These published papers resulted from Cure Alzheimer’s Fund support.
Title | Researchers | Date |
---|---|---|
Identification of late-stage tau accumulation using plasma phospho-tau217, eBioMedicine | Woo, M. S., Therriault, J., Jonaitis, E. M., Wilson, R., Langhough, R. E., Rahmouni, N., Benedet, A. L., Ashton, N. J., Tissot, C., Lantero-Rodriguez, J., Macedo, A. C., Servaes, S., Wang, Y. T., Arias, J. F., Hosseini, S. A., Betthauser, T. J., Lussier, F. Z., Hopewell, R., Triana-Baltzer, G., Kolb, H. C., … Rosa-Neto, P. | 2024-11-04 |
Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease, Neurology | Safransky, M., Groh, J. R., Blennow, K., Zetterberg, H., Tripodis, Y., Martin, B., Weller, J., Asken, B. M., Rabinovici, G. D., Qiu, W. W. Q., McKee, A. C., Stein, T. D., Mez, J., Henson, R. L., Long, J., Morris, J. C., Perrin, R. J., Schindler, S. E., & Alosco, M. L. | 2024-11-04 |
A luminescent-based protocol for NAD+/NADH detection in C. elegans, mice, and human whole blood, STAR Protocols | Wang, H. L., Zhang, J., Cao, S. Q., Lagartos-Donate, M. J., Zhang, S. Q., Lautrup, S., Hu, Z., Lyssiotis, C. A., Houtkooper, R. H., & Fang, E. F. | 2024-11-01 |
Costs of Care in Relation to Alzheimer’s Disease Severity in Sweden: A National Registry-Based Cohort Study, PharmacoEconomics | Aye, S., Frisell, O., Zetterberg, H., Skillbäck, T. B., Kern, S., Eriksdotter, M., Aho, E., Xia, X., Winblad, B., Wimo, A., & Jönsson, L. | 2024-11-01 |
Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice, Heliyon | Wang, N., Parsons, T. M., Ren, Y., Pan, Y., Kurti, A., Starling, S. C., Muolokwu, C., Singh, J., & Kanekiyo, T. | 2024-10-30 |
Myocardial infarction augments sleep to limit cardiac inflammation and damage, Nature | Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T., Ferreira da Silva, J., … McAlpine, C. S. | 2024-10-30 |
Anti-seizure effects of norepinephrine-induced free fatty acid release, Cell Metabolism | Li, B., Sun, Q., Ding, F., Xu, Q., Kang, N., Xue, Y., Ladron-de-Guevara, A., Hirase, H., Weikop, P., Gong, S., Nathan, S., & Nedergaard, M. | 2024-10-29 |
A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Brain | Warmenhoven, N., Salvadó, G., Janelidze, S., Mattsson-Carlgren, N., Bali, D., Orduña Dolado, A., Kolb, H., Triana-Baltzer, G., Barthélemy, N. R., Schindler, S. E., Aschenbrenner, A. J., Raji, C. A., Benzinger, T. L. S., Morris, J. C., Ibanez, L., Timsina, J., Cruchaga, C., Bateman, R. J., Ashton, N., Arslan, B., … Hansson, O. | 2024-10-28 |
Gut microbiome-derived metabolites in Alzheimer’s disease: Regulation of immunity and potential for therapeutics, Immunological Reviews | Chandra, S., & Vassar, R. J. | 2024-10-24 |
Current insights into apolipoprotein E and the immune response in Alzheimer’s disease, Immunological Reviews | Lin, P. B., & Holtzman, D. M. | 2024-10-24 |
Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes, Brain | Al-Diwani, A., Provine, N. M., Murchison, A., Laban, R., Swann, O. J., Koychev, I., Sheerin, F., Da Mesquita, S., Heslegrave, A., Zetterberg, H., Klenerman, P., & Irani, S. R. | 2024-10-21 |
Dietary salt, vascular dysfunction, and cognitive impairment, Cardiovascular Research | Faraco G. | 2024-10-21 |
Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study, Alzheimer's Research & Therapy | Götze, K., Vrillon, A., Dumurgier, J., Indart, S., Sanchez-Ortiz, M., Slimi, H., Raynaud-Simon, A., Cognat, E., Martinet, M., Zetterberg, H., Blennow, K., Hourrègue, C., Bouaziz-Amar, E., Paquet, C., & Lilamand, M. | 2024-10-19 |
Individualized, cross-validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms, Alzheimer's & Dementia | Borland, E., Mattson-Carlgren, N., Tideman, P., Alzheimer's Disease Neuroimaging Initiative, Stomrud, E., Hansson, O., & Palmqvist, S. | 2024-10-17 |
Comparison of nanoimaging and nanoflow based detection of extracellular vesicles at a single particle resolution, Journal of Extracellular biology | Xu, S., Zhang, Z., Melvin, B. C., Basu Ray, N., Ikezu, S., & Ikezu, T. | 2024-10-16 |
Biological mechanisms of resilience to tau pathology in Alzheimer’s disease, Alzheimer's Research & Therapy | Svenningsson, A. L., Bocancea, D. I., Stomrud, E., van Loenhoud, A., Barkhof, F., Mattsson-Carlgren, N., Palmqvist, S., Hansson, O., & Ossenkoppele, R. | 2024-10-12 |
Waste clearance shapes aging brain health, Neuron | Jiang-Xie, L. F., Drieu, A., & Kipnis, J. | 2024-10-11 |
Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?, The Journal of Neuroscience | Capocchi, J. K., Figueroa-Romero, C., Dunham, S. J. B., Faraci, G., Rothman, J. A., Whiteson, K. L., Seo, D. O., Holtzman, D. M., Grabrucker, S., Nolan, Y. M., Kaddurah-Daouk, R., & Jett, D. A. | 2024-10-09 |
Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments, Neuroscience Insights | Schrader, J. M., Majchrzak, M., Xu, F., Lee, H., Agostinucci, K., Davis, J., Benveniste, H., & Van Nostrand, W. E. | 2024-10-08 |
Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer’s disease at 20 Hz, 40 Hz, or 83 Hz, Scientific Reports | Patel, A. A., Zhu, M. H., Yan, R., & Antic, S. D. | 2024-10-08 |
Plateau depolarizations in spontaneously active neurons detected by calcium or voltage imaging, Scientific Reports | Milicevic, K. D., Ivanova, V. O., Lovic, D. D., Platisa, J., Andjus, P. R., & Antic, S. D. | 2024-10-04 |
Letter to the editor: critical evaluation of the reliability of DNA methylation probes on the illumina MethylationEPIC v1.0 BeadChip microarrays, Epigenetics | Hecker, J., Weiss, S. T., Lasky-Su, J. A., DeMeo, D. L., & Lange, C. | 2024-10-04 |
Salience network segregation mediates the effect of tau pathology on mild behavioral impairment, Alzheimer's & Dementia | Iordan, A. D., Ploutz-Snyder, R., Ghosh, B., Rahman-Filipiak, A., Koeppe, R., Peltier, S., Giordani, B., Albin, R. L., & Hampstead, B. M. | 2024-10-04 |
Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders, The Journal of Neuroscience | Wlodarczyk, J., Bhattacharyya, R., Dore, K., Ho, G. P. H., Martin, D. D. O., Mejias, R., & Hochrainer, K. | 2024-10-02 |
Intracranial arteriosclerosis is not associated with cerebral amyloid deposition, Alzheimer's & Dementia | Streiber, A. M., Neitzel, J., Nguyen Ho, P. T., Vernooij, M. W., & Bos, D. | 2024-10-01 |
Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players, Alzheimer's & Dementia | Miner, A. E., Groh, J. R., Tripodis, Y., Adler, C. H., Balcer, L. J., Bernick, C., Zetterberg, H., Blennow, K., Peskind, E., Ashton, N. J., Gaudet, C. E., Martin, B., Palmisano, J. N., Banks, S. J., Barr, W. B., Wethe, J. V., Cantu, R. C., Dodick, D. W., Katz, D. I., Mez, J., … DIAGNOSE CTE Research Project | 2024-10-01 |
Therapeutic targeting of senescent cells in the CNS, Nature Reviews Drug Discovery | Riessland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E. | 2024-09-30 |
Engineered 3D human neurovascular model of Alzheimer’s disease to study vascular dysfunction, Biomaterials | Pavlou, G., Spitz, S., Pramotton, F. M., Tsai, A., Li, B. M., Wang, X., Barr, O. M., Ko, E. C., Zhang, S., Ashley, S. J., Maaser-Hecker, A., Choi, S. H., Jorfi, M., Tanzi, R. E., & Kamm, R. D. | 2024-09-28 |
Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease, Alzheimer's Research & Therapy | Johansson, C., Thordardottir, S., Laffita-Mesa, J., Pannee, J., Rodriguez-Vieitez, E., Zetterberg, H., Blennow, K., & Graff, C. | 2024-09-25 |
Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model, Neuron | Carling, G. K., Fan, L., Foxe, N. R., Norman, K., Wong, M. Y., Zhu, D., Corona, C., Razzoli, A., Yu, F., Yarahmady, A., Ye, P., Chen, H., Huang, Y., Amin, S., Sereda, R., Lopez-Lee, C., Zacharioudakis, E., Chen, X., Xu, J., Cheng, F., … Gan, L. | 2024-09-24 |
REAL AD—Validation of a realistic screening approach for early Alzheimer’s disease, Alzheimer's & Dementia | Leuzy, A., Heeman, F., Bosch, I., Lenér, F., Dottori, M., Quitz, K., Moscoso, A., Kern, S., Zetterberg, H., Blennow, K., & Schöll, M. | 2024-09-23 |
Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions, Acta Neuropathologica | Freiburghaus, T., Pawlik, D., Oliveira Hauer, K., Ossenkoppele, R., Strandberg, O., Leuzy, A., Rittmo, J., Tremblay, C., Serrano, G. E., Pontecorvo, M. J., Beach, T. G., Smith, R., & Hansson, O. | 2024-09-19 |
The prion principle and Alzheimer’s disease, Science | Walker, L. C., & Jucker, M. | 2024-09-19 |
Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome, ACS Chemical Neuroscience | Biby, S., Mondal, P., Xu, Y., Gomm, A., Kaur, B., Namme, J. N., Wang, C., Tanzi, R. E., Zhang, S., & Zhang, C. | 2024-09-19 |
Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease, Alzheimer's Research & Therapy | Wuestefeld, A., Pichet Binette, A., van Westen, D., Strandberg, O., Stomrud, E., Mattsson-Carlgren, N., Janelidze, S., Smith, R., Palmqvist, S., Baumeister, H., Berron, D., Yushkevich, P. A., Hansson, O., Spotorno, N., & Wisse, L. E. M. | 2024-09-16 |
Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease, Nature Communications | Collij, L. E., Mastenbroek, S. E., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Janelidze, S., Palmqvist, S., Ossenkoppele, R., & Hansson, O. | 2024-09-14 |
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies, Trends in Immunology | Chen, Y., & Holtzman, D. M. | 2024-09-14 |
The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center study, Multiple Sclerosis and Related Disorders | Sandgren, S., Novakova, L., Nordin, A., Sabir, H., Axelsson, M., Malmeström, C., Zetterberg, H., & Lycke, J. | 2024-09-13 |
Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome, Cell Calcium | Filadi, R., & Pizzo, P. | 2024-09-12 |
Associations between misfolded alpha-synuclein aggregates and Alzheimer’s disease pathology in vivo, Allheimer's & Dementia | Pichet Binette, A., Mammana, A., Wisse, L., Rossi, M., Strandberg, O., Smith, R., Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., ADNI, Ticca, A., Stomrud, E., Parchi, P., & Hansson, O. | 2024-09-11 |
A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions, Experimental Gerontology | Borda, M. G., Barreto, G. E., Baldera, J. P., de Lucia, C., Khalifa, K., Bergland, A. K., Pola, I., Botero-Rodríguez, F., Siow, R. C., Kivipelto, M., Zetterberg, H., Ashton, N. J., Ballard, C., Aarsland, D., & NJ FINGER | 2024-09-09 |
A γδ T cell–IL-3 axis controls allergic responses through sensory neurons, Nature | Flayer, C. H., Kernin, I. J., Matatia, P. R., Zeng, X., Yarmolinsky, D. A., Han, C., Naik, P. R., Buttaci, D. R., Aderhold, P. A., Camire, R. B., Zhu, X., Tirard, A. J., McGuire, J. T., Smith, N. P., McKimmie, C. S., McAlpine, C. S., Swirski, F. K., Woolf, C. J., Villani, A. C., & Sokol, C. L. | 2024-09-04 |
An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein, Advanced Healthcare Materials | Li, Y., Luo, L., Senicar, L., Asrosa, R., Kizilates, B., Xing, K., Torres, E., Xu, L., Li, D., Graham, N., Heslegrave, A., Zetterberg, H., Sharp, D. J., & Li, B. | 2024-09-02 |
Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination, Immunity | das Neves, S. P., Delivanoglou, N., Ren, Y., Cucuzza, C. S., Makuch, M., Almeida, F., Sanchez, G., Barber, M. J., Rego, S., Schrader, R., Faroqi, A. H., Thomas, J. L., McLean, P. J., Oliveira, T. G., Irani, S. R., Piehl, F., & Da Mesquita, S. | 2024-08-31 |
Blood-based multivariate methylation risk score for cognitive impairment and dementia, Alzheimer's & Dementia | Koetsier, J., Cavill, R., Reijnders, R., Harvey, J., Homann, J., … Dobricic, V., … Scheltens, P., … Zetterberg, H., … Lill, C. L., Bertram, L., … Pishva, E. | 2024-08-28 |
Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies, Nature Neuroscience | Pichet Binette, A., Gaiteri, C., Wennström, M., Kumar, A., Hristovska, I., Spotorno, N., Salvadó, G., Strandberg, O., Mathys, H., Tsai, L. H., Palmqvist, S., Mattsson-Carlgren, N., Janelidze, S., Stomrud, E., Vogel, J. W., & Hansson, O. | 2024-08-26 |
Regression convolutional neural network models implicate peripheral immune regulatory variants in the predisposition to Alzheimer’s disease, PLoS Computational Biology | Ramamurthy, E., Agarwal, S., Toong, N., Sestili, H., Kaplow, I. M., Chen, Z., Phan, B., & Pfenning, A. R. | 2024-08-26 |
Overview of the role of purinergic signaling and insights into its role in cancer therapy, Pharmacology & Therapeutics | Di Virgilio, F., Vultaggio-Poma, V., Tarantini, M., & Giuliani, A. L. | 2024-08-22 |
Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer’s disease, Alzheimer's & Dementia | Norambuena, A., Sagar, V. K., Wang, Z., Raut, P., Feng, Z., Wallrabe, H., Pardo, E., Kim, T., Alam, S. R., Hu, S., Periasamy, A., & Bloom, G. S. | 2024-08-22 |
Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA, Neurobiology of Aging | Quaresima, V., Pilotto, A., Trasciatti, C., Tolassi, C., Parigi, M., Bertoli, D., Mordenti, C., Galli, A., Rizzardi, A., Caratozzolo, S., Benussi, A., Ashton, N. J., Blennow, K., Zetterberg, H., Giliani, S., Brugnoni, D., & Padovani, A. | 2024-08-22 |
Fluid biomarkers in multiple sclerosis: from current to future applications, The Lancet Regional Health Europe | Di Filippo, M., Gaetani, L., Centonze, D., Hegen, H., Kuhle, J., Teunissen, C. E., Tintoré, M., Villar, L. M., Willemse, E. A. J., Zetterberg, H., & Parnetti, L. | 2024-08-22 |
Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration, Brain | Malpetti, M., Swann, P., Tsvetanov, K. A., Chouliaras, L., Strauss, A., Chikaura, T., Murley, A. G., Ashton, N. J., Barker, P., Jones, P. S., Fryer, T. D., Hong, Y. T., Cope, T. E., Savulich, G., Street, D., Bevan-Jones, W. R., Rittman, T., Blennow, K., Zetterberg, H., Aigbirhio, F. I., … Rowe, J. B. | 2024-08-19 |
Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606, Alzheimer's & Dementia | Godoy-Lugo, J. A., Thorwald, M. A., Cacciottolo, M., D'Agostino, C., Chakhoyan, A., Sioutas, C., Tanzi, R. E., Rynearson, K. D., & Finch, C. E. | 2024-08-12 |
Melatonin: A potential nighttime guardian against Alzheimer’s, Molecular Psychiatry | Zhang, Z., Xue, P., Bendlin, B. B., Zetterberg, H., De Felice, F., Tan, X., & Benedict, C. | 2024-08-11 |
Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer’s disease, Alzheimer's & Dementia | Arnold, S. E., Hendrix, S., Nicodemus-Johnson, J., Knowlton, N., Williams, V. J., Burns, J. M., Crane, M., McManus, A. J., Vaishnavi, S. N., Arvanitakis, Z., Neugroschl, J., Bell, K., Trombetta, B. A., Carlyle, B. C., Kivisäkk, P., Dodge, H. H., Tanzi, R. E., Yeramian, P. D., & Leslie, K. | 2024-08-09 |
Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism, Neuron | Profaci, C. P., Harvey, S. S., Bajc, K., Zhang, T. Z., Jeffrey, D. A., Zhang, A. Z., Nemec, K. M., Davtyan, H., O'Brien, C. A., McKinsey, G. L., Longworth, A., McMullen, T. P., Capocchi, J. K., Gonzalez, J. G., Lawson, D. A., Arnold, T. D., Davalos, D., Blurton-Jones, M., Dabertrand, F., Bennett, F. C., Daneman, R. | 2024-08-08 |
Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis, Multiple sclerosis and related disorders | Emeršič, A., Karikari, T. K., Kac, P. R., Gonzalez-Ortiz, F., Dulewicz, M., Ashton, N. J., Brecl Jakob, G., Horvat Ledinek, A., Hanrieder, J., Zetterberg, H., Rot, U., Čučnik, S., & Blennow, K. | 2024-08-05 |
Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology, Cell Reports | Zwang, T. J., Sastre, E. D., Wolf, N., Ruiz-Uribe, N., Woost, B., Hoglund, Z., Fan, Z., Bailey, J., Nfor, L., Buée, L., Nilsson, K. P. R., Hyman, B. T., & Bennett, R. E. | 2024-08-02 |
Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming, Science | Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E., Holtzman, D. M., Yoo, A. S. | 2024-08-08 |
Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers, Frontiers in Medicine | Ivanova, K., Zolovs, M., Blennow, K., Zetterberg, H., Kurjāne, N., & Ķēniņa, V. | 2024-08-01 |
Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis, Cardiovascular Research | Gerhardt, T., Huynh, P., & McAlpine, C. S. | 2024-08-01 |
The choroid plexus synergizes with immune cells during neuroinflammation, Cell | Xu, H., Lotfy, P., Gelb, S., Pragana, A., Hehnly, C., Byer, L. I. J., Shipley, F. B., Zawadzki, M. E., Cui, J., Deng, L., Taylor, M., Webb, M., Lidov, H. G. W., Andermann, M. L., Chiu, I. M., Ordovas-Montanes, J., & Lehtinen, M. K. | 2024-07-31 |
Intravesical Bacille Calmette-Guerin (BCG) Vaccine Affects Cognition, Journal of Alzheimer's Disease | Greenblatt, C. L., Bercovier, H., Klein, B. Y., & Gofrit, O. N. | 2024-07-30 |
Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care, JAMA | Palmqvist, S., Tideman, P., Mattsson-Carlgren, N., Schindler, S. E., Smith, R., Ossenkoppele, R., Calling, S., West, T., Monane, M., Verghese, P. B., Braunstein, J. B., Blennow, K., Janelidze, S., Stomrud, E., Salvadó, G., & Hansson, O. | 2024-07-28 |
MRI Signature of α-Synuclein Pathology in Asymptomatic Stages and a Memory Clinic Population, JAMA Neurology | Wisse, L. E. M., Spotorno, N., Rossi, M., Grothe, M. J., Mammana, A., Tideman, P., Baiardi, S., Strandberg, O., Ticca, A., van Westen, D., Mattsson-Carlgren, N., Palmqvist, S., Stomrud, E., Parchi, P., Hansson, O., & Alzheimer’s Disease Neuroimaging Initiative | 2024-07-28 |
Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment, JAMA Neurology | Janelidze, S., Barthélemy, N. R., Salvadó, G., Schindler, S. E., Palmqvist, S., Mattsson-Carlgren, N., Braunstein, J. B., Ovod, V., Bollinger, J. G., He, Y., Li, Y., Raji, C. A., Morris, J. C., Holtzman, D. M., Ashton, N. J., Blennow, K., Stomrud, E., Bateman, R. J., & Hansson, O. | 2024-07-28 |
Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease, Alzheimer's Research & Therapy | Knapskog, A. B., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Giil, L. M., Saltvedt, I., Watne, L. O., & Aksnes, M. | 2024-07-27 |
Single-cell multiregion dissection of Alzheimer’s disease, Nature | Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., Band, N., James, B. T., Babu, S., Galiana-Melendez, F., Louderback, K., Prokopenko, D., Tanzi, R. E., Bennett, D. A., Tsai, L. H., & Kellis, M. | 2024-07-24 |
The role of the gut microbiome in the regulation of astrocytes in Alzheimer’s disease, Neurotherapeutics | Chandra, S., & Vassar, R. | 2024-07-24 |
Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer’s disease, Neurotherapeutics | Saha, P., & Sisodia, S. S. | 2024-07-24 |
Harmonizing tau positron emission tomography in Alzheimer’s disease: The CenTauR scale and the joint propagation model, Alzheimer's & Dementia | Leuzy, A., Raket, L. L., Villemagne, V. L., Klein, G., Tonietto, M., … Petersen, R. C., ... Ossenkoppele, R., ... Hansson, O., ... Doré, V. | 2024-07-23 |
CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery, Annals of Clinical and Translational Neurology | Fernström, E., Jarfelt, M., Blomstrand, M., Lannering, B., Axelsson, M., Wasling, P., Björk-Eriksson, T., Zetterberg, H., & Kalm, M. | 2024-07-19 |
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia | 10. Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. | 2024-07-19 |
Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling, eLife | Zoltowska, K. M., Das, U., Lismont, S., Enzlein, T., Maesako, M., Houser, M. C. Q., Franco, M. L., Özcan, B., Gomes Moreira, D., Karachentsev, D., Becker, A., Hopf, C., Vilar, M., Berezovska, O., Mobley, W., & Chávez-Gutiérrez, L. | 2024-07-19 |
Tau protein profiling in tauopathies: a human brain study, Molecular Neurodegeneration | Lantero-Rodriguez, J., Camporesi, E., Montoliu-Gaya, L., Gobom, J., Piotrowska, D., Olsson, M., Burmann, I. M., Becker, B., Brinkmalm, A., Burmann, B. M., Perkinton, M., Ashton, N. J., Fox, N. C., Lashley, T., Zetterberg, H., Blennow, K., & Brinkmalm, G. | 2024-07-19 |
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Astrocytic LRP1 Mediates Brain A beta Clearance and Impacts Amyloid Deposition, Journal of Neuroscience | Liu, C. C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. | 2017-04-12 |
Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid beta clearance and aggregation in Alzheimer’s disease, Science Translational Medicine | Liu, C. C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. | 2016-03-30 |
Mimicry of Central-Peripheral Immunity in Alzheimer’s Disease and Discovery of Neurodegenerative Roles in neutrophil, Frontiers in Immunology | Park, J., Baik, S. H., Mook-Jung, I., Irimia, D., & Cho, H. | 2019-09-25 |
Elucidating the interactive roles of glia in Alzheimer’s disease using established and newly developed experimental models, Frontiers in Neurology | Chun, H., Marriott, I., Lee, C. J., & Cho, H. | 2018-09-26 |
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Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons, PLoS One | Gan, M., Jiang, P., McLean, P., Kanekiyo, T., & Bu, G. | 2014-12-12 |
Soluble TREM2 induces inflammatory responses and enhnaces microglial survival, Journal of Experimental Medicine | Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H., & Bu, G. | 2017-03-06 |
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The role of APOE in cerebrovascular dysfunction, Acta Neuropathologica | Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W., & Bu, G. (2016). | 2016-02-16 |
Apolipoprotein E regulates lipid metabolism and alpha-synuclein pathology in human iPSC-derived cerebral organoids, Acta Neuropathologica | Zhao, J., Lu, W., Ren, Y., Fu, Y., Martens, Y. A., Shue, F., Davis, M. D., Wang, X., … Kanekiyo, T., Bu, G. | 2021-08-28 |
Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease, Acta Neuropathologica Communications | Reddy, J. S., Allen, M., Ho, C. C. G., Oatman, S. R., İş, Ö., Quicksall, Z. S., Wang, X., Jin, J., Patel, T. A., Carnwath, T. P., Nguyen, T. T., Malphrus, K. G., Lincoln, S. J., Carrasquillo, M. M., Crook, J. E., Kanekiyo, T., Murray, M. E., Bu, G., Dickson, D. W., & Ertekin-Taner, N. | 2021-05-21 |
ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components, Arteriosclerosis, Thrombosis, and Vascular Biology | Yamazaki, Y., Shinohara, M., Yamazaki, A., Ren, Y., Asmann, Y. W., Kanekiyo, T., & Bu, G. | 2019-10-31 |
Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-beta pathology in amyloid model mice, Experimental Neurology | Tachibana M, Yamazaki Y, Liu CC, Bu G, Kanekiyo T. | 2017-10-26 |
ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation, Frontiers in Neuroscience | Aikawa, T., Ren, Y., Holm, M. L., Asmann, Y. W., Alam, A., Fitzgerald, M. L., Bu, G., & Kanekiyo, T. | 2021-04-07 |
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5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway, International Journal of Molecular Sciences | Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C. C., Kanekiyo, T., & Bu, G. | 2019-03-25 |
LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4, JCI Insight | Oue, H., Yamazaki, Y., Qiao, W., Yuanxin, C., Ren, Y., Kurti, A., … Bu, G., & Kanekiyo, T. | 2023-04-10 |
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway, Journal of Biological Chemistry | Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G., & Kanekiyo, T. | 2015-04-22 |
Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies, Journal of Lipid Research | Shinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. | 2017-04-04 |
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Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, Journal of Neuroscience | Liu, C. C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T., & Bu, G. | 2015-04-08 |
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer’s Neuronal Pathology, Journal of Neuroscience | Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., … Bu, G & Kanekiyo, T. | 2016-03-30 |
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells, Molecular Neurodegeneration | Wren, M. C., Zhao, J., Liu, C. C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T., & Bu, G. | 2015-09-15 |
APP-Mediated signaling prevents memory decline in Alzheimer’s disease mouse model, Cell Reports | Deyts, C., Clutter, M., Pierce, N., Chakrabarty, P., Ladd, T. B., Goddi, A., Rosario, A. M., Cruz, P., Vetrivel, K., Wagner, S. L., Thinakaran, G., Golde, T. E., & Parent, A. T. | 2019-04-30 |
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Lipoproteins in the Central Nervous System: From Biology to Pathobiology, Annual Review of Biochemistry | Raulin AC, Martens YA, Bu G. | 2022-03-18 |
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The AD Knowledge Portal: A Repository for Multi-Omic Data on Alzheimer’s Disease and Aging, Current Protocols in Human Genetics | Greenwood AK, Montgomery KS, Kauer N, Woo KH, Leanza ZJ, Poehlman WL, Gockley J, Sieberts SK, Bradic L, Logsdon BA, Peters MA, Omberg L, Mangravite LM. | 2020-10-21 |
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ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer’s disease, Neurobiology of Aging | Li, Y., Macyczko, J. R., Liu, C. C., & Bu, G. | 2022-03-22 |
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ApoE4 Accelerates Early Seeding of Amyloid Pathology, Neuron | Liu, C. C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W., & Bu, G. | 2017-12-06 |
An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells, STAR Protocols | Raulin, A. C., Liu, C. C., & Bu, G. | 2023-03-17 |
A Novel Link between Trafficking and Lewy body disorder, The Lancet Neurology | Ross, O. A., & Bu, G. | 2018-06-07 |
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