These published papers resulted from Cure Alzheimer’s Fund support.
| Title | Researchers | Date |
|---|---|---|
| Exercise and Improved Cognition, Science | Rudy Tanzi, Se Hoon Choi | |
| Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzheimer’s mice, Neurobiology of Aging, 72 | Nina Fainstein, Nadav Dan-Goor, Tamir Ben-Hur | |
| The secret sulfate code that lets the bad Tau in, Science Daily | Marc Diamond | |
| 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes, ScienceDirect, Volume 180 | Marco Campisi, Yoojin Shin, Tatsuya Osaki, Cynthia Hajal, Valeria Chiono, Roger D.Kamm | |
| Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression, Cell, volume 24, Issue 3 | Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang | |
| N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer’s disease, Alzheimer's and Dementia | Erin J. Kodis, Sophie Choi, Eric Swanson, Gonzalo Ferreira, George S. Bloom | |
| A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience | Joseph Park, Isaac Wetzel, Ian Marriott, Didier Dréau, Carla D’Avanzo, Doo Yeon Kim, Rudolph E. Tanzi & Hansang Cho | |
| Alzheimer’s Disease-Associated b-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection, Neuron (Cell) | William A. Eimer,1,2 Deepak Kumar Vijaya Kumar,1,2 Nanda Kumar Navalpur Shanmugam,Alex S. Rodriguez, Teryn Mitchell, Kevin J. Washicosky, Bence Gyorgy, Xandra O. Breakefield, Rudolph E. Tanzi, and Robert D. Moir | |
| Alzheimer’s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia | Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph Tanzi, Marco Colonna | |
| Accelerating stem cell trials for Alzheimer’s disease, The Lancet Neurology | Joshua G Hunsberger, Ph.D., Mahendra Rao, M.D., Joanne Kurtzberg, M.D., Jeff W. M. Bulte, Ph.D., Anthony Atala, M.D., Frank M. LaFerla, Ph.D., Henry T. Greely, J.D., Akira Sawa, M.D., Sam Gandy, M.D., Lon S. Schneider, M.D., P. Murali Doraiswamy, M.B.B.S. | |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia | Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS | |
| Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology, Nature Communications, 8 | Tal Nuriel, Sergio L. Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y. Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S. Gross, S. Abid Hussaini, Herman Moreno, Scott A. Small, Karen E. Duff | |
| Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica, 134(5) | Jean-Vianney Haure-Mirande, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, William L. Klein, Charles Glabe, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Minghui Wang, Bin Zhang, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich | |
| CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5 | Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy | |
| Apolipoprotein E4 Impairs Neuronal Insulin Signaling, Neuron, 96(1) | Na Zhao, Chia-Chen Liu, Alexandra J. Van Ingelgom, Yuka A. Martens, Cynthia Linares, Joshua A. Knight, Meghan M. Painter, Patrick M. Sullivan, Guojun Bu | |
| Enhanced liver gene transfer and evasion of preexisting humoral immunity with exosome-enveloped AAV vectors, Blood Advances, 1(23) | Amine Meliani, Florence Boisgerault, Zachary Fitzpatrick, Solenne Marmier, Christian Leborgne, Fanny Collaud, Marcelo Simon Sola, Severine Charles, Giuseppe Ronzitti, Alban Vignaud, Laetitia van Wittenberghe, Beatrice Marolleau, Fabienne Jouen, Sisareuth Tan, Olivier Boyer, Olivier Christophe, Alain R. Brisson, Casey A. Maguire, Federico Mingozzi | |
| TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy, Proceedings of the National Academy of Sciences of the United States of America, 114(43) | Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, David M. Holtzman | |
| Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing, Nature, 550(7674) | Christina D. Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y. Nguyen, Allison Wing, Emily L. Goldberg, Yun-Hee Youm, Chester W. Brown, John Elsworth, Matthew S. Rodeheffer, Joachim L. Schultze, Vishwa Deep Dixit | |
| Regulating protein breakdown through proteasome phosphorylation, Biochemical Journal, 474(19) | Jordan J.S. VerPlank, Alfred L. Goldberg | |
| New Approaches to Difficult Drug Targets: The Phosphatase Story, SLAS DISCOVERY, 22(9) | John S. Lazo, Kelley E. McQueeney, Elizabeth R. Sharlow | |
| An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function, EMBO Molecular Medicine, 9(10) | Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass | |
| Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging, Nature Neuroscience, 20(10) | Petra Füger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M. Wegenast-Braun, Jonas J. Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras, Mathias Jucker | |
| Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology | George S.Bloom, John S.Lazo, Andrés Norambuena | |
| Toward Personalized Network Biomarkers in Alzheimer’s Disease: Computing Individualized Genomic and Protein Crosstalk Maps, Frontiers in Aging Neuroscience | Kanchana Padmanabhan, Katie Shpanskaya, Gonzalo Bello, P. Murali Doraiswamy, Nagiza F. Samatova | |
| ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy, Nature | Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T. Smith, Lingzhi Zhao, Wenjie Luo, Richard M. Tsai, Salvatore Spina, Lea T. Grinberg, Julio C. Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M. Sullivan, Caroline Baufeld, Michael W. Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L. Del-Aguila, John C. Morris, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Anne M. Fagan, Bruce L. Miller, Adam L. Boxer, William W. Seeley, Oleg Butovsky, Ben A. Barres, Steven M. Paul, David M. Holtzman | |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases, Immunity, 47(3) | Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O’Loughlin, Yang Xu, Zain Fanek, David J. Greco, Scott T. Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D. Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L. Heppner, Vladimir Litvak, David M. Holtzman, Hans Lassmann, Howard L. Weiner, Jordi Ochando, Christian Haass, Oleg Butovsky | |
| MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts, Cell Stem Cell, 21(3) | Daniel G. Abernathy, Woo Kyung Kim, Matthew J. McCoy, Allison M. Lake, Rebecca Ouwenga, Seong Won Lee, Xiaoyun Xing, Daofeng Li, Hyung Joo Lee, Robert O. Heuckeroth, Joseph D. Dougherty, Ting Wang, Andrew S. Yoo | |
| Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(Delta E9) murine model of Alzheimer’s disease, Scientific Reports, 7 | Myles R. Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W. Musch, Xunuo Shen, Bana Jabri, Eugene B. Change, Rudolph E. Tanzi, Sangram Sisodia | |
| Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer’s disease, Current Opinion In Hematology, 24(5) | Hyung Jin Ahn, Zu-Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland | |
| Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer’s Disease: A New Computational Approach, Processes, 5(3) | Kanchana Padmanabhan, Kelly Nudelman, Steve Harenberg, Gonzalo Bello, Dongwha Sohn, Katie Shpanskaya, Priyanka Tiwari Dikshit, Pallavi S. Yerramsetty, Rudolph E. Tanzi, Andrew J. Saykin, Jeffrey R. Petrella, P. Murali Doraiswamy, Nagiza F. Samatova, Alzheimer’s Disease Neuroimaging Initiative | |
| Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain, Scientific Reports, 7 | Norelle C. Wildburger, Thomas J. Esparza, Richard D. LeDuc, Ryan T. Fellers, Paul M. Thomas, Nigel J. Cairns, Neil L. Kelleher, Randall J. Bateman, David L. Brody | |
| Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease, Alzheimers Research & Therapy, 9(1) | David L. Brody, Hao Jiang, Norelle Wildburger, Thomas J. Esparza | |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease, Cell, 170(4) | Tyler K. Ulland, Wilbur M. Song, 7, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna | |
| Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease, Scientific Reports, 7 | Dragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, P. Murali Doraiswamy | |
| Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s diseaserelated oligomers by curcumin, Scientific Reports, 7 | Feng Liang, Yu Wan, Diane Schaak, Joseph Ward, Xunuo Shen, Rudolph E. Tanzi, Can Zhang, Qimin Quan | |
| APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics, 26(14) | Jing Zhao, Mary D. Davis, Yuka A. Martens, Mitsuru Shinohara, Neill R. Graff-Radford, Steven G. Younkin, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu | |
| Identification and characterization of Nanobodies targeting the EphA4 receptor, Journal Of Biological Chemistry, 292(27) | Lies Schoonaert, Laura Rue, Bart Roucourt, Mieke Timmers, Susan Little, Lucia Chavez-Gutierrez, Maarten Dewilde, Peter Joyce, Adam Curnock, Peter Weber, Jurgen Haustraete, Gholamreza Hassanzadeh-Ghassabeh, Bart De Strooper, Ludo Van den Bosch, Philip Van Damme, Robin Lemmens, Wim Robberecht | |
| The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, Embo Journal, 36(13) | Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez‐Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass | |
| Pharmacological and Toxicological Properties of the Potent Oral gamma-Secretase Modulator BPN-15606, Journal Of Pharmacology And Experimental Therapeutics, 362(1) | Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman, Rudolph E. Tanzi | |
| Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies, Journal Of Lipid Research, 58(7) | Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu | |
| TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers In Aging Neuroscience, 9 | Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Chen | |
| The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis, Journal Of Biological Chemistry, 292(23) | Hyoung Tae Kim, Alfred L. Goldberg | |
| Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue, Acta Neuropathologica Communications, 5 | Sarah K. Kaufman, Talitha L. Thomas, Kelly Del Tredici, Heiko Braak, Marc I. Diamond | |
| Disease-Modifying Effects of M-1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer’s Disease Mouse Model, Acs Chemical Neuroscience, 8(6) | Evan P. Lebois, Jason P. Schroeder, Thomas J. Esparza, Thomas M. Bridges, Craig W. Lindsley, P. Jeffrey Conn, David L. Brody, J. Scott Daniels, Allan I. Levey | |
| Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell, 169(6) | Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S. Boyden | |
| The Logic of the 26S Proteasome, Cell, 169(5) | Galen Andrew Collins, Alfred L. Goldberg | |
| TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports | Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass | |
| Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice, Blood, 129(18) | Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland | |
| Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging, 53 | Justin T. Rogers, Chia-Chen Liu, Na Zhao, Jian Wang, Travis Putzke, Longyu Yang, Mitsuru Shinohara, John D. Fryer, Takahisa Kanekiyo, Guojun Bu | |
| Elucidating the Role of TREM2 in Alzheimer’s Disease, Neuron, 94 | Jason D. Ulrich, Tyler K. Ulland, Marco Colonna, and David M. Holtzman | |
| The Retromer Supports AMPA Receptor Trafficking During LTP, Neuron, 94(1) | Paul Temkin, Wade Morishita, Debanjan Goswami, Kristin Arendt, Lu Chen, Robert Malenka | |
| In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology, 43 | L Ashley Watson, Li-Huei Tsai | |
| Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, 11 | Bevan S. Main, Myles R. Minter | |
| On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology, 41(4) | Heide Loehlein Fier, Dmitry Prokopenko, Julian Hecker, Michael H. Cho, Edwin K. Silverman, Scott T. Weiss, Rudolph E. Tanzi, Christoph Lange | |
| Altered sleep and EEG power in the P301S Tau transgenic mouse model, Ann Clin Transl Neurol, 4(3) | Jerrah K. Holth, Thomas E. Mahan, Grace O. Robinson, Andreia Rocha, David M. Holtzman | |
| Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage, PNAS, 114(6) | William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos | |
| Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?, Evol Med Public Health, 2017(1) | Randolph M. Nesse, Caleb E. Finch, and Charles L. Nunn | |
| Precise and efficient scarless genome editing in stem cells using CORRECT, Nature Protocols, 12 | Dylan Kwart, Dominik Paquet, Shaun Teo and Marc Tessier-Lavigne | |
| BIN1 localization is distinct from Tau tangles in Alzheimer’s disease, Matters | Pierre De Rossi, Virginie Buggia-Prevot, Robert J Andrew, Sofia V Krause, Elizabeth Woo, Peter T Nelson, Peter Pytel, Gopal Thinakaran | |
| The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer’s disease but not those of sTREM2, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 6 | Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo | |
| Chapter Three – Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins, Methods in Enzymology, 584 | S. Veugelen, M. Dewilde, B. De Strooper, L. Chávez-Gutiérrez | |
| The Alzheimer’s Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement, Alzheimer's & Dementia | Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, John C. Morris, Ronald C. Petersen, Jennifer Salazar, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski | |
| Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer’s disease, Alzheimer's & Dementia, 12(12) | Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monté, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo | |
| Chronic Progressive Neurodegeneration in a Transgenic Mouse Model of Prion Disease, Frontiers in Neuroscience, 10 | Nina Fainstein, Dvir Dori, Kati Frid, Alexa T. Fritz, Ilona Shapiro, Ruth Gabizon, and Tamir Ben-Hur | |
| The road to restoring neural circuits for the treatment of Alzheimer’s disease, Nature, 539(7628) | Rebecca G. Canter, Jay Penney, and Li-Huei Tsai | |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia, 13(2) | Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S. Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W. Mandell, George S. Bloom | |
| Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells, PLOS ONE, 11(9) | Han-Kyu Lee, Clara Velazquez Sanchez, Mei Chen, Peter J. Morin, John M. Wells, Eugene B. Hanlon, Weiming Xia | |
| Alzheimer’s disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide, Neurodegenerative Disease Management, 6(5) | Deepak Kumar Vijaya Kumar , William A Eimer , Rudolph E Tanzi and Robert D Moir | |
| TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine, 8(9) | Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass | |
| Alzheimer’s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 13(4) | Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph E. Tanzi, Marco Colonna | |
| Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia, 12(8) | Henry H. Ruiz, Tiffany Chi, Andrew C. Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettner | |
| Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes, Neurol Neuroimmunol Neuroinflamm, 3(3) | Elysse M. Knight, PhD, Soong Ho Kim, PhD, Jessica C. Kottwitz, BS, Asa Hatami, PhD, Ricardo Albay, BS, Akinobu Suzuki, PhD, Alex Lublin, PhD, Cristina M. Alberini, PhD, William L. Klein, PhD, Paul Szabo, PhD, Norman R. Relkin, MD, PhD, Michelle Ehrlich, MD, Charles G. Glabe, PhD, Sam Gandy, MD, PhD and John W. Steele, PhD | |
| Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature, 533(7601) | Dominik Paquet, Dylan Kwart, Antonia Chen, Andrew Sproul, Samson Jacob, Shaun Teo, Kimberly Moore Olsen, Andrew Gregg, Scott Noggle and Marc Tessier-Lavigne | |
| Interaction of tau with the RNA-binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Cell Reports | Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin | |
| A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer’s disease, Thrombosis Research, 141(2) | Daria Zamolodchikov, Sidney Strickland | |
| ABCA7 Deficiency Accelerates Amyloid- Generation and Alzheimer’s Neuronal Pathology, Neurobiology of Disease, 36(13) | Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M. Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D. Fryer, Michael L. Fitzgerald, Yasumasa Ohyagi, Steven G. Younkin, Guojun Bu, and Takahisa Kanekiyo | |
| Evidence That the “Lid” Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity, Journal of Biological Chemistry, 291(13) | Xulun Zhang, Eric Sullivan, Maggie Scimeca, Xianzhong Wu, Yue-ming Li and Sangram S. Sisodia | |
| APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations, Annals of Neurology, 79(5) | Mitsuru Shinohara, Takahisa Kanekiyo, Longyu Yang, Duane Linthicum, Motoko Shinohara, Yuan Fu, Laura Price, Jessica L. Frisch-Daiello, Xianlin Han, John D. Fryer, Guojun Bu | |
| sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer’s disease and associate with neuronal injury markers, EMBO Molecular Medicine, 8(3) | Marc Suárez‐Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez‐Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass | |
| Tau: The Center of a Signaling Nexus in Alzheimer’s Disease, Frontiers in Neuroscience | Shahzad S. Khan and George S. Bloom | |
| Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer’s disease with OSBPL6, PTPRG, and PDCL3, Molecular Psychiatry | C Herold, B V Hooli, K Mullin, T Liu, J T Roehr, M Mattheisen, A R Parrado, L Bertram, C Lange and R E Tanzi | |
| Chronic Traumatic Encephalopathy: Diagnosing the Repetitively Injured Brains of Athletes and Soldiers, Current Research: Concussion | Dara L. Dickstein, Effie M. Mitsis, Corey Fernandez, Mariel Pullman, Patrick R. Hof, Jennifer Short, Gregory Elder, Barry Jordan, Stephen Ahlers, Heidi Bender, Martin L. Goldstein, John F. Crary, Kristen Dams-O’Connor, Wayne Gordon, Robert Cantu, Karin Knesaurek, Mary Sano, James R. Stone6, Lale Kostakoglu, Steven T. DeKosky, and Sam Gandy | |
| Accelerating stem cell trials for Alzheimer’s disease, The Lancet Neurology, 15(2) | Joshua G Hunsberger, PhD, Mahendra Rao, MD, Joanne Kurtzberg, MD, Jeff W M Bulte, PhD, Anthony Atala, MD, Frank M LaFerla, PhD, Henry T Greely, JD, Akira Sawa,MD, Sam Gandy, MD, Lon S Schneider, MD, P Murali Doraiswamy, MBBS | |
| Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS, Journal of Neuroinflammation, 12(1) | L. Schrewe, C. M. Lill, T. Liu, A. Salmen, L. A. Gerdes, L. Guillot-Noel, D. A. Akkad, P. Blaschke, C. Graetz, S. Hoffjan, A. Kroner, S. Demir, A. Böhme, P. Rieckmann, A. ElAli, N. Hagemann, D. M. Hermann, I. Cournu-Rebeix, F. Zipp, T. Kümpfel, M. Buttmann, U. K. Zettl, B. Fontaine, L. Bertram, R. Gold and A. Chan | |
| The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease, Alzheimer's & Dementia, 11(12) | Christina M. Lill, Aina Rengmark, Lasse Pihlstrøm, Isabella Fogh, Aleksey Shatunov, Patrick M. Sleiman, Li-San Wang, Tian Liu, Christina F. Lassen, Esther Meissner, Panos Alexopoulos, Andrea Calvo, Adriano Chio, Nil Dizdar, Frank Faltraco, Lars Forsgren, Julia Kirchheiner, Alexander Kurz, Jan P. Larsen, Maria Liebsch, Jan Linder, Karen E. Morrison, Hans Nissbrandt, Markus Otto, Jens Pahnke, Amanda Partch, Gabriella Restagno, Dan Rujescu, Cathrin Schnack, Christopher E. Shaw, Pamela J. Shaw, Hayrettin Tumani, Ole-Bjørn Tysnes, Otto Valladares, Vincenzo Silani, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Ulman Lindenberger, Elisabeth Steinhagen-Thiessen, Stefan Teipel, Robert Perneczky, Hakon Hakonarson, Harald Hampel, Christine A.F. von Arnim, Jørgen H. Olsen, Vivianna M. Van Deerlin, Ammar Al-Chalabi, Mathias Toft, Beate Ritz, Lars Bertram | |
| Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex, PLOS ONE, 10(11) | Ezekiel Crenshaw, Brian P. Leung, Chun Kit Kwok, Michal Sharoni, Kalee Olson, Neeraj P. Sebastian, Sara Ansaloni, Reinhard Schweitzer-Stenner, Michael R. Akins, Philip C. Bevilacqua, Aleister J. Saunders | |
| Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin, Scientific Reports, 5 | Hannah Brautigam, Cesar L. Moreno, John W. Steele, Alexey Bogush, Dara L. Dickstein, John B.J. Kwok, Peter R. Schofield, Gopal Thinakaran, Paul M. Mathews, Patrick R. Hof, Sam Gandy, and Michelle E. Ehrlich | |
| Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1Δexon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology, Molecular Psychiatry | B Readhead, J-V Haure-Mirande, B Zhang, V Haroutunian, S Gandy, EE Schadt, JT Dudley, and ME Ehrlich | |
| Alzheimer disease: Solanezumab—prospects for meaningful interventions in AD?, Nature Reviews Neurology, 11 | Sam Gandy, Mary Sano | |
| Current thinking on the mechanistic basis of Alzheimer’s and implications for drug development, Clinical Pharmacology & Therapeutics, 98(5) | C. Ising, M. Stanley and D.M. Holtzman | |
| Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), The Journal of Biological Chemistry, 290(43) | Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G | |
| Is there a link between the sleep–wake cycle and Alzheimer’s pathology?, Future Neurology, 10(3) | Jee Hoon Roh and David M. Holtzman | |
| Alzheimer’s in 3D culture: Challenges and perspectives, BioEssays, 37(10) | Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi and Doo Yeon Kim | |
| Surgery plus anesthesia induces loss of attention in mice, Frontiers in Cellular Neuroscience, 9 | Quan Ren, Mian Peng, Yuanlin Dong, Yiying Zhang, Ming Chen, Ning Yin, Edward R. Marcantonio, and Zhongcong Xie | |
| Identifying amyloid pathology–related cerebrospinal fluid biomarkers for Alzheimer’s disease in a multicohort study, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(3) | Yuk Yee Leung, Jon B. Toledo, Alexey Nefedov, Robi Polikar, Nandini Raghavan, Sharon X. Xie, Michael Farnum, Tim Schultz, Young Baek, Vivianna M. Van Deerlin, William T. Hu, David M. Holtzman, Anne M. Fagan, Richard J. Perrin, Murray Grossman, Holly D. Soares, Mitchel A. Kling, Matthew Mailman, Steven E. Arnold, Vaibhav A. Narayan, Virginia M-Y. Lee, Leslie M. Shaw, David Baker, Gayle M. Wittenberg, John Q. Trojanowski, and Li-San Wang | |
| Lessons from a Rare Familial Dementia: Amyloid and Beyond, Journal of Parkinson's Disease and Alzheimer's Disease, 2(1) | Adam Cantlon, Carlo Sala Frigerio, and Dominic M. Walsh | |
| Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues, PLoS One, 10(7) | Pavel V. Belichenko, Alexander M. Kleschevnikov, Ann Becker, Grant E. Wagner, Larisa V. Lysenko, Y. Eugene Yu, and William C. Mobley | |
| Clinical and imaging assessment of acute combat mild traumatic brain injury in Afghanistan, Neurology, 85(3) | Octavian Adam, M.D., Christine L. Mac Donald, Ph.D., Dennis Rivet, M.D., John Ritter, M.D., Todd May, D.O., Maria Barefield, O.T.D., Josh Duckworth, M.D., Donald LaBarge, M.D., Dean Asher, M.D., Benjamin Drinkwine, M.D., Yvette Woods, Ph.D., Michael Connor, Psy.D. and David L. Brody, M.D., Ph.D. | |
| Significance of transcytosis in Alzheimer’s disease: BACE1 takes the scenic route to axons, BioEssays, 37(7) | Virginie Buggia-Prévot, Gopal Thinakaran | |
| Using Network Methodology to Infer Population Substructure, Plos | Dmitry Prokopenko , Julian Hecker, Edwin Silverman, Markus M. Nöthen, Matthias Schmid, Christoph Lange, Heide Loehlein Fier | |
| How amyloid, sleep and memory connect, Nature Neuroscience, 18 | Brendan P Lucey, David M Holtzman | |
| Impact of Parkinson’s disease risk loci on age at onset, Movement Disorders, 30(6) | Christina M. Lill MD, Johnni Hansen PhD, Jørgen H. Olsen MD, Harald Binder PhD, Beate Ritz MD, PhD and Lars Bertram MD | |
| The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers, Journal of Biological Chemistry, 290 | Adam Cantlon, Carlo Sala Frigerio, Darragh B. Freir, Barry Boland, Ming Jin and Dominic M. Walsh | |
| Impact of the Alzheimer’s Disease Neuroimaging Initiative, 2004 to 2014, Alzheimer's & Dementia, 11(7) | Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Jesse Cedarbaum, Michael C. Donohue, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, John C. Morris, Ronald C. Petersen, Andrew J. Saykin, Leslie Shaw, Paul M. Thompson, Arthur W. Toga, and John Q. Trojanowski | |
| A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols, 10(7) | Young Hye Kim, Se Hoon Choi, Carla D'Avanzo, Matthias Hebisch, Christopher Sliwinski, Enjana Bylykbashi, Kevin J Washicosky, Justin B Klee, Oliver Brüstle, Rudolph E Tanzi & Doo Yeon Kim | |
| Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T, Journal of Biological Chemistry, 290(22) | ||
| Three dimensions of the amyloid hypothesis: time, space and ‘wingmen’, Nature Neuroscience | Erik S Musiek & David M Holtzman | |
| γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal, 29(8) | Carla D’Avanzo, Christopher Sliwinski, Steven L. Wagner, Rudolph E. Tanzi, Doo Yeon Kim, and Dora M. Kovacs | |
| Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, The Journal of Neuroscience, 35(14) | Chia-Chen Liu, Jin Hu, Chih-Wei Tsai, Mei Yue, Heather L. Melrose, Takahisa Kanekiyo, and Guojun Bu | |
| Anti-tau antibody reduces insoluble tau and decreases brain atrophy, Annals of Clinical and Translational Neurology, 2(3) | Kiran Yanamandra, Hong Jiang, Thomas E. Mahan, Susan E. Maloney, David F. Wozniak, Marc I. Diamond and David M. Holtzman | |
| Tau immunization: a cautionary tale?, Neurobiology of Aging, 36(3) | Alexandra J. Mably, Daniel Kanmert, Jessica M. Mc Donald, Wen Liu, Barbara J. Caldarone, Cynthia A. Lemere, Brian O'Nuallain, Kenneth S. Kosik, Dominic M. Walsh | |
| Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies, American Journal of Physiology - Cell Physiology, 308(3) | Michael W. Nestor, Samson Jacob, Bruce Sun, Deborah Prè, Andrew A. Sproul, Seong Im Hong, Chris Woodard, Matthew Zimmer, Vorapin Chinchalongporn, Ottavio Arancio, Scott A. Noggle | |
| Recommendations of the International Parkinson and Movement Disorder Society Task Force on Nomenclature of Genetic Movement Disorders | Connie Marras MD, PhD, Anthony Lang MD, Bart P. van de Warrenburg, Carolyn Sue, Sarah J. Tabrizi MBChB, PhD, Lars Bertram MD, Katja Lohmann PhD, Saadet Mercimek-Mahmutoglu MD, PhD, Alexandra Durr, Vladimir Kostic, Christine Klein MD | |
| Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome, PLoS One, 9(12) | Larisa V. Lysenko, Jeesun Kim, Cassandra Henry, Anna Tyrtyshnaia, Rebecca A. Kohnz, Francisco Madamba, Gabriel M. Simon, Natalia E. Kleschevnikova, Daniel K. Nomura, R . Alan B. Ezekowitz, and Alexander M. Kleschevnikov | |
| The sleep–wake cycle and Alzheimer’s disease: what do we know?, Neurodegenerative Disease Management, Vol. 4, No. 5 | Miranda M Lim, Jason R Gerstner. David M Holtzman | |
| Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors, Br. J. Anaesth. | H. Wang, Y. Dong, J. Zhang, Z. Xu, G. Wang, C. A. Swain, Y. Zhang and Z. Xie | |
| Characterization and Molecular Profiling of PSEN1 Familial Alzheimer’s Disease iPSC-Derived Neural Progenitors, PLoS ONE, 9(1) | Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W. Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W. Steele, David J. Kahler, Alex Dranovsky, Ottavio Arancio, John F. Crary, Sam Gandy, and Scott A. Noggle | |
| Targeting the β secretase BACE1 for Alzheimer’s disease therapy, The Lancet Neurology, 13(3) | Riqiang Yan, Robert Vassar | |
| Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium, Annals of Clinical and Translational Neurology | Zhongcong Xie, Celeste A. Swain, Sarah A. P. Ward, Hui Zheng, Yuanlin Dong, Neelakantan Sunder, Dennis W. Burke, Diana Escobar, Yiying Zhang and Edward R. Marcantonio | |
| High Accuracy of a Microarray-Based Blood Test for Alzheimer’s Disease (S38.002), Neurology, 82(10) | (S38.002) Lucas Restrepo, Phillip Stafford and Stephen Johnston | |
| Assessment of microRNA-related SNP effects in the 3′ untranslated region of theIL22RA2 risk locus in multiple sclerosis, Neurogenetics, 15(2) | Christina M. Lill, Marcel Schilling, Sara Ansaloni, Julia Schröder, Marian Jaedicke, Felix Luessi, Brit-Maren M. Schjeide, Andriy Mashychev, Christiane Graetz, Denis A. Akkad, Lisa-Ann Gerdes, Antje Kroner, Paul Blaschke, Sabine Hoffjan, Alexander Winkelmann, Thomas Dörner, Peter Rieckmann, Elisabeth Steinhagen-Thiessen, Ulman Lindenberger, Andrew Chan, Hans-Peter Hartung, Orhan Aktas, Peter Lohse, Mathias Buttmann, Tania Kümpfel, Christian Kubisch, Uwe K. Zettl, Joerg T. Epplen, Frauke Zipp, Lars Bertram | |
| Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control, Cereb. Cortex | David Cantu, Kendall Walker, Lauren Andresen, Amaro Taylor-Weiner, David Hampton, Giuseppina Tesco and Chris G. Dulla | |
| Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons, J Neurosci, 34(10) | Karthikeyan Veeraraghavalu, Can Zhang, Xiaoqiong Zhang, Rudolph E. Tanzi, and Sangram S. Sisodia | |
| Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Sci Rep, 4 | Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z | |
| Intra-Hippocampal Transplantation of Neural Precursor Cells with Transgenic Over-Expression of IL-1 Receptor Antagonist Rescues Memory and Neurogenesis Impairments in an Alzheimer’s Disease Model, Neuropsychopharmacology, 39(2) | Ofra Ben Menachem-Zidon, Yair Ben Menahem, Tamir Ben-Hur, Raz Yirmiya | |
| ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2) | Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi | |
| A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer’s disease, PLOS ONE, 8(11) | Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G | |
| Amyloid and neurodegeneration: converging and diverging paths, Neurology, 81(20) | Klunk WE, Perani D | |
| Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice, J Neurosci, 33(45) | Zhang X, Xin X, Dong Y, Zhang Y, Yu B, Mao J, Xie Z | |
| Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults, Neurology, 81(19) | Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, Klunk WE, Aizenstein HJ, Cohen AD, Snitz BE, Mathis CA, Dekosky ST, Lopez OL | |
| Clinical presentation of chronic traumatic encephalopathy, Neurology, 81(13) | Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC | |
| Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Hum Mol Genet, 22(18) | Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE | |
| Decoding Alzheimer’s in the age of genome-wide analyses, Mol Neurodegener, 8(suppl 1) | Rudolph E Tanzi | |
| Preclinical Alzheimer’s disease and its outcome: a longitudinal cohort study, The Lancet Neurology, 12(10) | Vos SJ, Xiong C, Visser PJ, Jasielec MS, Hassenstab J, Grant EA, Cairns NJ, Morris JC, Holtzman DM, Fagan AM | |
| Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model, Mol Psychiatry, 18(8) | J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim, L M Delgado, I E Alfaro, S Bernales, G Verdile, P Bharadwaj, V Gupta, R Barr, A Friss, G Dolios, R Wang, D Ringe, P Fraser, D Westaway, P H St George-Hyslop, P Szabo, N R Relkin, J D Buxbaum, C G Glabe, A A Protter, R N Martins, M E Ehrlich, G A Petsko, Z Yue and S Gandy | |
| Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain, Mol Psychiatry, 18(8) | Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S | |
| Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice, J Neurochem, 126(4) | Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG | |
| Molecular mechanisms of cognitive dysfunction following traumatic brain injury, Front Aging Neurosci, 5(29) | Walker KR, Tesco G | |
| Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts, The Journal of Neuroscience, 33(27) | Raja Bhattacharyya, Cory Barren, Dora M. Kovacs | |
| Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change, Annals of Surgery, Ann Surg 2013;00 | Zhongcong Xie, MD, PhD, Sayre McAuliffe, Celeste A. Swain, Sarah A. P. Ward, Catherine A. Crosby, Hui Zheng, Janet Sherman, Yuanlin Dong, Yiying Zhang, Neelakantan Sunder, Dennis Burke, Kevin Washicosky, Rudolph E. Tanzi, and Edward R. Marcantonio | |
| Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychology | BV Hooli1, ZM Kovacs-Vajna2, K Mullin1, MA Blumenthal1, M Mattheisen3, C Zhang1, C Lange4, G Mohapatra5, L Bertram6 and RE Tanzi1 | |
| MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis, Brain, 1386 (Pt 6) | International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F | |
| BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels, FASEB J, 27(6) | Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY | |
| Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study, PLOS Med, 10(6) | Irene Pichler, Fabiola Del Greco M., Martin Gögele, Christina M. Lill, Lars Bertram, Chuong B. Do, Nicholas Eriksson, Tatiana Foroud, Richard H. Myers, PD GWAS Consortium, Michael Nalls, Margaux F. Keller, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium, Beben Benyamin, John B. Whitfield, Genetics of Iron Status Consortium, Peter P. Pramstaller, Andrew A. Hicks, John R. Thompson, and Cosetta Minelli | |
| Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, Br. J. Anaesth., 111(2) | Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr | |
| Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia | Zhang L, Zhang J, Yang L, Dong Y, Zhang Y, Xie Z | |
| Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer’s Amyloid-β Peptide, J Neurosci, 33(16) | Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S | |
| Traumatic Brain Injury (TBI) can lead to Neurodegenerative Syndromes that include Alzheimer Disease (AD) and Chronic Traumatic Encephalopathy (CTE), Nature Reviews Neurology, Volume 9, No 4 | Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy | |
| Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia, Neurology, 80(15) | Snitz BE, Weissfeld LA, Lopez OL, Kuller LH, Saxton J, Singhabahu DM, Klunk WE, Mathis CA, Price JC, Ives DG, Cohen AD, McDade E, Dekosky ST | |
| The aging brain and cognition: contribution of vascular injury and aβ to mild cognitive dysfunction, JAMA Neurol, 70(4) | Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ | |
| Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers, Nature Reviews Neurology | Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy | |
| Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer’s-like tauopathy, J NeuroScience, 33(3) | Michiyo Iba, Jing L. Guo, Jennifer D. McBride, Bin Zhang, John Q. Trojanowski, Virginia M.-Y. Lee | |
| Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk, J Med Genet, 50(30) | Lill CM, Schjeide BM, Graetz C, Liu T, Damotte V, Akkad DA, Blaschke P, Gerdes LA, Kroner A, Luessi F, Cournu-Rebeix I, Hoffjan S, Winkelmann A, Touze E, Pico F, Corcia P, Otaegui D, Antigüedad A, Alcina A, Comabella M, Montalban X, Olascoaga J, Matesanz F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Rieckmann P, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Fontaine B, Zipp F, Vandenbroeck K, Bertram L | |
| Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment, Anesthesiology | Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z | |
| Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls, Ann. Neurol, 73(1) | Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL | |
| Rapid doubling of Alzheimer’s amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution, F1000Research, 1:70 | Soong Ho Kim1, Elysse M Knight, Eric L Saunders, Azita K Cuevas, Marusia Popovech, Lung-Chi Chen, Sam Gandy | |
| Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochim Biophys Acta, 1820(12) | Arai H, Glabe C, Luecke H | |
| Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers, Brain, A Journal of Neurology, doi:10.1093/brain/aws289 | Aida Attar, Cristian Ripoli, Elisa Riccardi, Panchanan Maiti, Domenica D. Li Puma, Tingyu Liu, Jane Hayes, Mychica R. Jones, Kristin Lichti-Kaiser, Fusheng Yang, Greg D. Gale, Chi-hong Tseng, Miao Tan, Cui-Wei Xie, Jeffrey L. Straudinger, Frank-Gerrit Klarner, Thomas Schrader, Sally A. Frautschy, Claudio Grassi and Gal Bitan | |
| Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis, J Exp Med., 209(12) | Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM | |
| Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes, The Journal of Neuroscience, 32(41) | Rachel F. Lane, Peter St George-Hyslop, Barbara L. Hempstead, Scott A. Small, Stephen M. Strittmatter, and Sam Gandy | |
| Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of Amyloid-b in Mice with Alzheimer’s Disease Pathology, Science Translational Medicine Home, Vol. 4, Issue 150 | Jee Hoon Roh,1,2,3 Yafei Huang,1 Adam W. Bero,1,2,3 Tom Kasten,1 Floy R. Stewart,1,2,3 Randall J. Bateman,1,2,3 David M. Holtzman1,2,3,4* | |
| Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Curr Mol Med. | Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z | |
| Developing the ‘next generation’ of genetic association databases for complex diseases, Hum. Mutat., 33(9) | Lill CM, Bertram L | |
| Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects, J Med Genet., 49(9) | Lill CM, Liu T, Schjeide BM, Roehr JT, Akkad DA, Damotte V, Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes LA, Luessi F, Fernadez O, Izquierdo G, Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S, Faber H, Liebsch M, Meissner E, Chanvillard C, Touze E, Pico F, Corcia P; ANZgene Consortium, Dörner T, Steinhagen-Thiessen E, Baeckman L, Heekeren HR, Li SC, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Fontaine B, Vandenbroeck K, Matesanz F, Urcelay E, Bertram L, Zipp F | |
| General anesthetics and β-amyloid protein, Prog Neuropsychopharmacol Biol Psychiatry | Xie Z, Xu Z | |
| Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1, The Journal of Neuroscience, 32 (30) | Kendall R. Walker, Eugene L. Kang, Michael J. Whalen, Yong Shen, and Giuseppina Tesco | |
| Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease, Arch Neurol. | Wagner SL, Tanzi RE, Mobley WC, Galasko D | |
| Disrupted cortical function underlies behavior dysfunction due to social isolation, J Clin Invest., 122(7) | Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T | |
| The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β, Neurobiology of Aging, 33(7) | Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z | |
| Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining, Genet Med., 14(7) | Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen JT, Trikalinos TA | |
| A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2, The Journal of Neuroscience, 32(25) | Xulun Zhang1, Krassimira Garbett2, Karthikeyan Veeraraghavalu, Brian Wilburn, Reid Gilmore, Karoly Mirnics, and Sangram S. Sisodia | |
| Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies, Proc Natl Acad Sci U S A, 109(22) | Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS | |
| Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β, Nature, 485 | Nussbaum, JM; Schilling, S; Cynis, H; Silva, A; Swanson, E; Wangsanut, T; Tayler, K; Wiltgen, B; Hatami, A; Ronicke, R; Reymann, K; Hutter-Paier, B; Alexandru, A; Jagla, W; Graubner, S; Glabe, CG; Demuth, HU; Bloom, GS | |
| Role of common and rare APP DNA sequence variants in Alzheimer disease, Neurology 78, 78/16 | B.V. Hooli, PhD, G. Mohapatra, PhD, M. Mattheisen, MD, A.R. Parrado, PhD, J.T. Roehr, MS, Y. Shen, PhD, J.F. Gusella, PhD, R. Moir, PhD, A.J. Saunders, PhD, C. Lange, PhD, R.E. Tanzi, PhD and L. Bertram, MD | |
| Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory, J Biol Chem., 287(16) | Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC | |
| Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain, J Neurosci., 32(13) | Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM | |
| RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing, Transl Neurodegener., 1:8 | Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE | |
| Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene database, PLoS Genet., 8(3) | Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L | |
| Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory, Annals of Neurology, Volume 71, Issue 5 | Yiying Zhang MD, MS1, Zhipeng Xu MD, PhD1, Hui Wang MD1,2, Yuanlin Dong MD, MS1, Hai Ning Shi PhD, DVM3, Deborah J. Culley MD4, Gregory Crosby MD4, Edward R. Marcantonio MD5, Rudolph E. Tanzi PhD.6, Zhongcong Xie MD, PhD1,* | |
| Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample, Neurogenetics, 13(1) | Lill CM, Schjeide BM, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Bertram L, Zipp F | |
| On the Meta-Analysis of Genome-Wide Association Studies: A Robust and Efficient Approach to Combine Population and Family-Based Studies, Human Heredity, 73 | Sungho Wona, Qing Luc, Lars Bertram, Rudolph E. Tanzi, Christoph Lange | |
| Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD, Neurobiol Aging, 33(1) | Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Özer E, Bertram L, von Einem B, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, von Arnim CA | |
| Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation, PLoS One, 7(6) | Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying Zhang, Zhongcong Xie | |
| The role of genetics for biomarker development in neurodegeneration, Prog Neurobiol., 95(4) | Bertram L, Hampel H | |
| Towards unveiling the genetics of neurodegenerative diseases, Semin Neurol., 31(5) | Lill CM, Bertram L | |
| Heterogeneity of CNS myeloid cells and their roles in neurodegeneration, Nat Neurosci., 14(10) | Prinz M, Priller J, Sisodia SS, Ransohoff RM | |
| Call for participation in the neurogenetics consortium within the Human Variome Project, Neurogenetics, 12(3) | Haworth A, Bertram L, Carrera P, Elson JL, Braastad CD, Cox DW, Cruts M, den Dunnen JT, Farrer MJ, Fink JK, Hamed SA, Houlden H, Johnson DR, Nuytemans K, Palau F, Rayan DL, Robinson PN, Salas A, Schüle B, Sweeney MG, Woods MO, Amigo J, Cotton RG, Sobrido MJ | |
| Alzheimer’s genetics in the GWAS era: a continuing story of ‘replications and refutations’, Curr Neurol Neurosci Rep., 11(3) | Bertram, L | |
| Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking, Mol Cell Biol., 31(11) | Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M | |
| Changes in the Expression of the Alzheimer’s Disease- Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction, NIHPA Author Manuscripts, 8/3 | A. Li, C. Zhou, J. Moore, P. Zhang, T.-H. Tsai, H.-C. Lee, D.M. Romano, M.L. McKee, D.A. Schoenfeld, M.J. Serra,3 K. Raygor, H.F. Cantiello, J.G. Fujimoto, and R.E. Tanzi | |
| Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias, Plos One, 6:3 | Thomas Pfeiffer, Lars Bertram, John P. A. Ioannidis | |
| Alzheimer’s Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation, Traffic, 12(3) | Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KMA, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Nertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M | |
| Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles, The Journal of Biological Chemistry, 286/17 | Jing L. Guo and Virginia M.-Y. Lee | |
| The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels, Arch Gen Psychiatry, 68(2) | Brit-Maren M. Schjeide, BS; Cathrin Schnack, PhD; Jean-Charles Lambert, PhD; Christina M. Lill, MD; Julia Kirchheiner, MD, PhD; Hayrettin Tumani, MD; Markus Otto, MD; Rudolph E. Tanzi, PhD; Hans Lehrach, PhD; Philippe Amouyel, PhD; Christine A. F. von Arnim, MD; Lars Bertram, MD | |
| Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice, Journal of Cerebral Blood Flow & Metabolism, 31 | Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ | |
| Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study, Neurobiology of Disease, Volume 40, Issue 3 | Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL | |
| The Genetics of Alzheimer Disease: Back to the Future, Neuron, 68(2) | Bertram L, Lill CM, Tanzi RE | |
| Activation and Intrinsic γ-Secretase Activity of Presenilin 1, Proc. Natl. Acad. Sci USA, 50 | Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming Li | |
| Diabetes-Associated SorCS1 Regulates Alzheimer’s Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex, The Journal of Neuroscience, 30(39) | Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S | |
| Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein, The Journal of Biological Chemistry, 285(37) | Zhang C, Browne A, Child D, Tanzi RE | |
| Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia, Neurology, 75(7) | Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM-Y, Trojanowski JQ, Grossman M | |
| The prion protein as a receptor for beta-amyloid, Nature, 466(7308) | Kessels HW, Nguyen LN, Nabavi S, Malinow R | |
| Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers, Annals of Neurology, Volume 68, Issue 2 | Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME | |
| The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice, Journal of Neuropathology and Experimental Neurology, 69(8) | Huttunen HJ, Hutter-Paier B, Barren C, Peach C, Havas D, Duller S, Xia W, Frosch MP, Windisch M, Kovacs DM. | |
| Alzheimer’s Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome, PLoS ONE, 5(5) | Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE | |
| Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene), Public Health Genomics, 13(7-8) | Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, Nace J, Lin BK, Khoury MJ, Ioannidis JP, Bagade S, Zheng X, Dubin RA, Bertram L, Velez Edwards DR, Menon R | |
| Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling, The Journal of Neuroscience, 30(20) | Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS | |
| Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein, The Journal of Neuroscience, 30(18) | Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Lauren J, Gimbel ZA, Strittmatter SM | |
| Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer’s Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP, The Journal of Neuroscience, 30(17) | Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ | |
| Loss-of-Function of ATXN1 Increases Amyloid-Beta Levels by Potentiating Beta-Secretase Processing of APP, Journal of Biological Chemistry, 285(12) | Zhang C, Browne A, Child D, DiVito JR, Stevenson JA, Tanzi RE | |
| Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer’s Amyloid β42 from Isolated Intact Nerve Terminals, The Journal of Neuroscience, 30(11) | Kim SH, Fraser PE, Westaway D, George-Hyslop PH, Ehrlich ME, Gandy S | |
| Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy, Circulation: Journal of the American Heart Association, 121(10) | Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, delMonte F. | |
| Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system, Brain Research, Volume 1319 | Zeng C, Pan F, Jones LA, Lim MM, Griffin EA, Sheline YI, Mintun MA, Holtzman DM, Mach RH | |
| The pursuit of susceptibility genes for Alzheimer’s disease: progress and prospects, Trends in Genetics, Volume 26, Issue 2 | Sleegers K, Lambert J-C, Bertram L, Cruts M, Amouyel P, Broeckhoven CV | |
| Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience, 13(2) | Wei W, Nguyen L, Kessels HW, Hagiwara H, Sisodia S, Malinow R | |
| The COPD genetic association compendium: a comprehensive online database of COPD genetic associations, Hum. Mol. Genet., 10.1093/hmg/ddp519 | Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA | |
| Familial Alzheimer’s Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secretase Amyloid-Beta Protein Precursor Generated by Beta-Secretase Cleavage, Current Alzheimer Research, 7(1) | Zhang C, Browne A, Kim DY, Tanzi RE | |
| Wakefulness and loss of awareness: Brain and brainstem interaction in the vegetative state, Neurology, 74(4) | Silva S, Alacoque X, Fourcade O, Samii K, Marque P, Woods R, Mazziotta J, Chollet F, Loubinoux I | |
| CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid, Neuroscience Letters, Volume 469, Issue 2 | Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M | |
| Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer’s Disease, Mount Sinai Joural of Medicine, 77 | Lublin AL, Gandy S | |
| Online databases and systematic meta-analyses of genetically complex diseases, Medizin Genet, 22 | Lill CM, Bertram L | |
| Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction, The Journal of Biological Chemistry, 284(52) | Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins R, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T | |
| Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4 | Choi SH, Li Y, Parada LF, Sisodia SS | |
| Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration, 4:51 | Steele JW, Kim HS, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PSG, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S | |
| APOE ε4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics, Neurology, 73(24) | Kaufer D, Gandy S. | |
| CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease, Neurology, 73(23) | Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JSK | |
| Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle, Science, 326(5955) | Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM | |
| A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer’s β-Amyloid Levels and Tau Phosphorylation, Neuron, 64(3) | Zhang Y-w, Liu Shijie, Zhang X, Li W-B, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen S, Greengard P, Liao F-F, Li L, Xu H | |
| Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family – Based Association Tests, Statistics in Biosciences, 1(2) | Won S, Bertram L, Becker D, Tanzi RE, Lange C. | |
| Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers, Archives of Neurology, 66(11) | Nygaard HB, Strittmatter SM | |
| Degradation of Amyloid β Protein by Purified Myelin Basic Protein, The Journal of Biological Chemistry, 284(42) | Liao M-C, Ahmed M, Smith SO, Norstrand WEV | |
| Genome-wide association studies in Alzheimer’s disease, Human Molecular Genetics, Vol 18, Review Issue 2 | Bertram, L, Tanzi RE | |
| Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity., Human Molecular Genetics, Vol 18 | Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE. | |
| Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice, The Journal of Neuroscience, 29(34) | Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee J-M | |
| Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses, Chemical Biology, 4:8 | ||
| A current view of Alzheimer’s disease, F1000 Biology Rep., 1 | Hooli BV, Tanzi RE | |
| Caffeine suppresses beta-amyloid levels in plasma and brain of Alzheimer’s transgenic mice., Journal of Alzheimer's disease | Cao C, Cirrito JR, Lin X, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H | |
| Myelin basic protein binds to and inhibits the fibrillar assembly of Aß42 in vitro, Biochemistry, 48 | Hoos MD, Ahmed M, Smith SO, Van Nostrand WE | |
| Alzheimer’s Disease Genetics: Current Status and Future Perspectives, International Review of Neurobiology, Vol. 84 | Bertram L | |
| The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels, Archives of Neurology, Vol. 66 No. 5 | Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z | |
| Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer, J Biol Chem, 284 | Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., and Glabe, C | |
| Assessment of Alzheimer’s disease case-control associations using family-based methods, Neurogenetics, DOI 10.1007/s10048-008-1051-3, | Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, and Bertram L. | |
| Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8 | Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF | |
| GAB2 as an Alzheimer Disease Susceptibility Gene, Follow up of Genomewide Association Results, Arch Neurol, 66 | Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L | |
| No association between CALHM1 and Alzheimer’s disease risk., Cell, 135(6) | Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE. | |
| The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo., Annals of Neurology, Volume 64 | Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. | |
| The Human Variome Project, Science., 322(5903) | Cotton RG, Auerbach AD, Axton M, Barash CI, Berkovic SF, Brookes AJ, Burn J, Cutting G, den Dunnen JT, Flicek P, Freimer N, Greenblatt MS, Howard HJ, Katz M, Macrae FA, Maglott D, Möslein G, Povey S, Ramesar RS, Richards CS, Seminara D, Smith TD, Sobrido MJ, Solbakk JH, Tanzi RE, Tavtigian SV, Taylor GR, Utsunomiya J, Watson M | |
| Genome-wide Association Analysis Reveals Putative Alzheimer’s Disease Susceptibility Loci in Addition to APOE, Am. J. Hum. Genet., 83 | Bertram L, Lange CL, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BMM, Hooli B, DeVito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. | |
| Structural classification of toxic amyloid oligomers, J Biol Chem, 283 | Glabe, CG | |
| Evaluation of the potential excess of statistically significant findings reported genetic association studies: application to Alzheimer’s disease, Am. J. Epidemiol. | Kavvoura FK, McQueen MP, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JPA. | |
| Cdk5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Science, Vol. 105 No. 47 | Lagace D, Benavides D, Kansy J, Mapelli M, Greengard P, Bibb J, Eisch A | |
| Association of GSK3B with Alzheimer’s Disease and Frontotemporal Dementia, Arch. Neurol., 65(10) | Schaffer B, Bertram L, Miller L, Mullin K, Weintraub S, Johnson N, Bigio E, Mesulam M, Wiedau-Pazos M, Jackson G, Cummings J, Cantor R, Levey A, Tanzi RE, and Geschwind D | |
| Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neurosci. | Bertram L, Tanzi RE | |
| Amyloid-beta dynamics correlate with neurological status in the injured human brain, Science, 321(5893) | Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM | |
| Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4 | Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS | |
| Active and Passive Immunotherapy for Neurodegenerative Disorders, Annu Rev Neurosci., 31 | Brody DL, Holtzman DM | |
| The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions., J Biol Chem., 2;283(18) | Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z | |
| Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4, 5-bisphosphate metabolism., Nature Neuroscience | Berman DE, Dall’Armi C, Voronov SV, McIntire LBJ, Zhang H, Moore AZ, Staniszewski A, Arancio O, Kim T, Di Paolo G. | |
| Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine., J Neurosci, 28 | Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. | |
| Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo., Neuron, 58(1) | Cirrito JR, Kang J, Lee J, Stewart FR, Verges D, Silverio LM, Bu G, Mennerick S, Holtzman DM. | |
| Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers, Mol Neurodegener, 2(18) | Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., et al | |
| Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26) | Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS | |
| Depletion of GGA3 stabilizes BACE and enhances β-secretase activity, Neuron, 54(5) | Tesco G, Koh YH, Kang E, Cameron A, Das S, Sena-Esteves M, Hiltunen, Yang S-H, Zhong Z, Shen Y, Simpkins J, Tanzi RE. | |
| Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity, Neurology, Vol. 75/no. 7 | Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM | |
| Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer’s disease families., Journal of Biological Chemistry, 282(11) | Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE | |
| The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation., J. Neurosci., 27 | Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE. | |
| Exploring Candidate Gene Associations with Neuropsychological Performance., Am J Med Genet B Neuropsychiatr Genet, 144(8) | McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. |
