. P., Smirnov, I., Kamm, R. D., & Kipnis, J. 2023-04-07
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Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer’s disease., Discovery Medicine Ward, J., Wang, H., Saunders, A. J., Tanzi, R. E., & Zhang, C. 2017-02-01
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Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience, Nature Neuroscience Udeochu, J. C., Amin, S., … Tsai, L. H., Subhash, S. C., & Gan, L. 2023-04-24
Sex and Gender Driven Modifiers of Alzheimer’s: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risk, Frontiers in Aging Neuroscience Rahman, A., Jackson, H., Hristov, H., Isaacson, R. S., Saif, N., Shetty, T., Etingin, O., Henchcliffe, C., Brinton, R. D., & Mosconi, L. 2019-11-15
Endogenous and Exogenous Estrogen Exposures: How Women’s Reproductive Health Can Drive Brain Aging and Inform Alzheimer’s Prevention, Frontiers in Aging Neuroscience Jett, S., Malviya, N., Schelbaum, E., Jang, G., Jahan, E., Clancy, K., Hristov, H., Pahlajani, S., Niotis, K., Loeb-Zeitlin, S., Havryliuk, Y., Isaacson, R., Brinton, R. D., & Mosconi, L. 2022-03-09
Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disea, Frontiers in Aging Neuroscience Jett, S., Schelbaum, E., Jang, G., Boneu Yepez, C., Dyke, J. P., Pahlajani, S., Diaz Brinton, R., & Mosconi, L. 2022-07-19
Vitamin D supplementation is associated with slower epigenetic aging, GeroScience Vetter, V. M., Sommerer, Y., Kalies, C. H., Spira, D., Bertram, L., & Demuth, I. 2022-05-13
Common signatures of differential microRNA expression in Parkinson’s and Alzheimer’s disease brains, Brain Communications Dobricic, V., Schilling, M., Farkas, I., Gveric, D. O., Ohlei, O., Schulz, J., Middleton, L., Gentleman, S. M., Parkkinen, L., Bertram, L., & Lill, C. M. 2022-10-28
Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families, BMC Medical Genetics Park, S., Lee, S., Lee, Y., Herold, C., Hooli, B., Mullin, K., Park, T., Park, C., Bertram, L., Lange, C., Tanzi, R., & Won, S. 2015-08-19
Genome-wide Association Analysis Reveals Putative Alzheimer’s Disease Susceptibility Loci in Addition to APOE, American Journal of Human Genetics Bertram, L., Lange, C., Mullin, K., Parkinson, M., Hsiao, M., Hogan, M. F., Schjeide, B. M., Hooli, B., Divito, J., Ionita, I., Jiang, H., Laird, N., Moscarillo, T., Ohlsen, K. L., Elliott, K., Wang, X., Hu-Lince, D., Ryder, M., Murphy, A., Wagner, S. L., Blacker, D., … Tanzi, R. E. 2008-10-30
The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzhiemer Disease risk and cerebrospinal fluid biomarker levels, Archives of General Psychiatry Schjeide, B. M., Schnack, C., Lambert, J. C., Lill, C. M., Kirchheiner, J., Tumani, H., Otto, M., Tanzi, R. E., Lehrach, H., Amouyel, P., von Arnim, C. A., & Bertram, L. 2011-02-01
On the Meta-Analysis of Genome-Wide Association studies: a robust and efficient approach to combine population and family-based studies, Human Heredity Won, S., Lu, Q., Bertram, L., Tanzi, R. E., & Lange, C. 2012-01-18
Genome-wide association studies in Alzheimer’s Disease, Human Molecular Genetics Bertram, L., & Tanzi, R. E. 2009-10-15
Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neuroscience Bertram, L., & Tanzi, R. E. 2008-10-01
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk, Neurology Hooli, B. V., Parrado, A. R., Mullin, K., Yip, W. K., Liu, T., Roehr, J. T., Qiao, D., Jessen, F., Peters, O., Becker, T., Ramirez, A., Lange, C., Bertram, L., & Tanzi, R. E. 2014-10-07
The Genetics of Alzheimer’s disease: back to the future, Neuron Bertram, L., Lill, C. M., & Tanzi, R. E. 2010-10-21
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid, Neuroscience Letters Giedraitis, V., Glaser, A., Sarajärvi, T., Brundin, R., Gunnarsson, M. D., Schjeide, B. M., Tanzi, R. E., Helisalmi, S., Pirttilä, T., Kilander, L., Lannfelt, L., Soininen, H., Bertram, L., Ingelsson, M., & Hiltunen, M. 2010-01-22
Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson’s Disease Genetics: the PDGene database, PLoS Genetics Lill, C. M., Roehr, J. T., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B. M., Schjeide, L. M., Meissner, E., … Tanzi, R. E., ... Bertram, L. 2012-03-15
Genomic Mechanisms in Alzheimer’s Disease, Brain Pathology Bertram, L., & Tanzi, R. E. 2020-09-08
GAB2 as an Alzheimer Disease Susceptibility Gene, Archives of Neurology Schjeide, B. M., Hooli, B., Parkinson, M., Hogan, M. F., DiVito, J., Mullin, K., Blacker, D., Tanzi, R. E., & Bertram, L. 2009-02-01
Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2, Molecular Psychiatry Prokopenko, D., Lee, S., Hecker, J., Mullin, K., Morgan, S., Katsumata, Y., Alzheimer’s Disease Neuroimaging Initiative (ADNI), Weiner, M. W., Fardo, D. W., Laird, N., Bertram, L., Hide, W., Lange, C., & Tanzi, R. E. 2022-03-04
The gut microbiota is an emerging target for improving brain health during ageing, Gut Microbiome Boehme, M., Guzzetta, K. E., Wasén, C., & Cox, L. M. 2022-12-12
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss, Neuron Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E., & Rajendran, L. 2017-07-19
Abeta-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice, Science Translational Medicine Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B. A., Hofmann, O., Hide, W., Procissi, D., Hanania, T., Leiser, S. C., Tanzi, R. E., & Vassar, R. 2020-09-30
Chronic Traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model, Science Translational Medicine Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X. L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., Goletiani, C. J., Maglakelidze, G. M., Casey, N., Moncaster, J. A., Minaeva, O., Moir, R. D., … Tanzi, R. E., ... McKee, A. C. 2012-05-16
The endolysosomal pathway and ALS/FTD, Trends in Neurosciences Todd, T. W., Shao, W., Zhang, Y. J., & Petrucelli, L. 2023-10-10
Alzheimer’s Genetics in the GWAS Era: A Continuing Story of ‘Replications and Refutations’, Current Neurology and Neuroscience Reports Bertram L. 2011-03-30
Distinguishing true from false positives in genomic studies: p values, European Journal of Epidemiology Broer, L., Lill, C. M., Schuur, M., Amin, N., Roehr, J. T., Bertram, L., Ioannidis, J. P., & van Duijn, C. M. 2013-02-01
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining, Genetics in Medicine Wallace, B. C., Small, K., Brodley, C. E., Lau, J., Schmid, C. H., Bertram, L., Lill, C. M., Cohen, J. T., & Trikalinos, T. A. 2023-07-12
Developing the “Next Generation: of genetic association databases for complex diseases, Human Mutation Lill, C. M., & Bertram, L. 2023-07-12
Systematic Analysis of Candidate Genes for Alzheimer’s Disease in a French, Genome-Wide Association Study, Journal of Alzheimer's Disease Laumet, G., Chouraki, V., Grenier-Boley, B., Legry, V., Heath, S., Zelenika, D., Fievet, N., Hannequin, D., Delepine, M., Pasquier, F., Hanon, O., Brice, A., Epelbaum, J., Berr, C., Dartigues, J. F., Tzourio, C., Campion, D., Lathrop, M., Bertram, L., Amouyel, P., … Lambert, J. C. 2010-06-13
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects, Journal of Medical Genetics Lill, C. M., Liu, T., Schjeide, B. M., Roehr, J. T., Akkad, D. A., Damotte, V., Alcina, A., Ortiz, M. A., … Bertram, L., Zipp, F. 2012-09-01
Genome-wide significant associations of ANKRD55 rs6859219 and multiple sclerosis risk, Journal of Medical Genetics Lill, C. M., Schjeide, B. M., Graetz, C., Liu, T., Damotte, V., Akkad, D. A., Blaschke, P., Gerdes, L. A., Kroner, A., Luessi, F., Cournu-Rebeix, I., Hoffjan, S., Winkelmann, A., Touze, E., Pico, F., Corcia, P., Otaegui, D., Antigüedad, A., Alcina, A., Comabella, M., … Bertram, L. 2013-01-12
Impact of Parkinson’s disease risk loci on age at onset, Movement Disorders Lill, C. M., Hansen, J., Olsen, J. H., Binder, H., Ritz, B., & Bertram, L. 2015-04-25
Genetic variants in PSEN2 and correlation to CSF beta-amyloid 42 levels in AD, Neurobiology of Aging Lebedeva, E., Stingl, J. C., Thal, D. R., Ghebremedhin, E., Strauss, J., Özer, E., Bertram, L., von Einem, B., Tumani, H., Otto, M., Riepe, M. W., Högel, J., Ludolph, A. C., & von Arnim, C. A. 2010-09-20
Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample, Neurogenetics Lill, C. M., Schjeide, B. M., Akkad, D. A., Blaschke, P., Winkelmann, A., Gerdes, L. A., Hoffjan, S., Luessi, F., … Bertram, L., Zipp, F. 2012-11-18
Assessment of micro-RNA-related SNP effects in the 3′ untranslated region of the IL22RA2 risk locus in multiple sclerosis, Neurogenetics Lill, C. M., Schilling, M., Ansaloni, S., Schröder, J., Jaedicke, M., … Bertram, L. 2014-03-18
Call for participation in the neurogenetics consortium within the Human Variome Project, Neurogenetics Haworth, A., Bertram, L., … Sobrido, M. J. 2011-06-01
Serum iron levels and the risk of Parkinson Disease: A mendelian randomization study., PLoS Medicine Pichler, I., Del Greco M, F., Gögele, M., Lill, C. M., Bertram, L., Do, C. B., Eriksson, N., Foroud, T., Myers, R. H., PD GWAS Consortium, Nalls, M., Keller, M. F., International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin, B., Whitfield, J. B., Genetics of Iron Status Consortium, Pramstaller, P. P., Hicks, A. A., Thompson, J. R., … Minelli, C. 2013-06-04
Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias, PLoS One Pfeiffer, T., Bertram, L., & Ioannidis, J. P. 2011-03-29
Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene), Public Health Genomics Dolan, S. M., Hollegaard, M. V., Merialdi, M., Betran, A. P., Allen, T., Abelow, C., Nace, J., Lin, B. K., Khoury, M. J., Ioannidis, J. P., Bagade, S., Zheng, X., Dubin, R. A., Bertram, L., Velez Edwards, D. R., & Menon, R. 2010-05-20
Towards Unveiling the Genetics of Neurodegenerative Diseases, Seminars in Neurology Lill, C. M., & Bertram, L. 2012-01-21
Relationship Between 5 Epigenetic Clocks, Telomere Length, and Functional Capacity Assessed in Older Adults: Cross-Sectional and Longitudinal Analyses, The Journals of Gerontology: Series A Vetter, V. M., Kalies, C. H., Sommerer, Y., Spira, D., Drewelies, J., Regitz-Zagrosek, V., Bertram, L., Gerstorf, D., & Demuth, I. 2022-01-15
Epigenetic aging and perceived psychological stress in old age, Translational Psychiatry Vetter, V. M., Drewelies, J., Sommerer, Y., Kalies, C. H., Regitz-Zagrosek, V., Bertram, L., Gerstorf, D., & Demuth, I. 2022-09-26
The pursuit of susceptibility genes for Alzhiemer’s disease: progress and prospects, Trends in Genetics Sleegers, K., Lambert, J. C., Bertram, L., Cruts, M., Amouyel, P., & Van Broeckhoven, C. 2010-01-18
Seven-CpG DNA Methylation Age Determined by Single Nucleotide Primer Extension and Illumina’s Infinium MethylationEPIC Array Provide Highly Comparable Results, Frontiers in Genetics Vetter, V. M., Kalies, C. H., Sommerer, Y., Bertram, L., & Demuth, I. 2022-01-17
The Endosomal-Lysosomal Pathway is Dysregulated by APOE4 Expression in Vivo, Frontiers in Neuroscience Nuriel, T., Peng, K. Y., Ashok, A., Dillman, A. A., Figueroa, H. Y., Apuzzo, J., Ambat, J., Levy, E., Cookson, M. R., Mathews, P. M., & Duff, K. E. 2017-12-12
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology, Nature Communications Nuriel, T., Angulo, S. L., Khan, U., Ashok, A., Chen, Q., Figueroa, H. Y., Emrani, S., Liu, L., Herman, M., Barrett, G., Savage, V., Buitrago, L., Cepeda-Prado, E., Fung, C., Goldberg, E., Gross, S. S., Hussaini, S. A., Moreno, H., Small, S. A., & Duff, K. E. 2017-11-13
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology, Nature Neuroscience Fu, H., Possenti, A., Freer, R., Nakano, Y., Hernandez Villegas, N. C., Tang, M., Cauhy, P. V. M., Lassus, B. A., Chen, S., Fowler, S. L., Figueroa, H. Y., Huey, E. D., Johnson, G. V. W., Vendruscolo, M., & Duff, K. E. 2018-12-17
Targeting the 26S Proteasome to Protect against Proteotoxic Diseases, Trends in Molecular Medicine Myeku, N., & Duff, K. E. 2017-12-09
Selective vulnerability in neurodegenerative diseases, Nature Neuroscience Fu, H., Hardy, J., & Duff, K. E. 2018-09-24
Neuronal activity enhances tau propagation and tau pathology in vivo, Nature Neuroscience Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S., & Duff, K. E. 2016-06-20
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice, Scientific Reports Area-Gomez, E., Larrea, D., Pera, M., Agrawal, R. R., Guilfoyle, D. N., Pirhaji, L., Shannon, K., Arain, H. A., Ashok, A., Chen, Q., Dillman, A. A., Figueroa, H. Y., Cookson, M. R., Gross, S. S., Fraenkel, E., Duff, K. E., & Nuriel, T. 2020-03-09
Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice, Translational Psychiatry Miranda, A. M., Ashok, A., Chan, R. B., Zhou, B., Xu, Y., McIntire, L. B., Area-Gomez, E., Di Paolo, G., Duff, K. E., Oliveira, T. G., & Nuriel, T. 2022-03-29
Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease, JAMA Neurology Taddei, R. N., Perbet, R., Mate de Gerando, A., Wiedmer, A. E., Sanchez-Mico, M., Connors Stewart, T., Gaona, A., Melloni, A., Amaral, A. C., Duff, K., Frosch, M. P., & Gómez-Isla, T. 2023-10-09
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator, Annals of Neurology Chen, X. Q., Sawa, M., Becker, A., Karachentsev, D., Zuo, X., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. 2023-04-11
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators, Bioorganic and Medicinal Chemistry Rynearson, K. D., Buckle, R. N., Herr, R. J., Mayhew, N. J., Chen, X., Paquette, W. D., Sakwa, S. A., Yang, J., Barnes, K. D., Nguyen, P., Mobley, W. C., Johnson, G., Lin, J. H., Tanzi, R. E., & Wagner, S. L. 2020-09-01
African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants, Neurology Genetics Schindler, S. E., Cruchaga, C., Joseph, A., McCue, L., Farias, F. H. G., Wilkins, C. H., Deming, Y., Henson, R. L., Mikesell, R. J., Piccio, L., Llibre-Guerra, J. J., Moulder, K. L., Fagan, A. M., Ances, B. M., Benzinger, T. L. S., Xiong, C., Holtzman, D. M., & Morris, J. C. 2021-03-04
Distinct Cytokine Profiles in human brains resilient to Alzheimer’s pathology, Neuroiology of Disease Barroeta-Espar, I., Weinstock, L. D., Perez-Nievas, B. G., Meltzer, A. C., Siao Tick Chong, M., Amaral, A. C., Murray, M. E., Moulder, K. L., Morris, J. C., Cairns, N. J., Parisi, J. E., Lowe, V. J., Petersen, R. C., Kofler, J., Ikonomovic, M. D., López, O., Klunk, W. E., … Gomez-Isla, T. 2018-10-15
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light, Neurology Schindler, S. E., Karikari, T. K., Ashton, N. J., Henson, R. L., Yarasheski, K. E., West, T., Meyer, M. R., Kirmess, K. M., Li, Y., Saef, B., Moulder, K. L., Bradford, D., Fagan, A. M., Gordon, B. A., Benzinger, T. L. S., Balls-Berry, J., Bateman, R. J., Xiong, C., Zetterberg, H., Blennow, K., … Morris, J. C. 2022-04-21
Liver-ing in your head rent free: peripheral ApoE4 drives CNS pathology, Molecular Neurodegeneration Golden, L. R., & Johnson, L. A. 2022-10-04
Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias, Alzheimer's & Dementia Yassine, H. N., Self, W., Kerman, B. E., Santoni, G., Navalpur Shanmugam, N., Abdullah, L., Golden, L. R., Fonteh, A. N., Harrington, M. G., Gräff, J., Gibson, G. E., Kalaria, R., Luchsinger, J. A., Feldman, H. H., Swerdlow, R. H., Johnson, L. A., Albensi, B. C., Zlokovic, B. V., Tanzi, R., Cunnane, S., … Bowman, G. L. 2022-12-08
The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease, Alzheimer's & Dementia Lill, C. M., Rengmark, A., Pihlstrøm, L., Fogh, I., Shatunov, A., Sleiman, P. M., Wang, L. S., Liu, T., Lassen, C. F., Meissner, E., Alexopoulos, P., Calvo, A., Chio, A., Dizdar, N., Faltraco, F., Forsgren, L., Kirchheiner, J., Kurz, A., Larsen, J. P., Liebsch, M., … Bertram, L. 2015-04-30
Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study, BMJ Open Demuth, I., Banszerus, V., Drewelies, J., Düzel, S., Seeland, U., Spira, D., Tse, E., Braun, J., Steinhagen-Thiessen, E., Bertram, L., Thiel, A., Lindenberger, U., Regitz-Zagrosek, V., Gerstorf, D., & Additional BASE-II/GendAge investigators 2021-07-23
MANBA, CXCR5, SOX8, RPS6KB1, ZBTB46 are genetic risk loci for multiple sclerosis, Brain International Multiple Sclerosis Genetics Consortium, Lill, C. M., Schjeide, B. M., Graetz, C., Ban, M., Alcina, A., Ortiz, M. A., Pérez, J., Damotte, V., Booth, D., Lopez de Lapuente, A., Broer, L., Schilling, M., Akkad, D. A., Aktas, O., Alloza, I., Antigüedad, A., Arroyo, R., Blaschke, P., Buttmann, M., … Bertram, L., Zipp, F. 2013-06-04
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition, and biomarkers, Brain Imaging and Behavior Shen, L., Thompson, P. M., Potkin, S. G., Bertram, L., Farrer, L. A., Foroud, T. M., Green, R. C., … Alzheimer’s Disease Neuroimaging Initiative 2013-10-05
Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase, Journal of Pharmacology and Experimental Therapeutics Lazo, J. S., Isbell, K. N., Vasa, S. A., Llaneza, D. C., Rastelli, E. J., Wipf, P., & Sharlow, E. R. 2023-02-23
Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin, Molecular Pharmacology Czub, M. P., Boulton, A. M., Rastelli, E. J., Tasker, N. R., Maskrey, T. S., Blanco, I. K., McQueeney, K. E., Bushweller, J. H., Minor, W., Wipf, P., Sharlow, E. R., & Lazo, J. S. 2020-09-25
New Approaches to Difficult Drug Discovery, SLAS Discovery Lazo, J. S., McQueeney, K. E., & Sharlow, E. R. 2017-07-26
Functional characterization of the dural sinuses as a neuroimmune interface, Cell Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., Erdmann-Gilmore, P., … Kipnis, J. 2021-01-27
Cerebrovascular Anomalies: Perspectives From Immunology and Cerebrospinal Fluid Flow, Circulation Research Rustenhoven, J., Tanumihardja, C., & Kipnis, J. 2021-06-25
Immune Cells and CNS physiology: microglia and beyond, Journal of Experimental Medicine Norris, G. T., & Kipnis, J. 2018-11-30
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease, Nature Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., … Kipnis, J. 2018-07-25
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels, Nature Neuroscience Mazzitelli, J. A., Smyth, L. C. D., Cross, K. A., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J., & Kipnis, J. 2022-03-17
Lymphatics in Neurological Disorders: a neuro-lympho-vascular component of multiple sclerosis and Alzheimer’s disease?, Neuron Louveau, A., Da Mesquita, S., & Kipnis, J. 2016-09-07
The meningeal lymphatic system: a new player in neurophysiology, Neuron Da Mesquita, S., Fu, Z., & Kipnis, J. 2018-10-24
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology, Scientific Advances Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J. 2021-05-21
Skull bone marrow channels as immune gateways to the central nervous system, Nature Neuroscience Mazzitelli, J. A., Pulous, F. E., Smyth, L. C. D., Kaya, Z., Rustenhoven, J., Moskowitz, M. A., Kipnis, J., & Nahrendorf, M. 2023-11-23
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport, JCI Insight Ozturk, B., Koundal, S., Al Bizri, E., Chen, X., Gursky, Z. H., Dai, F., Lim, A. S., Heerdt, P., Kipnis, J., Tannenbaum, A., Lee, H., & Benveniste, H. 2023-05-09
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling, Neuron Kim, E., Kim, H., Jedrychowski, M. P., Bakiasi, G., Park, J., Kruskop, J., Choi, Y., Kwak, S. S., Quinti, L., Kim, D. Y., Wrann, C. D., Spiegelman, B. M., Tanzi, R. E., & Choi, S. H. 2023-09-08
3D Miniaturization of Human Organs for Drug Discovery, Advanced Healthcare Materials Park, J., Wetzel, I., Dréau, D., & Cho, H. 2017-09-08
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ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation, Frontiers in Neuroscience Aikawa, T., Ren, Y., Holm, M. L., Asmann, Y. W., Alam, A., Fitzgerald, M. L., Bu, G., & Kanekiyo, T. 2021-04-07
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Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, Journal of Neuroscience Liu, C. C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T., & Bu, G. 2015-04-08
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer’s Neuronal Pathology, Journal of Neuroscience Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., … Bu, G & Kanekiyo, T. 2016-03-30
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells, Molecular Neurodegeneration Wren, M. C., Zhao, J., Liu, C. C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T., & Bu, G. 2015-09-15
APP-Mediated signaling prevents memory decline in Alzheimer’s disease mouse model, Cell Reports Deyts, C., Clutter, M., Pierce, N., Chakrabarty, P., Ladd, T. B., Goddi, A., Rosario, A. M., Cruz, P., Vetrivel, K., Wagner, S. L., Thinakaran, G., Golde, T. E., & Parent, A. T. 2019-04-30
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Apolipoprotein E, Receptors, and Modulation of Alzhiemer’s disease, Biological Psychiatry Zhao N, Liu CC, Qiao W, Bu G. 2017-03-14
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APOE ε2 is associated with increased tau pathology in primary tauopathy, Nature Communications Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S., … Bu, G. 2018-10-22
Apolipoprotein E and Alzheimer’s disease: pathobiology and targeting strategies, Nature Reviews Neurology Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C. C., & Bu, G. 2019-07-31
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ApoE4 Accelerates Early Seeding of Amyloid Pathology, Neuron Liu, C. C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W., & Bu, G. 2017-12-06
An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells, STAR Protocols Raulin, A. C., Liu, C. C., & Bu, G. 2023-03-17
A Novel Link between Trafficking and Lewy body disorder, The Lancet Neurology Ross, O. A., & Bu, G. 2018-06-07
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Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. 2012-05-02
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Dietary salt promotes cognitive impairment through tau phosphorylation, Nature Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. 2019-10-23
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ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models, Science Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., Brunden, K. R., Wilson, D. A., & Landreth, G. E. 2023-03-23
Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model, Nature Communications Lordén, G., Wozniak, J. M., Doré, K., Dozier, L. E., Cates-Gatto, C., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., Tanzi, R. E., & Newton, A. C. 2022-11-23
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Following spatial Aβ aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics, Science Advances Michno, W., Stringer, K. M., Enzlein, T., Passarelli, M. K., Escrig, S., Vitanova, K., Wood, J., Blennow, K., Zetterberg, H., Meibom, A., Hopf, C., Edwards, F. A., & Hanrieder, J. 2021-06-16
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Unorthodox localization of P2X7 receptor in subcellular compartments of skeletal system cells, Frontiers in Cell and Developmental Biology Penolazzi, L., Notarangelo, M. P., Lambertini, E., Vultaggio-Poma, V., Tarantini, M., Di Virgilio, F., & Piva, R. 2023-05-04
The Coming of Age of the P2X7 Receptor in Diagnostic Medicine, International Journal of Molecular Sciences Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. 2023-05-30
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