Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Title Researchers Date
Identification of late-stage tau accumulation using plasma phospho-tau217, eBioMedicine Woo, M. S., Therriault, J., Jonaitis, E. M., Wilson, R., Langhough, R. E., Rahmouni, N., Benedet, A. L., Ashton, N. J., Tissot, C., Lantero-Rodriguez, J., Macedo, A. C., Servaes, S., Wang, Y. T., Arias, J. F., Hosseini, S. A., Betthauser, T. J., Lussier, F. Z., Hopewell, R., Triana-Baltzer, G., Kolb, H. C., … Rosa-Neto, P. 2024-11-04
Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease, Neurology Safransky, M., Groh, J. R., Blennow, K., Zetterberg, H., Tripodis, Y., Martin, B., Weller, J., Asken, B. M., Rabinovici, G. D., Qiu, W. W. Q., McKee, A. C., Stein, T. D., Mez, J., Henson, R. L., Long, J., Morris, J. C., Perrin, R. J., Schindler, S. E., & Alosco, M. L. 2024-11-04
A luminescent-based protocol for NAD+/NADH detection in C. elegans, mice, and human whole blood, STAR Protocols Wang, H. L., Zhang, J., Cao, S. Q., Lagartos-Donate, M. J., Zhang, S. Q., Lautrup, S., Hu, Z., Lyssiotis, C. A., Houtkooper, R. H., & Fang, E. F. 2024-11-01
Costs of Care in Relation to Alzheimer’s Disease Severity in Sweden: A National Registry-Based Cohort Study, PharmacoEconomics Aye, S., Frisell, O., Zetterberg, H., Skillbäck, T. B., Kern, S., Eriksdotter, M., Aho, E., Xia, X., Winblad, B., Wimo, A., & Jönsson, L. 2024-11-01
Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice, Heliyon Wang, N., Parsons, T. M., Ren, Y., Pan, Y., Kurti, A., Starling, S. C., Muolokwu, C., Singh, J., & Kanekiyo, T. 2024-10-30
Myocardial infarction augments sleep to limit cardiac inflammation and damage, Nature Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T., Ferreira da Silva, J., … McAlpine, C. S. 2024-10-30
Anti-seizure effects of norepinephrine-induced free fatty acid release, Cell Metabolism Li, B., Sun, Q., Ding, F., Xu, Q., Kang, N., Xue, Y., Ladron-de-Guevara, A., Hirase, H., Weikop, P., Gong, S., Nathan, S., & Nedergaard, M. 2024-10-29
A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Brain Warmenhoven, N., Salvadó, G., Janelidze, S., Mattsson-Carlgren, N., Bali, D., Orduña Dolado, A., Kolb, H., Triana-Baltzer, G., Barthélemy, N. R., Schindler, S. E., Aschenbrenner, A. J., Raji, C. A., Benzinger, T. L. S., Morris, J. C., Ibanez, L., Timsina, J., Cruchaga, C., Bateman, R. J., Ashton, N., Arslan, B., … Hansson, O. 2024-10-28
Gut microbiome-derived metabolites in Alzheimer’s disease: Regulation of immunity and potential for therapeutics, Immunological Reviews Chandra, S., & Vassar, R. J. 2024-10-24
Current insights into apolipoprotein E and the immune response in Alzheimer’s disease, Immunological Reviews Lin, P. B., & Holtzman, D. M. 2024-10-24
Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes, Brain Al-Diwani, A., Provine, N. M., Murchison, A., Laban, R., Swann, O. J., Koychev, I., Sheerin, F., Da Mesquita, S., Heslegrave, A., Zetterberg, H., Klenerman, P., & Irani, S. R. 2024-10-21
Dietary salt, vascular dysfunction, and cognitive impairment, Cardiovascular Research Faraco G. 2024-10-21
Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study, Alzheimer's Research & Therapy Götze, K., Vrillon, A., Dumurgier, J., Indart, S., Sanchez-Ortiz, M., Slimi, H., Raynaud-Simon, A., Cognat, E., Martinet, M., Zetterberg, H., Blennow, K., Hourrègue, C., Bouaziz-Amar, E., Paquet, C., & Lilamand, M. 2024-10-19
Individualized, cross-validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms, Alzheimer's & Dementia Borland, E., Mattson-Carlgren, N., Tideman, P., Alzheimer's Disease Neuroimaging Initiative, Stomrud, E., Hansson, O., & Palmqvist, S. 2024-10-17
Comparison of nanoimaging and nanoflow based detection of extracellular vesicles at a single particle resolution, Journal of Extracellular biology Xu, S., Zhang, Z., Melvin, B. C., Basu Ray, N., Ikezu, S., & Ikezu, T. 2024-10-16
Biological mechanisms of resilience to tau pathology in Alzheimer’s disease, Alzheimer's Research & Therapy Svenningsson, A. L., Bocancea, D. I., Stomrud, E., van Loenhoud, A., Barkhof, F., Mattsson-Carlgren, N., Palmqvist, S., Hansson, O., & Ossenkoppele, R. 2024-10-12
Waste clearance shapes aging brain health, Neuron Jiang-Xie, L. F., Drieu, A., & Kipnis, J. 2024-10-11
Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?, The Journal of Neuroscience Capocchi, J. K., Figueroa-Romero, C., Dunham, S. J. B., Faraci, G., Rothman, J. A., Whiteson, K. L., Seo, D. O., Holtzman, D. M., Grabrucker, S., Nolan, Y. M., Kaddurah-Daouk, R., & Jett, D. A. 2024-10-09
Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments, Neuroscience Insights Schrader, J. M., Majchrzak, M., Xu, F., Lee, H., Agostinucci, K., Davis, J., Benveniste, H., & Van Nostrand, W. E. 2024-10-08
Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer’s disease at 20 Hz, 40 Hz, or 83 Hz, Scientific Reports Patel, A. A., Zhu, M. H., Yan, R., & Antic, S. D. 2024-10-08
Plateau depolarizations in spontaneously active neurons detected by calcium or voltage imaging, Scientific Reports Milicevic, K. D., Ivanova, V. O., Lovic, D. D., Platisa, J., Andjus, P. R., & Antic, S. D. 2024-10-04
Letter to the editor: critical evaluation of the reliability of DNA methylation probes on the illumina MethylationEPIC v1.0 BeadChip microarrays, Epigenetics Hecker, J., Weiss, S. T., Lasky-Su, J. A., DeMeo, D. L., & Lange, C. 2024-10-04
Salience network segregation mediates the effect of tau pathology on mild behavioral impairment, Alzheimer's & Dementia Iordan, A. D., Ploutz-Snyder, R., Ghosh, B., Rahman-Filipiak, A., Koeppe, R., Peltier, S., Giordani, B., Albin, R. L., & Hampstead, B. M. 2024-10-04
Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders, The Journal of Neuroscience Wlodarczyk, J., Bhattacharyya, R., Dore, K., Ho, G. P. H., Martin, D. D. O., Mejias, R., & Hochrainer, K. 2024-10-02
Intracranial arteriosclerosis is not associated with cerebral amyloid deposition, Alzheimer's & Dementia Streiber, A. M., Neitzel, J., Nguyen Ho, P. T., Vernooij, M. W., & Bos, D. 2024-10-01
Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players, Alzheimer's & Dementia Miner, A. E., Groh, J. R., Tripodis, Y., Adler, C. H., Balcer, L. J., Bernick, C., Zetterberg, H., Blennow, K., Peskind, E., Ashton, N. J., Gaudet, C. E., Martin, B., Palmisano, J. N., Banks, S. J., Barr, W. B., Wethe, J. V., Cantu, R. C., Dodick, D. W., Katz, D. I., Mez, J., … DIAGNOSE CTE Research Project 2024-10-01
Therapeutic targeting of senescent cells in the CNS, Nature Reviews Drug Discovery Riessland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E. 2024-09-30
Engineered 3D human neurovascular model of Alzheimer’s disease to study vascular dysfunction, Biomaterials Pavlou, G., Spitz, S., Pramotton, F. M., Tsai, A., Li, B. M., Wang, X., Barr, O. M., Ko, E. C., Zhang, S., Ashley, S. J., Maaser-Hecker, A., Choi, S. H., Jorfi, M., Tanzi, R. E., & Kamm, R. D. 2024-09-28
Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease, Alzheimer's Research & Therapy Johansson, C., Thordardottir, S., Laffita-Mesa, J., Pannee, J., Rodriguez-Vieitez, E., Zetterberg, H., Blennow, K., & Graff, C. 2024-09-25
Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model, Neuron Carling, G. K., Fan, L., Foxe, N. R., Norman, K., Wong, M. Y., Zhu, D., Corona, C., Razzoli, A., Yu, F., Yarahmady, A., Ye, P., Chen, H., Huang, Y., Amin, S., Sereda, R., Lopez-Lee, C., Zacharioudakis, E., Chen, X., Xu, J., Cheng, F., … Gan, L. 2024-09-24
REAL AD—Validation of a realistic screening approach for early Alzheimer’s disease, Alzheimer's & Dementia Leuzy, A., Heeman, F., Bosch, I., Lenér, F., Dottori, M., Quitz, K., Moscoso, A., Kern, S., Zetterberg, H., Blennow, K., & Schöll, M. 2024-09-23
Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions, Acta Neuropathologica Freiburghaus, T., Pawlik, D., Oliveira Hauer, K., Ossenkoppele, R., Strandberg, O., Leuzy, A., Rittmo, J., Tremblay, C., Serrano, G. E., Pontecorvo, M. J., Beach, T. G., Smith, R., & Hansson, O. 2024-09-19
The prion principle and Alzheimer’s disease, Science Walker, L. C., & Jucker, M. 2024-09-19
Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome, ACS Chemical Neuroscience Biby, S., Mondal, P., Xu, Y., Gomm, A., Kaur, B., Namme, J. N., Wang, C., Tanzi, R. E., Zhang, S., & Zhang, C. 2024-09-19
Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease, Alzheimer's Research & Therapy Wuestefeld, A., Pichet Binette, A., van Westen, D., Strandberg, O., Stomrud, E., Mattsson-Carlgren, N., Janelidze, S., Smith, R., Palmqvist, S., Baumeister, H., Berron, D., Yushkevich, P. A., Hansson, O., Spotorno, N., & Wisse, L. E. M. 2024-09-16
Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease, Nature Communications Collij, L. E., Mastenbroek, S. E., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Janelidze, S., Palmqvist, S., Ossenkoppele, R., & Hansson, O. 2024-09-14
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies, Trends in Immunology Chen, Y., & Holtzman, D. M. 2024-09-14
The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center study, Multiple Sclerosis and Related Disorders Sandgren, S., Novakova, L., Nordin, A., Sabir, H., Axelsson, M., Malmeström, C., Zetterberg, H., & Lycke, J. 2024-09-13
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome, Cell Calcium Filadi, R., & Pizzo, P. 2024-09-12
Associations between misfolded alpha-synuclein aggregates and Alzheimer’s disease pathology in vivo, Allheimer's & Dementia Pichet Binette, A., Mammana, A., Wisse, L., Rossi, M., Strandberg, O., Smith, R., Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., ADNI, Ticca, A., Stomrud, E., Parchi, P., & Hansson, O. 2024-09-11
A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions, Experimental Gerontology Borda, M. G., Barreto, G. E., Baldera, J. P., de Lucia, C., Khalifa, K., Bergland, A. K., Pola, I., Botero-Rodríguez, F., Siow, R. C., Kivipelto, M., Zetterberg, H., Ashton, N. J., Ballard, C., Aarsland, D., & NJ FINGER 2024-09-09
A γδ T cell–IL-3 axis controls allergic responses through sensory neurons, Nature Flayer, C. H., Kernin, I. J., Matatia, P. R., Zeng, X., Yarmolinsky, D. A., Han, C., Naik, P. R., Buttaci, D. R., Aderhold, P. A., Camire, R. B., Zhu, X., Tirard, A. J., McGuire, J. T., Smith, N. P., McKimmie, C. S., McAlpine, C. S., Swirski, F. K., Woolf, C. J., Villani, A. C., & Sokol, C. L. 2024-09-04
An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein, Advanced Healthcare Materials Li, Y., Luo, L., Senicar, L., Asrosa, R., Kizilates, B., Xing, K., Torres, E., Xu, L., Li, D., Graham, N., Heslegrave, A., Zetterberg, H., Sharp, D. J., & Li, B. 2024-09-02
Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination, Immunity das Neves, S. P., Delivanoglou, N., Ren, Y., Cucuzza, C. S., Makuch, M., Almeida, F., Sanchez, G., Barber, M. J., Rego, S., Schrader, R., Faroqi, A. H., Thomas, J. L., McLean, P. J., Oliveira, T. G., Irani, S. R., Piehl, F., & Da Mesquita, S. 2024-08-31
Blood-based multivariate methylation risk score for cognitive impairment and dementia, Alzheimer's & Dementia Koetsier, J., Cavill, R., Reijnders, R., Harvey, J., Homann, J., … Dobricic, V., … Scheltens, P., … Zetterberg, H., … Lill, C. L., Bertram, L., … Pishva, E. 2024-08-28
Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies, Nature Neuroscience Pichet Binette, A., Gaiteri, C., Wennström, M., Kumar, A., Hristovska, I., Spotorno, N., Salvadó, G., Strandberg, O., Mathys, H., Tsai, L. H., Palmqvist, S., Mattsson-Carlgren, N., Janelidze, S., Stomrud, E., Vogel, J. W., & Hansson, O. 2024-08-26
Regression convolutional neural network models implicate peripheral immune regulatory variants in the predisposition to Alzheimer’s disease, PLoS Computational Biology Ramamurthy, E., Agarwal, S., Toong, N., Sestili, H., Kaplow, I. M., Chen, Z., Phan, B., & Pfenning, A. R. 2024-08-26
Overview of the role of purinergic signaling and insights into its role in cancer therapy, Pharmacology & Therapeutics Di Virgilio, F., Vultaggio-Poma, V., Tarantini, M., & Giuliani, A. L. 2024-08-22
Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer’s disease, Alzheimer's & Dementia Norambuena, A., Sagar, V. K., Wang, Z., Raut, P., Feng, Z., Wallrabe, H., Pardo, E., Kim, T., Alam, S. R., Hu, S., Periasamy, A., & Bloom, G. S. 2024-08-22
Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA, Neurobiology of Aging Quaresima, V., Pilotto, A., Trasciatti, C., Tolassi, C., Parigi, M., Bertoli, D., Mordenti, C., Galli, A., Rizzardi, A., Caratozzolo, S., Benussi, A., Ashton, N. J., Blennow, K., Zetterberg, H., Giliani, S., Brugnoni, D., & Padovani, A. 2024-08-22
Fluid biomarkers in multiple sclerosis: from current to future applications, The Lancet Regional Health Europe Di Filippo, M., Gaetani, L., Centonze, D., Hegen, H., Kuhle, J., Teunissen, C. E., Tintoré, M., Villar, L. M., Willemse, E. A. J., Zetterberg, H., & Parnetti, L. 2024-08-22
Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration, Brain Malpetti, M., Swann, P., Tsvetanov, K. A., Chouliaras, L., Strauss, A., Chikaura, T., Murley, A. G., Ashton, N. J., Barker, P., Jones, P. S., Fryer, T. D., Hong, Y. T., Cope, T. E., Savulich, G., Street, D., Bevan-Jones, W. R., Rittman, T., Blennow, K., Zetterberg, H., Aigbirhio, F. I., … Rowe, J. B. 2024-08-19
Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606, Alzheimer's & Dementia Godoy-Lugo, J. A., Thorwald, M. A., Cacciottolo, M., D'Agostino, C., Chakhoyan, A., Sioutas, C., Tanzi, R. E., Rynearson, K. D., & Finch, C. E. 2024-08-12
Melatonin: A potential nighttime guardian against Alzheimer’s, Molecular Psychiatry Zhang, Z., Xue, P., Bendlin, B. B., Zetterberg, H., De Felice, F., Tan, X., & Benedict, C. 2024-08-11
Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer’s disease, Alzheimer's & Dementia Arnold, S. E., Hendrix, S., Nicodemus-Johnson, J., Knowlton, N., Williams, V. J., Burns, J. M., Crane, M., McManus, A. J., Vaishnavi, S. N., Arvanitakis, Z., Neugroschl, J., Bell, K., Trombetta, B. A., Carlyle, B. C., Kivisäkk, P., Dodge, H. H., Tanzi, R. E., Yeramian, P. D., & Leslie, K. 2024-08-09
Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism, Neuron Profaci, C. P., Harvey, S. S., Bajc, K., Zhang, T. Z., Jeffrey, D. A., Zhang, A. Z., Nemec, K. M., Davtyan, H., O'Brien, C. A., McKinsey, G. L., Longworth, A., McMullen, T. P., Capocchi, J. K., Gonzalez, J. G., Lawson, D. A., Arnold, T. D., Davalos, D., Blurton-Jones, M., Dabertrand, F., Bennett, F. C., Daneman, R. 2024-08-08
Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis, Multiple sclerosis and related disorders Emeršič, A., Karikari, T. K., Kac, P. R., Gonzalez-Ortiz, F., Dulewicz, M., Ashton, N. J., Brecl Jakob, G., Horvat Ledinek, A., Hanrieder, J., Zetterberg, H., Rot, U., Čučnik, S., & Blennow, K. 2024-08-05
Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology, Cell Reports Zwang, T. J., Sastre, E. D., Wolf, N., Ruiz-Uribe, N., Woost, B., Hoglund, Z., Fan, Z., Bailey, J., Nfor, L., Buée, L., Nilsson, K. P. R., Hyman, B. T., & Bennett, R. E. 2024-08-02
Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming, Science Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E., Holtzman, D. M., Yoo, A. S. 2024-08-08
Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers, Frontiers in Medicine Ivanova, K., Zolovs, M., Blennow, K., Zetterberg, H., Kurjāne, N., & Ķēniņa, V. 2024-08-01
Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis, Cardiovascular Research Gerhardt, T., Huynh, P., & McAlpine, C. S. 2024-08-01
The choroid plexus synergizes with immune cells during neuroinflammation, Cell Xu, H., Lotfy, P., Gelb, S., Pragana, A., Hehnly, C., Byer, L. I. J., Shipley, F. B., Zawadzki, M. E., Cui, J., Deng, L., Taylor, M., Webb, M., Lidov, H. G. W., Andermann, M. L., Chiu, I. M., Ordovas-Montanes, J., & Lehtinen, M. K. 2024-07-31
Intravesical Bacille Calmette-Guerin (BCG) Vaccine Affects Cognition, Journal of Alzheimer's Disease Greenblatt, C. L., Bercovier, H., Klein, B. Y., & Gofrit, O. N. 2024-07-30
Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care, JAMA Palmqvist, S., Tideman, P., Mattsson-Carlgren, N., Schindler, S. E., Smith, R., Ossenkoppele, R., Calling, S., West, T., Monane, M., Verghese, P. B., Braunstein, J. B., Blennow, K., Janelidze, S., Stomrud, E., Salvadó, G., & Hansson, O. 2024-07-28
MRI Signature of α-Synuclein Pathology in Asymptomatic Stages and a Memory Clinic Population, JAMA Neurology Wisse, L. E. M., Spotorno, N., Rossi, M., Grothe, M. J., Mammana, A., Tideman, P., Baiardi, S., Strandberg, O., Ticca, A., van Westen, D., Mattsson-Carlgren, N., Palmqvist, S., Stomrud, E., Parchi, P., Hansson, O., & Alzheimer’s Disease Neuroimaging Initiative 2024-07-28
Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment, JAMA Neurology Janelidze, S., Barthélemy, N. R., Salvadó, G., Schindler, S. E., Palmqvist, S., Mattsson-Carlgren, N., Braunstein, J. B., Ovod, V., Bollinger, J. G., He, Y., Li, Y., Raji, C. A., Morris, J. C., Holtzman, D. M., Ashton, N. J., Blennow, K., Stomrud, E., Bateman, R. J., & Hansson, O. 2024-07-28
Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease, Alzheimer's Research & Therapy Knapskog, A. B., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Giil, L. M., Saltvedt, I., Watne, L. O., & Aksnes, M. 2024-07-27
Single-cell multiregion dissection of Alzheimer’s disease, Nature Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., Band, N., James, B. T., Babu, S., Galiana-Melendez, F., Louderback, K., Prokopenko, D., Tanzi, R. E., Bennett, D. A., Tsai, L. H., & Kellis, M. 2024-07-24
The role of the gut microbiome in the regulation of astrocytes in Alzheimer’s disease, Neurotherapeutics Chandra, S., & Vassar, R. 2024-07-24
Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer’s disease, Neurotherapeutics Saha, P., & Sisodia, S. S. 2024-07-24
Harmonizing tau positron emission tomography in Alzheimer’s disease: The CenTauR scale and the joint propagation model, Alzheimer's & Dementia Leuzy, A., Raket, L. L., Villemagne, V. L., Klein, G., Tonietto, M., … Petersen, R. C., ... Ossenkoppele, R., ... Hansson, O., ... Doré, V. 2024-07-23
CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery, Annals of Clinical and Translational Neurology Fernström, E., Jarfelt, M., Blomstrand, M., Lannering, B., Axelsson, M., Wasling, P., Björk-Eriksson, T., Zetterberg, H., & Kalm, M. 2024-07-19
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia 10. Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. 2024-07-19
Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling, eLife Zoltowska, K. M., Das, U., Lismont, S., Enzlein, T., Maesako, M., Houser, M. C. Q., Franco, M. L., Özcan, B., Gomes Moreira, D., Karachentsev, D., Becker, A., Hopf, C., Vilar, M., Berezovska, O., Mobley, W., & Chávez-Gutiérrez, L. 2024-07-19
Tau protein profiling in tauopathies: a human brain study, Molecular Neurodegeneration Lantero-Rodriguez, J., Camporesi, E., Montoliu-Gaya, L., Gobom, J., Piotrowska, D., Olsson, M., Burmann, I. M., Becker, B., Brinkmalm, A., Burmann, B. M., Perkinton, M., Ashton, N. J., Fox, N. C., Lashley, T., Zetterberg, H., Blennow, K., & Brinkmalm, G. 2024-07-19
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome, Acta Neuropathologica Kasri, A., Camporesi, E., Gkanatsiou, E., Boluda, S., Brinkmalm, G., Stimmer, L., Ge, J., Hanrieder, J., Villain, N., Duyckaerts, C., Vermeiren, Y., Pape, S. E., Nicolas, G., Laquerrière, A., De Deyn, P. P., Wallon, D., Blennow, K., Strydom, A., Zetterberg, H., & Potier, M. C. 2024-07-18
A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells, Frontiers in Cellular Neuroscience Inoue, Y., Ren, Y., Zhang, S., Bamkole, M., Islam, N. N., Selvaraj, M., Lu, W., Caulfield, T. R., Li, Y., & Kanekiyo, T. 2024-07-18
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SNX8 Enhances Non-Amyloidogenic APPP Trafficking and Attenuates A beta Accumulation and Memory Deficits in an AD mouse, Frontiers in Cellular Neuroscience Xie, Y., Niu, M., Ji, C., Huang, T. Y., Zhang, C., Tian, Y., Shi, Z., Wang, C., Zhao, Y., Luo, H., Can, D., Xu, H., Zhang, Y. W., & Zhang, X. 2019-09-06
SORLA attenuates EphA4 signaling and amyloid beta-induced neurodegeneration, Journal of Experimental Medicine Huang, T. Y., Zhao, Y., Jiang, L. L., Li, X., Liu, Y., Sun, Y., Piña-Crespo, J. C., Zhu, B., Masliah, E., Willnow, T. E., Pasquale, E. B., & Xu, H. 2017-12-04
Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease, Neuron Liu, C. C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T., & Bu, G. 2014-09-18
ApoE and Aβ in Alzheimer’s disease: accidental encounters or partners?, Neuron Kanekiyo, T., Xu, H., & Bu, G. 2014-02-19
Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons, PLoS One Gan, M., Jiang, P., McLean, P., Kanekiyo, T., & Bu, G. 2014-12-12
Soluble TREM2 induces inflammatory responses and enhnaces microglial survival, Journal of Experimental Medicine Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H., & Bu, G. 2017-03-06
Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2), Molecular Neurodegeneration Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., Can, D., Xu, H., Bu, G., & Chen, X. F. 2018-03-27
The role of APOE in cerebrovascular dysfunction, Acta Neuropathologica Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W., & Bu, G. (2016). 2016-02-16
Apolipoprotein E regulates lipid metabolism and alpha-synuclein pathology in human iPSC-derived cerebral organoids, Acta Neuropathologica Zhao, J., Lu, W., Ren, Y., Fu, Y., Martens, Y. A., Shue, F., Davis, M. D., Wang, X., … Kanekiyo, T., Bu, G. 2021-08-28
Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease, Acta Neuropathologica Communications Reddy, J. S., Allen, M., Ho, C. C. G., Oatman, S. R., İş, Ö., Quicksall, Z. S., Wang, X., Jin, J., Patel, T. A., Carnwath, T. P., Nguyen, T. T., Malphrus, K. G., Lincoln, S. J., Carrasquillo, M. M., Crook, J. E., Kanekiyo, T., Murray, M. E., Bu, G., Dickson, D. W., & Ertekin-Taner, N. 2021-05-21
ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components, Arteriosclerosis, Thrombosis, and Vascular Biology Yamazaki, Y., Shinohara, M., Yamazaki, A., Ren, Y., Asmann, Y. W., Kanekiyo, T., & Bu, G. 2019-10-31
Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-beta pathology in amyloid model mice, Experimental Neurology Tachibana M, Yamazaki Y, Liu CC, Bu G, Kanekiyo T. 2017-10-26
ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation, Frontiers in Neuroscience Aikawa, T., Ren, Y., Holm, M. L., Asmann, Y. W., Alam, A., Fitzgerald, M. L., Bu, G., & Kanekiyo, T. 2021-04-07
APOE epsilon 4/ epsilon 4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics Zhao J, Davis MD, Martens YA, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G. 2017-04-21
5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway, International Journal of Molecular Sciences Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C. C., Kanekiyo, T., & Bu, G. 2019-03-25
LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4, JCI Insight Oue, H., Yamazaki, Y., Qiao, W., Yuanxin, C., Ren, Y., Kurti, A., … Bu, G., & Kanekiyo, T. 2023-04-10
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway, Journal of Biological Chemistry Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G., & Kanekiyo, T. 2015-04-22
Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies, Journal of Lipid Research Shinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. 2017-04-04
LRP1 modulates the microglial immune response via regulation of JNK and NF-kappa B signaling pathways, Journal of Neuroinflammation Yang, L., Liu, C. C., Zheng, H., Kanekiyo, T., Atagi, Y., Jia, L., Wang, D., N'songo, A., Can, D., Xu, H., Chen, X. F., & Bu, G. 2016-12-08
Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, Journal of Neuroscience Liu, C. C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T., & Bu, G. 2015-04-08
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer’s Neuronal Pathology, Journal of Neuroscience Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., … Bu, G & Kanekiyo, T. 2016-03-30
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells, Molecular Neurodegeneration Wren, M. C., Zhao, J., Liu, C. C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T., & Bu, G. 2015-09-15
APP-Mediated signaling prevents memory decline in Alzheimer’s disease mouse model, Cell Reports Deyts, C., Clutter, M., Pierce, N., Chakrabarty, P., Ladd, T. B., Goddi, A., Rosario, A. M., Cruz, P., Vetrivel, K., Wagner, S. L., Thinakaran, G., Golde, T. E., & Parent, A. T. 2019-04-30
Microglia use TAM receptors to detect and engulf amyloid β plaques, Nature Immunology Huang, Y., Happonen, K. E., Burrola, P. G., O'Connor, C., Hah, N., Huang, L., Nimmerjahn, A., & Lemke, G. 2021-04-15
How macrophages deal with death, Nature Reviews Immunology Lemke G. 2019-04-24
Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling, Proceedings of the National Academy of Sciences of the United States of America Huang, Y., & Lemke, G. 2022-10-03
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APOE2 eases cognitve declne during aging: clinical and pre-clinival evaluations, Annals of Neurology Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G. 2016-03-29
Lipoproteins in the Central Nervous System: From Biology to Pathobiology, Annual Review of Biochemistry Raulin AC, Martens YA, Bu G. 2022-03-18
Apolipoprotein E, Receptors, and Modulation of Alzhiemer’s disease, Biological Psychiatry Zhao N, Liu CC, Qiao W, Bu G. 2017-03-14
The AD Knowledge Portal: A Repository for Multi-Omic Data on Alzheimer’s Disease and Aging, Current Protocols in Human Genetics Greenwood AK, Montgomery KS, Kauer N, Woo KH, Leanza ZJ, Poehlman WL, Gockley J, Sieberts SK, Bradic L, Logsdon BA, Peters MA, Omberg L, Mangravite LM. 2020-10-21
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2), Journal of Biological Chemistry Atagi, Y., Liu, C. C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R., Kang, S. S., Xu, H., Younkin, S., Das, P., Fryer, J. D., & Bu, G. 2015-09-15
APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease, Molecular Neurodegeneration Li, Z., Shue, F., Zhao, N., Shinohara, M., & Bu, G. 2020-11-04
ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies, Molecular Neurodegeneration Raulin, A. C., Doss, S. V., Trottier, Z. A., Ikezu, T. C., Bu, G., & Liu, C. C. 2022-11-08
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination, Molecular Neurodegeneration Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., Asmann, Y. W., Zhang, B., Bu, G., & Liu, C. C. 2022-11-23
APOE ε2 is associated with increased tau pathology in primary tauopathy, Nature Communications Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S., … Bu, G. 2018-10-22
Apolipoprotein E and Alzheimer’s disease: pathobiology and targeting strategies, Nature Reviews Neurology Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C. C., & Bu, G. 2019-07-31
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer’s disease, Neurobiology of Aging Li, Y., Macyczko, J. R., Liu, C. C., & Bu, G. 2022-03-22
Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes, Neuron Zhao, N., Liu, C. C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M., & Bu, G. 2017-09-27
ApoE4 Accelerates Early Seeding of Amyloid Pathology, Neuron Liu, C. C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W., & Bu, G. 2017-12-06
An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells, STAR Protocols Raulin, A. C., Liu, C. C., & Bu, G. 2023-03-17
A Novel Link between Trafficking and Lewy body disorder, The Lancet Neurology Ross, O. A., & Bu, G. 2018-06-07
SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers, Neurobiology of Disease Norambuena, A., Sun, X., Wallrabe, H., Cao, R., Sun, N., Pardo, E., Shivange, N., Wang, D. B., Post, L. A., Ferris, H. A., Hu, S., Periasamy, A., & Bloom, G. S. 2022-04-20
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Selective Detection of Misfolded Tau From Postmortem Alzheimer’s Disease Brains, Frontiers in Aging Neuroscience Wu, L., Wang, Z., Lad, S., Gilyazova, N., Dougharty, D. T., Marcus, M., Henderson, F., Ray, W. K., Siedlak, S., Li, J., Helm, R. F., Zhu, X., Bloom, G. S., Wang, S. J., Zou, W. Q., & Xu, B. 2022-07-20
Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. 2012-05-02
Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology Bloom, G. S., Lazo, J. S., & Norambuena, A. 2017-09-27
A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. 2020-02-19
Dietary salt promotes cognitive impairment through tau phosphorylation, Nature Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. 2019-10-23
Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic Control, Cerebral Cortex Cantu, D., Walker, K., Andresen, L., Taylor-Weiner, A., Hampton, D., Tesco, G., & Dulla, C. G. 2014-03-07
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Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1, Journal of Neuroscience Walker, K. R., Kang, E. L., Whalen, M. J., Shen, Y., & Tesco, G. 2012-07-25
Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?, Seminars in Immunology Tesco, G., & Lomoio, S. 2022-06-30
Significance of transcytosis in Alzheimer’s disease: BACE1 takes the scenic route to axons, BioEssays Buggia-Prévot, V., & Thinakaran, G. 2015-06-30
Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in trasngenic models, Brain Pathology De Rossi, P., Andrew, R. J., Musial, T. F., Buggia-Prevot, V., Xu, G., Ponnusamy, M., Ly, H., Krause, S. V., Rice, R. C., de l'Estoile, V., Valin, T., Salem, S., Despa, F., Borchelt, D. R., Bindokas, V. P., Nicholson, D. A., & Thinakaran, G. 2018-12-27
A paired RNAi and RabGAP Overexpression screen identifies Rab11 as a regulator of beta-amyloid production, Cell Reports Udayar, V., Buggia-Prévot, V., Guerreiro, R. L., Siegel, G., Rambabu, N., Soohoo, A. L., Ponnusamy, M., Siegenthaler, B., Bali, J., AESG, Simons, M., Ries, J., Puthenveedu, M. A., Hardy, J., Thinakaran, G., & Rajendran, L. 2013-12-26
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Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation, Cell Reports De Rossi, P., Nomura, T., Andrew, R. J., Masse, N. Y., Sampathkumar, V., Musial, T. F., Sudwarts, A., Recupero, A. J., Le Metayer, T., Hansen, M. T., Shim, H. N., Krause, S. V., Freedman, D. J., Bindokas, V. P., Kasthuri, N., Nicholson, D. A., Contractor, A., & Thinakaran, G. 2020-03-10
Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by “molecular tweezers” — from the test tube to animal models, Current Pharmaceutical Design Attar, A., & Bitan, G. 2014-05-01
Molecular tweezers targeting transthyretin amyloidosis, Neurotherapeutics Ferreira, N., Pereira-Henriques, A., Attar, A., Klärner, F. G., Schrader, T., Bitan, G., Gales, L., Saraiva, M. J., & Almeida, M. R. 2014-04-01
A shortened Barnes Maze Protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer’s disease, PLoS One Attar, A., Liu, T., Chan, W. T., Hayes, J., Nejad, M., Lei, K., & Bitan, G. 2013-11-13
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Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers, Alzheimer's & Dementia Sun, X., Eastman, G., Shi, Y., Saibaba, S., Oliveira, A. K., Lukens, J. R., Norambuena, A., Thompson, J. A., Purdy, M. D., Dryden, K., Pardo, E., Mandell, J. W., & Bloom, G. S. 2023-12-09
Bidirectional modulation of Alzhiemer’s phenotype by alpha-synuclein in mice and primary neurons, Acta Neuropathologica Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S., & Lesné, S. E. 2018-10-01
Localization, induction, and cellular effects of tau phosphorylated at threonine 217, Alzheimer's & Dementia Rajbanshi, B., Guruacharya, A., M|ell, J. W., & Bloom, G. S. 2023-01-12
mTOR and neuronal cell cycle re-entry: how impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia Rajbanshi, B., Guruacharya, A., Mandell, J. W., & Bloom, G. S. 2017-02-01
N-methyl-D-aspartate receptor-mediated calciuym influx connects amyloid-beta oligomers to ectopic neuronal cell cycle re-entry in Alzheimer’s Disease, Alzheimer's & Dementia Kodis, E. J., Choi, S., Swanson, E., Ferreira, G., & Bloom, G. S. 2018-10-01
Dysregulation of mTOR by tau in Alzheimer’s disease, Cytoskeleton Bloom, G. S., & Norambuena, A. 2023-08-28
A half-century of tau, Cytoskeleton Bloom, G. S., & Baas, P. W. 2023-08-28
Tau: the center of a signaling nexus in Alzheimer’s disease, Frontiers in Neuroscience Khan, S. S., & Bloom, G. S. 2016-02-09
Amyloid-beta and Tau: the trigger and bullet in Alzheimer’s disease pathogenesis, JAMA Neurology Bloom, G. S. 2014-04-01
A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice, Journal of Alzheimer's Disease Kuwar, R., Rolfe, A., Di, L., Blevins, H., Xu, Y., Sun, X., Bloom, G. S., Zhang, S., & Sun, D. 2021-01-01
Extracellular Tau Oligomers Damage the Axon Initial Segment, Journal of Alzheimer's Disease Best, M. N., Lim, Y., Ferenc, N. N., Kim, N., Min, L., Wang, D. B., Sharifi, K., Wasserman, A. E., McTavish, S. A., Siller, K. H., Jones, M. K., Jenkins, P. M., Mandell, J. W., & Bloom, G. S. 2023-05-09
Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers, Journal of Alzheimer's Disease Rudenko, L. K., Wallrabe, H., Periasamy, A., Siller, K. H., Svindrych, Z., Seward, M. E., Best, M. N., & Bloom, G. S. 2019-10-15
Extracellular tau oligomers induce invasion of endogenous tau into the somatodendritic compartment and axonal transport dysfunction, Journal of Alzhiemer's Disease Swanson, E., Breckenridge, L., McMahon, L., Som, S., McConnell, I., & Bloom, G. S. 2017-01-01
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A unifying hypothesis for Alzheimer’s disease: from plaques to neurodegeneration, Trends in Neurosciences Edwards, F. E. 2019-05-01
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia, Molecular Neurodegeneration Benitez, D. P., Jiang, S., Wood, J., Wang, R., Hall, C. M., Peerboom, C., Wong, N., Stringer, K. M., Vitanova, K. S., Smith, V. C., Joshi, D., Saito, T., Saido, T. C., Hardy, J., Hanrieder, J., De Strooper, B., Salih, D. A., Tripathi, T., Edwards, F. A., & Cummings, D. M. 2021-07-15
Following spatial Aβ aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics, Science Advances Michno, W., Stringer, K. M., Enzlein, T., Passarelli, M. K., Escrig, S., Vitanova, K., Wood, J., Blennow, K., Zetterberg, H., Meibom, A., Hopf, C., Edwards, F. A., & Hanrieder, J. 2021-06-16
P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells, Biomolecules Vultaggio-Poma, V., & Di Virgilio, F. 2022-07-14
Extracellular ATP: A powerful inflammatory mediator in the central nervous system, Neuropharmacology Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. 2022-11-15
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Unorthodox localization of P2X7 receptor in subcellular compartments of skeletal system cells, Frontiers in Cell and Developmental Biology Penolazzi, L., Notarangelo, M. P., Lambertini, E., Vultaggio-Poma, V., Tarantini, M., Di Virgilio, F., & Piva, R. 2023-05-04
The Coming of Age of the P2X7 Receptor in Diagnostic Medicine, International Journal of Molecular Sciences Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. 2023-05-30
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Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar A beta by multiple endoproteolytic cleavages within the beta-sheet domain, Proceedings of the National Academy of Sciences of the United States of America Solé-Domènech, S., Rojas, A. V., Maisuradze, G. G., Scheraga, H. A., Lobel, P., & Maxfield, F. R. 2018-02-13
Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in vitro Phosphorylated Tau and their Modulation by Potential Inhibitors, ACS Chemical Biology Despres, C., Di, J., Cantrelle, F. X., Li, Z., Huvent, I., Chambraud, B., Zhao, J., Chen, J., Chen, S., Lippens, G., Zhang, F., Linhardt, R., Wang, C., Klärner, F. G., Schrader, T., Landrieu, I., Bitan, G., & Smet-Nocca, C. 2019-05-02
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Further understanding the connection between Alzheimer’s disease and Down syndrome, Alzheimer's & Dementia Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., Hendrix, J., Kishnani, P. S., Lai, F., Lao, P., Lemere, C., Mobley, W., Mufson, E. J., Potter, H., Zaman, S. H., Granholm, A. C., … Rafii, M. S. 2020-06-16
ApoE mimetic improves pathology and memory in a model of Alzheimer’s disease, Brain Research Krishnamurthy, K., Cantillana, V., Wang, H., Sullivan, P. M., Kolls, B. J., Ge, X., Lin, Y., Mace, B., & Laskowitz, D. T. 2020-01-30
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Untangling senescent and damage-associated microglia in the aging and diseased brain, FEBS Journal Ng, P. Y., McNeely, T. L., & Baker, D. J. 2021-12-14
Cellular senescence in ageing: from mechanisms to therapeutic opportunities, Nature Reviews Molecular Cell Biology Di Micco, R., Krizhanovsky, V., Baker, D., & d'Adda di Fagagna, F. 2021-08-06
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Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans, Biomedicines Sommerer, Y., Dobricic, V., Schilling, M., Ohlei, O., Bartrés-Faz, D., Cattaneo, G., Demuth, I., Düzel, S., Franzenburg, S., Fuß, J., Lindenberger, U., Pascual-Leone, Á., Sabet, S. S., Solé-Padullés, C., Tormos, J. M., Vetter, V. M., Wesse, T., Franke, A., Lill, C. M., & Bertram, L. 2022-11-03
Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts, GeroScience Drewelies, J., Hueluer, G., Duezel, S., Vetter, V. M., Pawelec, G., Steinhagen-Thiessen, E., Wagner, G. G., Lindenberger, U., Lill, C. M., Bertram, L., Gerstorf, D., & Demuth, I. 2022-09-24
Genome-wide analysis furthers decoding of Alzheimer disease genetics, Nature Reviews Neurology Lill, C. M., & Bertram, L. 2022-05-27
Genetic associations with learning over 100 days of practice, npj Science of Learning Youn, C., Grotzinger, A. D., Lill, C. M., Bertram, L., Schmiedek, F., Lövdén, M., Lindenberger, U., Nivard, M., Harden, K. P., & Tucker-Drob, E. M. 2022-05-04
Differential microRNA expression analyses across two brain regions in Alzheimer’s disease, Translational Psychiatry Dobricic, V., Schilling, M., Schulz, J., Zhu, L. S., Zhou, C. W., Fuß, J., Franzenburg, S., Zhu, L. Q., Parkkinen, L., Lill, C. M., & Bertram, L. 2022-08-29
A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests, Bioinformatics Hecker, J., Townes, F. W., Kachroo, P., Laurie, C., Lasky-Su, J., Ziniti, J., Cho, M. H., Weiss, S. T., Laird, N. M., & Lange, C. 2020-12-26
Utilizing the Jaccard index to reveal population stratification data: a simulation study and an application ot the 1000 Genome Project, Bioinformatics Prokopenko, D., Hecker, J., Silverman, E. K., Pagano, M., Nöthen, M. M., Dina, C., Lange, C., & Fier, H. L. 2016-05-01
Identification of genetic outliers due to sub-structure and cryptic relationships, Bioinformatics Schlauch, D., Fier, H., & Lange, C. 2017-03-03
PolyGEE: A generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies, Biostatistics Hecker, J., Prokopenko, D., Lange, C., & Fier, H. L. 2018-07-01
A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data, Epigenetics Hecker, J., Lee, S., Kachroo, P., Prokopenko, D., Maaser-Hecker, A., Lutz, S. M., Hahn, G., Irizarry, R., Weiss, S. T., DeMeo, D. L., & Lange, C. 2023-09-23
Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma, European Respiratory Journal Lee, S., Prokopenko, D., Kelly, R. S., Lutz, S., Ann Lasky-Su, J., Cho, M. H., Laurie, C., Celedón, J. C., Lange, C., Weiss, S. T., Hecker, J., & DeMeo, D. L. 2023-01-06
Family-based tests for associating haplotypes with general phenotype data, Genetic Epidemiology Hecker, J., Xu, X., Townes, F. W., Loehlein Fier, H., Corcoran, C., Laird, N., & Lange, C. 2017-11-21
Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus, Genetic Epidemiology Hahn, G., Lee, S., Weiss, S. T., & Lange, C. 2021-01-08
Selection bias when inferring the effect direction in Mendelian randomization, Genetic Epidemiology Lutz, S. M., Voorhies, K., Wu, A. C., Hokanson, J., Vansteelandt, S., & Lange, C. 2022-05-02
A Comparison of Popular TDT-generalizations for family-based association analysis, Genetic Epidemiology Hecker, J., Laird, N., & Lange, C. 2019-01-04
A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP, Genetic Epidemiology Hecker, J., Ruczinski, I., Cho, M. H., Silverman, E. K., Coull, B., & Lange, C. 2019-11-11
The effects of misspecification of the mediator and outcome in mediation analysis, Genetic Epidemiology Lutz, S. M., Sordillo, J. E., Hokanson, J. E., Chen Wu, A., & Lange, C. 2020-03-13
Integrating mulitple correlated phenotypes for genetic association analysis by maximizing heritability, Human Heredity Zhou, J. J., Cho, M. H., Lange, C., Lutz, S., Silverman, E. K., & Laird, N. M. 2015-06-20
An interaction of the 17q12-21 locus with mold exposure in childhood asthma, Pediatric Allergy and Immunology Lee, S., Lasky-Su, J., Kim, W., Won, S., Laurie, C., Celedón, J. C., Lange, C., Weiss, S. T., & Hecker, J. 2020-09-18
Using Network Methodology to infer population substructure, PLoS One Prokopenko, D., Hecker, J., Silverman, E., Nöthen, M. M., Schmid, M., Lange, C., & Loehlein Fier, H. 2015-06-22
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E, Molecular Neurodegeneration Robert, J., Button, E. B., Martin, E. M., McAlary, L., Gidden, Z., Gilmour, M., Boyce, G., Caffrey, T. M., Agbay, A., Clark, A., Silverman, J. M., Cashman, N. R., & Wellington, C. L. 2020-03-25
An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases, Molecular Neurodegeneration Robert, J., Weilinger, N. L., Cao, L. P., Cataldi, S., Button, E. B., Stukas, S., Martin, E. M., Seibler, P., Gilmour, M., Caffrey, T. M., Rowe, E. M., Fan, J., MacVicar, B., Farrer, M. J., & Wellington, C. L. 2020-11-19
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Assessing the importance of interleukin-6 in COVID-19, The Lancet Respiratory Medicine Chen, L. Y. C., Hoiland, R. L., Stukas, S., Wellington, C. L., & Sekhon, M. S. 2021-02-09
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer’s disease., Alzheimer's & Dementia Gispert, J. D., Suárez-Calvet, M., Monté, G. C., Tucholka, A., Falcon, C., Rojas, S., Rami, L., Sánchez-Valle, R., Lladó, A., Kleinberger, G., Haass, C., & Molinuevo, J. L. 2016-07-13
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, EMBO Journal Kleinberger, G., Brendel, M., Mracsko, E., Wefers, B., Groeneweg, L., Xiang, X., Focke, C., Deußing, M., Suárez-Calvet, M., Mazaheri, F., Parhizkar, S., Pettkus, N., Wurst, W., Feederle, R., Bartenstein, P., Mueggler, T., Arzberger, T., Knuesel, I., Rominger, A., & Haass, C. 2017-05-30
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine Xiang, X., Werner, G., Bohrmann, B., Liesz, A., Mazaheri, F., Capell, A., Feederle, R., Knuesel, I., Kleinberger, G., & Haass, C. 2016-07-08
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Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein, Cell Reports Ben Halima, S., Mishra, S., Raja, K. M. P., Willem, M., Baici, A., Simons, K., Brüstle, O., Koch, P., Haass, C., Caflisch, A., & Rajendran, L. 2016-02-25
Opposite microglial activations stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism, EMBO Molecular Medicine Götzl, J. K., Brendel, M., Werner, G., Parhizkar, S., Sebastian Monasor, L., Kleinberger, G., Colombo, A. V., Deussing, M., Wagner, M., Winkelmann, J., Diehl-Schmid, J., Levin, J., Fellerer, K., Reifschneider, A., Bultmann, S., Bartenstein, P., Rominger, A., Tahirovic, S., Smith, S. T., Madore, C., Butovsky, O., Capell, A., & Haass, C. 2019-06-01
Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury, Science Translational Medicine Suárez-Calvet, M., Araque Caballero, M. Á., Kleinberger, G., Bateman, R. J., Fagan, A. M., Morris, J. C., Levin, J., Danek, A., Ewers, M., & Haass, C. 2016-12-14
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Neurotoxicity of Diesel Exhaust Particles, Journal of Alzheimer's disease Shkirkova, K., Lamorie-Foote, K., Zhang, N., Li, A., Diaz, A., Liu, Q., Thorwald, M. A., Godoy-Lugo, J. A., Ge, B., D'Agostino, C., Zhang, Z., Mack, W. J., Sioutas, C., Finch, C. E., Mack, W. J., & Zhang, H. 2022-10-11
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