Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Title Researchers Date
Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitvie impariment induced by isoflurane in aged mice, Anesthesiology Li, X. M., Su, F., Ji, M. H., Zhang, G. F., Qiu, L. L., Jia, M., Gao, J., Xie, Z., & Yang, J. J. 2014-07-01
Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3 beta activation in young mice, Anesthesiology Tao, G., Zhang, J., Zhang, L., Dong, Y., Yu, B., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. 2014-09-01
Anaesthetic Neurotoxicity and Neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, British Journal of Anaesthesia Jevtovic-Todorovic, V., Absalom, A. R., Blomgren, K., Brambrink, A., Crosby, G., Culley, D. J., Fiskum, G., Giffard, R. G., Herold, K. F., Loepke, A. W., Ma, D., Orser, B. A., Planel, E., Slikker, W., Jr, Soriano, S. G., Stratmann, G., Vutskits, L., Xie, Z., & Hemmings, H. C., Jr. 2013-08-01
Isoflurane induces endoplasmic reticulum stress and caspase actication through ryanodine receptors, British Journal of Anaesthesia Wang, H., Dong, Y., Zhang, J., Xu, Z., Wang, G., Swain, C. A., Zhang, Y., & Xie, Z. 2014-04-03
Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia Zhang, L., Zhang, J., Yang, L., Dong, Y., Zhang, Y., & Xie, Z. 2013-04-19
Neurotoxicity of General Anesthetics: an update, Current Pharmaceutical Design Vlisides, P., & Xie, Z. 2012-12-01
Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochorne mice levels between m neural progenitor cells and neurons, Frontiers in Cellular Neuroscience Zhang, Y., Pan, C., Wu, X., Dong, Y., Culley, D. J., Crosby, G., Li, T., & Xie, Z. 2014-01-30
Surgery plus anesthesia induces loss of attention in mice, Frontiers in Cellular Neuroscience Ren, Q., Peng, M., Dong, Y., Zhang, Y., Chen, M., Yin, N., Marcantonio, E. R., & Xie, Z. 2015-09-08
Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA recptor 2B in mice, Journal of Neuroscience Zhang, X., Xin, X., Dong, Y., Zhang, Y., Yu, B., Mao, J., & Xie, Z. 2013-11-06
Perioperative cognitive decline in aging population, MAYO Clinic Proceedings Terrando, N., Brzezinski, M., Degos, V., Eriksson, L. I., Kramer, J. H., Leung, J. M., Miller, B. L., Seeley, W. W., Vacas, S., Weiner, M. W., Yaffe, K., Young, W. L., Xie, Z., & Maze, M. 2011-09-01
Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95, Molecular Neurobiology Zhang, J., Dong, Y., Zhou, C., Zhang, Y., & Xie, Z. 2014-05-29
Vitamin C attenuates isoflurane-induced caspase-3 activation and cognitive impairment, Molecular Neurobiology Cheng, B., Zhang, Y., Wang, A., Dong, Y., & Xie, Z. 2014-11-04
Sleep disturbance induces neuroinflammation and impariment of learning and memory, Neurobiology of Disease Zhu, B., Dong, Y., Xu, Z., Gompf, H. S., Ward, S. A., Xue, Z., Miao, C., Zhang, Y., Chamberlin, N. L., & Xie, Z. 2012-12-01
Anesthetic isoflurante increases phosphorylated tau levels mediated by caspase activation and A beta generation, PLoS One Dong, Y., Wu, X., Xu, Z., Zhang, Y., & Xie, Z. 2012-06-20
General anesthetics and beta-amyloid protein, Progress in Neuro-Psychopharmacology & Biological Psychiatry Xie, Z., & Xu, Z. 2012-08-13
Anesthetics isoflurane and desflurane directly affect mitochondrial function, learning, and memory, Annals of Neurology Zhang, Y., Xu, Z., Wang, H., Dong, Y., Shi, H. N., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. 2023-01-19
Cerebrospinal fluid Abeta to Tau ratio and postoperative cognitive change, Annals of Surgery Xie, Z., McAuliffe, S., Swain, C. A., Ward, S. A., Crosby, C. A., Zheng, H., Sherman, J., Dong, Y., Zhang, Y., Sunder, N., Burke, D., Washicosky, K. J., Tanzi, R. E., & Marcantonio, E. R. 2013-08-01
Amyloid-beta Production Via Cleavage of Amyloid-beta Protein Precursor is Modulated by Cell Density, Journal of Alzheimer's Disease Zhang, C., Browne, A., Divito, J. R., Stevenson, J. A., Romano, D., Dong, Y., Xie, Z., & Tanzi, R. E. 2010-10-01
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1 beta, Neurobiology of Aging Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. 2010-12-28
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta protein level in vivo, Annals of Neurology Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. 2008-11-11
Hybrid PET/MRI Enables High-Spatial Resolution, Quantitative Imaging of Amyloid Plaques in an Alzheimer’s Disease Mouse Model, Scientific Reports Frost, G. R., Longo, V., Li, T., Jonas, L. A., Judenhofer, M., Cherry, S., Koutcher, J., Lekaye, C., Zanzonico, P., & Li, Y. M. 2020-06-25
γ-Secretase Inhibitors and Modulators: Mechanistic Insights Into the Function and Regulation of γ-Secretase, Seminars in Cell & Developmental Biology Nie, P., Vartak, A., & Li, Y. M. 2020-04-02
Evidence that the “Lid” domain of nicastrin is not essential for regulating secretase activity, Journal of Biological Chemistry Zhang, X., Sullivan, E., Scimeca, M., Wu, X., Li, Y. M., & Sisodia, S. S. 2016-02-17
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of gamma-secrtase using synthetic antibodies, Proceedings of the National Academy of Sciences of the United States of America Zhang, X., Hoey, R. J., Lin, G., Koide, A., Leung, B., Ahn, K., Dolios, G., Paduch, M., Ikeuchi, T., Wang, R., Li, Y. M., Koide, S., & Sisodia, S. S. 2012-05-14
Therapeutic TVs for Crossing Barriers in the Brain, Cell Zhao, Z., & Zlokovic, B. V. 2020-07-23
Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo, Frontiers in Aging Neuroscience Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. 2020-04-29
Endothelial Tip Cell Finds Its Way with Piezo1, Neuron Zhao, Z., & Zlokovic, B. V. 2020-10-14
Blood-Brain Barrier: From Physiology to Disease and Back, Physiological Reviews Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. 2019-01-01
Prion Protein Antagonists Rescue Alzheimer’s Amyloid-Beta Related Cognitive Deficits, Trends in Molecular Medicine Sagare, A. P., Sweeney, M. D., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. 2019-02-01
Can prehospital “plasma supplement” neutralize the systemic storm in severe trauma?, Cell Reports Medicine Zhao, Z., & Zlokovic, B. V. 2021-12-21
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier, Molecular Neurodegeneration Kisler, K., Sagare, A. P., Lazic, D., Bazzi, S., Lawson, E., Hsu, C. J., Wang, Y., Ramanathan, A., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. 2023-01-27
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism, Molecular Neurodegeneration Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. 2018-10-19
Inflammatory pain may induce cognitive impairment through an interlukin-6 dependent and postsynaptic density-95 associated mechanism, ​​Anesthesia & Analgesia Yang, L., Xin, X., Zhang, J., Zhang, L., Dong, Y., Zhang, Y., Mao, J., & Xie, Z. 2014-05-30
2-Deoxy-D-Glucose Enhances Anesthetic Effects in Mice, ​​Anesthesia & Analgesia Wang, H., Xu, Z., Wu, A., Dong, Y., Zhang, Y., Yue, Y., & Xie, Z. 2015-02-01
Propofol Enhances Hemoglobin-induced cytotoxicity in Neurons, ​​Anesthesia & Analgesia Yuan, J., Cui, G., Li, W., Zhang, X., Wang, X., Zheng, H., Zhang, J., Xiang, S., & Xie, Z. 2016-01-14
Glucose May Attenuate Isoflurane-Induced Caspase-3 Activation in H4 Human Neuroglioma Cells, ​​Anesthesia & Analgesia Sun, Y., Zhang, Y., Cheng, B., Dong, Y., Pan, C., Li, T., & Xie, Z. 2014-07-26
Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment, Anesthesiology Shen, X., Dong, Y., Xu, Z., Wang, H., Miao, C., Soriano, S. G., Sun, D., Baxter, M. G., Zhang, Y., & Xie, Z. 2013-03-01
Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice, Anesthesiology Zheng, H., Dong, Y., Xu, Z., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. 2013-03-01
Effects of Anesthetic Isoflurane and Desflurane on Human Cerebrospinal Fluid Aβ and τ Level, Anesthesiology Zhang, B., Tian, M., Zheng, H., Zhen, Y., Yue, Y., Li, T., Li, S., Marcantonio, E. R., & Xie, Z. 2013-07-01
Cancer prognosis: can anesthesia play a role?, Anesthesiology Xie Z. 2013-09-01
Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro., Biochemistry Hoos, M. D., Ahmed, M., Smith, S. O., & Van Nostrand, W. E. 2009-04-22
Fine mapping of the amyloid β-protein binding site on myelin basic protein, Biochemistry Kotarba, A. E., Aucoin, D., Hoos, M. D., Smith, S. O., & Van Nostrand, W. E. 2013-04-04
Mechanism of Nucleated conformational conversion of A beta 42, Biochemistry Fu, Z., Aucoin, D., Davis, J., Van Nostrand, W. E., & Smith, S. O. 2015-06-12
Degradation of amyloid beta protein by purified myelin basic protein, Journal of Biological Chemistry Liao, M. C., Ahmed, M., Smith, S. O., & Van Nostrand, W. E. 2009-08-19
N-terminal Domain of Myelin Basic Protein Inhibits Amyloid beta-Protein Fibril Assembly, Journal of Biological Chemistry Liao, M. C., Hoos, M. D., Aucoin, D., Ahmed, M., Davis, J., Smith, S. O., & Van Nostrand, W. E. 2010-08-31
Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils., Nature Structural & Molecular Biology Ahmed, M., Davis, J., Aucoin, D., Sato, T., Ahuja, S., Aimoto, S., Elliott, J. I., Van Nostrand, W. E., & Smith, S. O. 2010-04-11
Small molecule amyloid-beta protein precurosr processing modulators lower amyloid beta peptide levels via cKit signaling, Journal of Alzheimer's Disease Chen, C. D., Zeldich, E., Khodr, C., Camara, K., Tung, T. Y., Lauder, E. C., Mullen, P., Polanco, T. J., Liu, Y. Y., Zeldich, D., Xia, W., Van Nostrand, W. E., Brown, L. E., Porco, J. A., & Abraham, C. R. 2019-02-12
PanomiR: a systems biology framework for analysis of multi-pathway targeting by miRNAs, Briefings in Bioinformatics Naderi Yeganeh, P., Teo, Y. Y., Karagkouni, D., Pita-Juárez, Y., Morgan, S. L., Slack, F. J., Vlachos, I. S., & Hide, W. A. 2023-11-20
The relative resistance of children to sepsis mortality: from pathways to drug candidates, Molecular Systems Biology Joachim, R. B., Altschuler, G. M., Hutchinson, J. N., Wong, H. R., Hide, W. A., & Kobzik, L. 2018-05-01
Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment, Human Molecular Genetics Li, A., Hooli, B., Mullin, K., Tate, R. E., Bubnys, A., Kirchner, R., Chapman, B., Hofmann, O., Hide, W., & Tanzi, R. E. 2017-02-10
Central regulation of stress-evoked peripheral immune responses, Nature Reviews Neuroscience Chan, K. L., Poller, W. C., Swirski, F. K., & Russo, S. J. 2023-08-25
Glial control of synapse number in healthy and diseased brain, Frontiers in Cellular Neuroscience Lee, E., & Chung, W. S. 2019-02-13
γ-Secretase fanning the fire of innate immunity, Biochemical Society Transactions Liu, C., Nikain, C., & Li, Y. M. 2023-08-31
Turning the tide on Alzheimer’s disease: modulation of γ-secretase., Cell & Bioscience Luo, J. E., & Li, Y. M. (2022) 2022-01-04
γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors, Frontiers in Aging Neuroscience Wong, E., Frost, G. R., & Li, Y. M. 2020-12-02
Friend, Foe or Both? Immune Activity in Alzheimer’s Disease, Frontiers in Aging Neuroscience Frost, G. R., Jonas, L. A., & Li, Y. M. 2019-12-10
The role of astrocytes in amyloid production and Alzheimer’s disease, Open Biology Frost, G. R., & Li, Y. M. 2017-12-13
Functional insight into LOAD-associated microglial response genes, Open Biology Jonas, L. A., Jain, T., & Li, Y. M. 2022-01-26
Versatility of presenilin 1, Proceedings of the National Academy of Sciences of the United States of America Frost, G. R., Wong, E., & Li, Y. M. 2017-06-23
Recent developments of small molecule γ-secretase modulators for Alzheimer’s disease, RSC Medicinal Chemistry Mekala, S., Nelson, G., & Li, Y. M. 2020-08-27
Gamma-Secretase and its modulators: Twenty years and beyond, Neuroscience Letters Xia W. 2019-02-11
Three dimensional human neuro-spherod model of Alzheimer’s disease based on differentiated induced pluripotent stem cells, PLoS One Lee, H. K., Velazquez Sanchez, C., Chen, M., Morin, P. J., Wells, J. M., Hanlon, E. B., & Xia, W. 2016-09-29
Diagnosis of Alzheimer’s disease using laser-induced breakdown spectroscopy and machine learning, Spectrochimica Acta Part B: Atomic Spectroscopy Gaudiuso, R., Ewusi-Annan, E., Xia, W., & Melikechi, N. 2020-07-15
The Acyl-coenzyme A: cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid pathology in aged amyloid precursor protein transgenic mice, Journal of Neuropathology & Experimental Neurology Huttunen, H. J., Havas, D., Peach, C., Barren, C., Duller, S., Xia, W., Frosch, M. P., Hutter-Paier, B., Windisch, M., & Kovacs, D. M. 2010-08-01
Reticulon 1 and 3 are essential for axonal growth and synaptic maintenance associated with the intellectual development, Human Molecular Genetics Zhou, J., Shi, Q., Ge, Y. Y., He, W., Hu, X., Xia, W., & Yan, R. 2023-05-25
OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages, eBioMedicine Li, X., Wang, L., Cykowski, M., He, T., Liu, T., Chakranarayan, J., Rivera, A., Zhao, H., Powell, S., Xia, W., & Wong, S. T. C. 2020-01-10
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease, Nature Communications Kwak, S. S., Washicosky, K. J., Brand, E., von Maydell, D., Aronson, J., Kim, S., Capen, D. E., Cetinbas, M., Sadreyev, R., Ning, S., Bylykbashi, E., Xia, W., Wagner, S. L., Choi, S. H., Tanzi, R. E., & Kim, D. Y. 2020-03-13
Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer’s disease., Alzheimer's & Dementia Jun, G. R., You, Y., Zhu, C., Meng, G., Chung, J., Panitch, R., Hu, J., Xia, W., Alzheimer's Disease Genetics Consortium, Bennett, D. A., Foroud, T. M., Wang, L. S., Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Schellenberg, G. D., Au, R., Lunetta, K. L., Ikezu, T., Stein, T. D., … Farrer, L. A. 2022-02-09
Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids, Methods Muraoka, S., Lin, W., Chen, M., Hersh, S. W., Emili, A., Xia, W., & Ikezu, T. 2020-02-05
Proteomic and biological profiling of extracellular vesicles from Alzheimer’s disease human brain tissues, Alzheimer's & Dementia Muraoka, S., DeLeo, A. M., Sethi, M. K., Yukawa-Takamatsu, K., Yang, Z., Ko, J., Hogan, J. D., Ruan, Z., You, Y., Wang, Y., Medalla, M., Ikezu, S., Chen, M., Xia, W., Gorantla, S., Gendelman, H. E., Issadore, D., Zaia, J., & Ikezu, T. 2020-04-17
Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain, Annual Review of Neuroscience Fu, X. D., & Mobley, W. C. 2023-07-10
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders, Annual Review of Pharmacology and Toxicology Bartesaghi, R., Vicari, S., & Mobley, W. C. 2022-01-06
Local TrkB signaling: themes in development and neural plasticity, Cell and Tissue Research Johnstone, A., & Mobley, W. 2020-09-16
Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses, Frontiers in Neuroscience Chen, X. Q., & Mobley, W. C. 2019-05-07
Alzheimer’s disease pathogenesis: insights from molecular and cellular biolgoy studies of oligomeric A beta and Tau species, Frontiers in Neuroscience Chen, X. Q., & Mobley, W. C. 2019-06-21
Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome, Neurobiology of Disease Kleschevnikov, A. M., Yu, J., Kim, J., Lysenko, L. V., Zeng, Z., Yu, Y. E., & Mobley, W. C. 2017-03-22
Down syndrome conitive phenotypes modeled in mice trisomic for all HAS 21 Homologues, PLoS One Belichenko, P. V., Kleschevnikov, A. M., Becker, A., Wagner, G. E., Lysenko, L. V., Yu, Y. E., & Mobley, W. C. 2015-07-31
Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis, Journal of Neuroscience Stupack, J., Xiong, X. P., Jiang, L. L., Zhang, T., Zhou, L., Campos, A., Ranscht, B., Mobley, W., Pasquale, E. B., Xu, H., & Huang, T. Y. 2020-06-29
Dementia in Down Syndrome, Lancet Neurology Ballard, C., Mobley, W., Hardy, J., Williams, G., & Corbett, A. 2016-04-11
Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease, Neurology Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Wuu, J., Mathis, C. A., Scheff, S. W., Mufson, E. J., & DeKosky, S. T. 2011-07-05
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia, Molecular Psychiatry Ledo, J. H., Liebmann, T., Zhang, R., Chang, J. C., Azevedo, E. P., Wong, E., Silva, H. M., Troyanskaya, O. G., Bustos, V., & Greengard, P. 2020-08-13
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles, Journal of Biological Chemistry Guo, J. L., & Lee, V. M. 2011-03-03
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice, Journal of Neuroscience Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M., & Holtzman, D. M. 2011-09-14
Tau pathology spreads in S19 tau transgenic mice following locus coeruleus (LC) injections of synthestic tau fibrils is determined by the LC’s afferent and efferent connections, Acta Neuropathologica Iba, M., McBride, J. D., Guo, J. L., Zhang, B., Trojanowski, J. Q., & Lee, V. M. 2015-07-07
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzhiemer’s like tauopathy, Journal of Neuroscience Iba, M., Guo, J. L., McBride, J. D., Zhang, B., Trojanowski, J. Q., & Lee, V. M. 2013-01-16
Aging induces an NLRP3 inflammasome-dependent expansion of adipose B cells that impair metabolic homeostasis, Cell Metabolism Camell, C. D., Günther, P., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y. H., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., Schultze, J., & Dixit, V. D. 2019-11-14
IL-33 causes thermogenic failure in aging by dysfunctional adipose ILC2, Cell Metabolism Goldberg, E. L., Shchukina, I., Youm, Y. H., Ryu, S., Tsusaka, T., Young, K. C., Camell, C. D., Dlugos, T., Artyomov, M. N., & Dixit, V. D. 2021-09-01
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging, Cell Metabolism Mihaylova, M. M., Chaix, A., Delibegovic, M., Ramsey, J. J., Bass, J., Melkani, G., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., Latimer, M. N., Mattison, J. A., Thalacker-Mercer, A. E., Dixit, V. D., Panda, S., & Lamming, D. W. 2023-06-30
Loss of Nucleobindin-2 causes insulin resistance in obesity without impacting satiety or adiposity, Cell Reports Ravussin, A., Youm, Y. H., Sander, J., Ryu, S., Nguyen, K., Varela, L., Shulman, G. I., Sidorov, S., Horvath, T. L., Schultze, J. L., & Dixit, V. D. 2018-07-31
Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice, eLife Ryu, S., Shchukina, I., Youm, Y. H., Qing, H., Hilliard, B., Dlugos, T., Zhang, X., Yasumoto, Y., Booth, C. J., Fernández-Hernando, C., Suárez, Y., Khanna, K., Horvath, T. L., Dietrich, M. O., Artyomov, M., Wang, A., & Dixit, V. D. 2021-06-21
Dietary Regulation of Immunity, Immunity Lee, A. H., & Dixit, V. D. 2020-09-15
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging, Immunity Ryu, S., Sidorov, S., Ravussin, E., Artyomov, M., Iwasaki, A., Wang, A., & Dixit, V. D. 2022-08-12
Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity, Journal of Clinical Investigation Ryu, S., Spadaro, O., Sidorov, S., Lee, A. H., Caprio, S., Morrison, C., Smith, S. R., Ravussin, E., Shchukina, I., Artyomov, M. N., Youm, Y. H., & Dixit, V. D. 2023-10-02
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing, Nature Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y. H., Brown, C. W., Elsworth, J., Rodeheffer, M. S., Schultze, J. L., & Dixit, V. D. 2017-09-27
Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome, Nature Aging Shchukina, I., Bagaitkar, J., Shpynov, O., … Dixit, V. D., … Artyomov, M. N. 2021-11-23
Caloric restriction in humans reveals immunometabolic regulators of health span, Science Spadaro, O., Youm, Y., Shchukina, I., Ryu, S., Sidorov, S., Ravussin, A., Nguyen, K., Aladyeva, E., Predeus, A. N., Smith, S. R., Ravussin, E., Galban, C., Artyomov, M. N., & Dixit, V. D. 2022-02-10
Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau, Journal of Alzheimer's Disease Chen, M., Song, H., Cui, J., Johnson, C. E., Hubler, G. K., DePalma, R. G., Gu, Z., & Xia, W. 2018-10-30
Proteomic Profiling of Plasma and Brain Tissue from Alzheimer’s Disease Patients Reveals Candidate Network of Plasma Biomarkers, Journal of Alzheimer's Disease Chen, M., & Xia, W. 2020-06-30
Multi-Focal Neuronal Ultrastructural Abnormalities and Synaptic Alterations in Mice after Low-Intensity Blast Exposure, Journal of Neurotrauma Konan, L. M., Song, H., Pentecost, G., Fogwe, D., Ndam, T., Cui, J., Johnson, C. E., Grant, D., White, T., Chen, M., Xia, W., Cernak, I., DePalma, R. G., & Gu, Z. 2019-03-13
Common Proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer’s patients, Journal of Proteomics Chen, M., Lee, H. K., Moo, L., Hanlon, E., Stein, T., & Xia, W. 2018-04-27
Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles, Aging and Disease Muraoka, S., Lin, W., Takamatsu-Yukawa, K., Hu, J., Ikezu, S., DeTure, M. A., Dickson, D. W., Emili, A., & Ikezu, T. 2021-09-01
Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons, Brain Ruan, Z., Pathak, D., Venkatesan Kalavai, S., Yoshii-Kitahara, A., Muraoka, S., Bhatt, N., Takamatsu-Yukawa, K., Hu, J., Wang, Y., Hersh, S., Ericsson, M., Gorantla, S., Gendelman, H. E., Kayed, R., Ikezu, S., Luebke, J. I., & Ikezu, T. 2020-11-27
Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study, Cells Muraoka, S., Jedrychowski, M. P., Yanamandra, K., Ikezu, S., Gygi, S. P., & Ikezu, T. 2020-08-25
Proteomic Profiling of Extracellular Vesicles Isolated from Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy, Frontiers in Neuroscience Muraoka, S., Jedrychowski, M. P., Tatebe, H., DeLeo, A. M., Ikezu, S., Tokuda, T., Gygi, S. P., Stern, R. A., & Ikezu, T. 2019-10-09
Activated Human Astrocyte-Derived Extracellular Vesicles Modulate Neuronal Uptake, Differentiation and Firing, Journal of Extracellular Vesicles You, Y., Borgmann, K., Edara, V. V., Stacy, S., Ghorpade, A., & Ikezu, T. 2019-12-26
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models., Journal of Proteome Research Muraoka, S., Jedrychowski, M. P., Iwahara, N., Abdullah, M., Onos, K. D., Keezer, K. J., Hu, J., Ikezu, S., Howell, G. R., Gygi, S. P., & Ikezu, T. 2021-02-03
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice, Molecular Neurodegeneration Ruan, Z., Delpech, J. C., Venkatesan Kalavai, S., Van Enoo, A. A., Hu, J., Ikezu, S., & Ikezu, T. 2020-08-18
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model, Molecular Neurodegeneration Clayton, K., Delpech, J. C., Herron, S., Iwahara, N., Ericsson, M., Saito, T., Saido, T. C., Ikezu, S., & Ikezu, T. 2021-03-22
Emerging Role of Extracellular Vesicles in Neurodegenerative Disorders, Neurobiology of Disease You, Y., & Ikezu, T. 2019-06-20
Cre-inducible Adeno Associated Virus-mediated Expression of P301L mutant tau causes motor deficits and neuronal degeneration in substantia nigra, Neuroscience You, Y., Botros, M. B., Enoo, A. A. V., Bockmiller, A., Herron, S., Delpech, J. C., & Ikezu, T. 2019-11-02
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice, Science Translational Medicine Delpech, J. C., Pathak, D., Varghese, M., Kalavai, S. V., Hays, E. C., Hof, P. R., Johnson, W. E., Ikezu, S., Medalla, M., Luebke, J. I., & Ikezu, T. 2021-09-15
Transcriptional and Epigenetic Regulation of Microglia in Health and Disease, Trends in Molecular Medicine Yeh, H., & Ikezu, T. 2018-12-12
Neuroimmune crosstalk through extracellular vesicles in health and disease, Trends in Neurosciences Delpech, J. C., Herron, S., Botros, M. B., & Ikezu, T. 2019-03-26
Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models, Acta Neuropathologica Communications Ikezu, S., Ingraham Dixie, K. L., Koro, L., Watanabe, T., Kaibuchi, K., & Ikezu, T. 2020-02-04
TIA1 regulates the generation and response to toxic tau oligomers, Acta Neuropathologica Jiang, L., Ash, P. E. A., Maziuk, B. F., Ballance, H. I., Boudeau, S., Abdullatif, A. A., Orlando, M., Petrucelli, L., Ikezu, T., & Wolozin, B. 2019-02-11
Reducing the RNA binding protein T1A1 protects against tau-mediated neurodegeneration in vivo, Nature Neuroscience Apicco, D. J., Ash, P. E. A., Maziuk, B., LeBlang, C., Medalla, M., Al Abdullatif, A., Ferragud, A., Botelho, E., Ballance, H. I., Dhawan, U., Boudeau, S., Cruz, A. L., Kashy, D., Wong, A., Goldberg, L. R., Yazdani, N., Zhang, C., Ung, C. Y., Tripodis, Y., Kanaan, N. M., Ikezu, T., Cottone, P., Leszyk, J., Li, H., Luebke, J., Bryant, C. D., & Wolozin, B. 2018-01-01
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia, Science Translational Medicine Liu, C. C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A. C., Rosenberg, C. L., Doss, S. V., Zhao, J., Wren, M. C., Jia, L., Ren, Y., Ikezu, T. C., Lu, W., Fu, Y., Caulfield, T., Trottier, Z.A., Knight, J., Chen, Y., Linares, C., Wang, X., Kurti, A., Asmann, Y.W., Wszolek, Z.K., Smith, G.E., Vemuri, P., Kantarci, K., Knopman, D.S., Lowe, V.J., Jack, C.R. Jr, Parisi, J.E., Ferman, T.J., Boeve, B.F., Graff-Radford, N.R., Petersen, R.C., Younkin, S.G., Fryer, J.D., Wang, H., Han, X., Frieden, C., Dickson, D.W., Ross, O.A., Bu, G. 2021-09-29
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints, Nature Immunology Yin, Z., Rosenzweig, N., … Ikezu, T., … Tanzi, R., E., … Holtzman, D., M., & Butovsky, O. 2023-09-25
Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice, Acta Neuropathologica Communications Yukawa, K., Yamamoto-Mcguire, S., Cafaro, L., Hong, C., Kamme, F., Ikezu, T., & Ikezu, S. 2023-10-19
Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels, ASC Chemical Biology Bustos, V. H., Sunkari, Y. K., Sinha, A., Pulina, M., Bispo, A., Hopkins, M., Lam, A., Kriegsman, S. F., Mui, E., Chang, E., Jedlicki, A., Rosenthal, H., Flajolet, M., & Sinha, S. C. 2023-12-11
Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression, Brain Yamazaki, Y., Shinohara, M., Shinohara, M., Yamazaki, A., Murray, M. E., Liesinger, A. M., Heckman, M. G., Lesser, E. R., Parisi, J. E., Petersen, R. C., Dickson, D. W., Kanekiyo, T., & Bu, G. 2019-02-15
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function, Nature Neuroscience Liu, C. C., Zhao, J., Fu, Y., … Kanekiyo, T., Fryer, J. D., … Bu, G. 2022-08-01
Clinicopathologic Factors Associated With Reversion to Normal Cognition in Patients With Mild Cognitive Impairment, Neurology Li, Z., Heckman, M. G., Kanekiyo, T., Martens, Y. A., Day, G. S., Vassilaki, M., Liu, C. C., Bennett, D. A., Petersen, R. C., Zhao, N., & Bu, G. 2022-05-17
ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids, Science Advances You, Y., Zhang, Z., Sultana, N., Ericsson, M., Martens, Y. A., Sun, M., Kanekiyo, T., Ikezu, S., Shaffer, S. A., & Ikezu, T. 2023-09-15
Chronic progressive neurodegeneration in a transgenic mouse model of Prion disease, Frontiers in Neuroscience Fainstein, N., Dori, D., Frid, K., Fritz, A. T., Shapiro, I., Gabizon, R., & Ben-Hur, T. 2016-11-11
Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzhiemer’s mice, Neurobiology of Aging Fainstein N, Dan-Goor N, Ben-Hur T. 2018-08-06
Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer’s disease model, Neuropsychopharmacology Ben-Menachem-Zidon, O., Ben-Menahem, Y., Ben-Hur, T., & Yirmiya, R. 2013-08-19
Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages, Acta Neuropathologica Communications Taddei, R. N., Sanchez-Mico, M. V., Bonnar, O., Connors, T., Gaona, A., Denbow, D., Frosch, M. P., & Gómez-Isla, T. 2022-05-09
Combined treatment with phenolics (-)-epigallocatecin-3 gallate and ferulic acid improves cognition and reduces Alzhiemer-like pathology in mice, Journal of Biological Chemistry Mori, T., Koyama, N., Tan, J., Segawa, T., Maeda, M., & Town, T. 2018-12-18
Gallic Acid is a Dual α/β-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice, Journal of Biological Chemistry Mori, T., Koyama, N., Yokoo, T., Segawa, T., Maeda, M., Sawmiller, D., Tan, J., & Town, T. 2020-09-10
Let’s make microglia great again in neurodegenerative disorders, Journal of Neural Transmission Guillot-Sestier, M. V., & Town, T. 2017-10-12
Mouse Brain Transcriptome Responses to Inhaled Nanoparticulate Matter Differed by Sex and APOE in Nrf2-Nfkb Interactions, eLife Haghani, A., Cacciottolo, M., Doty, K. R., D'Agostino, C., Thorwald, M., Safi, N., Levine, M. E., Sioutas, C., Town, T. C., Forman, H. J., Zhang, H., Morgan, T. E., & Finch, C. E. 2020-06-24
Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment, Journal of Clinical Investigation Jiang, L. L., Zhu, B., Zhao, Y., Li, X., Liu, T., Pina-Crespo, J., Zhou, L., Xu, W., Rodriguez, M. J., Yu, H., Cleveland, D. W., Ravits, J., Da Cruz, S., Long, T., Zhang, D., Huang, T. Y., & Xu, H. 2019-05-21
Atlas of the aging mouse brain reveals white matter as vulnerable foci, Cell Hahn, O., Foltz, A. G., Atkins, M., Kedir, B., Moran-Losada, P., Guldner, I. H., Munson, C., Kern, F., Pálovics, R., Lu, N., Zhang, H., Kaur, A., Hull, J., Huguenard, J. R., Grönke, S., Lehallier, B., Partridge, L., Keller, A., & Wyss-Coray, T. 2023-08-08
CD22 Blockade restores homeostatic microglial phagocytosis in ageing brains, Nature Pluvinage, J. V., Haney, M. S., Smith, B. A. H., Sun, J., Iram, T., Bonanno, L., Li, ... Wyss-Coray, T. 2019-04-03
Clonally Expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease, Nature Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, … Wyss-Coray, T. 2020-01-08
Undulating changes in human plasma proteome profiles across the lifespan, Nature Medicine Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., ... Wyss-Coray, T. 2019-12-05
Lipid-droplet accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain, Nature Neuroscience Marschallinger, J., Iram, T., Zardeneta, M., Lee, S. E., ... Wyss-Coray, T. 2020-01-20
CD4(+) T cells contribute to neurodegeneration in Lewy body dementia, Science Gate, D., Tapp, E., Leventhal, O., Shahid, M., ... Wyss-Coray, T. 2021-10-14
Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy, Aging and Disease Muraoka, S., DeLeo, A. M., Yang, Z., Tatebe, H., Yukawa-Takamatsu, K., Ikezu, S., Tokuda, T., Issadore, D., Stern, R. A., & Ikezu, T. 2021-09-01
Transcriptomic profiling of sporadic Alzheimer’s disease patients, Molecular Brain Caldwell, A. B., Anantharaman, B. G., Ramachandran, S., Nguyen, P., Liu, Q., Trinh, I., Galasko, D. R., Desplats, P. A., Wagner, S. L., & Subramaniam, S. 2022-10-12
Dedifferentiation and neuronal repression define familial Alzheimer’s disease., Science Advances Caldwell, A. B., Liu, Q., Schroth, G. P., Galasko, D. R., Yuan, S. H., Wagner, S. L., & Subramaniam, S. 2020-11-13
Pharmacological and Toxicological Properties of the Potent Oral gamma-secretase modulator BPN-15606, Journal of Pharmacology and Experimental Therapeutics Wagner, S. L., Rynearson, K. D., Duddy, S. K., Zhang, C., Nguyen, P. D., Becker, A., Vo, U., Masliah, D., Monte, L., Klee, J. B., Echmalian, C. M., Xia, W., Quinti, L., Johnson, G., Lin, J. H., Kim, D. Y., Mobley, W. C., Rissman, R. A., & Tanzi, R. E. 2017-07-01
Gamma-Secretase modulators reduce endogenous amyloid beta (42) levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal D'Avanzo, C., Sliwinski, C., Wagner, S. L., Tanzi, R. E., Kim, D. Y., & Kovacs, D. M. 2015-04-22
Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates, Journal of Experimental Medicine Xu, Y., Wang, C., Wey, H. Y., Liang, Y., Chen, Z., Choi, S. H., Ran, C., Rynearson, K. D., Bernales, D. R., Koegel, R. E., Fiedler, S. A., Striar, R., Wagner, S. L., Tanzi, R. E., & Zhang, C. 2020-12-07
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention, Journal of Experimental Medicine Rynearson, K. D., Ponnusamy, M., Prikhodko, O., … Mobley, W. C., Thinakaran, G., Tanzi, R. E., Wagner, S. L. 2021-03-02
Gamma-Secretase Partitioning Into Lipid Bilayers Remodels Membrane Microdomains After Direct Insertion, Langmuir Barros, M., Houlihan, W. J., Paresi, C. J., Brendel, M., Rynearson, K. D., Lee, C. W., Prikhodko, O., Cregger, C., Chang, G., Wagner, S. L., Gilchrist, M. L., & Li, Y. M. 2020-05-20
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzhiemer’s disease, Proceedings of the National Academy of Sciences of the United States of America Andrew, R. J., Fernandez, C. G., Stanley, M., Jiang, H., Nguyen, P., Rice, R. C., Buggia-Prévot, V., De Rossi, P., Vetrivel, K. S., Lamb, R., Argemi, A., Allaert, E. S., Rathbun, E. M., Krause, S. V., Wagner, S. L., Parent, A. T., Holtzman, D. M., & Thinakaran, G. 2017-10-23
A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of gamma-secretase, Journal of Biological Chemistry Zhang, X., Hoey, R., Koide, A., Dolios, G., Paduch, M., Nguyen, P., Wu, X., Li, Y., Wagner, S. L., Wang, R., Koide, S., & Sisodia, S. S. 2014-10-28
Soluble gamma-secretase modulators slectively inhibit the production of the 42 amino-acid amyloid beta peptide variant and augment the production of multiple carboxy-truncated amyloid beta species, Biochemistry Wagner, S. L., Zhang, C., Cheng, S., Nguyen, P., Zhang, X., Rynearson, K. D., Wang, R., Li, Y., Sisodia, S. S., Mobley, W. C., & Tanzi, R. E. 2014-01-22
Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders, Molecular Neurodegeneration Huang, Y., Liu, B., Sinha, S. C., Amin, S., & Gan, L. 2023-11-08
Reduction of synaptojanin1 ameliorates synaptic and behaviorla impariments in a mouse model of Alzheimer’s disease, Journal of Neuroscience McIntire, L. B., Berman, D. E., Myaeng, J., Staniszewski, A., Arancio, O., Di Paolo, G., & Kim, T. W. 2012-10-31
Linking Lipids to Alzheimer’s Disease: cholesterol and beyond, Nature Reviews Neuroscience Di Paolo, G., & Kim, T. W. 2011-05-30
ABCA7 and Pathogenic Pathways of Alzheimer’s Disease, Brain Sciences Aikawa, T., Holm, M. L., & Kanekiyo, T. 2018-02-05
Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms, The EMBO Journal Le, L. T. M., Thompson, J. R., Dehghani-Ghahnaviyeh, S., Pant, S., Dang, P. X., French, J. B., Kanikeyo, T., Tajkhorshid, E., & Alam, A. 2022-12-09
ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias, Neuron Martens, Y. A., Zhao, N., Liu, C. C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M., & Bu, G. 2022-03-16
The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer’s disease, Frontiers in Aging Neuroscience Kanekiyo, T., & Bu, G. 2014-05-20
Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins, Molecular Neurodegeneration Oatman, S. R., Reddy, J. S., Quicksall, Z., … Kanekiyo, T., … Bu, G., … Ertekin-Taner, N. 2023-01-07
APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids, Stem Cell Research & Therapy Zhao, J., Ikezu, T. C., Lu, W., Macyczko, J. R., Li, Y., Lewis-Tuffin, L. J., Martens, Y. A., Ren, Y., Zhu, Y., Asmann, Y. W., Ertekin-Taner, N., Kanekiyo, T., & Bu, G. 2023-08-21
Generation and validation of APOE knockout human iPSC-derived cerebral organoids, STAR Protocols Martens, Y. A., Xu, S., Tait, R., Li, G., Zhao, X. C., Lu, W., Liu, C. C., Kanekiyo, T., Bu, G., & Zhao, J. 2021-06-05
Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease, Proceedings of the National Academy of Sciences of the United States of America Baker, S. K., Chen, Z. L., Norris, E. H., Revenko, A. S., MacLeod, A. R., & Strickland, S. 2018-09-25
An antibody against HK blocks Alzheimer’s disease peptide beta-amyloid-induced bradykinin release in human plasma, Proceedings of the National Academy of Sciences of the United States of America Chen, Z. L., Singh, P., Wong, J., Horn, K., Strickland, S., & Norris, E. H. 2019-11-12
Cerebral amyloid angiopathy-linked beta-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen, Proceedings of the National Academy of Sciences of the United States of America Cajamarca, S. A., Norris, E. H., van der Weerd, L., Strickland, S., & Ahn, H. J. 2020-06-09
Editorial: New Insights on Neuron and Astrocyte Function from Cutting Edge Optical Techniques, Frontiers in Cellular Neuroscience Antic, S. D., Baker, B. J., & Canepari, M. 2019-10-15
Studying Synaptically Evoked Cortical Responses ex vivo With Combination of a Single Neuron Recording (Whole-Cell) and Population Voltage Imaging (Genetically Encoded Voltage Indicator), Frontiers in Neuroscience Jang, J., Zhu, M. H., Jogdand, A. H., & Antic, S. D. 2021-10-27
Imaging of Evoked Cortical Depolarizations Using Either ASAP2s, or chi-VSFP, or Di-4-Anepps, or Autofluorescence Optical Signals, Journal of Integrative Neuroscience Milicevic, K. D., Zhu, M. H., Barbeau, B. L., Baser, O., Erol, Z. Y., Liu, L. X., Lin, M. Z., & Antic, S. D. 2023-11-06
In Vitro Testing of Voltage Indicators: Archon1, ArcLightD, ASAP1, ASAP2s, ASAP3b, Bongwoori-Pos6, BeRST1, FlicR1 and Chi-VSFP-Butterfly, eNeuro Milosevic, M. M., Jang, J., McKimm, E. J., Zhu, M. H., & Antic, S. D. 2020-08-14
Population imaging discrepancies between a genetically-encoded calcium indicator (GECI) versus a genetically-encoded voltage indicator (GEVI), Scientific Reports Zhu, M. H., Jang, J., Milosevic, M. M., & Antic, S. D. 2021-03-05
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE, Nature Neuroscience Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., Krasemann, S., Lichtenthaler, S. F., Müller, S. A., Colombo, A., Monasor, L. S., Tahirovic, S., Herms, J., Willem, M., Pettkus, N., Butovsky, O., Bartenstein, P., Edbauer, D., Rominger, A., Erturk, A., Grathwohl, S. A., Neher, J. J., Holtzman, D., Meyer-Leuhmann, M., & Haass, C. 2019-02-01
CSF p-tau increase in response to A beta-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles, Acta Neuropathologica Kaeser, S. A., Häsler, L. M., Lambert, M., Bergmann, C., Bottelbergs, A., Theunis, C., Mercken, M., & Jucker, M. 2021-12-28
Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae, Nature Communications Rother, C., Uhlmann, R. E., Müller, S. A., Schelle, J., … Kaeser, S. A., … Jucker, M. 2022-11-28
A neuronal blood marker is associated with mortality in old age, Nature Aging Kaeser, S. A., Lehallier, B., Thinggaard, M., Häsler, L. M., Apel, A., Bergmann, C., Berdnik, D., Jeune, B., Christensen, K., Grönke, S., Partridge, L., Wyss-Coray, T., Mengel-From, J., & Jucker, M. 2021-02-11
The molecular identity of the TLQP-21 peptide receptor, Cellular and Molecular Life Sciences Sahu, B. S., Nguyen, M. E., Rodriguez, P., Pallais, J. P., Ghosh, V., Razzoli, M., Sham, Y. Y., Salton, S. R., & Bartolomucci, A. 2021-10-09
Role of VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy, Journal of Molecular Neuroscience Jiang, C., Lin, W. J., & Salton, S. R. 2019-07-18
An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function, Translational Psychiatry Lin, W. J., Zhao, Y., Li, Z., Zheng, S., Zou, J. L., Warren, N. A., Bali, P., Wu, J., Xing, M., Jiang, C., Tang, Y., Salton, S. R., & Ye, X. 2021-07-08
Cellular prion protein mediates the toxicity of beta-amyloid oligomers implications for Alzheimer Disease, Archives of Neurology Nygaard, H. B., & Strittmatter, S. M. 2009-11-01
Beta-amyloid oligomers and cellular prion protein in Alzheimer’s disease, Journal of Molecular Medicine Gunther, E. C., & Strittmatter, S. M. 2009-12-04
Memory impairment in transgenic Alzheimer mice requires cellular prion protein, Journal of Neuroscience Gimbel, D. A., Nygaard, H. B., Coffey, E. E., Gunther, E. C., Laurén, J., Gimbel, Z. A., & Strittmatter, S. M. 2010-05-05
Converging multi-modality datasets to build efficient drug repositioning pipelines against Alzheimer’s disease and related dementias, Medical Reviews Yin, Z., & Wong, S. T. C. 2022-02-14
Effect of potent gamma-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers., JAMA Neurology Liu, Q., Waltz, S., Woodruff, G., Ouyang, J., Israel, M. A., Herrera, C., Sarsoza, F., Tanzi, R. E., Koo, E. H., Ringman, J. M., Goldstein, L. S., Wagner, S. L., & Yuan, S. H. 2014-12-01
Blood will out: vascular contributions to Alzheimer’s disease, Journal of Clinical Investigation Strickland S. 2018-02-01
A critical role for plasminogen in inflammation, Journal of Experimental Medicine Baker, S. K., & Strickland, S. 2020-03-11
The Alzheimer’s disease peptide beta-amyloid promotes thrombin generation through activation of coagulation factor XII, Journal of Thrombosis and Haemostasis Zamolodchikov, D., Renné, T., & Strickland, S. 2016-02-29
Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma, Proceedings of the National Academy of Sciences of the United States of America Zamolodchikov, D., Chen, Z. L., Conti, B. A., Renné, T., & Strickland, S. 2015-03-16
Depletion of coagulation factor XII ameliorates brain pathology and cogntive impairment in Alzheimer disease mice, Blood Chen, Z. L., Revenko, A. S., Singh, P., MacLeod, A. R., Norris, E. H., & Strickland, S. 2017-05-04
Abnormal clotting of the intrinsic contact pathway in Alzhiemer’s disease patients is related to cognitive ability, Blood Advances Suidan, G. L., Singh, P. K., Patel-Hett, S., Chen, Z. L., Volfson, D., Yamamoto-Imoto, H., Norris, E. H., Bell, R. D., & Strickland, S. 2018-04-26
Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation, Blood Advances Chen, Z. L., Singh, P. K., Horn, K., Strickland, S., & Norris, E. H. 2022-05-24
Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer’s disease, Current Opinion in Hematology Ahn, H. J., Chen, Z. L., Zamolodchikov, D., Norris, E. H., & Strickland, S. 2017-09-01
Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits, Glia Farfara, D., Feierman, E., Richards, A., Revenko, A. S., MacLeod, R. A., Norris, E. H., & Strickland, S. 2019-03-18
Increased Contact System Activation in Mild Cognitive Impairment Patients with Impaired Short-Term Memory, Journal of Alzheimer's Disease Singh, P. K., Chen, Z. L., Strickland, S., & Norris, E. H. 2020-09-01
Plasminogen mediates communication between the peripheral and central immune system during systemic immune challenge with lipopolysaccharide, Journal of Neuroinflammation Baker, S. K., Chen, Z. L., Norris, E. H., & Strickland, S. 2019-08-28
Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer’s patients, Neurobiology of Disease Singh, P. K., Chen, Z. L., Ghosh, D., Strickland, S., & Norris, E. H. 2020-03-12
3D Culture Models of Alzheimer’s disease: a road map to a “cure-in-a-dish”, Molecular Neurodegeneration Choi, S. H., Kim, Y. H., Quinti, L., Tanzi, R. E., & Kim, D. Y. 2016-12-09
Combined Adult Neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model, Science Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., Aronson, J., Zhang, C., Miller, S. J., Lesinski, A., Chen, J. W., Kim, D. Y., van Praag, H., Spiegelman, B. M., Gage, F. H., & Tanzi, R. E. 2018-09-07
Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides, Angewandte Chemie (International ed. in English) Meier, M., Kennedy-Darling, J., Choi, S. H., Norstrom, E. M., Sisodia, S. S., & Ismagilov, R. F. 2009-01-30
Regulation of hippocampal progenitor cell survival, proliferation, and dendritic development by BDNF, Molecular Neurodegeneration Choi, S. H., Li, Y., Parada, L. F., & Sisodia, S. S. 2009-12-21
Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia, Cell Reports Ruan, Z., Takamatsu-Yukawa, K., Wang, Y., Ushman, M. L., Labadorf, A. T., Ericsson, M., Ikezu, S., & Ikezu, T. 2022-05-10
Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications, Journal of Extracellular Vesicles Zhang, Z., Yu, K., You, Y., Jiang, P., Wu, Z., DeTure, M. A., Dickson, D. W., Ikezu, S., Peng, J., & Ikezu, T. 2023-08-10
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia, Acta Neuropathologica Communications Shi, H., Yin, Z., Koronyo, Y., Fuchs, D. T., Sheyn, J., Davis, M. R., Wilson, J. W., Margeta, M. A., Pitts, K. M., Herron, S., Ikezu, S., Ikezu, T., Graham, S. L., Gupta, V. K., Black, K. L., Mirzaei, M., Butovsky, O., & Koronyo-Hamaoui, M. 2022-09-08
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease, Nature Neuroscience Yin, Z., Herron, S., Silveira, S., Kleemann, K., ... Ikezu, S., Ikezu, T., Butovsky, O. 2023-06-08
Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation, Neuron Choi, S. H., Veeraraghavalu, K., Lazarov, O., Marler, S., Ransohoff, R. M., Ramirez, J. M., & Sisodia, S. S. 2008-08-28
Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells., Proceedings of the National Academy of Sciences of the United States of America Veeraraghavalu, K., & Sisodia, S. S. 2013-05-14
DNA-based fluorescent probes of NOS2 activity in live brains, Proceedings of the National Academy of Sciences of the United States of America Veetil, A. T., Zou, J., Henderson, K. W., Jani, M. S., Shaik, S. M., Sisodia, S. S., Hale, M. E., & Krishnan, Y. 2020-06-17
Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice, Scientific Reports Dodiya, H. B., Frith, M., Sidebottom, A., Cao, Y., Koval, J., Chang, E., & Sisodia, S. S. 2020-05-18
Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia, Journal of Experimental Medicine Dodiya, H. B., Lutz, H. L., Weigle, I. Q., Patel, P., Michalkiewicz, J., Roman-Santiago, C. J., Zhang, C. M., Liang, Y., Srinath, A., Zhang, X., Xia, J., Olszewski, M., Zhang, X., Schipma, M. J., Chang, E. B., Tanzi, R. E., Gilbert, J. A., & Sisodia, S. S. 2022-01-03
Age-dependent, non-cell autonomous deposition of amyloid from synthesis of beta-amyloid by cells other than excitatory neurons, Journal of Neuroscience Veeraraghavalu, K., Zhang, C., Zhang, X., Tanzi, R. E., & Sisodia, S. S. 2014-03-05
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease, Scientific Reports Minter, M. R., Hinterleitner, R., Meisel, M., Zhang, C., Leone, V., Zhang, X., Oyler-Castrillo, P., Zhang, X., Musch, M. W., Shen, X., Jabri, B., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. 2017-09-05
Activation and intrinsic gamma-secretase activity of presenilin 1, Proceedings of the National Academy of Sciences of the United States of America Ahn, K., Shelton, C. C., Tian, Y., Zhang, X., Gilchrist, M. L., Sisodia, S. S., & Li, Y. M. 2010-11-29
Generation of iPSC lines from archived non-cryoprotected biobanked dura mater, Acta Neuropathologica Communications Sproul, A. A., Vensand, L. B., Dusenberry, C. R., Jacob, S., Vonsattel, J. P., Paull, D. J., Shelanski, M. L., Crary, J. F., & Noggle, S. A. 2014-01-07
Characterization of a subpopulation of developing cortical interneuons from human iPSCs within serum-free embryoid bodies, American Journal of Physiology-Cell Physiology Nestor, M. W., Jacob, S., Sun, B., Prè, D., Sproul, A. A., Hong, S. I., Woodard, C., Zimmer, M., Chinchalongporn, V., Arancio, O., & Noggle, S. A. 2014-11-12
A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs), PLoS One Prè, D., Nestor, M. W., Sproul, A. A., Jacob, S., Koppensteiner, P., Chinchalongporn, V., Zimmer, M., Yamamoto, A., Noggle, S. A., & Arancio, O. 2014-07-29
A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols Kim, Y. H., Choi, S. H., D'Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K. J., Klee, J. B., Brüstle, O., Tanzi, R. E., & Kim, D. Y. 2015-07-01
A Three-dimensional human neural cell culture model of Alzheimer’s disease, Nature Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J. B., Zhang, C., Wainger, B. J., Peitz, M., Kovacs, D. M., Woolf, C. J., Wagner, S. L., Tanzi, R. E., & Kim, D. Y. 2014-10-12
Rapid Biomarker Screening of Alzheimer’s Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy, ASC Nano Wang, Z., Ye, J., Zhang, K., Ding, L., Granzier-Nakajima, T., Ranasinghe, J. C., Xue, Y., Sharma, S., Biase, I., Terrones, M., Choi, S. H., Ran, C., Tanzi, R. E., Huang, S. X., Zhang, C., & Huang, S. 2022-03-25
Adult neurogenesis in Alzheimer’s disease, Hippocampus Choi, S. H., & Tanzi, R. E. 2023-02-07
Upregulation of Alzheimer’s Disease Amyloid-beta Protein Precursor in Astrocytes Both in vitro and in vivo, Journal of Alzheimer's Disease Liang, Y., Raven, F., Ward, J. F., Zhen, S., Zhang, S., Sun, H., Miller, S. J., Choi, S. H., Tanzi, R. E., & Zhang, C. 2020-08-04
Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models, Journal of Biological Chemistry Zhang, S., Bai, P., Lei, D., Liang, Y., Zhen, S., Bakiasi, G., Pang, H., Choi, S. H., Wang, C., Tanzi, R. E., & Zhang, C. 2022-03-03
Development of a potential PET probe for HDAC6 imaging in Alzheimer’s disease, Acta Pharmaceutica Sinica B Bai, P., Mondal, P., Bagdasarian, F. A., Rani, N., Liu, Y., Gomm, A., Tocci, D. R., Choi, S. H., Wey, H. Y., Tanzi, R. E., Zhang, C., & Wang, C. 2022-05-20
Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer’s Disease Neuropathology, Advanced Science Mondal, P., Bai, P., Gomm, A., Bakiasi, G., Lin, C. J., Wang, Y., Choi, S. H., Tanzi, R. E., Wang, C., & Zhang, C. 2023-11-21
Exercise hormone irisin is a critical regulator of cognitive function, Nature Metabolism Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., Christie, B. R., Schmider, A. B., Soberman, R. J., Besnard, A., Jedrychowski, M. P., Kim, H., Tu, H., Kim, E., Choi, S. H., Tanzi, R. E., … Wrann, C. D. 2021-08-20
Deficiency of TYROBP, an adaptor protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica Haure-Mirande, J. V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., Zhang, B., Schadt, E. E., Gandy, S., & Ehrlich, M. E. 2017-06-13
Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females, Cells Pan, A. L., Audrain, M., Sakakibara, E., Joshi, R., Zhu, X., Wang, Q., Wang, M., Beckmann, N. D., Schadt, E. E., Gandy, S., Zhang, B., Ehrlich, M. E., & Salton, S. R. 2022-12-01
Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease, Nature Communications Beckmann, N. D., Lin, W. J., Wang, M., … Gandy, S., Tu, Z., Ehrlich, M. E., Zhang, B., Schadt, E. E. 2020-08-07
VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice, Molecular Neurodegenration El Gaamouch, F., Audrain, M., Lin, W. J., Beckmann, N., Jiang, C., Hariharan, S., Heeger, P. S., Schadt, E. E., Gandy, S., Ehrlich, M. E., & Salton, S. R. 2020-01-10
Characterization and molecular profiling of PSEN1 familial Alzheimer’s disease iPSC-derived neural progenitors, PLoS One Sproul, A. A., Jacob, S., Pre, D., Kim, S. H., Nestor, M. W., Navarro-Sobrino, M., Santa-Maria, I., Zimmer, M., Aubry, S., Steele, J. W., Kahler, D. J., Dranovsky, A., Arancio, O., Crary, J. F., Gandy, S., & Noggle, S. A. 2014-01-08
Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes, Journal of Neuroscience Lane, R. F., St George-Hyslop, P., Hempstead, B. L., Small, S. A., Strittmatter, S. M., & Gandy, S. 2012-10-10
Editorial: Multifaceted Interactions Between Immunity and the Diseased Brain, Frontiers in Cellular Neuroscience Funk, K. E., Montagne, A., Falcao, A. M., & Da Mesquita, S. 2022-06-08
Charting the meningeal lymphatic network, Journal of Experimental Medicine Da Mesquita S. 2022-07-05
Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease, Molecular Neurodegeneration Rego, S., Sanchez, G., & Da Mesquita, S. 2023-08-14
Axonal Transport of APP and the spatial regulation of APP cleavage and function in neuronal cells, Experimental Brain Research Brunholz, S., Sisodia, S., Lorenzo, A., Deyts, C., Kins, S., & Morfini, G. 2011-09-30
Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience Main, B. S., & Minter, M. R. 2017-03-23
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone neuronal progenitors via cell-autonomous mechanisms involving Notch signaling, Journal of Neuroscience Veeraraghavalu, K., Choi, S. H., Zhang, X., & Sisodia, S. S. 2010-05-19
A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2, Journal of Neuroscience Zhang, X., Garbett, K., Veeraraghavalu, K., Wilburn, B., Gilmore, R., Mirnics, K., & Sisodia, S. S. 2012-06-20
Differential release of ss-Amyloid from Dendrite versus Axon-targeted APP, Journal of Neuroscience DeBoer, S. R., Dolios, G., Wang, R., & Sisodia, S. S. 2014-09-14
Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation, and survival of adult hippocampal progenitors., Molecular Neurodegeneration Veeraraghavalu, K., Choi, S. H., Zhang, X., & Sisodia, S. S. 2013-10-20
Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome, Molecular Neurodegeneration Shaik, S. M., Cao, Y., Gogola, J. V., Dodiya, H. B., Zhang, X., Boutej, H., Han, W., Kriz, J., & Sisodia, S. S. 2023-12-16
Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules, Nature Nanotechnology Veetil, A. T., Chakraborty, K., Xiao, K., Minter, M. R., Sisodia, S. S., & Krishnan, Y. 2017-08-21
Heterogeneity of CNS Myeloid Cells and their roles in Neurodegeneration, Nature Neuroscience Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. 2011-09-27
Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single cell imaging, Nature Neuroscience Füger, P., Hefendehl, J. K., Veeraraghavalu, K., Wendeln, A. C., Schlosser, C., Obermüller, U., Wegenast-Braun, B. M., Neher, J. J., Martus, P., Kohsaka, S., Thunemann, M., Feil, R., Sisodia, S. S., Skodras, A., & Jucker, M. 2017-08-28
Spatial memory is intact in aged rats after propofol anesthesia, ​​Anesthesia & Analgesia Lee, I. H., Culley, D. J., Baxter, M. G., Xie, Z., Tanzi, R. E., & Crosby, G. 2008-10-01
Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Scientific Reports Xu, Z., Dong, Y., Wang, H., Culley, D. J., Marcantonio, E. R., Crosby, G., Tanzi, R. E., Zhang, Y., & Xie, Z. 2014-01-20
Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid Beta Protein by Promoting microglial Phagocytosis, Scientific Reports Zhang, C., Griciuc, A., Hudry, E., Wan, Y., Quinti, L., Ward, J., Forte, A. M., Shen, X., Ran, C., Elmaleh, D. R., & Tanzi, R. E. 2018-01-18
Open peer commentary on “Prescribing anti‐amyloid immunotherapies to treat Alzheimer’s disease: Fully informing patient decisions”, Alzheimer's & Dementia Gandy S. 2023-11-20
Alzheimer’s disease: new data highlights nonneuronal cell types and the necessity for presymptomatic prevention strategies., Biological Psychiatry Gandy S. 2013-11-28
Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast, Journal of Alzheimer's Disease Bharadwaj, P. R., Verdile, G., Barr, R. K., Gupta, V., Steele, J. W., Lachenmayer, M. L., Yue, Z., Ehrlich, M. E., Petsko, G., Ju, S., Ringe, D., Sankovich, S. E., Caine, J. M., Macreadie, I. G., Gandy, S., & Martins, R. N. 2012-11-14
Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzhiemer’s amyloid beta peptide, Journal of Neuroscience Lane, R. F., Steele, J. W., Cai, D., Ehrlich, M. E., Attie, A. D., & Gandy, S. 2013-04-17
A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition, Molecular Neurodegeneration Mitsis, E. M., Bender, H. A., Kostakoglu, L., Machac, J., Martin, J., Woehr, J. L., Sewell, M. C., Aloysi, A., Goldstein, M. A., Li, C., Sano, M., & Gandy, S. 2014-02-03
Chronic traumatic encephalopathy: clinical biomarker correlations and current concepts in pathogenesis, Molecular Neurodegeneration Gandy, S., Ikonomovic, M. D., Mitsis, E., Elder, G., Ahlers, S. T., Barth, J., Stone, J. R., & DeKosky, S. T. 2014-09-17
News & views: anti-amyloid antibodies and novel emerging approaches to Alzheimer’s disease in 2023, Molecular Neurodegeneration Gandy S. 2023-09-25
Latrepirdine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain, Molecular Psychiatry Steele, J. W., Ju, S., Lachenmayer, M. L., Liken, J., … Gandy, S. 2012-08-07
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model, Molecular Psychiatry Steele, J. W., Lachenmayer, M. L., … Gandy, S. 2012-07-31
Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer’s brain molecular pathology, Molecular Psychiatry Readhead, B., Haure-Mirande, J. V., Zhang, B., Haroutunian, V., Gandy, S., Schadt, E. E., Dudley, J. T., & Ehrlich, M. E. 2015-11-10
Amyloid-beta Oligomers: Possible Roles as Key Neurotoxins in Alzheimer’s Disease, Mount Sinai Journal of Medicine Lublin, A. L., & Gandy, S. 2010-01-25
Acute and traumatic encephalopathies: pathogenesis and biomarkers, Nature Reviews Neurology DeKosky, S. T., Blennow, K., Ikonomovic, M. D., & Gandy, S. 2013-04-01
Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and severe head injury, Translational Psychiatry Mitsis, E. M., Riggio, S., … Gandy, S. 2014-09-16
miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy, Journal of Neuroinflammation Gandy, S., & Ehrlich, M. E. 2023-09-25
Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer A beta oligomer mouse, Molecular Psychiatry Kim, S. H., Steele, J. W., Lee, S. W., Clemenson, G. D., Carter, T. A., Treuner, K., Gadient, R., Wedel, P., Glabe, C., Barlow, C., Ehrlich, M. E., Gage, F. H., & Gandy, S. 2014-08-12
Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau, Molecular Psychiatry Audrain, M., Haure-Mirande, J. V., Wang, M., Kim, S. H., Fanutza, T., Chakrabarty, P., Fraser, P., St George-Hyslop, P. H., Golde, T. E., Blitzer, R. D., Schadt, E. E., Zhang, B., Ehrlich, M. E., & Gandy, S. 2018-10-03
Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia Ruiz, H. H., Chi, T., Shin, A. C., Lindtner, C., Hsieh, W., Ehrlich, M., Gandy, S., & Buettner, C. 2016-02-28
Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies: Application to Alzheimer’s Disease, American Journal of Epidemiology Kavvoura, F. K., McQueen, M. B., Khoury, M. J., Tanzi, R. E., Bertram, L., & Ioannidis, J. P. 2008-09-09
Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells, Biochemsitry Viswanathan, J., Haapasalo, A., Kurkinen, K. M., Natunen, T., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., & Hiltunen, M. 2013-05-10
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking, Molecular and Cellular Biology Sarajärvi, T., Tuusa, J. T., Haapasalo, A., Lackman, J. J., Sormunen, R., Helisalmi, S., Roehr, J. T., Parrado, A. R., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., Petäjä-Repo, U. E., & Hiltunen, M. 2011-04-04
Alzheimer’s disease risk genes: 29 and counting, Nature Reviews Neurology Bertram, L., & Tanzi, R. E. 2019-03-04
Alzheimer’s disease-associated Ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation, Traffic Viswanathan, J., Haapasalo, A., Böttcher, C., Miettinen, R., Kurkinen, K. M., Lu, A., Thomas, A., Maynard, C. J., Romano, D., Hyman, B. T., Berezovska, O., Bertram, L., Soininen, H., Dantuma, N. P., Tanzi, R. E., & Hiltunen, M. 2011-01-07
Role of common and rare APP DNA sequence variants in Alzheimer’s Disease, Neurology Hooli, B. V., Mohapatra, G., Mattheisen, M., Parrado, A. R., Roehr, J. T., Shen, Y., Gusella, J. F., Moir, R., Saunders, A. J., Lange, C., Tanzi, R. E., & Bertram, L. 2012-04-17
Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease, Frontiers in Aging Neuroscience Morgan, S. L., Naderi, P., Koler, K., Pita-Juarez, Y., Prokopenko, D., Vlachos, I. S., Tanzi, R. E., Bertram, L., & Hide, W. A. 2022-06-24
Alzheimer’s disease Amyloid-beta links lens and brain pathology in Down syndrome, PLoS One Moncaster, J. A., Pineda, R., Moir, R. D., Lu, S., Burton, M. A., Ghosh, J. G., Ericsson, M., Soscia, S. J., Mocofanescu, A., Folkerth, R. D., Robb, R. M., Kuszak, J. R., Clark, J. I., Tanzi, R. E., Hunter, D. G., & Goldstein, L. E. 2010-05-20
The Zinc Dyshomeostasis Hypothesis of Alzheimer’s Disease, PLoS One Craddock, T. J., Tuszynski, J. A., Chopra, D., Casey, N., Goldstein, L. E., Hameroff, S. R., & Tanzi, R. E. 2012-03-23
Relevance of the COPI complex for Alzheimer’s disease progression in vivo, Proceedings of the National Academy of Sciences of the United States of America Bettayeb, K., Hooli, B. V., Parrado, A. R., Randolph, L., Varotsis, D., Aryal, S., Gresack, J., Tanzi, R. E., Greengard, P., & Flajolet, M. 2016-04-25
Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-beta metabolism: evidence for involvement of SorL1 and the Retromer Complex, Journal of Neuroscience Lane, R. F., Raines, S. M., Steele, J. W., Ehrlich, M. E., Lah, J. A., Small, S. A., Tanzi, R. E., Attie, A. D., & Gandy, S. 2010-09-29
Negative evidence for a role of APH1B T27I variant in Alzheimer’s disease, Human Molecular Genetics Zhang, X., Zhang, C., Prokopenko, D., Liang, Y., Han, W., Tanzi, R. E., & Sisodia, S. S. 2020-04-15
An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo, Journal of Experimental Medicine Zhang, X., Zhang, C. M., Prokopenko, D., Liang, Y., Zhen, S. Y., Weigle, I. Q., Han, W., Aryal, M., Tanzi, R. E., & Sisodia, S. S. 2021-06-07
iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling, Molecular Neurodegeneration Moreno, C. L., Della Guardia, L., Shnyder, V., Ortiz-Virumbrales, M., Kruglikov, I., Zhang, B., Schadt, E. E., Tanzi, R. E., Noggle, S., Buettner, C., & Gandy, S. 2018-06-26
Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance, Cell Stem Cell Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R., Lucassen, P. J., & Choi, S. H. 2023-02-02
Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer’s disease, Alzheimer's & Dementia Caldwell, A. B., Liu, Q., Zhang, C., Schroth, G. P., Galasko, D. R., Rynearson, K. D., Tanzi, R. E., Yuan, S. H., Wagner, S. L., & Subramaniam, S. 2022-01-27
The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer’s Disease, Journal of Alzheimer's Disease Prikhodko, O., Rynearson, K. D., Sekhon, T., Mante, M. M., Nguyen, P. D., Rissman, R. A., Tanzi, R. E., & Wagner, S. L. 2020-02-18
Soluble Gamma-secretase Modulators Attenuate Alzheimer’s beta amyloid pathology and induce conformational changes in presenili 1, eBioMedicine Raven, F., Ward, J. F., Zoltowska, K. M., Wan, Y., Bylykbashi, E., Miller, S. J., Shen, X., Choi, S. H., Rynearson, K. D., Berezovska, O., Wagner, S. L., Tanzi, R. E., & Zhang, C. 2017-09-04
A gamma secretase inhibitor, but not a gamma-secretase modulator, induced defects in BDNF Axonal trafficking and signaling: evidence for a role for APP, PLoS One Weissmiller, A. M., Natera-Naranjo, O., Reyna, S. M., Pearn, M. L., Zhao, X., Nguyen, P., Cheng, S., Goldstein, L. S., Tanzi, R. E., Wagner, S. L., Mobley, W. C., & Wu, C. 2015-02-24
Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Human Molecular Genetics Li, A., Ahsen, O. O., Liu, J. J., Du, C., McKee, M. L., Yang, Y., Wasco, W., Newton-Cheh, C. H., O'Donnell, C. J., Fujimoto, J. G., Zhou, C., & Tanzi, R. E. 2013-05-21
A circadian clock gene, cry, affects heart morphogenesis and function in Drosophila as revealed by optical coherence microscopy, PLoS One Alex, A., Li, A., Zeng, X., Tate, R. E., McKee, M. L., Capen, D. E., Zhang, Z., Tanzi, R. E., & Zhou, C. 2015-09-08
Functional Links between A beta toxicity, Endocytic trafficking, and Alzheimer’s disease risk factors in yeast, Science Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., Han, H., Lindhagen-Persson, M., Reiman, E. M., Evans, D. A., Bennett, D. A., Olofsson, A., DeJager, P. L., Tanzi, R. E., Caldwell, K. A., Caldwell, G. A., … Lindquist, S. 2011-12-02
Optogenetic pacing in Drosophila melanogaster, Science Advances Alex, A., Li, A., Tanzi, R. E., & Zhou, C. 2015-10-09
PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk, Scientific Reports Lopatko Lindman, K., Jonsson, C., Weidung, B., Olsson, J., Pandey, J. P., Prokopenko, D., Tanzi, R. E., Hallmans, G., Eriksson, S., Elgh, F., & Lövheim, H. 2022-08-02
Nanoplasmic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease related oligomers by curcumin, Scientific Reports Liang, F., Wan, Y., Schaak, D., Ward, J., Shen, X., Tanzi, R. E., Zhang, C., & Quan, Q. 2017-07-18
Molecular imaging of NAD(+) -dependent deacetylase SIRT1 in the brain, Alzheimer's & Dementia Xu, Y., Chen, Z., Wey, H. Y., Liang, Y., Tanzi, R. E., Zhang, C., & Wang, C. 2021-04-15
Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults, Alzheimer's & Dementia Yang, H. S., Zhang, C., Carlyle, B. C., Zhen, S. Y., Trombetta, B. A., Schultz, A. P., Pruzin, J. J., Fitzpatrick, C. D., Yau, W. W., Kirn, D. R., Rentz, D. M., Arnold, S. E., Johnson, K. A., Sperling, R. A., Chhatwal, J. P., & Tanzi, R. E. 2021-06-23
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease, Neuron Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., Hickman, S. E., El Khoury, J., Colonna, M., & Tanzi, R. E. 2019-07-10
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease, Nature Medicine Dujardin, S., Commins, C., Lathuiliere, A., Beerepoot, P., Fernandes, A. R., Kamath, T. V., De Los Santos, M. B., Klickstein, N., Corjuc, D. L., Corjuc, B. T., Dooley, P. M., Viode, A., Oakley, D. H., Moore, B. D., Mullin, K., Jean-Gilles, D., Clark, R., Atchison, K., Moore, R., Chibnik, L. B., Tanzi, R. E., … Hyman, B. T. 2020-06-22
Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors, European Journal of Medicinal Chemistry Liu, G., Mondal, P., Sang, N., Li, Z., Ding, W., Yang, L., Liu, Y., Birar, V. C., Gomm, A., Tanzi, R. E., Zhang, C., Shen, S., Wang, C., Lu, X., & Bai, P. 2023-03-31
Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice, Journal of Medicinal Chemistry Bai, P., Liu, Y., Yang, L., Ding, W., Mondal, P., Sang, N., Liu, G., Lu, X., Ho, T. T., Zhou, Y., Wu, R., Birar, V. C., Wilks, M. Q., Tanzi, R. E., Lin, H., Zhang, C., Li, W., Shen, S., & Wang, C. 2023-11-16
A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data, Genes Hahn, G., Prokopenko, D., Lutz, S. M., Mullin, K., Tanzi, R. E., Cho, M. H., Silverman, E. K., Lange, C., & On The Behalf Of The Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium 2022-01-06
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma, Immunity Margeta, M. A., Yin, Z., Madore, C., Pitts, K. M., Letcher, S. M., Tang, J., Jiang, S., Gauthier, C. D., Silveira, S. R., Schroeder, C. M., Lad, E. M., Proia, A. D., Tanzi, R. E., Holtzman, D. M., Krasemann, S., Chen, D. F., & Butovsky, O. 2022-08-16
The Impact of the Cellular Environment and Aging on Modeling Alzheimer’s Disease in 3D Cell Culture Models, Advanced Science Hebisch, M., Klostermeier, S., Wolf, K., Boccaccini, A. R., Wolf, S. E., Tanzi, R. E., & Kim, D. Y. 2023-01-15
Human Neurospheroid Arrays for in vitro studies of Alzheimer’s disease, Scientific Reports Jorfi, M., D'Avanzo, C., Tanzi, R. E., Kim, D. Y., & Irimia, D. 2018-02-05
Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings, Science Translational Medicine Lomoio, S., Willen, R., Kim, W., Ho, K. Z., Robinson, E. K., Prokopenko, D., Kennedy, M. E., Tanzi, R. E., & Tesco, G. 2020-11-18
A 3D Human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience Park, J., Wetzel, I., Marriott, I., Dréau, D., D'Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. 2018-06-27
Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription, Cell Suh, J., Romano, D. M., Nitschke, L., Herrick, S. P., DiMarzio, B. A., Dzhala, V., Bae, J. S., Oram, M. K., Zheng, Y., Hooli, B., Mullin, K., Gennarino, V. A., Wasco, W., Schmahmann, J. D., Albers, M. W., Zoghbi, H. Y., & Tanzi, R. E. 2019-08-22
Lack of hepatic apoE does not influence early A beta deposition: observations from a new APOE knock-in model, Molecular Neurodegeneration Huynh, T. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., Ulrich, J. D., & Holtzman, D. M. 2019-10-17
Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychiatry Hooli, B. V., Kovacs-Vajna, Z. M., Mullin, K., Blumenthal, M. A., Mattheisen, M., Zhang, C., Lange, C., Mohapatra, G., Bertram, L., & Tanzi, R. E. 2013-06-11
Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage, Journal of Experimental Medicine Rustenhoven, J., Pavlou, G., Storck, S. E., Dykstra, T., Du, S., Wan, Z., Quintero, D., Scallan, J. P., Smirnov, I., Kamm, R. D., & Kipnis, J. 2023-04-07
Blood Brain Barrier Dysfunction in a 3D in vitro model of Alzheimer’s Disease, Advanced Science Shin, Y., Choi, S. H., Kim, E., Bylykbashi, E., Kim, J. A., Chung, S., Kim, D. Y., Kamm, R. D., & Tanzi, R. E. 2019-08-12
Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-beta(42) in Alzheimer’s disease., Brain Shinohara, M., Koga, S., Konno, T., Nix, J., Shinohara, M., Aoki, N., Das, P., Parisi, J. E., Petersen, R. C., Rosenberry, T. L., Dickson, D. W., & Bu, G. 2017-11-17
Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease, Alzheimer's & Dementia Liu, C. C., Yamazaki, Y., Heckman, M. G., Martens, Y. A., Jia, L., Yamazaki, A., Diehl, N. N., Zhao, J., Zhao, N., DeTure, M., Davis, M. D., Felton, L. M., Qiao, W., Li, Y., Li, H., Fu, Y., Wang, N., Wren, M., Aikawa, T., Holm, M. L., Oue, H., Linares, C., Allen, M., Carrasquillo, M.M., Murray, M.E., Petersen, R.C., Ertekin-Taner, N., Dickson, D.W., Kanekiyo, T., Bu, G. 2020-08-22
Human sialoglycan ligands for immune inhibitory Siglecs, Molecular Aspects of Medicine Gonzalez-Gil, A., Li, T. A., Kim, J., & Schnaar, R. L. 2022-08-11
Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells, European Journal of Neuroscience Murai, N., Mitalipova, M., & Jaenisch, R. 2020-09-14
Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain, Proceedings of the National Academy of Sciences of the United States of America Svoboda, D. S., Barrasa, M. I., Shu, J., Rietjens, R., Zhang, S., Mitalipova, M., Berube, P., Fu, D., Shultz, L. D., Bell, G. W., & Jaenisch, R. 2019-11-26
Significant Upregulation of Alzheimer’s beta-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides, Angewandte Chemie (International ed. in English) Ma, C., Su, J., Sun, Y., Feng, Y., Shen, N., Li, B., Liang, Y., Yang, X., Wu, H., Zhang, H., Herrmann, A., Tanzi, R. E., Liu, K., & Zhang, C. 2019-11-04
Association of GSK3b with Alzheimer disease and frontotemporal dementia, Archives of Neurology Schaffer, B. A., Bertram, L., Miller, B. L., Mullin, K., Weintraub, S., Johnson, N., Bigio, E. H., Mesulam, M., Wiedau-Pazos, M., Jackson, G. R., Cummings, J. L., Cantor, R. M., Levey, A. I., Tanzi, R. E., & Geschwind, D. H. 2008-10-01
Non-invasive red-light optogenetic control of Drosophila cardiac function, Communications Biology Men, J., Li, A., Jerwick, J., Li, Z., Tanzi, R. E., & Zhou, C. 2020-06-29
Changes in the expression of the Alzheimer’s disease-associated presenilin gene in Drosophila heart leads to cardiac dysfunction, Current Alzheimer Research Li, A., Zhou, C., Moore, J., Zhang, P., Tsai, T. H., Lee, H. C., Romano, D. M., McKee, M. L., Schoenfeld, D. A., Serra, M. J., Raygor, K., Cantiello, H. F., Fujimoto, J. G., & Tanzi, R. E. 2011-05-01
Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer’s disease., Discovery Medicine Ward, J., Wang, H., Saunders, A. J., Tanzi, R. E., & Zhang, C. 2017-02-01
Optimizing animal models of autoimmune encephalitis using active immunization, Frontiers in Immunology Linnoila, J., Jalali Motlagh, N., Jachimiec, G., Lin, C. J., Küllenberg, E., Wojtkiewicz, G., Tanzi, R., & Chen, J. W. 2023-07-12
Analysis of hidradenitis suppurativa-linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages., Human Molecular Genetics Li, A., Peng, Y., Taiclet, L. M., & Tanzi, R. E. (2019). 2018-12-13
A Curcumin Analog Reduces Levels of the Alzheimer’s Disease-Associated Amyloid-beta Protein by Modulating A beta PP Processing and Autophagy, Journal of Alzheimer's Disease Wan, Y., Liang, Y., Liang, F., Shen, N., Shinozuka, K., Yu, J. T., Ran, C., Quan, Q., Tanzi, R. E., & Zhang, C. 2019-11-26
Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein, Journal of Biological Chemistry Zhang, C., Browne, A., Child, D., & Tanzi, R. E. 2010-09-10
Loss of Function of ATXN1 Increases Amyloid beta-Protein Levels by Potentiating beta-Secretase Processing of beta-Amyloid Precursor Protein, Journal of Biological Chemistry Zhang, C., Browne, A., Child, D., Divito, J. R., Stevenson, J. A., & Tanzi, R. E. 2010-01-22
Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography, Journal of Medicinal Chemistry Lan, Y., Bai, P., Liu, Y., Afshar, S., Striar, R., Rattray, A. K., Meyer, T. N., Langan, A. G., Posner, A. M., Shen, S., Tanzi, R. E., Zhang, C., & Wang, C. 2021-10-15
Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila, Journal of Visualized Experiments Wang, S., Tanzi, R. E., & Li, A. 2019-01-07
Drosophila preparation and longitudinal imaging of heart function in vivo using optical coherence microsopy (OCM), Journal of Visualized Experiments Men, J., Jerwick, J., Wu, P., Chen, M., Alex, A., Ma, Y., Tanzi, R. E., Li, A., & Zhou, C. 2016-12-12
Targeting the beta secretase BACE1 for Alzheimer’s disease therapy, Lancet Neurology Yan, R., & Vassar, R. 2014-02-17
Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease, Neuroscience & Behavioral Reviews Yan, R., Fan, Q., Zhou, J., & Vassar, R. 2016-04-01
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects, Journal of Neurochemistry Vassar, R., Kuhn, P. H., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., & Lichtenthaler, S. F. 2014-04-19
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased amyloid beta generation in Alzheimer’s disease, Acta Neuropathologica Sadleir, K. R., Kandalepas, P. C., Buggia-Prévot, V., Nicholson, D. A., Thinakaran, G., & Vassar, R. 2016-03-18
Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase, Molecular Neurodegeneration Buggia-Prévot, V., Fernandez, C. G., Riordan, S., Vetrivel, K. S., Roseman, J., Waters, J., Bindokas, V. P., Vassar, R., & Thinakaran, G. 2014-01-04
A function for EHD family proteins in unidirectional retrograde dendritic transprt of BACE1 and Alzheimer’s disease Ab production, Cell Reports Buggia-Prévot, V., Fernandez, C. G., Udayar, V., Vetrivel, K. S., Elie, A., Roseman, J., Sasse, V. A., Lefkow, M., Meckler, X., Bhattacharyya, S., George, M., Kar, S., Bindokas, V. P., Parent, A. T., Rajendran, L., Band, H., Vassar, R., & Thinakaran, G. 2013-12-26
Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity, Molecular Neurodegeneration Upadhyay, A., Chhangani, D., Rao, N. R., Kofler, J., Vassar, R., Rincon-Limas, D. E., & Savas, J. N. 2023-09-14
Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models, Scientific Reports Alia, A. O., Jeon, S., Popovic, J., Salvo, M. A., Sadleir, K. R., Vassar, R., & Cuddy, L. K. 2022-12-21
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease, Nature Hur, J. Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Vassar, R., … Greengard, P., ... Li, Y. M. 2020-09-02
Synapto-depressive effects of amyloid beta require PICK1, European Journal of Neuroscience Alfonso, S., Kessels, H. W., Banos, C. C., Chan, T. R., Lin, E. T., Kumaravel, G., Scannevin, R. H., Rhodes, K. J., Huganir, R., Guckian, K. M., Dunah, A. W., & Malinow, R. 2014-04-08
Cellular Pharmacology of Protein Kinase M zeta (PKM zeta) Contrasts with Its in Vitro Profile IMPLICATIONS FOR PKM zeta AS A MEDIATOR OF MEMORY, Journal of Biological Chemistry Wu-Zhang, A. X., Schramm, C. L., Nabavi, S., Malinow, R., & Newton, A. C. 2012-02-29
Engineering a memory with LTD and LTP, Nature Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. 2014-06-01
Metabotropic NMDA receptor function is required for beta-amyloid-induced synaptic depression, Proceedings of the National Academy of Sciences of the United States of America Kessels, H. W., Nabavi, S., & Malinow, R. 2012-02-19
Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience Wei, W., Nguyen, L. N., Kessels, H. W., Hagiwara, H., Sisodia, S., & Malinow, R. 2009-12-27
In vitro microfluidic models for neurodegenerative disorders, Advanced Healthcare Materials Osaki, T., Shin, Y., Sivathanu, V., Campisi, M., & Kamm, R. D. 2017-09-07
3D Self-Organized microvasclar model of the human blood-brain barrier with endothelial cells, pericytes, and astrocytes, Biomaterials Campisi, M., Shin, Y., Osaki, T., Hajal, C., Chiono, V., & Kamm, R. D. 2018-07-12
Microphysiological models of neurological disorders for drug development, Current Opinion in Biomedical Engineering Offeddu, G. S., Shin, Y., Kamm, R. D. 2020-03-01
3D Self-Organized Human Blood-Brain Barrier in a Microfluidic Chip, Methods in Molecular Biology Campisi, M., Lim, S. H., Chiono, V., & Kamm, R. D. 2020-12-20
Engineered human blood-brain barrier microfluidic model for vascular permeability analyses, Nature Protocols Hajal, C., Offeddu, G. S., Shin, Y., Zhang, S., Morozova, O., Hickman, D., Knutson, C. G., & Kamm, R. D. 2022-01-07
The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain, Science Advances Hajal, C., Shin, Y., Li, L., Serrano, J. C., Jacks, T., & Kamm, R. D. 2021-06-23
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes, Neuron Pulido, R. S., Munji, R. N., Chan, T. C., Quirk, C. R., Weiner, G. A., Weger, B. D., Rossi, M. J., Elmsaouri, S., Malfavon, M., Deng, A., Profaci, C. P., Blanchette, M., Qian, T., Foreman, K. L., Shusta, E. V., Gorman, M. R., Gachon, F., Leutgeb, S., & Daneman, R. 2020-09-25
Association of Depressive Symptoms and Cognition in Older Adults Without Dementia Across Different Biomarker Profiles, Journal of Alzheimer's disease Rubin-Norowitz, M., Lipton, R. B., Petersen, K., Ezzati, A., & Alzheimer’s Disease Neuroimaging Initiative 2022-06-28
Association of Alcohol Consumption with Cognition in Older Population: The A4 Study, Journal of Alzheimer's Disease Nallapu, B. T., Petersen, K. K., Lipton, R. B., Grober, E., Sperling, R. A., & Ezzati, A. 2023-06-13
White matter hyperintensities and cognition across different Alzheimer’s biomarker profiles., Journal of the American Geriatrics Society Lam, S., Lipton, R. B., Harvey, D. J., Zammit, A. R., Ezzati, A., & Alzheimer's Disease Neuroimaging Initiative 2021-04-23
Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI The A4 Study, Neurology Grober, E., Lipton, R. B., Sperling, R. A., Papp, K. V., Johnson, K. A., Rentz, D. M., Veroff, A. E., Aisen, P. S., & Ezzati, A. 2022-03-29
Predicting Amyloid Positivity in Cognitively Unimpaired Older Adults A Machine Learning Approach Using A4 Data, Neurology Petersen, K. K., Lipton, R. B., Grober, E., Davatzikos, C., Sperling, R. A., & Ezzati, A. 2022-06-14
Association of Stages of Objective Memory Impairment With Incident Symptomatic Cognitive Impairment in Cognitively Normal Individuals, Neurology Grober, E., Petersen, K. K., Lipton, R. B., Hassenstab, J., Morris, J. C., Gordon, B. A., & Ezzati, A. 2023-04-19
Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies, Brain Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M., Lee, E. B., & Hansson, O. 2023-05-08
The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling, Journal of Biological Chemistry Gayen, M., Benoit, M. R., Fan, Q., Hudobenko, J., & Yan, R. 2022-09-24
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides, Molecular Neurodegeneration Zhou, J., Singh, N., Galske, J., Hudobenko, J., Hu, X., & Yan, R. 2023-05-04
BACE1 controls synaptic function through modulating release of synaptic vesicles, Molecular Psychiatry Das, B., Singh, N., Yao, A. Y., Zhou, J., He, W., Hu, X., & Yan, R. 2021-06-22
Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration, Neural Regeneration Research Hudobenko, J., Gayen, M., Benoit, M. R., Singh, N., & Yan, R. 2023-04-20
Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance, Science Advances Singh, N., Das, B., Zhou, J., Hu, X., & Yan, R. 2022-07-20
The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology, Journal of Experimental Medicine Fan, Q., Gayen, M., Singh, N., Gao, F., He, W., Hu, X., Tsai, L. H., & Yan, R. 2019-06-17
Evoked Cortical Depolarizations Before and After the Amyloid Plaque Accumulation: Voltage Imaging Study, Journal of Alzheimer's Disease Zhu, M. H., Jogdand, A. H., Jang, J., Nagella, S. C., Das, B., Milosevic, M. M., Yan, R., & Antic, S. D. 2022-07-04
The Retromer supports AMPA Receptor Trafficking During LTP, Neuron Temkin, P., Morishita, W., Goswami, D., Arendt, K., Chen, L., & Malenka, R. 2017-04-05
Characterization of a Drosophila Alzheimer’s disease model: pharmacoogical rescue of cognitive defects, PLoS One Chakraborty, R., Vepuri, V., Mhatre, S. D., Paddock, B. E., Miller, S., Michelson, S. J., Delvadia, R., Desai, A., Vinokur, M., Melicharek, D. J., Utreja, S., Khandelwal, P., Ansaloni, S., Goldstein, L. E., Moir, R. D., Lee, J. C., Tabb, L. P., Saunders, A. J., & Marenda, D. R. 2011-06-06
The Antimicrobial protection hypothesis of Alzheimer’s disease, Alzheimer's & Dementia Moir, R. D., Lathe, R., & Tanzi, R. E. 2018-10-09
Low Evolutionary Selection Pressure in Senescence does not explain the persistence of amyloid-beta in the vertebrate genome, Frontiers in Aging Neuroscience Moir, R. D., & Tanzi, R. E. 2019-03-28
Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity, Human Molecular Genetics Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., Norton, D., Tesco, G., Elliott, K., Wagner, S. L., Moir, R. D., Becker, K. D., & Tanzi, R. E. 2009-10-15
ACAT Inhibition and amyloid beta reduction, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids Bhattacharyya, R., & Kovacs, D. M. 2010-08-01
Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes, Cell Reports Bhattacharyya, R., Black, S. E., Lotlikar, M. S., Fenn, R. H., Jorfi, M., Kovacs, D. M., & Tanzi, R. E. 2021-05-18
The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner, Scientific Reports Bhattacharyya, R., Teves, C. A. F., Long, A., Hofert, M., & Tanzi, R. E. 2022-03-03
Palmitoylation of Amyloid Precursor Protein regulates amyloidogenic processing in lipid rafts, Journal of Neuroscience Bhattacharyya, R., Barren, C., & Kovacs, D. M. 2013-07-03
Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway, The FASEB Journal Huttunen, H. J., Peach, C., Bhattacharyya, R., Barren, C., Pettingell, W., Hutter-Paier, B., Windisch, M., Berezovska, O., & Kovacs, D. M. 2009-07-22
Palmitoylated APP forms Dimers, Cleaved BACE1, PLoS One Bhattacharyya, R., Fenn, R. H., Barren, C., Tanzi, R. E., & Kovacs, D. M. 2016-11-22
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues, EMBO Molecular Medicine Young, L. E. A., Conroy, L. R., Clarke, H. A., Hawkinson, T. R., Bolton, K. E., Sanders, W. C., Chang, J. E., Webb, M. B., Alilain, W. J., Vander Kooi, C. W., Drake, R. R., Andres, D. A., Badgett, T. C., Wagner, L. M., Allison, D. B., Sun, R. C., & Gentry, M. S. 2022-09-05
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis, Nature Communications Conroy, L. R., Clarke, H. A., Allison, D. B., Valenca, S. S., Sun, Q., Hawkinson, T. R., Young, L. E. A., Ferreira, J. E., Hammonds, A. V., Dunne, J. B., McDonald, R. J., Absher, K. J., Dong, B. E., Bruntz, R. C., Markussen, K. H., Juras, J. A., Alilain, W. J., Liu, J., Gentry, M. S., Angel, P. M., … Sun, R. C. (2023). Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis. Nature communications, 14(1), 2759. https://doi.org/10.1038/s41467-023-38437-1 2023-05-13
Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model, Neurotherapeutics Donohue, K. J., Fitzsimmons, B., Bruntz, R. C., Markussen, K. H., Young, L. E. A., Clarke, H. A., Coburn, P. T., Griffith, L. E., Sanders, W., Klier, J., Burke, S. N., Maurer, A. P., Minassian, B. A., Sun, R. C., Kordasiewisz, H. B., & Gentry, M. S. 2023-09-12
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge, Cell Reports Lee, S., Devanney, N. A., Golden, L. R., Smith, C. T., Schwartz, J. L., Walsh, A. E., Clarke, H. A., Goulding, D. S., Allenger, E. J., Morillo-Segovia, G., Friday, C. M., Gorman, A. A., Hawkinson, T. R., MacLean, S. M., Williams, H. C., Sun, R. C., Morganti, J. M., & Johnson, L. A. 2023-03-03
Data-driven models of dominantly-inherited Alzheimer’s disease progression, Brain Oxtoby, N. P., Young, A. L., Cash, D. M., Benzinger, T. L. S., Fagan, A. M., Morris, J. C., Bateman, R. J., Fox, N. C., Schott, J. M., & Alexander, D. C. 2018-03-22
Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer’s disease, Brain Communications Vermunt, L., Dicks, E., Wang, G., Dincer, A., Flores, S., Keefe, S. J., … Morris. J., C., … Bateman, R. J., ... Dominantly Inherited Alzheimer Network (DIAN) 2020-07-15
Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease Small Windows, Big Picture, JAMA Neurology McDade, E., & Bateman, R. J. 2018-05-01
SILK Studies – Capturing the Turnover of Proteins Linked to Neurodegenerative Diseases, Nature Reviews Neurology Paterson, R. W., Gabelle, A., Lucey, B. P., Barthélemy, N. R., Leckey, C. A., Hirtz, C., Lehmann, S., Sato, C., Patterson, B. W., West, T., Yarasheski, K., Rohrer, J. D., Wildburger, N. C., Schott, J. M., Karch, C. M., Wray, S., Miller, T. M., Elbert, D. L., Zetterberg, H., Fox, N. C., … Bateman, R. J. 2019-06-20
The case for low-level BACE1 inhibition for the prevention of Alzheimer disease, Nature Reviews Neurology McDade, E., Voytyuk, I., Aisen, P., Bateman, R. J., Carrillo, M. C., De Strooper, B., Haass, C., Reiman, E. M., Sperling, R., Tariot, P. N., Yan, R., Masters, C. L., Vassar, R., & Lichtenthaler, S. F. 2021-09-21
Amyloid beta dynamics are regulated by orexin and the sleep wake cycle, Science Kang, J. E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. 2009-11-13
Disruption of the sleep-wake cycle and diurnal fluctuations of amyloid-beta in mice with Alzheimer’s disease pathology, Science Translational Medicine Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. 2012-09-05
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons, Cell Stem Cell Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J. S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E., & Yoo, A. S. 2022-06-02
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid, Nature Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., Harari, O., Karch, C. M., Bateman, R. J., Perrin, R., Farlow, M., Chhatwal, J., Dominantly Inherited Alzheimer Network, Hu, S., Randolph, G. J., Smirnov, I., … Kipnis, J. 2022-11-09
The structure of amyloid-β dimers in Alzheimer’s disease brain: a step forward for oligomers, Brain Bateman, R. J., Mawuenyega, K. G., & Wildburger, N. C. 2019-04-29
Synaptic proteostasis in Parkinson’s disease, Current Opinion in Neurobiology Nachman, E., & Verstreken, P. 2022-02-01
Presynaptic Autophagy and the Connection With Neurotransmission, Frontiers in Cell and Developmental Biology Decet, M., & Verstreken, P. 2021-12-17
Reduced levels of the tyrosine phosphatase STEP block beta-amyloid-mediated GluA1/GluA2 receptor internalization, Journal of Neurochemistry Zhang, Y., Kurup, P., Xu, J., Anderson, G. M., Greengard, P., Nairn, A. C., & Lombroso, P. J. 2011-09-21
A beta-mediated NMDA receptor endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP61, Journal of Neuroscience Kurup, P., Zhang, Y., Xu, J., Venkitaramani, D. V., Haroutunian, V., Greengard, P., Nairn, A. C., & Lombroso, P. J. 2010-04-28
A functional mouse retroposed gene Rps23r1 reduces Alzhiemer’s beta amyloid levels and tau phosphorylation, Neuron Zhang, Y. W., Liu, S., Zhang, X., Li, W. B., Chen, Y., Huang, X., Sun, L., Luo, W., Netzer, W. J., Threadgill, R., Wiegand, G., Wang, R., Cohen, S. N., Greengard, P., Liao, F. F., Li, L., & Xu, H. 2009-11-12
CDK5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Sciences of the United States of America Lagace, D. C., Benavides, D. R., Kansy, J. W., Mapelli, M., Greengard, P., Bibb, J. A., & Eisch, A. J. 2008-11-18
Gleevec shifts APP processing from a beta-cleavage to a nonamyloidogenic cleavage, Proceedings of the National Academy of Sciences of the United States of America Netzer, W. J., Bettayeb, K., Sinha, S. C., Flajolet, M., Greengard, P., & Bustos, V. 2017-01-23
δ-COP modulates Aβ peptide formation via retrograde trafficking of APP, Proceedings of the National Academy of Sciences of the United States of America Bettayeb, K., Chang, J. C., Luo, W., Aryal, S., Varotsis, D., Randolph, L., Netzer, W. J., Greengard, P., & Flajolet, M. 2016-04-25
Three-dimensional study of Alzheimer’s disease hallmarks using iDISCO clearing method, Cell Reports Liebmann, T., Renier, N., Bettayeb, K., Greengard, P., Tessier-Lavigne, M., & Flajolet, M. 2016-07-14
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development, PLoS One Ledo, J. H., Zhang, R., Mesin, L., Mourão-Sá, D., Azevedo, E. P., Troyanskaya, O. G., Bustos, V., & Greengard, P. 2020-08-21
C99 selectively accumulates in vulnerable neurons in Alzheimer’s disease, Alzheimer's & Dementia Pulina, M. V., Hopkins, M., Haroutunian, V., Greengard, P., & Bustos, V. 2020-01-06
Short-term treatment with dabigatran alters protein expression patterns in a late-stage tau-based Alzheimer’s disease mouse model, Biochemistry and Biophysics Reports Iannucci, J., Johnson, S. L., Majchrzak, M., Barlock, B. J., Akhlaghi, F., Seeram, N. P., Sen, A., & Grammas, P. 2020-11-19
High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro, Cellular and Molecular Neurobiology Iannucci, J., Rao, H. V., & Grammas, P. 2020-11-02
Dabigatran reduces thrombin-induced neuroinflammation and AD markers in vitro: Therapeutic relevance for Alzheimer’s disease, Cerebral Circulation - Cognition and Behavior Bihaqi, S. W., Rao, H. V., Sen, A., & Grammas, P. 2021-05-06
Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro, Current Issues in Molecular Biology Iannucci, J., Sen, A., & Grammas, P. 2021-05-27
Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease, Frontiers in Neuroscience Iannucci, J., Renehan, W., & Grammas, P. 2020-07-24
Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice, International Journal of Molecular Sciences Mattar, J. M., Majchrzak, M., Iannucci, J., Bartman, S., Robinson, J. K., & Grammas, P. 2022-04-01
Thrombin Signaling Contributes to High Glucose-Induced Injury of Human Brain Microvascular Endothelial Cells., Journal of Alzheimer's disease Vittal Rao, H., Bihaqi, S. W., Iannucci, J., Sen, A., & Grammas, P. 2021-01-05
Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset, Frontiers in Aging Neuroscience Homann, J., Osburg, T., Ohlei, O., Dobricic, V., Deecke, L., Bos, I., Vandenberghe, R., Gabel, S., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., Popp, J., Clark, C., Peyratout, G., Martinez-Lage, P., Tainta, M., Dobson, R.J.B., Legido-Quigley, C., Sleegers, K., Van Broeckhoven, C., Wittig, M., Franke, A., Lill, C.M., Blennow, K., Zetterberg, H., Lovestone, S., Streffer, J., Kate, M., Vos, S. J. B., Barkhof, F., Visser, P. J., & Bertram, L. 2022-03-21
Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning, Genome Medicine Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Timsina, J., Vos, S., Prokopenko, D., Tijms, B. M., Andreasson, U., Blennow, K., Vandenberghe, R., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., … EMIF-AD & ADNI study group 2023-10-04
Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease, Annals of Neurology Zheng, L., Rubinski, A., Denecke, J., Luan, Y., Smith, R., Strandberg, O., Stomrud, E., Ossenkoppele, R., Svaldi, D. O., Higgins, I. A., Shcherbinin, S., Pontecorvo, M. J., Hansson, O., Franzmeier, N., Ewers, M., & Alzheimer's Disease Neuroimaging Initiative 2023-10-14
Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis, Brain Bocancea, D. I., Svenningsson, A. L., van Loenhoud, A. C., Groot, C., Barkhof, F., Strandberg, O., Smith, R., Alzheimer’s Disease Neuroimaging Initiative, La Joie, R., Rosen, H. J., Pontecorvo, M. J., Rabinovici, G. D., van der Flier, W. M., Hansson, O., & Ossenkoppele, R. 2023-03-27
Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation, Brain Coomans, E. M., van Westen, D., Pichet Binette, A., Strandberg, O., Spotorno, N., Serrano, G. E., Beach, T. G., Palmqvist, S., Stomrud, E., Ossenkoppele, R., & Hansson, O. 2023-09-18
Sex‐specific biomarkers in Alzheimer’s disease progression: Framingham Heart Study, Alzheimer's & Dementia Liu, C., Li, Y., Nwosu, A., Ang, T. F. A., Liu, Y., Devine, S., Au, R., & Doraiswamy, P. M. 2022-11-03
Expanding the scope of health disparities research in Alzheimer’s disease and related dementias, Alzheimer's & Dementia Akushevich, I., Kravchenko, J., Yashkin, A., Doraiswamy, P. M., Hill, C. V., & Alzheimer's Disease and Related Dementia Health Disparities Collaborative Group 2023-03-16
Gut-microbiota-microglia-brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization, Alzheimer's Research & Therapy Wang, Q., Davis, P. B., Qi, X., Chen, S. G., Gurney, M. E., Perry, G., Doraiswamy, P. M., & Xu, R. 2021-10-20
Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s Disease, Computational and Mathematical Methods in Medicine Petrella, J. R., Hao, W., Rao, A., & Doraiswamy, P. M. 2019-02-03
Advancing Computerized Cognitive Training for MCI and Alzheimer’s Disease in a Pandemic and Post-pandemic World, Frontiers in Psychiatry Bodner, K. A., Goldberg, T. E., Devanand, D. P., & Doraiswamy, P. M. 2020-11-25
Controversies and Future Directions of Ocular Biomarkers in Alzheimer Disease, JAMA Neurology Ong, S. S., Doraiswamy, P. M., & Lad, E. M. 2018-06-01
Reproductive Markers in Alzheimer’s Disease Progression: The Framingham Heart Study, Journal of Prevention of Alzheimer's Disease Ding, H., Li, Y., Ang, T. F. A., Liu, Y., Devine, S., Au, R., Doraiswamy, P. M., & Liu, C. 2023-03-22
Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies, Journal of Prevention of Alzheimer's Disease Sabbagh, M. N., Boada, M., Borson, S., Chilukuri, M., Doraiswamy, P. M., Dubois, B., Ingram, J., Iwata, A., Porsteinsson, A. P., Possin, K. L., Rabinovici, G. D., Vellas, B., Chao, S., Vergallo, A., & Hampel, H. 2020-03-06
Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting, Journal of Prevention of Alzheimer's Disease Sabbagh, M. N., Boada, M., Borson, S., Doraiswamy, P. M., Dubois, B., Ingram, J., Iwata, A., Porsteinsson, A. P., Possin, K. L., Rabinovici, G. D., Vellas, B., Chao, S., Vergallo, A., & Hampel, H. 2020-04-06
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome, Nature Communications Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., John-Williams, L. S., Tenenbaum, J. D., Blach, C., Chang, R., Brinton, R. D., Baillie, R., Han, X., Trojanowski, J. Q., Shaw, L. M., Martins, R., … Doraiswamy, P. M., ... Kastenmüller, G. 2020-03-02
Characterizing Gene and Protein Crosstalks in Subjects at risk of developing Alzheimer’s disease: a new computational approach, Processes Padmanabhan, K., Nudelman, K., Harenberg, S., Bello, G., Sohn, D., Shpanskaya, K., Tiwari Dikshit, P., Yerramsetty, P.S., Tanzi, R.E., Saykin, A.J., Petrella, J.R., Doraiswamy, P. M., Samatova, N. & Alzheimer's Disease Neuroimaging Initiative 2017-09-01
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease, Scientific Reports Gamberger, D., Lavrač, N., Srivatsa, S., Tanzi, R. E., & Doraiswamy, P. M. 2017-07-28
Sex Differences in cognitive decline in subjects with high likelihood of mild cognitive impairments due to Alzheimer’s disease, Scientific Reports Sohn, D., Shpanskaya, K., Lucas, J. E., Petrella, J. R., Saykin, A. J., Tanzi, R. E., Samatova, N. F., & Doraiswamy, P. M. 2018-05-10
Accelerating Stem Cell Trials for Alzheimer’s Disease, Lancet Neurology Hunsberger, J. G., Rao, M., Kurtzberg, J., Bulte, J. W. M., Atala, A., LaFerla, F. M., Greely, H. T., Sawa, A., Gandy, S., Schneider, L. S., & Doraiswamy, P. M. 2015-12-17
Mitochondrial Ca2+ Signaling and Bioenergetics in Alzheimer’s Disease, Biomedicines Arnst, N., Redolfi, N., Lia, A., Bedetta, M., Greotti, E., & Pizzo, P. 2022-11-24
Mitochondrial Ca2+ signaling and Alzheimer’s disease: Too much or too little?, Cell Calcium Garcia-Casas, P., Rossini, M., Filadi, R., & Pizzo, P. 2023-05-11
Key Signalling Molecules in Aging and Neurodegeneration, Cells Filadi, R., & Pizzo, P. 2022-02-28
Microglia signatures and their role in health and disease, Nature Reviews Neuroscience Butovsky, O., & Weiner, H. L. 2018-09-11
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports Mazaheri, F., Snaidero, N., Kleinberger, G., Madore, C., Daria, A., Werner, G., Krasemann, S., Capell, A., Trümbach, D., Wurst, W., Brunner, B., Bultmann, S., Tahirovic, S., Kerschensteiner, M., Misgeld, T., Butovsky, O., & Haass, C. 2017-05-08
The TREM2-APOE Pathway drives the transcriptional phenotype of dysfunctional microglia in Neurodegenerative Diseases, Immunity Krasemann, S., Madore, C., Cialic, R., Baufeld, C., ... Ulrich, J. D., … Lemere, C., Ikezu, T., ... Holtzman, D. M. … Haass, C., Butovsky, O. 2017-09-19
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia, Neuron Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J. D., & Holtzman, D. M. 2021-04-07
Sex-specific effects of microbiome perturbations on cerebral amyloid beta amyloidosis and microglia phenotypes, Journal of Experimental Medicine Dodiya, H. B., Kuntz, T., Shaik, S. M., Baufeld, C., Leibowitz, J., Zhang, X., Gottel, N., Zhang, X., Butovsky, O., Gilbert, J. A., & Sisodia, S. S. 2019-05-16
Higher plasma beta-synuclein indicates early synaptic degeneration in Alzheimer’s disease, Alzheimer's & Dementia Oeckl, P., Janelidze, S., Halbgebauer, S., Stomrud, E., Palmqvist, S., Otto, M., & Hansson, O. 2023-04-27
Age-related and amyloid-beta-independent tau deposition and its downstream effects, Brain Wuestefeld, A., Pichet Binette, A., Berron, D., Spotorno, N., van Westen, D., Stomrud, E., Mattsson-Carlgren, N., Str|berg, O., Smith, R., Palmqvist, S., Glenn, T., Moes, S., Honer, M., Arfanakis, K., Barnes, L. L., Bennett, D. A., Schneider, J. A., Wisse, L. E. M., & Hansson, O. 2023-04-21
Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease, Brain Spotorno, N., Strandberg, O., Stomrud, E., Janelidze, S., Blennow, K., Nilsson, M., van Westen, D., & Hansson, O. 2023-12-21
Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia, Brain Communications Harper, L., de Boer, S., Lindberg, O., Lätt, J., Cullen, N., Clark, L., Irwin, D., Massimo, L., Grossman, M., Hansson, O., Pijnenburg, Y., McMillan, C. T., & Santillo, A. F. 2023-10-10
MRI BrainAGE demonstrates increased brain aging in systemic lupus erythematosus patients, Frontiers in Aging Neuroscience Kuchcinski, G., Rumetshofer, T., Zervides, K. A., Lopes, R., Gautherot, M., Pruvo, J. P., Bengtsson, A. A., Hansson, O., Jönsen, A., & Sundgren, P. C. M. 2023-10-20
Plasma IAPP-Autoantibody Levels in Alzheimer’s Disease Patients Are Affected by APOE4 Status, International Journal of Molecular Sciences Pocevičiūtė, D., Roth, B., Schultz, N., Nuñez-Diaz, C., Janelidze, S., The Netherl|s Brain Bank, Olofsson, A., Hansson, O., & Wennström, M. 2023-02-14
Clinical Utility of Tau Positron Emission Tomography in the Diagnostic Workup of Patients With Cognitive Symptoms, JAMA Neurology Smith, R., Hägerström, D., Pawlik, D., Klein, G., Jögi, J., Ohlsson, T., Stomrud, E., & Hansson, O. (2023). 2023-05-22
A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases, Nature Aging Brum, W. S., Cullen, N. C., Janelidze, S., Ashton, N. J., Zimmer, E. R., Therriault, J., Benedet, A. L., Rahmouni, N., Tissot, C., Stevenson, J., Servaes, S., Triana-Baltzer, G., Kolb, H. C., Palmqvist, S., Stomrud, E., Rosa-Neto, P., Blennow, K., & Hansson, O. 2023-08-31
DOPA decarboxylase is an emerging biomarker for Parkinsonian disorders including preclinical Lewy body disease, Nature Aging Pereira, J. B., Kumar, A., Hall, S., Palmqvist, S., Stomrud, E., Bali, D., Parchi, P., Mattsson-Carlgren, N., Janelidze, S., & Hansson, O. 2023-09-18
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases, Nature Communications Smith, R., Capotosti, F., Schain, M., Ohlsson, … Hansson, O. 2023-10-27
Cognitive effects of Lewy body pathology in clinically unimpaired individuals, Nature Medicine Palmqvist, S., Rossi, M., Hall, S., Quadalti, C., Mattsson-Carlgren, N., Dellavalle, S., Tideman, P., Pereira, J. B., Nilsson, M. H., Mammana, A., Janelidze, S., Baiardi, S., Stomrud, E., Parchi, P., & Hansson, O. 2023-07-18
Clinical effects of Lewy body pathology in cognitively impaired individuals, Nature Medicine Quadalti, C., Palmqvist, S., Hall, S., Rossi, M., Mammana, A., Janelidze, S., Dellavalle, S., Mattsson-Carlgren, N., Baiardi, S., Stomrud, E., Hansson, O., & Parchi, P. 2023-07-18
Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau, Molecular Psychiatry Van Egroo, M., Riphagen, J. M., Ashton, N. J., Janelidze, S., Sperling, R. A., Johnson, K. A., Yang, H. S., Bennett, D. A., Blennow, K., Hansson, O., Zetterberg, H., & Jacobs, H. I. L. 2023-04-05
Blood biomarkers for Alzheimer’s disease in clinical practice and trials, Nature Aging Hansson, O., Blennow, K., Zetterberg, H., & Dage, J. 2023-05-18
The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review, Alzheimer's Research & Therapy Brand, A. L., Lawler, P. E., Bollinger, J. G., Li, Y., Schindler, S. E., Li, M., Lopez, S., Ovod, V., Nakamura, A., Shaw, L. M., Zetterberg, H., Hansson, O., & Bateman, R. J. 2022-12-27
Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer’s amyloid beta (42) from isolated intact nerve terminals, Journal of Neuroscience Kim, S. H., Fraser, P. E., Westaway, D., St George-Hyslop, P. H., Ehrlich, M. E., & Gandy, S. 2010-03-17
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain, Science Translational Medicine Schaler, A. W., Runyan, A. M., Clelland, C. L., Sydney, E. J., Fowler, S. L., Figueroa, H. Y., Shioda, S., Santa-Maria, I., Duff, K. E., & Myeku, N. 2021-05-26
Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzhiemer’s disease transgenic mouse model, Journal of Neurochemistry Fabbro, S., Schaller, K., & Seeds, N. W. 2011-07-18
Neuroserpin up-regulation in the Alzheimer’s disease brain is associated with elevated throid hormone receptor-beta 1 and HuD expression, Neurochemistry International Subhadra, B., Schaller, K., & Seeds, N. W. 2013-09-11
Diversity of amyloid-beta proteoforms in the Alzheimer’s disease brain, Scientific Reports Wildburger, N. C., Esparza, T. J., LeDuc, R. D., Fellers, R. T., Thomas, P. M., Cairns, N. J., Kelleher, N. L., Bateman, R. J., & Brody, D. L. 2017-08-25
Solble Amyloid-beta aggregates from human Alzheimr’s disease brains, Scientific Reports Esparza, T. J., Wildburger, N. C., Jiang, H., Gangolli, M., Cairns, N. J., Bateman, R. J., & Brody, D. L. 2016-12-05
Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy, Acta Neuropathologica Communications Kempthorne, L., Yoon, H., Madore, C., Smith, S., Wszolek, Z. K., Rademakers, R., Kim, J., Butovsky, O., & Dickson, D. W. 2020-05-19
Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder, Brain, Behavior, and Immunity Guneykaya, D., Ugursu, B., Logiacco, F., Popp, O., Feiks, M. A., Meyer, N., Wendt, S., Semtner, M., Cherif, F., Gauthier, C., Madore, C., Yin, Z., Çınar, Ö., Arslan, T., Gerevich, Z., Mertins, P., Butovsky, O., Kettenmann, H., & Wolf, S. A. 2023-03-29
Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury, Glia Fiore, N. T., Yin, Z., Guneykaya, D., Gauthier, C. D., Hayes, J. P., D'Hary, A., Butovsky, O., & Moalem-Taylor, G. 2022-01-20
Microglia, Lifestyle Stress, and Neurodegeneration, Immunity Madore, C., Yin, Z., Leibowitz, J., & Butovsky, O. 2020-01-07
Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4., Investigative Ophtalmology & Visual Science Margeta, M. A., Letcher, S. M., Igo, R. P., Jr, Cooke Bailey, J. N., Pasquale, L. R., Haines, J. L., Butovsky, O., Wiggs, J. L., & NEIGHBORHOOD consortium 2020-07-01
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease, Journal of Clinical Investigation Roy, E. R., Wang, B., Wan, Y. W., Chiu, G., Cole, A., Yin, Z., Propson, N. E., Xu, Y., Jankowsky, J. L., Liu, Z., Lee, V. M., Trojanowski, J. Q., Ginsberg, S. D., Butovsky, O., Zheng, H., & Cao, W. 2020-03-09
Differential contribution of microglia and monocytes in neurodegenerative diseases, Journal of Neural Transmission Baufeld, C., O'Loughlin, E., Calcagno, N., Madore, C., & Butovsky, O. 2017-10-23
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis, Immunity Kiss, M. G., Mindur, J. E., Yates, A. G., … Nahrendorf, M., … Swirski, F.K. & McAlpine, C. S. 2023-05-08
Beyond the sleep-amyloid interactions in Alzheimer’s disease pathogenesis, Journal of Neurophysiology Ning, S., & Jorfi, M. 2019-03-13
The interplay between microglial states and major risk factors in Alzheimer’s disease through the eyes of single-cell RNA sequencing: beyond black and white, Journal of Neurophysiology von Maydell, D., & Jorfi, M. 2019-08-31
Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer’s Disease, Frontiers in Neuroscience Ning, S., Jorfi, M., Patel, S. R., Kim, D. Y., & Tanzi, R. E. 2022-03-24
Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix, STAR Protocols Lotlikar, M. S., Tarantino, M. B., Jorfi, M., Kovacs, D. M., Tanzi, R. E., & Bhattacharyya, R. 2022-01-07
Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model, Nature Neuroscience Jorfi, M., Park, J., Hall, C. K., Lin, C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., Irimia, D., Kim, D. Y., & Tanzi, R. E. 2023-08-24
The neuroimmune axis of Alzheimer’s disease, Genome Medicine Jorfi, M., Maaser-Hecker, A., & Tanzi, R. E. 2023-01-26
Patterning of interconnected human brain spheroids, Lab on a Chip Kim, J. J., Jorfi, M., Tanzi, R. E., Kim, D. Y., Doyle, P. S., & Irimia, D. 2021-09-14
Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model, Frontiers in Bioengineering and Biotechnology Ko, E. C., Spitz, S., Pramotton, F. M., Barr, O. M., Xu, C., Pavlou, G., Zhang, S., Tsai, A., Maaser-Hecker, A., Jorfi, M., Choi, S. H., Tanzi, R. E., & Kamm, R. D. 2023-10-09
Designed inhibitors to reduce amyloid virulence and cytotoxicity and combat neurodegenerative and infectious diseases, Current Opinion in Chemical Biology Indig, R. Y., & L|au, M. 2023-05-15
Differential fibril morphologies and thermostability determine functional roles of Staphylococcus aureus PSMα1 and PSMα3, Frontiers in Molecular Biosciences Rayan, B., Barnea, E., Khokhlov, A., Upcher, A., & Landau, M. 2023-07-04
What can AlphaFold do for antimicrobial amyloids?, Proteins Ragonis-Bachar, P., Axel, G., Blau, S., Ben-Tal, N., Kolodny, R., & Landau, M. 2023-10-19
Effective anti-Alzheimer A beta therapy involves depletion of specific A beta oligomer subtypes, Neurology Neuroimmunology & Neuroinflammation Knight, E. M., Kim, S. H., Kottwitz, J. C., Hatami, A., Albay, R., Suzuki, A., Lublin, A., Alberini, C. M., Klein, W. L., Szabo, P., Relkin, N. R., Ehrlich, M., Glabe, C. G., Gandy, S., & Steele, J. W. 2016-05-10
Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1, Acta Neuropathologica Communications Knight, E. M., Ruiz, H. H., Kim, S. H., Harte, J. C., Hsieh, W., Glabe, C., Klein, W. L., Attie, A. D., Buettner, C., Ehrlich, M. E., & Gandy, S. 2016-02-25
Days to criterion as an indicator of toxicity associated with Human Alzheimer Amyloid-beta Oligomers, Annals of Neurology Gandy, S., Simon, A. J., Steele, J. W., Lublin, A. L., Lah, J. J., Walker, L. C., Levey, A. I., Krafft, G. A., Levy, E., Checler, F., Glabe, C., Bilker, W. B., Abel, T., Schmeidler, J., & Ehrlich, M. E. 2010-08-01
Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2, Molecular Neurodegeneration Haure-Mirande, J. V., Audrain, M., Ehrlich, M. E., & Gandy, S. 2022-08-24
Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden, Molecular Psychiatry T., Kim, S. H., Heja, S., Readhead, B., Dudley, J. T., Blitzer, R. D., Schadt, E. E., Zhang, B., Gandy, S., & Ehrlich, M. E. 2018-10-03
Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development, Cells Bose, M., Farias Quipildor, G., Ehrlich, M. E., & Salton, S. R. 2022-11-16
Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration Steele, J. W., Kim, S. H., Cirrito, J. R., Verges, D. K., Restivo, J. L., Westaway, D., Fraser, P., Hyslop, P. S., Sano, M., Bezprozvanny, I., Ehrlich, M. E., Holtzman, D. M., & Gandy, S. 2009-12-17
CRISPR/Cas9- Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN (N141l) neurons, Acta Neuropathologica Communications Ortiz-Virumbrales, M., Moreno, C. L., Kruglikov, I., Marazuela, P., Sproul, A., Jacob, S., Zimmer, M., Paull, D., Zhang, B., Schadt, E. E., Ehrlich, M. E., Tanzi, R. E., Arancio, O., Noggle, S., & Gandy, S. 2017-10-27
Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism, Journal of Experimental Medicine Song, W. M., Joshita, S., Zhou, Y., Ulland, T. K., Gilfillan, S., & Colonna, M. 2018-01-10
Brain Parenchymal and Extraparenchymal Macrophages in Development, Homeostasis, and Disease, Journal of Immunology Brioschi, S., Zhou, Y., & Colonna, M. 2020-01-15
Microglia in Alzheimer’s Diseases: a target for immunotherapy, Journal of Leukocye Biology Wang, S., & Colonna, M. 2019-02-06
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia, Nature Immunology Zhou, Y., Tada, M., Cai, Z., |hey, P. S., Swain, A., Miller, K. R., Gilfillan, S., Artyomov, M. N., Takao, M., Kakita, A., & Colonna, M. 2023-01-19
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis, Nature Reviews Neuroscience Colonna, M., & Wang, Y. 2016-02-25
Regulation of microglial survival and proliferation in health and disease, Seminars in Immunology Ulland, T. K., Wang, Y., & Colonna, M. 2015-03-28
Fifty Shades of Microglia, Trends in Neurosciences Brioschi, S., Peng, V., & Colonna, M. 2019-04-18
TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4, Neuron Gratuze, M., Schlachetzki, J. C. M., D'Oliveira Albanus, R., Jain, N., Novotny, B., Brase, L., Rodriguez, L., Mansel, C., Kipnis, M., O'Brien, S., Pasillas, M. P., Lee, C., Manis, M., Colonna, M., Harari, O., Glass, C. K., Ulrich, J. D., & Holtzman, D. M. 2022-11-10
TREM2 maintains Microglial metabolic fitness in Alzheimer’s Disease, Cell Ulland, T. K., Song, W. M., Huang, S. C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., Loginicheva, E., Gilfillan, S., Cella, M., Virgin, H. W., Unanue, E. R., Wang, Y., Artyomov, M. N., Holtzman, D. M., & Colonna, M. 2017-08-10
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread, Cell Chen, Y., Song, S., Parhizkar, S., Lord, J., Zhu, Y., Strickland, M. R., Wang, C., Park, J., Tabor, G. T., Jiang, H., Li, K., Davis, A. A., Yuede, C. M., Colonna, M., Ulrich, J. D., & Holtzman, D. M. 2023-12-11
Alzheimer’s Disease-associated TREM2 variants exhibit either a decreased or increased lignad-dependent activation, Alzheimer's & Dementia Song, W., Hooli, B., Mullin, K., Jin, S. C., Cella, M., Ulland, T. K., Wang, Y., Tanzi, R. E., & Colonna, M. 2016-08-09
Targeting innate immunity for neurodegenerative disorders of the central nervous system., Journal of Neurochemistry Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, ... Town, T., … Colonna, M. , ... Van Eldik, L. J. 2016-09-01
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice, Cell Reports Kiani Shabestari, S., Morabito, S., Danhash, E. P., McQuade, A., Sanchez, J. R., Miyoshi, E., Chadarevian, J. P., Claes, C., Coburn, M. A., Hasselmann, J., Hidalgo, J., Tran, K. N., Martini, A. C., Chang Rothermich, W., Pascual, J., Head, E., Hume, D. A., Pridans, C., Davtyan, H., Swarup, V., … Blurton-Jones, M. 2022-06-14
Microglial APOE4: more is less and less is more, Molecular Neurodegeneration Eskandari-Sedighi, G., & Blurton-Jones, M. 2023-12-19
Human microglia maturation is underpinned by specific gene regulatory networks, Immunity Han, C. Z., Li, R. Z., Hansen, E., Trescott, S., Fixsen, B. R., Nguyen, C. T., Mora, C. M., Spann, N. J., Bennett, H. R., Poirion, O., Buchanan, J., Warden, A. S., Xia, B., Schlachetzki, J. C. M., Pasillas, M. P., Preissl, S., Wang, A., O'Connor, C., Shriram, S., Kim, R., … Coufal, N. G. 2023-08-14
Multi-omic comparison of Alzheimer’s variants inhuman ESC–derived microglia reveals convergence at APOE, Journal of Experimental Medicine Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. 2020-09-17
Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer’s disease brain, Journal of Extracellular Vesicles You, Y., Muraoka, S., Jedrychowski, M. P., Hu, J., McQuade, A. K., Young-Pearse, T., Aslebagh, R., Shaffer, S. A., Gygi, S. P., Blurton-Jones, M., Poon, W. W., & Ikezu, T. 2022-01-13
Alzheimer’s disease: From immunotherapy to immunoprevention, Cell Jucker, M., & Walker, L. C. 2023-09-19
Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease, Brain Vöglein, J., Paumier, K., Jucker, M., Preische, O., McDade, E., Hassenstab, J., Benzinger, T. L., Noble, J. M., Berman, S. B., Graff-Radford, N. R., Ghetti, B., Farlow, M. R., Chhatwal, J., Salloway, S., Xiong, C., Karch, C. M., Cairns, N., Mori, H., Schofield, P. R., Masters, C. L., … Dominantly Inherited Alzheimer Network 2019-03-20
Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzhiemer’s disease and PART, Acta Neuropathologica Kaufman, S. K., Del Tredici, K., Thomas, T. L., Braak, H., & Diamond, M. I. 2018-05-11
Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue, Acta Neuropathologica Communications Kaufman, S. K., Thomas, T. L., Del Tredici, K., Braak, H., & Diamond, M. I. 2017-06-07
Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns, Acta Neuropathologica Communications Stopschinski, B. E., Del Tredici, K., Estill-Terpack, S. J., Ghebremdehin, E., Yu, F. F., Braak, H., & Diamond, M. I. 2021-10-11
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus alpha synuclein and beta amyloid aggregates, Journal of Biological Chemistry Stopschinski, B. E., Holmes, B. B., Miller, G. M., Manon, V. A., Vaquer-Alicea, J., Prueitt, W. L., Hsieh-Wilson, L. C., & Diamond, M. I. 2018-07-06
A synthetic heparinoid blocks Tau aggregate cell uptake and amplification, Journal of Biological Chemistry Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S., & Diamond, M. I. 2020-01-23
The dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification, Journal of Biological Chemistry Kolay, S., Vega, A. R., Dodd, D. A., Perez, V. A., Kashmer, O. M., White, C. L., 3rd, & Diamond, M. I. 2022-05-05
Seed-competent tau monomer initiates pathology in a tauopathy mouse model, Journal of Biological Chemistry Mirbaha, H., Chen, D., Mullapudi, V., Terpack, S. J., White, C. L., 3rd, Joachimiak, L. A., & Diamond, M. I. 2022-06-22
Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo, Neuron Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M., & Diamond, M. I. 2016-11-23
Precise and Efficient Scarless genome editing in stem cells using CORRECT, Nature Protocols Kwart, D., Paquet, D., Teo, S., & Tessier-Lavigne, M. (2017). Precise and efficient scarless ge 2017-02-01
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature Paquet, D., Kwart, D., Chen, A., Sproul, A., Jacob, S., Teo, S., Olsen, K. M., Gregg, A., Noggle, S., & Tessier-Lavigne, M. 2016-04-27
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP beta-CTFs nto A beta, Neuron Kwart, D., Gregg, A., Scheckel, C., Murphy, E. A., Paquet, D., Duffield, M., Fak, J., Olsen, O., Darnell, R. B., & Tessier-Lavigne, M. 2019-08-12
The microglia response to neurodegenerative disease, Advances in Immunology Song, W. M., & Colonna, M. 2018-05-09
Disease-associated microglia: a universal immune sensor of neurodegeneration, Cell Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. 2018-05-17
Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination, Cell Reports Hou, J., Zhou, Y., Cai, Z., Terekhova, M., Swain, A., |hey, P. S., Guimaraes, R. M., Ulezko Antonova, A., Qiu, T., Sviben, S., Strout, G., Fitzpatrick, J. A. J., Chen, Y., Gilfillan, S., Kim, D. H., Van Dyken, S. J., Artyomov, M. N., & Colonna, M. 2023-03-21
The microglial immunoreceptor tyrosine-based motif-Syk signaling pathway is a promising target of immunotherapy for Alzheimer’s disease, Clinical and Translational Medicine Wang, S., & Colonna, M. 2023-02-11
Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations, Current Opinion in Immunology Chen, Y., & Colonna, M. 2022-07-12
TREM2-Dependent Effects on Microglia in Alzheimer’s Disease, Frontiers in Aging Neuroscience Zhou, Y., Ulland, T. K., & Colonna, M. 2018-07-09
A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages, Immunity Brioschi, S., Belk, J. A., Peng, V., Molgora, M., Rodrigues, P. F., Nguyen, K. M., Wang, S., Du, S., Wang, W. L., Grajales-Reyes, G. E., Ponce, J. M., Yuede, C. M., Li, Q., Baer, J. M., DeNardo, D. G., Gilfillan, S., Cella, M., Satpathy, A. T., & Colonna, M. 2023-02-14
TREM2 sustains microglial expansion during aging and response to demyelination, Journal of Clinical Investigation Poliani, P. L., Wang, Y., Fontana, E., Robinette, M. L., Yamanishi, Y., Gilfillan, S., & Colonna, M. 2015-04-20
Anti-human TREM2 Induces Microglia Proliferation and Reduces Pathology in an Alzheimer’s Disease Model, Journal of Experimental Medicine Wang, S., Mustafa, M., Yuede, C. M., Salazar, S. V., Kong, P., Long, H., Ward, M., Siddiqui, O., Paul, R., Gilfillan, S., Ibrahim, A., Rhinn, H., Tassi, I., Rosenthal, A., Schwabe, T., & Colonna, M. 2020-06-24
Sex-driven Modifiers of Alzheimer Risk: A Multimodality Brain Imaging Study, Neurology Rahman, A., Schelbaum, E., Hoffman, K., Diaz, I., Hristov, H., Andrews, R., Jett, S., Jackson, H., Lee, A., Sarva, H., Pahlajani, S., Matthews, D., Dyke, J., de Leon, M. J., Isaacson, R. S., Brinton, R. D., & Mosconi, L. 2020-06-24
Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife, Neurology Schelbaum, E., Loughlin, L., Jett, S., Zhang, C., Jang, G., Malviya, N., Hristov, H., Pahlajani, S., Isaacson, R., Dyke, J. P., Kamel, H., Brinton, R. D., & Mosconi, L. 2021-11-03
Increased Alzheimer’s Risk during the menopause transition: a 3-year longitudinal brain imaging study, PLoS One Mosconi, L., Rahman, A., Diaz, I., Wu, X., Scheyer, O., Hristov, H. W., Vallabhajosula, S., Isaacson, R. S., de Leon, M. J., & Brinton, R. D. 2018-12-12
Effects of sex and APOE ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for Alzheimer’s disease: A 31Phosphorus MR spectroscopy study, PLoS One Jett, S., Dyke, J. P., Boneu Yepez, C., Zarate, C., Carlton, C., Schelbaum, E., Jang, G., Pahlajani, S., Williams, S., Diaz Brinton, R., & Mosconi, L. 2023-02-14
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition, Scientific Reports Mosconi, L., Berti, V., Dyke, J., Schelbaum, E., Jett, S., Loughlin, L., Jang, G., Rahman, A., Hristov, H., Pahlajani, S., Andrews, R., Matthews, D., Etingin, O., Ganzer, C., de Leon, M., Isaacson, R., & Brinton, R. D. 2021-06-09
Sex and menopause impact 31P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with 11C-PiB PET amyloid-beta load, Scientific Reports Jett, S., Dyke, J. P., Andy, C., Schelbaum, E., Jang, G., Boneu Yepez, C., Pahlajani, S., Diaz, I., Diaz Brinton, R., & Mosconi, L. 2022-12-21
Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer’s disease, Phytomedicine Liang, Y., Lee, D. Y. W., Zhen, S., Sun, H., Zhu, B., Liu, J., Lei, D., Lin, C. J., Zhang, S., Jacques, N. A., Quinti, L., Ran, C., Wang, C., Griciuc, A., Choi, S. H., Dai, R. H., Efferth, T., Tanzi, R. E., & Zhang, C. 2022-05-13
Age- and glaucoma-induced changes to the ocular glymphatic system, Neurobiology of Disease Wang, X., Delle, C., Peng, W., Plá, V., Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, T., Libby, R. T., & Nedergaard, M. 2023-10-12
An Ocular Glymphatic Clearance System Removes β-Amyloid From the Rodent Eye, Science Translational Medicine Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Förstera, B., Peng, S., Shi, M., Ladrón-de-Guevara, A., Delle, C., Sigurdsson, B., Xavier, A. L. R., Ertürk, A., Libby, R. T., Chen, L., Thrane, A. S., & Nedergaard, M. 2020-03-25
The glymphatic pathway in neurological disorders, The Lancet Neurology Rasmussen, M. K., Mestre, H., & Nedergaard, M. 2018-11-01
Vascular dysfunction — The disregarded partner of Alzheimer’s disease, Alzheimer's & Dementia Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M., … Zlokovic, B. V. 2019-01-01
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology, Cell Mathys, H., Peng, Z., Boix, C. A., … Kellis, M. & Tsai, L. H. 2023-09-28
Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion, Cell Xiong, X., James, B. T., Boix, C. A., Park, Y. P., Galani, K., Victor, M. B., Sun, N., Hou, L., Ho, L. L., Mantero, J., Scannail, A. N., Dileep, V., Dong, W., Mathys, H., Bennett, D. A., Tsai, L. H., & Kellis, M. 2023-09-28
Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration, Cell Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., Kellis, M., & Tsai, L. H. 2023-09-28
Human microglial state dynamics in Alzheimer’s disease progression, Cell Sun, N., Victor, M. B., Park, Y. P., Xiong, X., Scannail, A. N., Leary, N., Prosper, S., Viswanathan, S., Luna, X., Boix, C. A., James, B. T., Tanigawa, Y., Galani, K., Mathys, H., Jiang, X., Ng, A. P., Bennett, D. A., Tsai, L. H., & Kellis, M. 2023-09-28
Single-Cell Transcriptomic Analysis of Alzheimer’s Disease, Nature Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., Martorell, A. J., Ransohoff, R. M., Hafler, B. P., Bennett, D. A., Kellis, M., & Tsai, L. H. 2019-05-01
Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes, Nature Medicine Blanchard, J. W., Bula, M., Davila-Velderrain, J., Akay, L. A., Zhu, L., Frank, A., Victor, M. B., Bonner, J. M., Mathys, H., Lin, Y. T., Ko, T., Bennett, D. A., Cam, H. P., Kellis, M., & Tsai, L. H. 2020-06-08
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble, Nature Neuroscience Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., & Tsai, L. H. 2020-10-05
MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration, Science Translational Medicine Barker, S. J., Raju, R. M., Milman, N. E. P., Wang, J., Davila-Velderrain, J., Gunter-Rahman, F., Parro, C. C., Bozzelli, P. L., Abdurrob, F., Abdelaal, K., Bennett, D. A., Kellis, M., & Tsai, L. H. 2021-11-03
BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1, Science Advances Singh, N., Benoit, M. R., Zhou, J., Das, B., Davila-Velderrain, J., Kellis, M., Tsai, L. H., Hu, X., & Yan, R. 2022-06-17
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains, Cell Arakhamia, T., Lee, C. E., Carlomagno, Y., Duong, D. M., Kundinger, S. R., Wang, K., Williams, D., DeTure, M., Dickson, D. W., Cook, C. N., Seyfried, N. T., Petrucelli, L., & Fitzpatrick, A. W. P. 2020-02-20
Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice, Nature Communications Lee, J., Dimitry, J. M., Song, J. H., Son, M., Sheehan, P. W., King, M. W., Travis Tabor, G., Goo, Y. A., Lazar, M. A., Petrucelli, L., & Musiek, E. S. 2023-08-25
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell Grossman, N., Bono, D., Dedic, N., Kodandaramaiah, S. B., Rudenko, A., Suk, H. J., Cassara, A. M., Neufeld, E., Kuster, N., Tsai, L. H., Pascual-Leone, A., & Boyden, E. S. 2017-06-01
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease, Cell Reports Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K. H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y. T., Su, S. C., Church, G. M., Tsai, L. H., & Yankner, B. A. 2019-01-29
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity, Cell Stem Cell Victor, M. B., Leary, N., Luna, X., Meharena, H. S., Scannail, A. N., Bozzelli, P. L., Samaan, G., Murdock, M. H., von Maydell, D., Effenberger, A. H., Cerit, O., Wen, H. L., Liu, L., Welch, G., Bonner, M., & Tsai, L. H. 2022-08-04
In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology Watson, L. A., & Tsai, L. H. 2017-12-23
Three-dimensional chromatin organization in brain function and dysfunction, Current Opinion in Neurobiology Dileep, V., & Tsai, L. H. 2021-06-07
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function, Genes & Development Akay, L. A., Effenberger, A. H., & Tsai, L. H. 2021-02-01
iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss, Glia Penney, J., Ralvenius, W. T., Loon, A., Cerit, O., Dileep, V., Milo, B., Pao, P. C., Woolf, H., & Tsai, L. H. 2023-11-15
Modeling Alzheimer’s Disease With iPSC-derived Brain Cells, Molecular Psychiatry Penney, J., Ralvenius, W. T., & Tsai, L. H. 2019-08-07
The road to restoring neural circuits for the treatment of Alzheiemer’s disease, Nature Canter, R. G., Penney, J., & Tsai, L. H. 2016-11-10
Insights into Alzheimer’s disease from single-cell genomic approaches, Nature Neuroscience Murdock, M. H., & Tsai, L. H. 2023-01-02
APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types., Neuron Lin, Y. T., Seo, J., Gao, F., Feldman, H. M., Wen, H. L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., Rueda, R., Kritskiy, O., Abdurrob, F., Peng, Z., Milo, B., Yu, C. J., Elmsaouri, S., Dey, D., Ko, T., Yankner, B. A., … Tsai, L. H. 2018-06-27
Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics, Frontiers in Molecular Neuroscience Ramamurthy, E., Welch, G., Cheng, J., Yuan, Y., Gunsalus, L., Bennett, D. A., Tsai, L. H., & Pfenning, A. R. 2023-01-06
Single-cell dissection of the human brain vasculature, Nature Garcia, F. J., Sun, N., Lee, H., Godlewski, B., Mathys, H., Galani, K., Zhou, B., Jiang, X., Ng, A. P., Mantero, J., Tsai, L. H., Bennett, D. A., Sahin, M., Kellis, M., & Heiman, M. 2022-02-14
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease., Nature Aging Sun, N., Akay, L. A., Murdock, M. H., Park, Y., Galiana-Melendez, F., Bubnys, A., Galani, K., Mathys, H., Jiang, X., Ng, A. P., Bennett, D. A., Tsai, L. H., & Kellis, M. 2023-06-01
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience, Nature Neuroscience Udeochu, J. C., Amin, S., … Tsai, L. H., Subhash, S. C., & Gan, L. 2023-04-24
Sex and Gender Driven Modifiers of Alzheimer’s: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risk, Frontiers in Aging Neuroscience Rahman, A., Jackson, H., Hristov, H., Isaacson, R. S., Saif, N., Shetty, T., Etingin, O., Henchcliffe, C., Brinton, R. D., & Mosconi, L. 2019-11-15
Endogenous and Exogenous Estrogen Exposures: How Women’s Reproductive Health Can Drive Brain Aging and Inform Alzheimer’s Prevention, Frontiers in Aging Neuroscience Jett, S., Malviya, N., Schelbaum, E., Jang, G., Jahan, E., Clancy, K., Hristov, H., Pahlajani, S., Niotis, K., Loeb-Zeitlin, S., Havryliuk, Y., Isaacson, R., Brinton, R. D., & Mosconi, L. 2022-03-09
Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disea, Frontiers in Aging Neuroscience Jett, S., Schelbaum, E., Jang, G., Boneu Yepez, C., Dyke, J. P., Pahlajani, S., Diaz Brinton, R., & Mosconi, L. 2022-07-19
Vitamin D supplementation is associated with slower epigenetic aging, GeroScience Vetter, V. M., Sommerer, Y., Kalies, C. H., Spira, D., Bertram, L., & Demuth, I. 2022-05-13
Common signatures of differential microRNA expression in Parkinson’s and Alzheimer’s disease brains, Brain Communications Dobricic, V., Schilling, M., Farkas, I., Gveric, D. O., Ohlei, O., Schulz, J., Middleton, L., Gentleman, S. M., Parkkinen, L., Bertram, L., & Lill, C. M. 2022-10-28
Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families, BMC Medical Genetics Park, S., Lee, S., Lee, Y., Herold, C., Hooli, B., Mullin, K., Park, T., Park, C., Bertram, L., Lange, C., Tanzi, R., & Won, S. 2015-08-19
Genome-wide Association Analysis Reveals Putative Alzheimer’s Disease Susceptibility Loci in Addition to APOE, American Journal of Human Genetics Bertram, L., Lange, C., Mullin, K., Parkinson, M., Hsiao, M., Hogan, M. F., Schjeide, B. M., Hooli, B., Divito, J., Ionita, I., Jiang, H., Laird, N., Moscarillo, T., Ohlsen, K. L., Elliott, K., Wang, X., Hu-Lince, D., Ryder, M., Murphy, A., Wagner, S. L., Blacker, D., … Tanzi, R. E. 2008-10-30
The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzhiemer Disease risk and cerebrospinal fluid biomarker levels, Archives of General Psychiatry Schjeide, B. M., Schnack, C., Lambert, J. C., Lill, C. M., Kirchheiner, J., Tumani, H., Otto, M., Tanzi, R. E., Lehrach, H., Amouyel, P., von Arnim, C. A., & Bertram, L. 2011-02-01
On the Meta-Analysis of Genome-Wide Association studies: a robust and efficient approach to combine population and family-based studies, Human Heredity Won, S., Lu, Q., Bertram, L., Tanzi, R. E., & Lange, C. 2012-01-18
Genome-wide association studies in Alzheimer’s Disease, Human Molecular Genetics Bertram, L., & Tanzi, R. E. 2009-10-15
Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neuroscience Bertram, L., & Tanzi, R. E. 2008-10-01
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk, Neurology Hooli, B. V., Parrado, A. R., Mullin, K., Yip, W. K., Liu, T., Roehr, J. T., Qiao, D., Jessen, F., Peters, O., Becker, T., Ramirez, A., Lange, C., Bertram, L., & Tanzi, R. E. 2014-10-07
The Genetics of Alzheimer’s disease: back to the future, Neuron Bertram, L., Lill, C. M., & Tanzi, R. E. 2010-10-21
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid, Neuroscience Letters Giedraitis, V., Glaser, A., Sarajärvi, T., Brundin, R., Gunnarsson, M. D., Schjeide, B. M., Tanzi, R. E., Helisalmi, S., Pirttilä, T., Kilander, L., Lannfelt, L., Soininen, H., Bertram, L., Ingelsson, M., & Hiltunen, M. 2010-01-22
Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson’s Disease Genetics: the PDGene database, PLoS Genetics Lill, C. M., Roehr, J. T., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B. M., Schjeide, L. M., Meissner, E., … Tanzi, R. E., ... Bertram, L. 2012-03-15
Genomic Mechanisms in Alzheimer’s Disease, Brain Pathology Bertram, L., & Tanzi, R. E. 2020-09-08
GAB2 as an Alzheimer Disease Susceptibility Gene, Archives of Neurology Schjeide, B. M., Hooli, B., Parkinson, M., Hogan, M. F., DiVito, J., Mullin, K., Blacker, D., Tanzi, R. E., & Bertram, L. 2009-02-01
Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2, Molecular Psychiatry Prokopenko, D., Lee, S., Hecker, J., Mullin, K., Morgan, S., Katsumata, Y., Alzheimer’s Disease Neuroimaging Initiative (ADNI), Weiner, M. W., Fardo, D. W., Laird, N., Bertram, L., Hide, W., Lange, C., & Tanzi, R. E. 2022-03-04
The gut microbiota is an emerging target for improving brain health during ageing, Gut Microbiome Boehme, M., Guzzetta, K. E., Wasén, C., & Cox, L. M. 2022-12-12
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss, Neuron Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E., & Rajendran, L. 2017-07-19
Abeta-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice, Science Translational Medicine Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B. A., Hofmann, O., Hide, W., Procissi, D., Hanania, T., Leiser, S. C., Tanzi, R. E., & Vassar, R. 2020-09-30
Chronic Traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model, Science Translational Medicine Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X. L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., Goletiani, C. J., Maglakelidze, G. M., Casey, N., Moncaster, J. A., Minaeva, O., Moir, R. D., … Tanzi, R. E., ... McKee, A. C. 2012-05-16
The endolysosomal pathway and ALS/FTD, Trends in Neurosciences Todd, T. W., Shao, W., Zhang, Y. J., & Petrucelli, L. 2023-10-10
Alzheimer’s Genetics in the GWAS Era: A Continuing Story of ‘Replications and Refutations’, Current Neurology and Neuroscience Reports Bertram L. 2011-03-30
Distinguishing true from false positives in genomic studies: p values, European Journal of Epidemiology Broer, L., Lill, C. M., Schuur, M., Amin, N., Roehr, J. T., Bertram, L., Ioannidis, J. P., & van Duijn, C. M. 2013-02-01
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining, Genetics in Medicine Wallace, B. C., Small, K., Brodley, C. E., Lau, J., Schmid, C. H., Bertram, L., Lill, C. M., Cohen, J. T., & Trikalinos, T. A. 2023-07-12
Developing the “Next Generation: of genetic association databases for complex diseases, Human Mutation Lill, C. M., & Bertram, L. 2023-07-12
Systematic Analysis of Candidate Genes for Alzheimer’s Disease in a French, Genome-Wide Association Study, Journal of Alzheimer's Disease Laumet, G., Chouraki, V., Grenier-Boley, B., Legry, V., Heath, S., Zelenika, D., Fievet, N., Hannequin, D., Delepine, M., Pasquier, F., Hanon, O., Brice, A., Epelbaum, J., Berr, C., Dartigues, J. F., Tzourio, C., Campion, D., Lathrop, M., Bertram, L., Amouyel, P., … Lambert, J. C. 2010-06-13
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects, Journal of Medical Genetics Lill, C. M., Liu, T., Schjeide, B. M., Roehr, J. T., Akkad, D. A., Damotte, V., Alcina, A., Ortiz, M. A., … Bertram, L., Zipp, F. 2012-09-01
Genome-wide significant associations of ANKRD55 rs6859219 and multiple sclerosis risk, Journal of Medical Genetics Lill, C. M., Schjeide, B. M., Graetz, C., Liu, T., Damotte, V., Akkad, D. A., Blaschke, P., Gerdes, L. A., Kroner, A., Luessi, F., Cournu-Rebeix, I., Hoffjan, S., Winkelmann, A., Touze, E., Pico, F., Corcia, P., Otaegui, D., Antigüedad, A., Alcina, A., Comabella, M., … Bertram, L. 2013-01-12
Impact of Parkinson’s disease risk loci on age at onset, Movement Disorders Lill, C. M., Hansen, J., Olsen, J. H., Binder, H., Ritz, B., & Bertram, L. 2015-04-25
Genetic variants in PSEN2 and correlation to CSF beta-amyloid 42 levels in AD, Neurobiology of Aging Lebedeva, E., Stingl, J. C., Thal, D. R., Ghebremedhin, E., Strauss, J., Özer, E., Bertram, L., von Einem, B., Tumani, H., Otto, M., Riepe, M. W., Högel, J., Ludolph, A. C., & von Arnim, C. A. 2010-09-20
Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample, Neurogenetics Lill, C. M., Schjeide, B. M., Akkad, D. A., Blaschke, P., Winkelmann, A., Gerdes, L. A., Hoffjan, S., Luessi, F., … Bertram, L., Zipp, F. 2012-11-18
Assessment of micro-RNA-related SNP effects in the 3′ untranslated region of the IL22RA2 risk locus in multiple sclerosis, Neurogenetics Lill, C. M., Schilling, M., Ansaloni, S., Schröder, J., Jaedicke, M., … Bertram, L. 2014-03-18
Call for participation in the neurogenetics consortium within the Human Variome Project, Neurogenetics Haworth, A., Bertram, L., … Sobrido, M. J. 2011-06-01
Serum iron levels and the risk of Parkinson Disease: A mendelian randomization study., PLoS Medicine Pichler, I., Del Greco M, F., Gögele, M., Lill, C. M., Bertram, L., Do, C. B., Eriksson, N., Foroud, T., Myers, R. H., PD GWAS Consortium, Nalls, M., Keller, M. F., International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin, B., Whitfield, J. B., Genetics of Iron Status Consortium, Pramstaller, P. P., Hicks, A. A., Thompson, J. R., … Minelli, C. 2013-06-04
Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias, PLoS One Pfeiffer, T., Bertram, L., & Ioannidis, J. P. 2011-03-29
Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene), Public Health Genomics Dolan, S. M., Hollegaard, M. V., Merialdi, M., Betran, A. P., Allen, T., Abelow, C., Nace, J., Lin, B. K., Khoury, M. J., Ioannidis, J. P., Bagade, S., Zheng, X., Dubin, R. A., Bertram, L., Velez Edwards, D. R., & Menon, R. 2010-05-20
Towards Unveiling the Genetics of Neurodegenerative Diseases, Seminars in Neurology Lill, C. M., & Bertram, L. 2012-01-21
Relationship Between 5 Epigenetic Clocks, Telomere Length, and Functional Capacity Assessed in Older Adults: Cross-Sectional and Longitudinal Analyses, The Journals of Gerontology: Series A Vetter, V. M., Kalies, C. H., Sommerer, Y., Spira, D., Drewelies, J., Regitz-Zagrosek, V., Bertram, L., Gerstorf, D., & Demuth, I. 2022-01-15
Epigenetic aging and perceived psychological stress in old age, Translational Psychiatry Vetter, V. M., Drewelies, J., Sommerer, Y., Kalies, C. H., Regitz-Zagrosek, V., Bertram, L., Gerstorf, D., & Demuth, I. 2022-09-26
The pursuit of susceptibility genes for Alzhiemer’s disease: progress and prospects, Trends in Genetics Sleegers, K., Lambert, J. C., Bertram, L., Cruts, M., Amouyel, P., & Van Broeckhoven, C. 2010-01-18
Seven-CpG DNA Methylation Age Determined by Single Nucleotide Primer Extension and Illumina’s Infinium MethylationEPIC Array Provide Highly Comparable Results, Frontiers in Genetics Vetter, V. M., Kalies, C. H., Sommerer, Y., Bertram, L., & Demuth, I. 2022-01-17
The Endosomal-Lysosomal Pathway is Dysregulated by APOE4 Expression in Vivo, Frontiers in Neuroscience Nuriel, T., Peng, K. Y., Ashok, A., Dillman, A. A., Figueroa, H. Y., Apuzzo, J., Ambat, J., Levy, E., Cookson, M. R., Mathews, P. M., & Duff, K. E. 2017-12-12
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology, Nature Communications Nuriel, T., Angulo, S. L., Khan, U., Ashok, A., Chen, Q., Figueroa, H. Y., Emrani, S., Liu, L., Herman, M., Barrett, G., Savage, V., Buitrago, L., Cepeda-Prado, E., Fung, C., Goldberg, E., Gross, S. S., Hussaini, S. A., Moreno, H., Small, S. A., & Duff, K. E. 2017-11-13
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology, Nature Neuroscience Fu, H., Possenti, A., Freer, R., Nakano, Y., Hernandez Villegas, N. C., Tang, M., Cauhy, P. V. M., Lassus, B. A., Chen, S., Fowler, S. L., Figueroa, H. Y., Huey, E. D., Johnson, G. V. W., Vendruscolo, M., & Duff, K. E. 2018-12-17
Targeting the 26S Proteasome to Protect against Proteotoxic Diseases, Trends in Molecular Medicine Myeku, N., & Duff, K. E. 2017-12-09
Selective vulnerability in neurodegenerative diseases, Nature Neuroscience Fu, H., Hardy, J., & Duff, K. E. 2018-09-24
Neuronal activity enhances tau propagation and tau pathology in vivo, Nature Neuroscience Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S., & Duff, K. E. 2016-06-20
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice, Scientific Reports Area-Gomez, E., Larrea, D., Pera, M., Agrawal, R. R., Guilfoyle, D. N., Pirhaji, L., Shannon, K., Arain, H. A., Ashok, A., Chen, Q., Dillman, A. A., Figueroa, H. Y., Cookson, M. R., Gross, S. S., Fraenkel, E., Duff, K. E., & Nuriel, T. 2020-03-09
Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice, Translational Psychiatry Miranda, A. M., Ashok, A., Chan, R. B., Zhou, B., Xu, Y., McIntire, L. B., Area-Gomez, E., Di Paolo, G., Duff, K. E., Oliveira, T. G., & Nuriel, T. 2022-03-29
Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease, JAMA Neurology Taddei, R. N., Perbet, R., Mate de Gerando, A., Wiedmer, A. E., Sanchez-Mico, M., Connors Stewart, T., Gaona, A., Melloni, A., Amaral, A. C., Duff, K., Frosch, M. P., & Gómez-Isla, T. 2023-10-09
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator, Annals of Neurology Chen, X. Q., Sawa, M., Becker, A., Karachentsev, D., Zuo, X., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. 2023-04-11
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators, Bioorganic and Medicinal Chemistry Rynearson, K. D., Buckle, R. N., Herr, R. J., Mayhew, N. J., Chen, X., Paquette, W. D., Sakwa, S. A., Yang, J., Barnes, K. D., Nguyen, P., Mobley, W. C., Johnson, G., Lin, J. H., Tanzi, R. E., & Wagner, S. L. 2020-09-01
African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants, Neurology Genetics Schindler, S. E., Cruchaga, C., Joseph, A., McCue, L., Farias, F. H. G., Wilkins, C. H., Deming, Y., Henson, R. L., Mikesell, R. J., Piccio, L., Llibre-Guerra, J. J., Moulder, K. L., Fagan, A. M., Ances, B. M., Benzinger, T. L. S., Xiong, C., Holtzman, D. M., & Morris, J. C. 2021-03-04
Distinct Cytokine Profiles in human brains resilient to Alzheimer’s pathology, Neuroiology of Disease Barroeta-Espar, I., Weinstock, L. D., Perez-Nievas, B. G., Meltzer, A. C., Siao Tick Chong, M., Amaral, A. C., Murray, M. E., Moulder, K. L., Morris, J. C., Cairns, N. J., Parisi, J. E., Lowe, V. J., Petersen, R. C., Kofler, J., Ikonomovic, M. D., López, O., Klunk, W. E., … Gomez-Isla, T. 2018-10-15
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light, Neurology Schindler, S. E., Karikari, T. K., Ashton, N. J., Henson, R. L., Yarasheski, K. E., West, T., Meyer, M. R., Kirmess, K. M., Li, Y., Saef, B., Moulder, K. L., Bradford, D., Fagan, A. M., Gordon, B. A., Benzinger, T. L. S., Balls-Berry, J., Bateman, R. J., Xiong, C., Zetterberg, H., Blennow, K., … Morris, J. C. 2022-04-21
Liver-ing in your head rent free: peripheral ApoE4 drives CNS pathology, Molecular Neurodegeneration Golden, L. R., & Johnson, L. A. 2022-10-04
Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias, Alzheimer's & Dementia Yassine, H. N., Self, W., Kerman, B. E., Santoni, G., Navalpur Shanmugam, N., Abdullah, L., Golden, L. R., Fonteh, A. N., Harrington, M. G., Gräff, J., Gibson, G. E., Kalaria, R., Luchsinger, J. A., Feldman, H. H., Swerdlow, R. H., Johnson, L. A., Albensi, B. C., Zlokovic, B. V., Tanzi, R., Cunnane, S., … Bowman, G. L. 2022-12-08
The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease, Alzheimer's & Dementia Lill, C. M., Rengmark, A., Pihlstrøm, L., Fogh, I., Shatunov, A., Sleiman, P. M., Wang, L. S., Liu, T., Lassen, C. F., Meissner, E., Alexopoulos, P., Calvo, A., Chio, A., Dizdar, N., Faltraco, F., Forsgren, L., Kirchheiner, J., Kurz, A., Larsen, J. P., Liebsch, M., … Bertram, L. 2015-04-30
Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study, BMJ Open Demuth, I., Banszerus, V., Drewelies, J., Düzel, S., Seeland, U., Spira, D., Tse, E., Braun, J., Steinhagen-Thiessen, E., Bertram, L., Thiel, A., Lindenberger, U., Regitz-Zagrosek, V., Gerstorf, D., & Additional BASE-II/GendAge investigators 2021-07-23
MANBA, CXCR5, SOX8, RPS6KB1, ZBTB46 are genetic risk loci for multiple sclerosis, Brain International Multiple Sclerosis Genetics Consortium, Lill, C. M., Schjeide, B. M., Graetz, C., Ban, M., Alcina, A., Ortiz, M. A., Pérez, J., Damotte, V., Booth, D., Lopez de Lapuente, A., Broer, L., Schilling, M., Akkad, D. A., Aktas, O., Alloza, I., Antigüedad, A., Arroyo, R., Blaschke, P., Buttmann, M., … Bertram, L., Zipp, F. 2013-06-04
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition, and biomarkers, Brain Imaging and Behavior Shen, L., Thompson, P. M., Potkin, S. G., Bertram, L., Farrer, L. A., Foroud, T. M., Green, R. C., … Alzheimer’s Disease Neuroimaging Initiative 2013-10-05
Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase, Journal of Pharmacology and Experimental Therapeutics Lazo, J. S., Isbell, K. N., Vasa, S. A., Llaneza, D. C., Rastelli, E. J., Wipf, P., & Sharlow, E. R. 2023-02-23
Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin, Molecular Pharmacology Czub, M. P., Boulton, A. M., Rastelli, E. J., Tasker, N. R., Maskrey, T. S., Blanco, I. K., McQueeney, K. E., Bushweller, J. H., Minor, W., Wipf, P., Sharlow, E. R., & Lazo, J. S. 2020-09-25
New Approaches to Difficult Drug Discovery, SLAS Discovery Lazo, J. S., McQueeney, K. E., & Sharlow, E. R. 2017-07-26
Functional characterization of the dural sinuses as a neuroimmune interface, Cell Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., Erdmann-Gilmore, P., … Kipnis, J. 2021-01-27
Cerebrovascular Anomalies: Perspectives From Immunology and Cerebrospinal Fluid Flow, Circulation Research Rustenhoven, J., Tanumihardja, C., & Kipnis, J. 2021-06-25
Immune Cells and CNS physiology: microglia and beyond, Journal of Experimental Medicine Norris, G. T., & Kipnis, J. 2018-11-30
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease, Nature Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., … Kipnis, J. 2018-07-25
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels, Nature Neuroscience Mazzitelli, J. A., Smyth, L. C. D., Cross, K. A., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J., & Kipnis, J. 2022-03-17
Lymphatics in Neurological Disorders: a neuro-lympho-vascular component of multiple sclerosis and Alzheimer’s disease?, Neuron Louveau, A., Da Mesquita, S., & Kipnis, J. 2016-09-07
The meningeal lymphatic system: a new player in neurophysiology, Neuron Da Mesquita, S., Fu, Z., & Kipnis, J. 2018-10-24
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology, Scientific Advances Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J. 2021-05-21
Skull bone marrow channels as immune gateways to the central nervous system, Nature Neuroscience Mazzitelli, J. A., Pulous, F. E., Smyth, L. C. D., Kaya, Z., Rustenhoven, J., Moskowitz, M. A., Kipnis, J., & Nahrendorf, M. 2023-11-23
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport, JCI Insight Ozturk, B., Koundal, S., Al Bizri, E., Chen, X., Gursky, Z. H., Dai, F., Lim, A. S., Heerdt, P., Kipnis, J., Tannenbaum, A., Lee, H., & Benveniste, H. 2023-05-09
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling, Neuron Kim, E., Kim, H., Jedrychowski, M. P., Bakiasi, G., Park, J., Kruskop, J., Choi, Y., Kwak, S. S., Quinti, L., Kim, D. Y., Wrann, C. D., Spiegelman, B. M., Tanzi, R. E., & Choi, S. H. 2023-09-08
3D Miniaturization of Human Organs for Drug Discovery, Advanced Healthcare Materials Park, J., Wetzel, I., Dréau, D., & Cho, H. 2017-09-08
Dynamic DNA methylation in the right place at the right time, Science Luo, C., Hajkova, P., & Ecker, J. R. 2018-09-28
Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika virus microcephaly, iScience Fujimura, K., Guise, A. J., Nakayama, T., Schlaffner, C. N., Meziani, A., Kumar, M., Cheng, L., Vaughan, D. J., Kodani, A., Van Haren, S., Parker, K., Levy, O., Durbin, A. F., Bosch, I., Gehrke, L., Steen, H., Mochida, G. H., & Steen, J. A. 2023-05-19
A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics, Science Advances Viode, A., van Zalm, P., Smolen, K. K., Fatou, B., Stevenson, D., Jha, M., Levy, O., Steen, J., Steen, H., & IMPACC Network 2023-03-29
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function., EMBO Molecular Medicine Schlepckow, K., Kleinberger, G., Fukumori, A., Feederle, R., Lichtenthaler, S. F., Steiner, H., & Haass, C. 2017-08-30
P62 accumulates through neuroanatomical circuits in response to tauopathy propagation, Acta Neuropathologica Communications Blaudin de Thé, F. X., Lassus, B., Schaler, A. W., Fowler, S. L., Goulbourne, C. N., Jeggo, R., Mannoury la Cour, C., Millan, M. J., & Duff, K. E. 2021-11-02
Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro, Molecular Neurodegeneration Cadiz, M. P., Jensen, T. D., Sens, J. P., Zhu, K., Song, W. M., Zhang, B., Ebbert, M., Chang, R., & Fryer, J. D. 2022-03-28
Widespread choroid plexus contamination in sampling and profiling of brain tissue, Molecular Psychiatry Olney, K. C., Todd, K. T., Pallegar, P. N., Jensen, T. D., Cadiz, M. P., Gibson, K. A., Barnett, J. H., de Ávila, C., Bouchal, S. M., Rabichow, B. E., Ding, Z., Wojtas, A. M., Wilson, M. A., & Fryer, J. D. 2022-01-05
APOE2 is associated with longevity independent of Alzheimer’s disease, eLife Shinohara, M., Kanekiyo, T., Tachibana, M., Kurti, A., Shinohara, M., Fu, Y., Zhao, J., Han, X., Sullivan, P. M., Rebeck, G. W., Fryer, J. D., Heckman, M. G., & Bu, G. 2020-10-19
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation, Acta Neuropathologica Communications Wojtas, A. M., Carlomagno, Y., Sens, J. P., Kang, S. S., Jensen, T. D., Kurti, A., Baker, K. E., Berry, T. J., Phillips, V. R., Castanedes, M. C., Awan, A., DeTure, M., De Castro, C. H. F., Librero, A. L., Yue, M., Daughrity, L., Jansen-West, K. R., Cook, C. N., Dickson, D. W., Petrucelli, L., Fryer, J. D. 2020-12-01
Astrocyte-derived clusterin suppresses amyloid formation in vivo, Molecular Neurodegeneration Wojtas, A. M., Sens, J. P., Kang, S. S., Baker, K. E., Berry, T. J., Kurti, A., Daughrity, L., Jansen-West, K. R., Dickson, D. W., Petrucelli, L., Bu, G., Liu, C. C., & Fryer, J. D. 2020-11-27
Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function, Neuron Yamazaki, Y., Liu, C. C., Yamazaki, A., Shue, F., Martens, Y. A., Chen, Y., Qiao, W., Kurti, A., Oue, H., Ren, Y., Li, Y., Aikawa, T., Cherukuri, Y., Fryer, J. D., Asmann, Y. W., Kim, B. Y. S., Kanekiyo, T., & Bu, G. 2020-12-14
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease, Nature Immunology Liu, C. C., Wang, N., Chen, Y., Inoue, Y., … Fryer, J. D., … Bu, G. 2023-10-19
Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology, Cell Reports Wood, J. I., Wong, E., Joghee, R., Balbaa, A., Vitanova, K. S., Stringer, K. M., Vanshoiack, A., Phelan, S. J., Launchbury, F., Desai, S., Tripathi, T., Hanrieder, J., Cummings, D. M., Hardy, J., & Edwards, F. A. 2022-11-22
Wakefulness and loss of awareness: brain and brainstem interactio in the vegetative state, Neurology Silva, S., Alacoque, X., Fourcade, O., Samii, K., Marque, P., Woods, R., Mazziotta, J., Chollet, F., & Loubinoux, I. 2010-01-26
Increased soluble TREM2 in cerebospinal fluid is associated with reduced cognitvie and clinical decline, Science Translational Medicine Ewers, M., Franzmeier, N., Suárez-Calvet, M., Morenas-Rodriguez, E., Caballero, M. A. A., Kleinberger, G., Piccio, L., Cruchaga, C., Deming, Y., Dichgans, M., Trojanowski, J. Q., Shaw, L. M., Weiner, M. W., Haass, C., & Alzheimer’s Disease Neuroimaging Initiative 2019-08-28
The Alzheimer’s disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology, Alzheimer's & Dementia Samuels, J. D., Moore, K. A., Ennerfelt, H. E., Johnson, A. M., Walsh, A. E., Price, R. J., & Lukens, J. R. 2023-04-15
SYK coordinates neuroprotective microglial responses in neurodegenerative disease, Cell Ennerfelt, H., Frost, E. L., Shapiro, D. A., Holliday, C., Zengeler, K. E., Voithofer, G., Bolte, A. C., Lammert, C. R., Kulas, J. A., Ulland, T. K., & Lukens, J. R. 2022-10-17
Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer’s disease and multiple sclerosis, Clinical and Translational Medicine Ennerfelt, H., & Lukens, J. R. 2023-01-11
How neurons die in Alzheimer’s disease: Implications for neuroinflammation, Current Opinion in Neurobiology Mangalmurti A, Lukens JR. 2022-06-10
The innate immune response in tauopathies, European Journal of Immunoogy Johnson, A. M., & Lukens, J. R. 2023-03-18
An introduction to neuroimmunology, Immunological Reviews Lukens, J. R., & Williams, J. L. 2022-08-30
Emerging roles for ITAM and ITIM receptor signaling in microglial biology and Alzheimer’s disease-related amyloidosis, Journal of Neurochemistry Samuels, J. D., Lukens, J. R., & Price, R. J. 2023-10-11
CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model, Proceedings of the National Academy of Sciences of the United States of America Ennerfelt, H., Holliday, C., Shapiro, D. A., Zengeler, K. E., Bolte, A. C., Ull|, T. K., & Lukens, J. R. 2023-06-05
A potent selective allosteric PTP4A3 phosphatase inhibitor enhances microvascular barrier function and inhibits human tumor cell growth, The FASEB Journal Lazo, J. S., McQueeney, K. E., Salamoun. J. M., Barabutis, N., Catravas, J.D., Wipf, P. 2018-04-01
Small molecule targeting of PTPs in Cancer, International Journal of Biochemistry & Cell Biology Lazo, J. S., McQueeney, K. E., Burnett, J. C., Wipf, P., & Sharlow, E. R. 2017-09-21
Cellular Control of Brain Capillary Blood Flow: In vivo imaging veritas, Trends in Neurosciences Grutzendler, J., & Nedergaard, M. 2019-06-26
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy, Nature Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D., & Holtzman, D. M. 2023-03-08
Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system, Cellular and Molecular Life Sciences Gonuguntla, S., & Herz, J. 2023-11-20
TREM2 Function in Alzheimer’s Disease and Neurodegeneration, ACS Chemical Neuroscience Ulrich, J. D., & Holtzman, D. M. 2016-02-08
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A beta accumulation and plaque-related pathology in a mouse model of amyloidosi, Molecular Neurodegeneration Mahan, T. E., Wang, C., Bao, X., Choudhury, A., Ulrich, J. D., & Holtzman, D. M. 2022-02-02
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis, Molecular Neurodegeneration Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., Landreth, G. E., Castellano, J. M., Jiang, H., Cirrito, J. R., & Holtzman, D. M. 2013-04-19
Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration, Life Science Alliance Drieu, A., Du, S., Kipnis, M., Bosch, M. E., Herz, J., Lee, C., Jiang, H., Manis, M., Ulrich, J. D., Kipnis, J., Holtzman, D. M., & Gratuze, M. (2023). Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration. Life science alliance, 6(11), e202302087. https://doi.org/10.26508/lsa.202302087 2023-08-10
APoE facilitates the microglia response to amyloid plaque pathology, Journal of Experimental Medicine Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., Stewart, F. R., Anderson, E., Wang, Y., Colonna, M., & Holtzman, D. M. 2018-02-26
Elucidating the role of TREM2 in Alzheimer’s Disease, Neuron Ulrich, J. D., Ulland, T. K., Colonna, M., & Holtzman, D. M. 2017-04-19
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy, Proceedings of the National Academy of Sciences of the United States of America Leyns, C. E. G., Ulrich, J. D., Finn, M. B., Stewart, F. R., Koscal, L. J., Remolina Serrano, J., Robinson, G. O., Anderson, E., Colonna, M., & Holtzman, D. M. 2017-10-09
Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis, Neuron Roussarie, J. P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E. F., Dannenfelser, R., Tadych, A., Brichta, L., Barnea-Cramer, A., Heintz, N., Hof, P. R., Heiman, M., Dolinski, K., Flajolet, M., Troyanskaya, O. G., … Greengard, P. 2020-06-29
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals, Cell Systems Hark, T. J., Rao, N. R., Castillon, C., Basta, T., Smukowski, S., Bao, H., Upadhyay, A., Bomba-Warczak, E., Nomura, T., O'Toole, E. T., Morgan, G. P., Ali, L., Saito, T., Guillermier, C., Saido, T. C., Steinhauser, M. L., Stowell, M. H. B., Chapman, E. R., Contractor, A., & Savas, J. N. 2020-12-15
Using stable isotope labeling to advance our understanding of Alzheimer’s disease etiology and pathology, Journal of Neurochemistry Hark, T. J., & Savas, J. N. 2021-02-02
Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice, Journal of Proteome Research Rao, N. R., & Savas, J. N. 2021-06-09
Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease, Journal of Visualized Experiments Goldman, C., Suhy, N., Schwarz, J. E., Sartori, E. R., Rooklin, R. B., Schuldt, B. R., Mesentier-Louro, L. A., & Blanchard, J. W. 2023-10-20
Modeling the Blood-Brain Barrier Using Human-Induced Pluripotent Stem Cells, Methods in Molecular Biology Mesentier-Louro, L. A., Suhy, N., Broekaart, D., Bula, M., Pereira, A. C., & Blanchard, J. W. 2023-06-11
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes, Nature Blanchard, J. W., Akay, L. A., Davila-Velderrain, J., von Maydell, D., … Kellis, M., Tsai, L. H. 2022-11-16
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease, Nature Aging Barthélemy, N. R., Saef, B., Li, Y., Gordon, B. A., He, Y., Horie, K., Stomrud, E., Salvadó, G., Janelidze, S., Sato, C., Ovod, V., Henson, R. L., Fagan, A. M., Benzinger, T. L. S., Xiong, C., Morris, J. C., Hansson, O., Bateman, R. J., & Schindler, S. E. 2023-03-13
Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: a serial magnetic resonance imaging study, Alzheimer's & Dementia Kinnunen, K. M., Cash, D. M., Poole, T., Frost, C., Benzinger, T. L. S., Ahsan, R. L., Leung, K. K., Cardoso, M. J., Modat, M., Malone, I. B., Morris, J. C., Bateman, R. J., Marcus, D. S., Goate, A., Salloway, S. P., Correia, S., Sperling, R. A., Chhatwal, J. P., Mayeux, R. P., Brickman, A. M., Martins, R. N., Farlow, M. R., Ghetti, B., Saykin, A. J., Jack, Jr., C. R., Schofield, P. R., McDade, E., Weiner, M. W., Ringman, J. M., Thompson, P. M., Masters, C. L., Rowe, C. C., Rossor, M. N., Ourselin, S., & Fox, N. C. 2017-07-22
Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models, Translational Psychiatry Cacciottolo, M., Wang, X., Driscoll, I., Woodward, N., Saffari, A., Reyes, J., Serre, M. L., Vizuete, W., Sioutas, C., Morgan, T. E., Gatz, M., Chui, H. C., Shumaker, S. A., Resnick, S. M., Espeland, M. A., Finch, C. E., & Chen, J. C. 2017-01-01
Inhibition of PKC delta reduces amyloid-beta levels and reverses Alzheimer’s disease phenotypes, Journal of Experimental Medicine Du, Y., Zhao, Y., Li, C., Zheng, Q., Tian, J., Li, Z., Huang, T. Y., Zhang, W., & Xu, H. 2018-05-08
Arginine Methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons, Journal of Neuroscience Simandi Z, Pajer K, Karolyi K, Sieler T, Jiang LL, Kolostyak Z, Sari Z, Fekecs Z, Pap A, Patsalos A, Contreras GA, Reho B, Papp Z, Guo X, Horvath A, Kiss G, Keresztessy Z, Vámosi G, Hickman J, Xu H, Dormann D, Hortobagyi T, Antal M, Nógrádi A, Nagy L. 2018-08-29
ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating gamma-secretase activity, Nature Communications Zhu, B., Jiang, L., Huang, T., Zhao, Y., Liu, T., Zhong, Y., Li, X., Campos, A., Pomeroy, K., Masliah, E., Zhang, D., & Xu, H. 2017-11-13
Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathologicla phenotypes in Alzheimer’s disease models, Neuron Lee, C. Y. D., Daggett, A., Gu, X., Jiang, L. L., Langfelder, P., Li, X., Wang, N., Zhao, Y., Park, C. S., Cooper, Y., Ferando, I., Mody, I., Coppola, G., Xu, H., & Yang, X. W. 2018-03-07
TREM2 is a receptor for beta-amyloid that mediates microglia function, Neuron Zhao, Y., Wu, X., Li, X., Jiang, L. L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., Zhang, N., Chen, X., Bu, G., An, Z., Huang, T. Y., & Xu, H. 2018-03-07
Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 experssion, Cell Reports Zhuang, K., Huang, C., Leng, L., Zheng, H., Gao, Y., Chen, G., Ji, Z., Sun, H., Hu, Y., Wu, D., Shi, M., Li, H., Zhao, Y., Zhang, Y., Xue, M., Bu, G., Huang, T. Y., Xu, H., & Zhang, J. 2018-07-17
SNX27 Deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis, Journal of Neuroscience Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H. 2016-12-14
TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers in Aging Neuroscience Zhong L, Zhang ZL, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen XF. 2017-06-21
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes, Molecular Neurodegeneration Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY. 2022-09-02
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques, Immunity Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W. 2022-05-10
Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology, Journal of Clinical Investigation Gedam, M., Comerota, M. M., Propson, N. E., Chen, T., Jin, F., Wang, M. C., & Zheng, H. 2023-06-15
Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease, Molecular Neurodegeneration Comerota, M. M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M. C., Wang, J., & Zheng, H. 2023-08-15
TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy, Nature Neuroscience Wang, B., Martini-Stoica, H., Qi, C., Lu, T. C., Wang, S., Xiong, W., Qi, Y., Xu, Y., Sardiello, M., Li, H., & Zheng, H. 2023-11-20
Sensory processing deficits and related cortical pathological changes in Alzheimer’s disease, Frontiers in Aging Neuroscience Zhang, N. K., Zhang, S. K., Zhang, L. I., Tao, H. W., & Zhang, G. W. 2023-08-15
Identification and Prioritization of PET Neuroimaging Targets for Microglial Phenotypes Associated with Microglial Activity in Alzheimer’s Disease, ACS Chemical Neuroscience Bartolo, N. D., Mortimer, N., Manter, M. A., Sanchez, N., Riley, M., O'Malley, T. T., & Hooker, J. M. 2022-12-06
Analysis of brain region-specific mRNA synthesis and stability by utilizing adult mouse brain slice culture, STAR Protocols Dzhala, V., Fowler, A. J., DiMarzio, B. A., Staley, K. J., & Suh, J. 2022-06-17
ADAM10 Missense Mutations Potentiate beta-amyloid accumulation by impairing pro-domain chaperone function, Neuron Suh, J., Choi, S. H., Romano, D. M., Gannon, M. A., Lesinski, A. N., Kim, D. Y., & Tanzi, R. E. 2013-09-19
PLD3 affects axonal spheroids and network defects in Alzheimer’s disease, Nature Yuan, P., Zhang, M., Tong, L., Morse, T. M., McDougal, R. A., Ding, H., Chan, D., Cai, Y., & Grutzendler, J. 2022-11-30
Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo, Science Advances Damisah, E. C., Hill, R. A., Rai, A., Chen, F., Rothlin, C. V., Ghosh, S., & Grutzendler, J. 2020-06-26
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques, Journal of Experimental Medicine Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R. B., Cirrito, J. R., Holtzman, D. M., & Colonna, M. 2016-04-18
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease, Molecular Neurodegeneration Inoue, Y., Shue, F., Bu, G., & Kanekiyo, T. 2023-07-11
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism, Molecular Psychiatry Kawatani, K., Holm, M. L., Starling, S. C., Martens, Y. A., Zhao, J., Lu, W., Ren, Y., Li, Z., Jiang, P., Jiang, Y., Baker, S. K., Wang, N., Roy, B., Parsons, T. M., Perkerson, R. B., 3rd, Bao, H., Han, X., Bu, G., & Kanekiyo, T. 2023-12-22
Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging Rogers, J. T., Liu, C. C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T., & Bu, G. 2017-02-09
ABCA7 Haplodeficiency Distrubs Microglial immune Responses in the Mouse Brain, Proceedings of the National Academy of Sciences of the United States of America Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T. 2019-11-05
Astrocytic LRP1 Mediates Brain A beta Clearance and Impacts Amyloid Deposition, Journal of Neuroscience Liu, C. C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. 2017-04-12
Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid beta clearance and aggregation in Alzheimer’s disease, Science Translational Medicine Liu, C. C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. 2016-03-30
Mimicry of Central-Peripheral Immunity in Alzheimer’s Disease and Discovery of Neurodegenerative Roles in neutrophil, Frontiers in Immunology Park, J., Baik, S. H., Mook-Jung, I., Irimia, D., & Cho, H. 2019-09-25
Elucidating the interactive roles of glia in Alzheimer’s disease using established and newly developed experimental models, Frontiers in Neurology Chun, H., Marriott, I., Lee, C. J., & Cho, H. 2018-09-26
Therapeutic nanoplatforms and delivery strategies for neurological disorders, Nano Convergence Kang, Y. J., Cutler, E. G., & Cho, H. 2018-11-30
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease, Nature Communications McQuade, A., Kang, Y. J., Hasselmann, J., Jairaman, A., Sotelo, A., Coburn, M., Shabestari, S. K., Chadarevian, J. P., Fote, G., Tu, C. H., Danhash, E., Silva, J., Martinez, E., Cotman, C., Prieto, G. A., Thompson, L. M., Steffan, J. S., Smith, I., Davtyan, H., Cahalan, M., … Cho, H., Blurton-Jones, M. 2020-10-23
Visualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience, Journal of Scientific Computing Chen, X., Tran, A. P., Elkin, R., Benveniste, H., & Tannenbaum, A. R. 2023-09-19
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers, EMBO Molecular Medicine Suárez-Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., Sánchez-Valle, R., Antonell, A., Rami, L., Molinuevo, J. L., Brosseron, F., Traschütz, A., Heneka, M. T., Struyfs, H., Engelborghs, S., Sleegers, K., Van Broeckhove, C., Zetterberg, H., Nellgard, B., Blennow, K., Crispin, A., Ewers, M., & Haass, C. 2016-03-03
Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers, JAMA Neurology Brum, W. S., Docherty, K. F., Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V., & Blennow, K. 2023-12-18
The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice, Proceedings of the National Academy of Sciences of the United States of America Minis, A., Rodriguez, J. A., Levin, A., Liu, K., Govek, E. E., Hatten, M. E., & Steller, H. 2019-11-21
TREM2 in CNS homeostasis and neurodegenerative disease, Molecular Neurodegeneration Painter, M. M., Atagi, Y., Liu, C. C., Rademakers, R., Xu, H., Fryer, J. D., & Bu, G. 2015-09-04
The retromer complex and sorting nexins in neurodegenerative diseases, Frontiers in Aging Neuroscience Zhang, H., Huang, T., Hong, Y., Yang, W., Zhang, X., Luo, H., Xu, H., & Wang, X. 2018-03-26
Appoptosin mediates lesions induced by oxidative stress through the JNK-FoxO1 Pathway, Frontiers in Aging Neuroscience Zhang, C., Tan, Z., Xie, Y., Zhao, Y., Huang, T. Y., Lu, Z., Luo, H., Can, D., Xu, H., Zhang, Y. W., & Zhang, X. 2019-09-04
Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases, Frontiers in Aging Neuroscience Zheng, Q., Huang, T., Zhang, L., Zhou, Y., Luo, H., Xu, H., & Wang, X. 2016-12-15
SNX8 Enhances Non-Amyloidogenic APPP Trafficking and Attenuates A beta Accumulation and Memory Deficits in an AD mouse, Frontiers in Cellular Neuroscience Xie, Y., Niu, M., Ji, C., Huang, T. Y., Zhang, C., Tian, Y., Shi, Z., Wang, C., Zhao, Y., Luo, H., Can, D., Xu, H., Zhang, Y. W., & Zhang, X. 2019-09-06
SORLA attenuates EphA4 signaling and amyloid beta-induced neurodegeneration, Journal of Experimental Medicine Huang, T. Y., Zhao, Y., Jiang, L. L., Li, X., Liu, Y., Sun, Y., Piña-Crespo, J. C., Zhu, B., Masliah, E., Willnow, T. E., Pasquale, E. B., & Xu, H. 2017-12-04
Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease, Neuron Liu, C. C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T., & Bu, G. 2014-09-18
ApoE and Aβ in Alzheimer’s disease: accidental encounters or partners?, Neuron Kanekiyo, T., Xu, H., & Bu, G. 2014-02-19
Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons, PLoS One Gan, M., Jiang, P., McLean, P., Kanekiyo, T., & Bu, G. 2014-12-12
Soluble TREM2 induces inflammatory responses and enhnaces microglial survival, Journal of Experimental Medicine Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H., & Bu, G. 2017-03-06
Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2), Molecular Neurodegeneration Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., Can, D., Xu, H., Bu, G., & Chen, X. F. 2018-03-27
The role of APOE in cerebrovascular dysfunction, Acta Neuropathologica Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W., & Bu, G. (2016). 2016-02-16
Apolipoprotein E regulates lipid metabolism and alpha-synuclein pathology in human iPSC-derived cerebral organoids, Acta Neuropathologica Zhao, J., Lu, W., Ren, Y., Fu, Y., Martens, Y. A., Shue, F., Davis, M. D., Wang, X., … Kanekiyo, T., Bu, G. 2021-08-28
Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease, Acta Neuropathologica Communications Reddy, J. S., Allen, M., Ho, C. C. G., Oatman, S. R., İş, Ö., Quicksall, Z. S., Wang, X., Jin, J., Patel, T. A., Carnwath, T. P., Nguyen, T. T., Malphrus, K. G., Lincoln, S. J., Carrasquillo, M. M., Crook, J. E., Kanekiyo, T., Murray, M. E., Bu, G., Dickson, D. W., & Ertekin-Taner, N. 2021-05-21
ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components, Arteriosclerosis, Thrombosis, and Vascular Biology Yamazaki, Y., Shinohara, M., Yamazaki, A., Ren, Y., Asmann, Y. W., Kanekiyo, T., & Bu, G. 2019-10-31
Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-beta pathology in amyloid model mice, Experimental Neurology Tachibana M, Yamazaki Y, Liu CC, Bu G, Kanekiyo T. 2017-10-26
ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation, Frontiers in Neuroscience Aikawa, T., Ren, Y., Holm, M. L., Asmann, Y. W., Alam, A., Fitzgerald, M. L., Bu, G., & Kanekiyo, T. 2021-04-07
APOE epsilon 4/ epsilon 4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics Zhao J, Davis MD, Martens YA, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G. 2017-04-21
5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway, International Journal of Molecular Sciences Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C. C., Kanekiyo, T., & Bu, G. 2019-03-25
LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4, JCI Insight Oue, H., Yamazaki, Y., Qiao, W., Yuanxin, C., Ren, Y., Kurti, A., … Bu, G., & Kanekiyo, T. 2023-04-10
Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway, Journal of Biological Chemistry Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G., & Kanekiyo, T. 2015-04-22
Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies, Journal of Lipid Research Shinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. 2017-04-04
LRP1 modulates the microglial immune response via regulation of JNK and NF-kappa B signaling pathways, Journal of Neuroinflammation Yang, L., Liu, C. C., Zheng, H., Kanekiyo, T., Atagi, Y., Jia, L., Wang, D., N'songo, A., Can, D., Xu, H., Chen, X. F., & Bu, G. 2016-12-08
Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, Journal of Neuroscience Liu, C. C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T., & Bu, G. 2015-04-08
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer’s Neuronal Pathology, Journal of Neuroscience Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., … Bu, G & Kanekiyo, T. 2016-03-30
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells, Molecular Neurodegeneration Wren, M. C., Zhao, J., Liu, C. C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T., & Bu, G. 2015-09-15
APP-Mediated signaling prevents memory decline in Alzheimer’s disease mouse model, Cell Reports Deyts, C., Clutter, M., Pierce, N., Chakrabarty, P., Ladd, T. B., Goddi, A., Rosario, A. M., Cruz, P., Vetrivel, K., Wagner, S. L., Thinakaran, G., Golde, T. E., & Parent, A. T. 2019-04-30
Microglia use TAM receptors to detect and engulf amyloid β plaques, Nature Immunology Huang, Y., Happonen, K. E., Burrola, P. G., O'Connor, C., Hah, N., Huang, L., Nimmerjahn, A., & Lemke, G. 2021-04-15
How macrophages deal with death, Nature Reviews Immunology Lemke G. 2019-04-24
Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling, Proceedings of the National Academy of Sciences of the United States of America Huang, Y., & Lemke, G. 2022-10-03
Adaptable toolbox to characterize Alzheimer’s disease pathology in mouse models, STAR Protocols Huang, Y., & Lemke, G. 2022-12-16
APOE2 eases cognitve declne during aging: clinical and pre-clinival evaluations, Annals of Neurology Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G. 2016-03-29
Lipoproteins in the Central Nervous System: From Biology to Pathobiology, Annual Review of Biochemistry Raulin AC, Martens YA, Bu G. 2022-03-18
Apolipoprotein E, Receptors, and Modulation of Alzhiemer’s disease, Biological Psychiatry Zhao N, Liu CC, Qiao W, Bu G. 2017-03-14
The AD Knowledge Portal: A Repository for Multi-Omic Data on Alzheimer’s Disease and Aging, Current Protocols in Human Genetics Greenwood AK, Montgomery KS, Kauer N, Woo KH, Leanza ZJ, Poehlman WL, Gockley J, Sieberts SK, Bradic L, Logsdon BA, Peters MA, Omberg L, Mangravite LM. 2020-10-21
Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2), Journal of Biological Chemistry Atagi, Y., Liu, C. C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R., Kang, S. S., Xu, H., Younkin, S., Das, P., Fryer, J. D., & Bu, G. 2015-09-15
APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease, Molecular Neurodegeneration Li, Z., Shue, F., Zhao, N., Shinohara, M., & Bu, G. 2020-11-04
ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies, Molecular Neurodegeneration Raulin, A. C., Doss, S. V., Trottier, Z. A., Ikezu, T. C., Bu, G., & Liu, C. C. 2022-11-08
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination, Molecular Neurodegeneration Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., Asmann, Y. W., Zhang, B., Bu, G., & Liu, C. C. 2022-11-23
APOE ε2 is associated with increased tau pathology in primary tauopathy, Nature Communications Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S., … Bu, G. 2018-10-22
Apolipoprotein E and Alzheimer’s disease: pathobiology and targeting strategies, Nature Reviews Neurology Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C. C., & Bu, G. 2019-07-31
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer’s disease, Neurobiology of Aging Li, Y., Macyczko, J. R., Liu, C. C., & Bu, G. 2022-03-22
Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes, Neuron Zhao, N., Liu, C. C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M., & Bu, G. 2017-09-27
ApoE4 Accelerates Early Seeding of Amyloid Pathology, Neuron Liu, C. C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W., & Bu, G. 2017-12-06
An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells, STAR Protocols Raulin, A. C., Liu, C. C., & Bu, G. 2023-03-17
A Novel Link between Trafficking and Lewy body disorder, The Lancet Neurology Ross, O. A., & Bu, G. 2018-06-07
SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers, Neurobiology of Disease Norambuena, A., Sun, X., Wallrabe, H., Cao, R., Sun, N., Pardo, E., Shivange, N., Wang, D. B., Post, L. A., Ferris, H. A., Hu, S., Periasamy, A., & Bloom, G. S. 2022-04-20
Alzheimer disease A tale of two prions, Prion Nussbaum, J. M., Seward, M. E., & Bloom, G. S. 2012-09-10
Selective Detection of Misfolded Tau From Postmortem Alzheimer’s Disease Brains, Frontiers in Aging Neuroscience Wu, L., Wang, Z., Lad, S., Gilyazova, N., Dougharty, D. T., Marcus, M., Henderson, F., Ray, W. K., Siedlak, S., Li, J., Helm, R. F., Zhu, X., Bloom, G. S., Wang, S. J., Zou, W. Q., & Xu, B. 2022-07-20
Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. 2012-05-02
Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology Bloom, G. S., Lazo, J. S., & Norambuena, A. 2017-09-27
A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. 2020-02-19
A novel lysosome-to-micochondria signaling pathway disrupted by amyloid-beta oligomes, The EMBO Journal Norambuena, A., Wallrabe, H., Cao, R., Wang, D. B., Silva, A., Svindrych, Z., Periasamy, A., Hu, S., Tanzi, R. E., Kim, D. Y., & Bloom, G. S. 2018-10-22
Dietary salt promotes cognitive impairment through tau phosphorylation, Nature Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. 2019-10-23
Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic Control, Cerebral Cortex Cantu, D., Walker, K., Andresen, L., Taylor-Weiner, A., Hampton, D., Tesco, G., & Dulla, C. G. 2014-03-07
Molecular Mechanism of cognitive dysfunction following traumatic brain injury, Frontiers in Aging Neuroscience Walker, K. R., & Tesco, G. 2013-07-09
Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice, Journal of Cerebral Blood Flow & Metabolism Mannix, R. C., Zhang, J., Park, J., Zhang, X., Bilal, K., Walker, K., Tanzi, R. E., Tesco, G., & Whalen, M. J. 2010-06-30
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1, Journal of Neuroscience Walker, K. R., Kang, E. L., Whalen, M. J., Shen, Y., & Tesco, G. 2012-07-25
Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?, Seminars in Immunology Tesco, G., & Lomoio, S. 2022-06-30
Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy, Circulation Gianni, D., Li, A., Tesco, G., McKay, K. M., Moore, J., Raygor, K., Rota, M., Gwathmey, J. K., Dec, G. W., Aretz, T., Leri, A., Semigran, M. J., Anversa, P., Macgillivray, T. E., Tanzi, R. E., & del Monte, F. 2010-03-01
Significance of transcytosis in Alzheimer’s disease: BACE1 takes the scenic route to axons, BioEssays Buggia-Prévot, V., & Thinakaran, G. 2015-06-30
Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in trasngenic models, Brain Pathology De Rossi, P., Andrew, R. J., Musial, T. F., Buggia-Prevot, V., Xu, G., Ponnusamy, M., Ly, H., Krause, S. V., Rice, R. C., de l'Estoile, V., Valin, T., Salem, S., Despa, F., Borchelt, D. R., Bindokas, V. P., Nicholson, D. A., & Thinakaran, G. 2018-12-27
A paired RNAi and RabGAP Overexpression screen identifies Rab11 as a regulator of beta-amyloid production, Cell Reports Udayar, V., Buggia-Prévot, V., Guerreiro, R. L., Siegel, G., Rambabu, N., Soohoo, A. L., Ponnusamy, M., Siegenthaler, B., Bali, J., AESG, Simons, M., Ries, J., Puthenveedu, M. A., Hardy, J., Thinakaran, G., & Rajendran, L. 2013-12-26
Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and locatlization to white matter tracts, Molecular Neurodegeneration De Rossi, P., Buggia-Prévot, V., Clayton, B. L., Vasquez, J. B., van Sanford, C., Andrew, R. J., Lesnick, R., Botté, A., Deyts, C., Salem, S., Rao, E., Rice, R. C., Parent, A., Kar, S., Popko, B., Pytel, P., Estus, S., & Thinakaran, G. 2016-08-03
APP Receptor? To be or not to be, Trends in Pharmacological Sciences Deyts, C., Thinakaran, G., & Parent, A. T. 2016-01-31
Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation, Cell Reports De Rossi, P., Nomura, T., Andrew, R. J., Masse, N. Y., Sampathkumar, V., Musial, T. F., Sudwarts, A., Recupero, A. J., Le Metayer, T., Hansen, M. T., Shim, H. N., Krause, S. V., Freedman, D. J., Bindokas, V. P., Kasthuri, N., Nicholson, D. A., Contractor, A., & Thinakaran, G. 2020-03-10
Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by “molecular tweezers” — from the test tube to animal models, Current Pharmaceutical Design Attar, A., & Bitan, G. 2014-05-01
Molecular tweezers targeting transthyretin amyloidosis, Neurotherapeutics Ferreira, N., Pereira-Henriques, A., Attar, A., Klärner, F. G., Schrader, T., Bitan, G., Gales, L., Saraiva, M. J., & Almeida, M. R. 2014-04-01
A shortened Barnes Maze Protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer’s disease, PLoS One Attar, A., Liu, T., Chan, W. T., Hayes, J., Nejad, M., Lei, K., & Bitan, G. 2013-11-13
Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01, Translational Neuroscience Attar, A., Rahimi, F., & Bitan, G. 2013-12-20
ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models, Science Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., Brunden, K. R., Wilson, D. A., & Landreth, G. E. 2023-03-23
Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model, Nature Communications Lordén, G., Wozniak, J. M., Doré, K., Dozier, L. E., Cates-Gatto, C., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., Tanzi, R. E., & Newton, A. C. 2022-11-23
Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers, Alzheimer's & Dementia Sun, X., Eastman, G., Shi, Y., Saibaba, S., Oliveira, A. K., Lukens, J. R., Norambuena, A., Thompson, J. A., Purdy, M. D., Dryden, K., Pardo, E., Mandell, J. W., & Bloom, G. S. 2023-12-09
Bidirectional modulation of Alzhiemer’s phenotype by alpha-synuclein in mice and primary neurons, Acta Neuropathologica Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S., & Lesné, S. E. 2018-10-01
Localization, induction, and cellular effects of tau phosphorylated at threonine 217, Alzheimer's & Dementia Rajbanshi, B., Guruacharya, A., M|ell, J. W., & Bloom, G. S. 2023-01-12
mTOR and neuronal cell cycle re-entry: how impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia Rajbanshi, B., Guruacharya, A., Mandell, J. W., & Bloom, G. S. 2017-02-01
N-methyl-D-aspartate receptor-mediated calciuym influx connects amyloid-beta oligomers to ectopic neuronal cell cycle re-entry in Alzheimer’s Disease, Alzheimer's & Dementia Kodis, E. J., Choi, S., Swanson, E., Ferreira, G., & Bloom, G. S. 2018-10-01
Dysregulation of mTOR by tau in Alzheimer’s disease, Cytoskeleton Bloom, G. S., & Norambuena, A. 2023-08-28
A half-century of tau, Cytoskeleton Bloom, G. S., & Baas, P. W. 2023-08-28
Tau: the center of a signaling nexus in Alzheimer’s disease, Frontiers in Neuroscience Khan, S. S., & Bloom, G. S. 2016-02-09
Amyloid-beta and Tau: the trigger and bullet in Alzheimer’s disease pathogenesis, JAMA Neurology Bloom, G. S. 2014-04-01
A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice, Journal of Alzheimer's Disease Kuwar, R., Rolfe, A., Di, L., Blevins, H., Xu, Y., Sun, X., Bloom, G. S., Zhang, S., & Sun, D. 2021-01-01
Extracellular Tau Oligomers Damage the Axon Initial Segment, Journal of Alzheimer's Disease Best, M. N., Lim, Y., Ferenc, N. N., Kim, N., Min, L., Wang, D. B., Sharifi, K., Wasserman, A. E., McTavish, S. A., Siller, K. H., Jones, M. K., Jenkins, P. M., Mandell, J. W., & Bloom, G. S. 2023-05-09
Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers, Journal of Alzheimer's Disease Rudenko, L. K., Wallrabe, H., Periasamy, A., Siller, K. H., Svindrych, Z., Seward, M. E., Best, M. N., & Bloom, G. S. 2019-10-15
Extracellular tau oligomers induce invasion of endogenous tau into the somatodendritic compartment and axonal transport dysfunction, Journal of Alzhiemer's Disease Swanson, E., Breckenridge, L., McMahon, L., Som, S., McConnell, I., & Bloom, G. S. 2017-01-01
Alzheimer’s disease as a metabolic disorder, Lipids Bloom, G. S., & Norambuena, A. 2018-08-01
A unifying hypothesis for Alzheimer’s disease: from plaques to neurodegeneration, Trends in Neurosciences Edwards, F. E. 2019-05-01
Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia, Molecular Neurodegeneration Benitez, D. P., Jiang, S., Wood, J., Wang, R., Hall, C. M., Peerboom, C., Wong, N., Stringer, K. M., Vitanova, K. S., Smith, V. C., Joshi, D., Saito, T., Saido, T. C., Hardy, J., Hanrieder, J., De Strooper, B., Salih, D. A., Tripathi, T., Edwards, F. A., & Cummings, D. M. 2021-07-15
Following spatial Aβ aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics, Science Advances Michno, W., Stringer, K. M., Enzlein, T., Passarelli, M. K., Escrig, S., Vitanova, K., Wood, J., Blennow, K., Zetterberg, H., Meibom, A., Hopf, C., Edwards, F. A., & Hanrieder, J. 2021-06-16
P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells, Biomolecules Vultaggio-Poma, V., & Di Virgilio, F. 2022-07-14
Extracellular ATP: A powerful inflammatory mediator in the central nervous system, Neuropharmacology Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. 2022-11-15
Extracellular ATP: A powerful inflammatory mediator in the central nervous system, Neuropharmacology Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. 2023-02-15
Fetal bovine serum contains biologically available ATP, Purinergic Signaling Vultaggio-Poma, V., Scussel Bergamin, L., Falzoni, S., Tarantini, M., Giuliani, A. L., Sandonà, D., Polverino De Laureto, P., & Di Virgilio, F. 2023-04-19
Unorthodox localization of P2X7 receptor in subcellular compartments of skeletal system cells, Frontiers in Cell and Developmental Biology Penolazzi, L., Notarangelo, M. P., Lambertini, E., Vultaggio-Poma, V., Tarantini, M., Di Virgilio, F., & Piva, R. 2023-05-04
The Coming of Age of the P2X7 Receptor in Diagnostic Medicine, International Journal of Molecular Sciences Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. 2023-05-30
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology, Nature Communications Baglietto-Vargas, D., Forner, S., Cai, L., Martini, A. C., Trujillo-Estrada, L., Swarup, V., ... LaFerla, F. M. 2021-04-23
Intracranial arteriosclerosis and the risk of dementia: A population-based cohort study, Alzheimer's & Dementia van den Beukel, T. C., Wolters, F. J., Siebert, U., Spiering, W., Ikram, M. A., Vernooij, M. W., de Jong, P. A., & Bos, D. 2023-10-09
Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar A beta by multiple endoproteolytic cleavages within the beta-sheet domain, Proceedings of the National Academy of Sciences of the United States of America Solé-Domènech, S., Rojas, A. V., Maisuradze, G. G., Scheraga, H. A., Lobel, P., & Maxfield, F. R. 2018-02-13
Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in vitro Phosphorylated Tau and their Modulation by Potential Inhibitors, ACS Chemical Biology Despres, C., Di, J., Cantrelle, F. X., Li, Z., Huvent, I., Chambraud, B., Zhao, J., Chen, J., Chen, S., Lippens, G., Zhang, F., Linhardt, R., Wang, C., Klärner, F. G., Schrader, T., Landrieu, I., Bitan, G., & Smet-Nocca, C. 2019-05-02
Modulation of amyloid beta-protein (A beta) assembly by homologous C-terminal fragments strategy for inhibiting Amyloid beta toxicity, ACS Chemical Neuroscience Li, H., Rahimi, F., & Bitan, G. 2016-07-05
The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice, Alzheimer's Research & Therapy Di, J., Siddique, I., Li, Z., Malki, G., Hornung, S., Dutta, S., Hurst, I., Ishaaya, E., Wang, A., Tu, S., Boghos, A., Ericsson, I., Klärner, F. G., Schrader, T., & Bitan, G. 2021-01-04
Tranilast binds to A beta monomers and promotes A beta fibrillation, Biochemistry Connors, C. R., Rosenman, D. J., Lopes, D. H., Mittal, S., Bitan, G., Sorci, M., Belfort, G., Garcia, A., & Wang, C. 2013-05-31
Safety and pharmacological characterization of the molecular tweezer CLR01- a broad spectrum inhibitor of amyloid protein’s toxicity, BMC Pharmacology and Toxicology Attar, A., Chan, W. T., Klärner, F. G., Schrader, T., & Bitan, G. 2014-04-16
Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers, Brain Attar, A., Ripoli, C., Riccardi, E., Maiti, P., Li Puma, D. D., Liu, T., Hayes, J., Jones, M. R., Lichti-Kaiser, K., Yang, F., Gale, G. D., Tseng, C. H., Tan, M., Xie, C. W., Straudinger, J. L., Klärner, F. G., Schrader, T., Frautschy, S. A., Grassi, C., & Bitan, G. 2012-11-24
Molecular tweezers for lysine and arginine — powerful inhibitors of pathologic protein aggregation, Chemical Communications Schrader, T., Bitan, G., & Klärner, F. G. 2016-08-22
Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: strategies and mechanisms, ChemMedChem Liu, T., & Bitan, G. 2012-02-09
Effects of cerebral amyloid angiopathy on the brain vasculome, Aging Cell Deng, W., Guo, S., van Veluw, S. J., Yu, Z., Chan, S. J., Takase, H., Arai, K., Ning, M., Greenberg, S. M., Lo, E. H., & Bacskai, B. J. 2022-07-18
REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis, eLife Griffin, P., Sheehan, P. W., Dimitry, J. M., Guo, C., Kanan, M. F., Lee, J., Zhang, J., & Musiek, E. S. 2020-12-01
Origins of Alzheiemr’s disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid beta and tau involvement, Current Opinion in Neurology Musiek, E. S., & Holtzman, D. M. 2023-12-12
Sleep, circadian rhythms and the pathogenesis of Alzheimer Disease, Experimental and Molecular Medicine Musiek, E. S., Xiong, D. D., & Holtzman, D. M. 2015-03-01
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, Journal of Clinical Investigation Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., Herzog, E. D., Hogenesch, J. B., Wozniak, D. F., Dikranian, K., Giasson, B. I., Weaver, D. R., Holtzman, D. M., & Fitzgerald, G. A. 2013-12-02
Three dimensions of the amyloid hypothesis: time, space, and ‘wingmen’, Nature Neuroscience Musiek, E. S., & Holtzman, D. M. 2015-06-01
APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading, Journal of Clinical Investigation Wang, C., Nambiar, A., Strickland, M. R., Lee, C., Parhizkar, S., Moore, A. C., Musiek, E. S., Ulrich, J. D., & Holtzman, D. M. 2023-07-17
Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease, Frontiers in Aging Neuroscience Berk-Rauch, H. E., Choudhury, A., Richards, A. T., Singh, P. K., Chen, Z. L., Norris, E. H., Strickland, S., & Ahn, H. J. 2023-03-09
Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer’s Disease, Neurobiology of Aging Tataryn, N. M., Singh, V., Dyke, J. P., Berk-Rauch, H. E., Clausen, D. M., Aronowitz, E., Norris, E. H., Strickland, S., & Ahn, H. J. 2021-07-28
Spreading of Tau Protein Does Not Depend on Aggregation Propensity, Journal of Molecular Neuroscience Rodrigues, S., Anglada-Huguet, M., Hochgräfe, K., Kaniyappan, S., Wegmann, S., & Mandelkow, E. M. 2023-08-22
Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau, Journal of Biological Chemistry Wischhof, L., Adhikari, A., Mondal, M., Marsal-Cots, A., Biernat, J., Mandelkow, E. M., Mandelkow, E., Ehninger, D., Nicotera, P., & Bano, D. 2022-02-24
The release and trans-synaptic transmission of Tau via exosomes, Molecular Neurodegeneration Wang, Y., Balaji, V., Kaniyappan, S., Krüger, L., Irsen, S., Tepper, K., Chandupatla, R., Maetzler, W., Schneider, A., Mandelkow, E., & Mandelkow, E. M. 2017-01-13
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments, Molecular Neurodegeneration Kaniyappan, S., Tepper, K., Biernat, J., Chandupatla, R. R., Hübschmann, S., Irsen, S., Bicher, S., Klatt, C., Mandelkow, E. M., & Mandelkow, E. 2020-07-16
A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging, Aging Cell Pun, F. W., Leung, G. H. D., Leung, H. W., Rice, J., Schmauck-Medina, T., Lautrup, S., Long, X., Liu, B. H. M., Wong, C. W., Ozerov, I. V., Aliper, A., Ren, F., Rosenberg, A. J., Agrawal, N., Izumchenko, E., Fang, E. F., & Zhavoronkov, A. 2023-10-27
Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer’s disease, Alzheimer's & Dementia Knapskog, A. B., Aksnes, M., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Saltvedt, I., Giil, L. M., & Watne, L. O. 2023-06-02
Editorial: Mitophagy in health and disease, volume II, Frontiers in Cell and Developmental Biology Fang, E. F., Tavernarakis, N., & Palikaras, K. 2023-06-29
Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms, Pharmacological Research Dong, Y., Zhuang, X. X., Wang, Y. T., Tan, J., Feng, D., Li, M., Zhong, Q., Song, Z., Shen, H. M., Fang, E. F., & Lu, J. H. 2023-06-20
Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice, Cell Reports Lin, C. J., Herisson, F., Le, H., Jaafar, N., Chetal, K., Oram, M. K., Flynn, K. L., Gavrilles, E. P., Sadreyev, R. I., Schiffino, F. L., & Tanzi, R. E. 2023-09-13
Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenges, Immunity Hoyer, F. F., Naxerova, K., Schloss, M. J., Hulsmans, M., Nair, A. V., Dutta, P., Calcagno, D. M., Herisson, F., Anzai, A., Sun, Y., Wojtkiewicz, G., Rohde, D., Frodermann, V., Vandoorne, K., Courties, G., Iwamoto, Y., Garris, C. S., Williams, D. L., Breton, S., Brown, D., Whalen, M., Libby, P., Pittet, M. J., King, K. R., Weissleder, R., Swirski, F. K., & Nahrendorf, M., 2019-11-19
Direct Vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration, Nature Neuroscience Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., Kim, D. E., Weissleder, R., Swirski, F. K., Moskowitz, M. A., & Nahrendorf, M. 2018-08-27
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro, Alzheimer’s Research & Therapy Aillaud, I., Kaniyappan, S., Chandupatla, R. R., Ramirez, L. M., Alkhashrom, S., Eichler, J., Horn, A. H. C., Zweckstetter, M., Mandelkow, E., Sticht, H., & Funke, S. A. 2022-01-21
A current view on Tau protein phosphorylation in Alzheimer’s disease., Current Opinion in Neurobiology Wegmann, S., Biernat, J., & Mandelkow, E. 2021-04-20
Tau and Membranes: Interactions That Promote Folding and Condensation, Frontiers in Cell and Developmental Biology Sallaberry, C. A., Voss, B. J., Majewski, J., Biernat, J., Mandelkow, E., Chi, E. Y., & Vander Zanden, C. M. 2021-09-21
Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer’s Disease, Methods in Molecular Biology Kaniyappan, S., Balaji, V., Wang, Y., & Mandelkow, E. 2022-10-31
Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice, Alzheimer's & Dementia Anglada-Huguet, M., Rodrigues, S., Hochgräfe, K., Mandelkow, E., & Mandelkow, E. M. 2021-04-19
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems, Autophagy Balaji, V., Kaniyappan, S., Mandelkow, E., Wang, Y., & Mandelkow, E. M. 2018-09-01
Fragmentation of functional resting state brain networks in a transgenic mouse model of tau pathology: A metabolic connectivity study using [18F]FDG-PET, Experimental Neurology Endepols, H., Anglada-Huguet, M., Mandelkow, E., Neumaier, B., Mandelkow, E. M., & Drzezga, A. 2023-12-03
Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy, International Journal of Molecular Sciences Anglada-Huguet, M., Endepols, H., Sydow, A., Hilgers, R., Neumaier, B., Drzezga, A., Kaniyappan, S., Mandelkow, E., & Mandelkow, E. M. 2023-05-25
Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study, Molecular Neurodegeneration Endepols, H., Anglada-Huguet, M., Mandelkow, E., Schmidt, Y., Krapf, P., Zlatopolskiy, B. D., Neumaier, B., Mandelkow, E. M., & Drzezga, A. 2022-03-21
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia, Cell Tcw, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., & Goate, A. M. 2022-06-23
Emerging drug discovery ecosystems, SLAS Discovery Sharlow, E. R. 2023-05-30
Benefits of Strategic Small-Scale Targeted Screening, Assay and Drug Development Technologies Sharlow, E. R. 2016-08-01
Revisiting repurposing, Assay and Drug Development Technologies Sharlow, E. R. 2016-12-01
A Small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis, ACS Chemical Biology Sharlow, E. R., Leimgruber, S., Lira, A., McConnell, M. J., Norambuena, A., Bloom, G. S., Epperly, M. W., Greenberger, J. S., & Lazo, J. S. 2016-05-14
The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons, Assay and Drug Development Technologies Sharlow, E. R., Koseoglu, M. M., Bloom, G. S., & Lazo, J. S. 2020-02-14
Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations, FEBS Journal Sharlow, E. R., Llaneza, D. C., Tewari, B. P., Mingledorff, G. A., Mendelson, A. J., Sontheimer, H., Bloom, G. S., & Lazo, J. S. 2023-07-10
Aberrant neuronal cell-cycle re-entry: the pathological confluence fo Alzheimer’s disease and brain insulin resistance, and its relation to cancer., Journal of Alzheimer's Disease Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. 2019-01-08
Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer, Journal of Alzheimer's Disease Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. 2019-01-08
High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons, SLAS Discovery Sharlow, E. R., Llaneza, D. C., Grever, W. E., Mingledorff, G. A., Mendelson, A. J., Bloom, G. S., & Lazo, J. S. 2022-10-20
Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice, Journal of Alzheimer's Disease Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. 2022-03-08
Disease-modifying effects of M-1 muscarinic acetylcholine receptor activation in an Alzheimer’s disease mouse model, ACS Chemical Neuroscience Lebois, E. P., Schroeder, J. P., Esparza, T. J., Bridges, T. M., Lindsley, C. W., Conn, P. J., Brody, D. L., Daniels, J. S., & Levey, A. I. 2017-06-21
Use of Repetitive Transcranial Magnetic Stimulation in the Treatment of Neuropsychiatric and Neurocognitive Symptoms Associated With Concussion in Military Populations, Journal of Head Trauma Rehabilitation Oberman, L. M., Exley, S., Philip, N. S., Siddiqi, S. H., Adamson, M. M., & Brody, D. L. 2020-11-25
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid beta accumulation and independently accelerates the development of tau abnormalities, Journal of Neuroscience Tran, H. T., LaFerla, F. M., Holtzman, D. M., & Brody, D. L. 2011-06-29
Traumatic brain injury reduces solubl extracellular amyloid-beta in mice: a methodologically novel combined microdialysis-controlled cortical impact study, Neurobiology of Disease Schwetye, K. E., Cirrito, J. R., Esparza, T. J., Mac Donald, C. L., Holtzman, D. M., & Brody, D. L. 2010-12-01
Amyloid-beta dynamics correlate with neurological status in the injured human brain, Science Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. 2008-08-29
Non-canonical soluble amyloid beta aggregates and plaque buffering: controversies and future direction for target discovery in Alzheier’s disease., Alzheimer's Research & Therapy Brody, D. L., Jiang, H., Wildburger, N., & Esparza, T. J. 2017-08-17
New Perspectives on Immune Involvement in Parkinson’s Disease Pathogenesis, Journal of Parkinson's disease Gate D. 2022-09-27
Infection and inflammation: New perspectives on Alzheimer’s disease, Brain, Behavior, & Immunity - Health Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., Heneka, M. T., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members 2022-04-22
Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment, Cell Piehl, N., van Olst, L., Ramakrishnan, A., Teregulova, V., Simonton, B., Zhang, Z., Tapp, E., Channappa, D., Oh, H., Losada, P. M., Rutledge, J., Trelle, A. N., Mormino, E. C., Elahi, F., Galasko, D. R., Henderson, V. W., Wagner, A. D., Wyss-Coray, T., & Gate, D. 2022-12-13
Alzheimer’s disease beta-amyloid is rapidly seeded by herpesviridae to protet against brain infection, Neuron Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. 2018-07-11
Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease, Science Translational Medicine Kumar, D. K., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., & Moir, R. D. 2016-05-25
C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death, Journal of Neuroscience Kanmert, D., Cantlon, A., Muratore, C. R., Jin, M., O'Malley, T. T., Lee, G., Young-Pearse, T. L., Selkoe, D. J., & Walsh, D. M. 2015-07-20
The Familial British dementia mutation promates formation of neurotoxic cystine cross-linked amyloid Bri (Abri) Oligomers, Journal of Biological Chemistry Cantlon, A., Frigerio, C. S., Freir, D. B., Boland, B., Jin, M., & Walsh, D. M. 2015-07-03
Tau immunization: a cautionary tale?, Neurobiology of Aging Mably, A. J., Kanmert, D., Mc Donald, J. M., Liu, W., Caldarone, B. J., Lemere, C. A., O'Nuallain, B., Kosik, K. S., & Walsh, D. M. 2015-03-01
Alzheimer’s secretases regulate voltage-gated sodium channels, Neuroscience Letters Kovacs, D. M., Gersbacher, M. T., & Kim, D. Y. 2010-12-10
BACE1 and presenilin/gamma-secretase regulate proteolytic processing of KCNE1 and 2, auxilary subunits of voltage-gated potassium channels, The FASEB Journal Sachse, C. C., Kim, Y. H., Agsten, M., Huth, T., Alzheimer, C., Kovacs, D. M., & Kim, D. Y. 2013-03-15
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H 2 O 2- production, Nature Neuroscience Chun, H., Im, H., Kang, Y. J., Kim, Y., Shin, J. H., Won, W., Lim, J., Ju, Y., Park, Y. M., Kim, S., Lee, S. E., Lee, J., Woo, J., Hwang, Y., Cho, H., Jo, S., Park, J. H., Kim, D., Kim, D. Y., Seo, J. S., Gwag, B. J., Kim, Y. S., Park K. D., Kaang, B. K., Cho, H., Ryu, H., & Lee, C. J. 2020-11-16
Three-Dimensional Models of the Human Brain Development and Disease, Advanced Healthcare Materials Jorfi, M., D'Avanzo, C., Kim, D. Y., & Irimia, D. 2017-08-28
Alzheimer’s in 3D culture: Challenges and Perspectives, BioEssays D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., & Kim, D. Y. 2015-10-01
Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Current Molecular Medicine Dong, Y., Wu, X., Zhang, G., Xu, Z., Zhang, Y., Gautam, V., Kovacs, D. M., Wu, A., Yue, Y., & Xie, Z. 2013-05-01
Emerging roles of innate and adaptive immunity in Alzheimer’s disease, Immunity Chen, X., & Holtzman, D. M. 2022-12-13
Microglia derived APOE-dependent neurodegneration in a tauopathy mouse model, Journal of Experimental Medicine Shi, Y., Manis, M., Long, J., Wang, K., Sullivan, P. M., Remolina Serrano, J., Hoyle, R., & Holtzman, D. M. 2019-11-04
Alternatives to Amyloid for Alzheimer’s Disease Therapies-A Symposium Report, Annals of the New York Academy of Sciences Cable, J., Holtzman, D. M., Hyman, B. T., Tansey, M. G., Colonna, M., Kellis, M., Brinton, R. D., Albert, M., Wellington, C. L., Sisodia, S. S., & Tanzi, R. E. 2020-05-29
The levels of water-soluble and triton-soluble A beta are increased in Alzheimer’s disease brain, Brain Research McDonald, J. M., Cairns, N. J., Taylor-Reinwald, L., Holtzman, D., & Walsh, D. M. 2023-04-23
Antibody Therapeutics targeting Abeta and Tau, Cold Spring Harbor Perspectives in Medicine Gallardo, G., & Holtzman, D. M. 2017-10-01
Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model, Science Translational Medicine Mann, C. N., Devi, S. S., Kersting, C. T., Bleem, A. V., Karch, C. M., Holtzman, D. M., & Gallardo, G. 2022-02-16
Hallmarks of neurodegenerative diseases, Cell Wilson, D. M., 3rd, Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. 2023-02-16
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease, Nature Medicine Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A., Nichols, M. R., Beausoleil, S. A., Ulrich, J., Holtzman, D. M., Artyomov, M. N., & Colonna, M. 2020-01-13
Driving cessation over a 24-hour period: dementia severity and cerebrospinal fluid markers, Alzheimer's & Dementia Stout, S. H., Babulal, G. M., Ma, C., Carr, D. B., Head, D. M., Grant, E. A., Williams, M. M., Holtzman, D. M., Fagan, A. M., Morris, J. C., & Roe, C. M. 2018-05-01
NIA-AA staging of preclinical Alzhiemer disease: discordance and concordance of CSF and imaging biomarkers, Neurobiology of Aging Vos, S. J. B., Gordon, B. A., Su, Y., Visser, P. J., Holtzman, D. M., Morris, J. C., Fagan, A. M., & Benzinger, T. L. S. 2016-04-04
Cognitively unimpaired HIV-positive subjects do not have icreased C-11 PiB A case-control study, Neurology Ances, B. M., Christensen, J. J., Teshome, M., Taylor, J., Xiong, C., Aldea, P., Fagan, A. M., Holtzman, D. M., Morris, J. C., Mintun, M. A., & Clifford, D. B. 2010-07-13
Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis, Alzheimer's & Dementia Ovod, V., Ramsey, K. N., Mawuenyega, K. G., Bollinger, J. G., Hicks, T., Schneider, T., Sullivan, M., Paumier, K., Holtzman, D. M., Morris, J. C., Benzinger, T., Fagan, A. M., Patterson, B. W., & Bateman, R. J. 2017-07-19
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy, Nature Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., Smirnov, I., Rich, S. S., Dominantly Inherited Alzheimer Network, Benitez, B. A., Karch, C. M., Perrin, R. J., Farlow, M., Chhatwal, J. P., Holtzman, D. M., Cruchaga, C., Harari, O., & Kipnis, J. 2021-04-28
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways, Cell Wang, S., Sudan, R., Peng, V., Zhou, Y., Du, S., Yuede, C. M., Lei, T., Hou, J., Cai, Z., Cella, M., Nguyen, K., Poliani, P. L., Beatty, W. L., Chen, Y., Cao, S., Lin, K., Rodrigues, C., Ellebedy, A. H., Gilfillan, S., Brown, G. D., Holtzman, D. M., Brioschi, S., & Colonna, M. 2022-10-27
Altered microglial response to A beta plaques in APPPS1-21 mice heterozygous for TREM2, Molecular Neurodegeneration Ulrich, J. D., Finn, M. B., Wang, Y., Shen, A., Mahan, T. E., Jiang, H., Stewart, F. R., Piccio, L., Colonna, M., & Holtzman, D. M. 2014-06-03
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model, Cell Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., Holtzman, D. M., Cirrito, J. R., & Colonna, M. 2015-03-12
TREM2 Function Impedes Tau Seeding in Neuritic Plaques, Nature Neuroscience Leyns, C. E. G., Gratuze, M., Narasimhan, S., Jain, N., Koscal, L. J., Jiang, H., Manis, M., Colonna, M., Lee, V. M. Y., Ulrich, J. D., & Holtzman, D. M. 2019-06-01
Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype, Analytical Biochemistry Lawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M., & Bateman, R. J. 2023-04-16
Amyloid beta oligomerization in Alzheimer’s dementia versus high pathology controls, Annals of Neurology Esparza, T. J., Zhao, H., Cirrito, J. R., Cairns, N. J., Bateman, R. J., Holtzman, D. M., & Brody, D. L. 2013-01-01
CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. 2023-07-13
The binding of apolipoprotein E to oligomers and fibrils of amyloid-beta alters the kinetics of amyloid aggregation, Biochemistry Garai, K., Verghese, P. B., Baban, B., Holtzman, D. M., & Frieden, C. 2014-09-25
Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system, Brain Research Zeng, C., Pan, F., Jones, L. A., Lim, M. M., Griffin, E. A., Sheline, Y. I., Mintun, M. A., Holtzman, D. M., & Mach, R. H. 2010-03-01
Alzhiemer’s Disease: an update on pathobiology and treatment strategies, Cell Long, J. M., & Holtzman, D. M. 2019-09-26
Is there a link between the sleep-wake cycle and Alzheimer’s pathology, Future Neurology Roh, J. H., & Holtzman, D. M. 2015-05-01
Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer’s disease transgenic mice, Journal of Alzheimers Disease Cao, C., Cirrito, J. R., Lin, X., Wang, L., Verges, D. K., Dickson, A., Mamcarz, M., Zhang, C., Mori, T., Arendash, G. W., Holtzman, D. M., & Potter, H. 2009-07-01
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of A beta amyloidosis, Journal of Experimental Medicine Kim, J., Eltorai, A. E., Jiang, H., Liao, F., Verghese, P. B., Kim, J., Stewart, F. R., Basak, J. M., & Holtzman, D. M. 2012-11-19
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease, Journal of Experimental Medicine Roh, J. H., Jiang, H., Finn, M. B., Stewart, F. R., Mahan, T. E., Cirrito, J. R., Heda, A., Snider, B. J., Li, M., Yanagisawa, M., de Lecea, L., & Holtzman, D. M. 2014-11-24
Characterizing the Appearance and Growth of Amyloid plaques in APP/PS1 Mice, Journal of Neuroscience Yan, P., Bero, A. W., Cirrito, J. R., Xiao, Q., Hu, X., Wang, Y., Gonzales, E., Holtzman, D. M., & Lee, J. M. 2009-08-26
Opposing synaptic regulation of amyloid-beta metabolism by NMDA Receptors in vivo, Journal of Neuroscience Verges, D. K., Restivo, J. L., Goebel, W. D., Holtzman, D. M., & Cirrito, J. R. 2011-08-03
Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain, Journal of Neuroscience Bero, A. W., Bauer, A. Q., Stewart, F. R., White, B. R., Cirrito, J. R., Raichle, M. E., Culver, J. P., & Holtzman, D. M. 2023-03-28
Effects of CD2-associated protein deficiency on amyloid-beta in neuroblastoma cells and in an APP transgenic mouse model., Molecular Neurodegeneration Liao, F., Jiang, H., Srivatsan, S., Xiao, Q., Lefton, K. B., Yamada, K., Mahan, T. E., Lee, J. M., Shaw, A. S., & Holtzman, D. M. 2015-03-19
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy, Molecular Neurodegenration Xiong, M., Wang, C., Gratuze, M., Saadi, F., Bao, X., Bosch, M. E., Lee, C., Jiang, H., Serrano, J. R., Gonzales, E. R., Kipnis, M., & Holtzman, D. M. 2023-03-16
Emerging diagnostics and therapeutics for Alzheimer disease, Nature Medicine Self, W. K., & Holtzman, D. M. 2023-09-04
Neuronal activity regulates the regional vulnerability to amyloid-beta deposition, Nature Neuroscience Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J. M., & Holtzman, D. M. 2011-06-01
Interplay between Innate immunity and Alzheimer’s disease: APOE ad TREM2 in the spotlight, Nature Reviews Immunology Shi, Y., & Holtzman, D. M. 2018-08-23
Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis, Neuron Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. 2020-11-10
Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum, NeuroReport Lim, M. M., Xu, J., Holtzman, D. M., & Mach, R. H. 2011-07-13
Current status of amyloid-targeting immunotherapies for Alzheimer’s disease, Science Translational Medicine Tabor, G. T., & Holtzman, D. M. 2023-11-08
APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease, Seminars in Immunology Parhizkar, S., & Holtzman, D. M. 2022-02-26
Minocycline reduces spontaneous hemorrhage in mouse models of cerebral amyloid angiopathy, Stroke Yan, P., Zhu, A., Liao, F., Xiao, Q., Kraft, A., Gonzales, E., Perez, R., Greenberg, S. M., Holtzman, D., & Lee, J. M. 2015-06-01
On the Recombination Rate Estimation in the Presence of Populaion Substructure, PLoS One Hecker, J., Prokopenko, D., Lange, C., & Fier, H. L. 2015-12-30
A novel locus for exertional dyspnoea in childhood asthma, The European respiratory journal Lee, S., Lasky-Su, J. A., Lange, C., Kim, W., Kumar, P. L., McDonald, M. N., Vaz Fragoso, C. A., Laurie, C., Raby, B. A., Celedón, J. C., Cho, M. H., Won, S., Weiss, S. T., Hecker, J., & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium 2021-02-04
Novel recessive locus for body mass index in childhood asthma, Thorax Lee, S., Lasky-Su, J., Won, S., Laurie, C., Celedón, J. C., Lange, C., Weiss, S., & Hecker, J. 2021-04-22
Assessment of Alzheimer’s disease case-control associations using family-based methods, Neurogenetics Schjeide, B. M., McQueen, M. B., Mullin, K., DiVito, J., Hogan, M. F., Parkinson, M., Hooli, B., Lange, C., Blacker, D., Tanzi, R. E., & Bertram, L. 2009-02-01
On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology Loehlein Fier, H., Prokopenko, D., Hecker, J., Cho, M. H., Silverman, E. K., Weiss, S. T., Tanzi, R. E., & Lange, C. 2017-04-20
Identification of Novel Alzheimer’s Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data, Scientific Reports Prokopenko, D., Hecker, J., Kirchner, R., Chapman, B. A., Hoffman, O., Mullin, K., Hide, W., Bertram, L., Laird, N., DeMeo, D. L., Lange, C., & Tanzi, R. E. 2020-03-19
Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development, Alzheimer's & Dementia Prokopenko, D., Morgan, S. L., Mullin, K., Hofmann, O., Chapman, B., Kirchner, R., Alzheimer's Disease Neuroimaging Initiative (ADNI), Amberkar, S., Wohlers, I., Lange, C., Hide, W., Bertram, L., & Tanzi, R. E. 2021-04-02
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro, Nature Immunology Dolan, M. J., Therrien, M., Jereb, S., Kamath, T., Gazestani, V., Atkeson, T., Marsh, S. E., Goeva, A., Lojek, N. M., Murphy, S., White, C. M., Joung, J., Liu, B., Limone, F., Eggan, K., Hacohen, N., Bernstein, B. E., Glass, C. K., Leinonen, V., Blurton-Jones, M., … Stevens, B. 2023-07-27
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity, Nature Immunology Fixsen, B. R., Han, C. Z., Zhou, Y., Spann, N. J., Saisan, P., Shen, Z., Balak, C., Sakai, M., Cobo, I., Holtman, I. R., Warden, A. S., Ramirez, G., Collier, J. G., Pasillas, M. P., Yu, M., Hu, R., Li, B., Belhocine, S., Gosselin, D., Coufal, N. G., Ren, B., & Glass, C. K. 2023-06-15
Nuclei isolation of multiple brain cell types for omics interrogation, Nature Protocols Nott, A., Schlachetzki, J. C. M., Fixsen, B. R., & Glass, C. K. 2021-01-25
Brain cell type-specific enhancer-promoter interactome maps and disease risk association., Science Nott, A., Holtman, I. R., Coufal, N. G., Schlachetzki, J. C. M., Yu, M., Hu, R., Han, C. Z., Pena, M., Xiao, J., Wu, Y., Keulen, Z., Pasillas, M. P., O'Connor, C., Nickl, C. K., Schafer, S. T., Shen, Z., Rissman, R. A., Brewer, J. B., Gosselin, D., Gonda, D. D., Levy, M. L., Rosenfeld, M.G., McVicker, G., Gage, F. H., & Glass, C. K. 2019-11-14
Exosomes neutralize synaptic-plasticity-disrupting activity of A beta assemblies in vivo, Molecular Brain An, K., Klyubin, I., Kim, Y., Jung, J. H., Mably, A. J., O'Dowd, S. T., Lynch, T., Kanmert, D., Lemere, C. A., Finan, G. M., Park, J. W., Kim, T. W., Walsh, D. M., Rowan, M. J., & Kim, J. H. 2013-11-13
Further understanding the connection between Alzheimer’s disease and Down syndrome, Alzheimer's & Dementia Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., Hendrix, J., Kishnani, P. S., Lai, F., Lao, P., Lemere, C., Mobley, W., Mufson, E. J., Potter, H., Zaman, S. H., Granholm, A. C., … Rafii, M. S. 2020-06-16
ApoE mimetic improves pathology and memory in a model of Alzheimer’s disease, Brain Research Krishnamurthy, K., Cantillana, V., Wang, H., Sullivan, P. M., Kolls, B. J., Ge, X., Lin, Y., Mace, B., & Laskowitz, D. T. 2020-01-30
Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain, Basic & Clinical Pharmacology & Toxicology Graves, S. I., & Baker, D. J. 2020-03-11
Insights from In Vivo Studies of Cellular Senescence, Cells Prieto, L. I., Graves, S. I., & Baker, D. J. 2020-04-13
Untangling senescent and damage-associated microglia in the aging and diseased brain, FEBS Journal Ng, P. Y., McNeely, T. L., & Baker, D. J. 2021-12-14
Cellular senescence in ageing: from mechanisms to therapeutic opportunities, Nature Reviews Molecular Cell Biology Di Micco, R., Krizhanovsky, V., Baker, D., & d'Adda di Fagagna, F. 2021-08-06
Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease, Acta Neuropathologica Communications Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J. D., Wang, S. J., Lin, F. C., Scott, W. K., Holtzman, D. M., & Cohen, T. J. 2022-08-08
Altered sleep and EEG power in the P301S tau transgenic mouse model, Annals of Clinical and Translational Neurology Holth, J. K., Mahan, T. E., Robinson, G. O., Rocha, A., & Holtzman, D. M. 2017-03-01
Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans, Biomedicines Sommerer, Y., Dobricic, V., Schilling, M., Ohlei, O., Bartrés-Faz, D., Cattaneo, G., Demuth, I., Düzel, S., Franzenburg, S., Fuß, J., Lindenberger, U., Pascual-Leone, Á., Sabet, S. S., Solé-Padullés, C., Tormos, J. M., Vetter, V. M., Wesse, T., Franke, A., Lill, C. M., & Bertram, L. 2022-11-03
Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts, GeroScience Drewelies, J., Hueluer, G., Duezel, S., Vetter, V. M., Pawelec, G., Steinhagen-Thiessen, E., Wagner, G. G., Lindenberger, U., Lill, C. M., Bertram, L., Gerstorf, D., & Demuth, I. 2022-09-24
Genome-wide analysis furthers decoding of Alzheimer disease genetics, Nature Reviews Neurology Lill, C. M., & Bertram, L. 2022-05-27
Genetic associations with learning over 100 days of practice, npj Science of Learning Youn, C., Grotzinger, A. D., Lill, C. M., Bertram, L., Schmiedek, F., Lövdén, M., Lindenberger, U., Nivard, M., Harden, K. P., & Tucker-Drob, E. M. 2022-05-04
Differential microRNA expression analyses across two brain regions in Alzheimer’s disease, Translational Psychiatry Dobricic, V., Schilling, M., Schulz, J., Zhu, L. S., Zhou, C. W., Fuß, J., Franzenburg, S., Zhu, L. Q., Parkkinen, L., Lill, C. M., & Bertram, L. 2022-08-29
A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests, Bioinformatics Hecker, J., Townes, F. W., Kachroo, P., Laurie, C., Lasky-Su, J., Ziniti, J., Cho, M. H., Weiss, S. T., Laird, N. M., & Lange, C. 2020-12-26
Utilizing the Jaccard index to reveal population stratification data: a simulation study and an application ot the 1000 Genome Project, Bioinformatics Prokopenko, D., Hecker, J., Silverman, E. K., Pagano, M., Nöthen, M. M., Dina, C., Lange, C., & Fier, H. L. 2016-05-01
Identification of genetic outliers due to sub-structure and cryptic relationships, Bioinformatics Schlauch, D., Fier, H., & Lange, C. 2017-03-03
PolyGEE: A generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies, Biostatistics Hecker, J., Prokopenko, D., Lange, C., & Fier, H. L. 2018-07-01
A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data, Epigenetics Hecker, J., Lee, S., Kachroo, P., Prokopenko, D., Maaser-Hecker, A., Lutz, S. M., Hahn, G., Irizarry, R., Weiss, S. T., DeMeo, D. L., & Lange, C. 2023-09-23
Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma, European Respiratory Journal Lee, S., Prokopenko, D., Kelly, R. S., Lutz, S., Ann Lasky-Su, J., Cho, M. H., Laurie, C., Celedón, J. C., Lange, C., Weiss, S. T., Hecker, J., & DeMeo, D. L. 2023-01-06
Family-based tests for associating haplotypes with general phenotype data, Genetic Epidemiology Hecker, J., Xu, X., Townes, F. W., Loehlein Fier, H., Corcoran, C., Laird, N., & Lange, C. 2017-11-21
Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus, Genetic Epidemiology Hahn, G., Lee, S., Weiss, S. T., & Lange, C. 2021-01-08
Selection bias when inferring the effect direction in Mendelian randomization, Genetic Epidemiology Lutz, S. M., Voorhies, K., Wu, A. C., Hokanson, J., Vansteelandt, S., & Lange, C. 2022-05-02
A Comparison of Popular TDT-generalizations for family-based association analysis, Genetic Epidemiology Hecker, J., Laird, N., & Lange, C. 2019-01-04
A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP, Genetic Epidemiology Hecker, J., Ruczinski, I., Cho, M. H., Silverman, E. K., Coull, B., & Lange, C. 2019-11-11
The effects of misspecification of the mediator and outcome in mediation analysis, Genetic Epidemiology Lutz, S. M., Sordillo, J. E., Hokanson, J. E., Chen Wu, A., & Lange, C. 2020-03-13
Integrating mulitple correlated phenotypes for genetic association analysis by maximizing heritability, Human Heredity Zhou, J. J., Cho, M. H., Lange, C., Lutz, S., Silverman, E. K., & Laird, N. M. 2015-06-20
An interaction of the 17q12-21 locus with mold exposure in childhood asthma, Pediatric Allergy and Immunology Lee, S., Lasky-Su, J., Kim, W., Won, S., Laurie, C., Celedón, J. C., Lange, C., Weiss, S. T., & Hecker, J. 2020-09-18
Using Network Methodology to infer population substructure, PLoS One Prokopenko, D., Hecker, J., Silverman, E., Nöthen, M. M., Schmid, M., Lange, C., & Loehlein Fier, H. 2015-06-22
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E, Molecular Neurodegeneration Robert, J., Button, E. B., Martin, E. M., McAlary, L., Gidden, Z., Gilmour, M., Boyce, G., Caffrey, T. M., Agbay, A., Clark, A., Silverman, J. M., Cashman, N. R., & Wellington, C. L. 2020-03-25
An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases, Molecular Neurodegeneration Robert, J., Weilinger, N. L., Cao, L. P., Cataldi, S., Button, E. B., Stukas, S., Martin, E. M., Seibler, P., Gilmour, M., Caffrey, T. M., Rowe, E. M., Fan, J., MacVicar, B., Farrer, M. J., & Wellington, C. L. 2020-11-19
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia, Molecular Neurodegenration Poliakova, T., & Wellington, C. L. 2023-11-16
Assessing the importance of interleukin-6 in COVID-19, The Lancet Respiratory Medicine Chen, L. Y. C., Hoiland, R. L., Stukas, S., Wellington, C. L., & Sekhon, M. S. 2021-02-09
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer’s disease., Alzheimer's & Dementia Gispert, J. D., Suárez-Calvet, M., Monté, G. C., Tucholka, A., Falcon, C., Rojas, S., Rami, L., Sánchez-Valle, R., Lladó, A., Kleinberger, G., Haass, C., & Molinuevo, J. L. 2016-07-13
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, EMBO Journal Kleinberger, G., Brendel, M., Mracsko, E., Wefers, B., Groeneweg, L., Xiang, X., Focke, C., Deußing, M., Suárez-Calvet, M., Mazaheri, F., Parhizkar, S., Pettkus, N., Wurst, W., Feederle, R., Bartenstein, P., Mueggler, T., Arzberger, T., Knuesel, I., Rominger, A., & Haass, C. 2017-05-30
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine Xiang, X., Werner, G., Bohrmann, B., Liesz, A., Mazaheri, F., Capell, A., Feederle, R., Knuesel, I., Kleinberger, G., & Haass, C. 2016-07-08
Asymmetry of fibrillar plaque burden in amyloid mouse models, Journal of Nuclear Medicine Sacher, C., Blume, T., Beyer, L., Biechele, G., Sauerbeck, J., Eckenweber, F., Deussing, M., Focke, C., Parhizkar, S., Lindner, S., Gildehaus, F. J., von Ungern-Sternberg, B., Baumann, K., Tahirovic, S., Kleinberger, G., Willem, M., Haass, C., Bartenstein, P., Cumming, P., Rominger, A., Herms, J., & Brendel, M. 2020-05-15
CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals, NeuroImage: Clinical Falcon, C., Monté-Rubio, G. C., Grau-Rivera, O., Suárez-Calvet, M., Sánchez-Valle, R., Rami, L., Bosch, B., Haass, C., Gispert, J. D., & Molinuevo, J. L. 2019-04-01
Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein, Cell Reports Ben Halima, S., Mishra, S., Raja, K. M. P., Willem, M., Baici, A., Simons, K., Brüstle, O., Koch, P., Haass, C., Caflisch, A., & Rajendran, L. 2016-02-25
Opposite microglial activations stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism, EMBO Molecular Medicine Götzl, J. K., Brendel, M., Werner, G., Parhizkar, S., Sebastian Monasor, L., Kleinberger, G., Colombo, A. V., Deussing, M., Wagner, M., Winkelmann, J., Diehl-Schmid, J., Levin, J., Fellerer, K., Reifschneider, A., Bultmann, S., Bartenstein, P., Rominger, A., Tahirovic, S., Smith, S. T., Madore, C., Butovsky, O., Capell, A., & Haass, C. 2019-06-01
Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury, Science Translational Medicine Suárez-Calvet, M., Araque Caballero, M. Á., Kleinberger, G., Bateman, R. J., Fagan, A. M., Morris, J. C., Levin, J., Danek, A., Ewers, M., & Haass, C. 2016-12-14
Signatures of glial activity can be detected in the CSF proteome, Proceedings of the National Academy of Sciences of the United States of America Eninger, T., Müller, S. A., Bacioglu, M., Schweighauser, M., Lambert, M., Maia, L. F., Neher, J. J., Hornfeck, S. M., Obermüller, U., Kleinberger, G., Haass, C., Kahle, P. J., Staufenbiel, M., Ping, L., Duong, D. M., Levey, A. I., Seyfried, N. T., Lichtenthaler, S. F., Jucker, M., & Kaeser, S. A. 2022-06-06
Role of estrogen in women’s Alzheimer’s disease risk as modified by APOE, Journal of Neuroendocrinology Valencia-Olvera, A. C., Maldonado Weng, J., Christensen, A., LaDu, M. J., & Pike, C. J. 2022-10-20
APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice, Journal of Neuroinflammation Stephen, T. L., Breningstall, B., Suresh, S., McGill, C. J., & Pike, C. J. 2022-12-01
Effects of APOE Genotype and Western Diet on Metabolic Phenotypes in Female Mice, Metabolites Christensen, A., & Pike, C. J. 2023-02-16
APOE, Genotype, and Sex affect microglial interactions with plaques in Alzheimer’s disease mice, Acta Neuropathologica Communications Stephen, T. L., Cacciottolo, M., Balu, D., Morgan, T. E., LaDu, M. J., Finch, C. E., & Pike, C. J. 2019-05-21
Transcriptome-wide Association Study in Frontotemporal Dementia Identifies New Disease Loci by In Silico Analysis, Biological Psychiatry Lill C. M. 2021-04-15
MicroRNAs as Molecular Biomarkers for Parkinson’s Disease Progression, Movement Disorders Schilling, M., & Lill, C. M. 2021-07-05
Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease, Alzheimer's Research & Therapy Sommerer, Y., Dobricic, V., Schilling, M., Ohlei, O., Sabet, S. S., Wesse, T., Fuß, J., Franzenburg, S., Franke, A., Parkkinen, L., Lill, C. M., & Bertram, L. 2023-05-06
Positron Emission Tomography Imaging of Fibrillar Parenchymal and Vascular Amyloid-beta in TgCRND8 Mice, ACS Chemical Neuroscience McLean, D., Cooke, M. J., Albay, R., 3rd, Glabe, C., & Shoichet, M. S. 2013-03-19
Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochimica et Biophysica Acta - General Subjects Arai, H., Glabe, C., & Luecke, H. 2023-12-12
The anti-amyloid beta monoclonal antibody 4G8 recognizes a generic sequence-independent epitope associated with alpha-synuclein and islet amyloid polypeptide amyloid fibrils, Journal of Alzheimer's Disease Hatami, A., Monjazeb, S., & Glabe, C. 2016-12-01
Epitomic Characterization of the specificity of the Anti-Amyloid A beta Monoclonal Antibodies 6E10 and 4G8, Journal of Alzheimer's Disease Baghallab, I., Reyes-Ruiz, J. M., Abulnaja, K., Huwait, E., & Glabe, C. 2018-11-05
Monoclonal antibodies against A beta 42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer’s disease brain, Journal of Biological Chemistry Hatami, A., Albay, R., 3rd, Monjazeb, S., Milton, S., & Glabe, C. 2014-10-03
Familial Alzheimer’s Disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-beta peptide, Journal of Biological Chemistry Hatami, A., Monjazeb, S., Milton, S., & Glabe, C. G. 2017-01-03
An “epitomic” analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies, Journal of Biological Chemistry Reyes-Ruiz, J. M., Nakajima, R., Baghallab, I., Goldschmidt, L., Sosna, J., Mai Ho, P. N., Kumosani, T., Felgner, P. L., & Glabe, C. 2020-12-14
Structural Classification of Toxic Amyloid Oligomers, Journal of Biological Chemistry Glabe C. G. 2008-10-31
Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer, Journal of Biological Chemistry Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., & Glabe, C. 2009-02-13
Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid beta but Do Not Seed Fibril Formation, Journal of Biological Chemistry Wu, J. W., Breydo, L., Isas, J. M., Lee, J., Kuznetsov, Y. G., Langen, R., & Glabe, C. 2009-12-15
Systematic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing A deposition and tau pathology in 3xTg AD mice, Journal of Neurochemistry Rasool, S., Martinez-Coria, H., Wu, J. W., LaFerla, F., & Glabe, C. G. 2013-08-01
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers, Molecular Neurodegeneration Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., Rasool, S., Gurlo, T., Butler, P., & Glabe, C. G. 2007-09-26
Conformational dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar A beta oligomers, Molecular Neurodegeneration Kayed, R., Canto, I., Breydo, L., Rasool, S., Lukacsovich, T., Wu, J., Albay, R., 3rd, Pensalfini, A., Yeung, S., Head, E., Marsh, J. L., & Glabe, C. 2010-12-13
Early long-term administration of CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in FXFAD mouse models of Alzheimer’s disease., Molecular Neurodegeneration Sosna, J., Philipp, S., Albay, R., 3rd, Reyes-Ruiz, J. M., Baglietto-Vargas, D., LaFerla, F. M., & Glabe, C. G. 2018-03-01
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques, Neurobiology of Disease Pensalfini, A., Albay, R., 3rd, Rasool, S., Wu, J. W., Hatami, A., Arai, H., Margol, L., Milton, S., Poon, W. W., Corrada, M. M., Kawas, C. H., & Glabe, C. G. 2014-11-01
Soluble fibrillar oligomer levels are elevated in Alzheimer’s disease brain and correlate with cognitive dysfunction, Neurobiology of Disease Tomic, J. L., Pensalfini, A., Head, E., & Glabe, C. G. 2009-09-01
Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury, Alzheimer's Research & Therapy Button, E. B., Cheng, W. H., Barron, C., Cheung, H., Bashir, A., Cooper, J., Gill, J., Stukas, S., Baron, D. C., Robert, J., Rowe, E. M., Cripton, P. A., & Wellington, C. L. 2021-03-07
The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19, Blood Advances Hoiland, R. L., Fergusson, N. A., Mitra, A. R., Griesdale, D. E. G., Devine, D. V., Stukas, S., Cooper, J., Thiara, S., Foster, D., Chen, L. Y. C., Lee, A. Y. Y., Conway, E. M., Wellington, C. L., & Sekhon, M. S. 2020-10-14
Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome, Cell Reports Medicine Chen, L. Y. C., Biggs, C. M., Jamal, S., Stukas, S., Wellington, C. L., & Sekhon, M. S. 2021-04-19
Confronting the controversy: Interleukin-6 and the COVID-19 cytokine storm syndrome, European Respiratory Journal Chen, L. Y. C., Hoiland, R. L., Stukas, S., Wellington, C. L., & Sekhon, M. S. 2020-10-01
Neurotoxicity of Diesel Exhaust Particles, Journal of Alzheimer's disease Shkirkova, K., Lamorie-Foote, K., Zhang, N., Li, A., Diaz, A., Liu, Q., Thorwald, M. A., Godoy-Lugo, J. A., Ge, B., D'Agostino, C., Zhang, Z., Mack, W. J., Sioutas, C., Finch, C. E., Mack, W. J., & Zhang, H. 2022-10-11
Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo, Journal of Neuroinflammation Woodward, N. C., Levine, M. C., Haghani, A., Shirmohammadi, F., Saffari, A., Sioutas, C., Morgan, T. E., & Finch, C. E. 2017-04-14
Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice, Neurobiology of Aging Cacciottolo, M., Morgan, T. E., & Finch, C. E. 2021-02-28
Female vulnerability to the effects of smoking on health outcomes in older people, PLoS One Haghani, A., Arpawong, T. E., Kim, J. K., Lewinger, J. P., Finch, C. E., & Crimmins, E. 2020-06-04
The Exposome in Human Evolution from Dust to Diesel, Quarterly Review of Biology Trumble, B. C., & Finch, C. E. 2019-12-01
Air Pollution alters C. elegans development and lifespan: responses to traffic-related nanoparticulate matter, The Journals of Gerontology: Series A Haghani, A., Dalton, H. M., Safi, N., Shirmohammadi, F., Sioutas, C., Morgan, T. E., Finch, C. E., & Curran, S. P. 2019-03-04
Apolipoprotein E and Sex Bias in Cerebrovascular aging of men and mice, Trends in Neurosciences Finch, C. E., & Shams, S. 2016-08-18
Interleukin-3 gets a fresh start in the brain, Genes & Immunity Yates, A. G., Khamhoung, A., & McAlpine, C. S. 2023-12-08
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. 2021-07-14
Sleep exerts lasting effects on hematopoietic stem cell function and diversity, Journal of Experimental Medicine McAlpine, C. S., Kiss, M. G., Zuraikat, F. M., Cheek, D., Schiroli, G., Amatullah, H., Huynh, P., Bhatti, M. Z., Wong, L. P., Yates, A. G., Poller, W. C., Mindur, J. E., Chan, C. T., Janssen, H., Downey, J., Singh, S., Sadreyev, R. I., Nahrendorf, M., Jeffrey, K. L., Scadden, D. T., Naxerova, K., St-Onge, M., & Swirski, F.K. 2022-09-21
Monocytes re-enter the bone marrow during fasting and alter the host response to infection, Immunity Janssen, H., Kahles, F., Liu, D., Downey, J., Koekkoek, L. L., Roudko, V., D'Souza, D., McAlpine, C. S., Halle, L., Poller, W. C., Chan, C. T., He, S., Mindur, J. E., Kiss, M. G., Singh, S., Anzai, A., Iwamoto, Y., Kohler, R. H., Chetal, K., Sadreyev, R. I., Weissleder, R., Kim-Schulze, S., Merad, M., Nahrendorf, M., & Swirski, F. K. 2023-02-23
Antibiotic-induced perturbation in gut microbial diversity influences neuro-inflammation and amylodiosis in a murine model of Alzheimer’s disease, Scientific Reports Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. 2016-07-16
Familial Alzhiemer’s Disease mutations in presenilin 1 do not alter levels of the secreted amyloid-protein precursor generated by beta-secretase cleavage, Current Alzheimer Research Zhang, C., Browne, A., Kim, D. Y., & Tanzi, R. E. 2010-02-01
Enhanced liver gene transfer and evasion of pre-existing humoral immunity with exosome-envelope AAV vectors, Blood Advances Meliani, A., Boisgerault, F., Fitzpatrick, Z., Marmier, S., Leborgne, C., Collaud, F., Simon Sola, M., Charles, S., Ronzitti, G., Vignaud, A., van Wittenberghe, L., Marolleau, B., Jouen, F., Tan, S., Boyer, O., Christophe, O., Brisson, A. R., Maguire, C. A., & Mingozzi, F. 2017-10-16
Rescue of Hearing by Gene Delivery to inner-ear hair cells using exome associated AAV, Molecular Therapy György, B., Sage, C., Indzhykulian, A. A., Scheffer, D. I., Brisson, A. R., Tan, S., Wu, X., Volak, A., Mu, D., Tamvakologos, P. I., Li, Y., Fitzpatrick, Z., Ericsson, M., Breakefield, X. O., Corey, D. P., & Maguire, C. A. 2017-02-01
Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate, Molecular Therapy - Methods & Clinical Development Berezovskii, V. K., Born, R. T., O'Brien, M., Lafond, J. F., Arsenijevic, Y., Kenna, M. A., Maguire, C. A., & Corey, D. P. 2018-11-18
Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2, Molecular Therapy - Methods & Clinical Development Prabhakar, S., Beauchamp, R. L., Cheah, P. S., Yoshinaga, A., Haidar, E. A., Lule, S., Mani, G., Maalouf, K., Stemmer-Rachamimov, A., Jung, D. H., Welling, D. B., Giovannini, M., Plotkin, S. R., Maguire, C. A., Ramesh, V., & Breakefield, X. O. 2022-06-22
Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection, Scientific Reports Wassmer, S. J., Carvalho, L. S., György, B., Vandenberghe, L. H., & Maguire, C. A. 2017-03-31
Gene therapy for Alzheimer’s Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation., Human Molecular Genetics Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., Volak, A., LeRoy, S., Gandhi, S., Lerner, E. P., Hudry, E., Tanzi, R. E., & Maguire, C. A. 2020-08-17
Using mass spectrometry to validate mouse models of tauopathy, Molecular Neurodegenration Yan, Y., & Cook, C. N. 2023-04-05
Reconstitution of the Alzheimer’s Disease Tau Core Structure from Recombinant Tau297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM, Biochemistry Glynn, C., Chun, J. E., Donahue, C. C., Nadler, M. J. S., Fan, Z., & Hyman, B. T. 2023-12-28
APOE4 derived from astrocytes leads to blood-brain barrier impairment, Brain Jackson, R. J., Meltzer, J. C., Nguyen, H., Commins, C., Bennett, R. E., Hudry, E., & Hyman, B. T. 2021-12-27
The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue, Journal of Neuropathology & Experimental Neurology Oakley, D. H., Chung, M., Klickstein, N., Commins, C., Hyman, B. T., & Frosch, M. P. 2020-04-04
Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons, Journal of Neuroscience Oakley, D. H., Klickstein, N., Commins, C., Chung, M., Dujardin, S., Bennett, R. E., Hyman, B. T., & Frosch, M. P. 2021-04-23
Virus vector mediated genetic modification of brain tumor stromal cells after intravenous delivery, Journal of Neuro-Oncology Volak, A., LeRoy, S. G., Natasan, J. S., Park, D. J., Cheah, P. S., Maus, A., Fitzpatrick, Z., Hudry, E., Pinkham, K., Gandhi, S., Hyman, B. T., Mu, D., GuhaSarkar, D., Stemmer-Rachamimov, A. O., Sena-Esteves, M., Badr, C. E., & Maguire, C. A. 2018-09-01
Efficient Gene Transfer to the Central Nervous System by single-stranded Anc80L65, Molecular Therapy - Methods & Clinical Development Hudry, E., Andres-Mateos, E., Lerner, E. P., Volak, A., Cohen, O., Hyman, B. T., Maguire, C. A., & Vandenberghe, L. H. 2018-09-21
A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples, Clinical Epigenetics Sommerer, Y., Ohlei, O., Dobricic, V., Oakley, D. H., Wesse, T., Sedghpour Sabet, S., Demuth, I., Franke, A., Hyman, B. T., Lill, C. M., & Bertram, L. 2022-11-01
Anti-ApoE Antibody given after plaque onset decreases A beta accumulation and improves brain function in a mouse model of a beta amyloidosis, Journal of Neuroscience Liao, F., Hori, Y., Hudry, E., Bauer, A. Q., Jiang, H., Mahan, T. E., Lefton, K. B., Zhang, T. J., Dearborn, J. T., Kim, J., Culver, J. P., Betensky, R., Wozniak, D. F., Hyman, B. T., & Holtzman, D. M. 2014-05-21
The Alzheimer’s Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide, PLoS One Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., & Moir, R. D. 2010-03-03
Massachusetts Alzheimer’s Disease Research Center: Progress and Challenges, Alzheimer's & Dementia Hyman, B. T., Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. T., Haass, C., Hudry, E., Jack, C. R., Jr, Johnson, K. A., Khachaturian, Z. S., Kim, D. Y., Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L., Young, A. B., Phelps, C. H., & McCaffrey, P.M. 2015-10-01
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer’s disease mouse model, Alzheimer's & Dementia Claes, C., England, W. E., Danhash, E. P., Kiani Shabestari, S., Jairaman, A., Chadarevian, J. P., Hasselmann, J., Tsai, A. P., Coburn, M. A., Sanchez, J., Lim, T. E., Hidalgo, J. L. S., Tu, C., Cahalan, M. D., Lamb, B. T., Landreth, G. E., Spitale, R. C., Blurton-Jones, M., & Davtyan, H. 2022-02-09
ARMADA: Assessing reliable measurement in Alzheimer’s disease and cognitive aging project methods, Alzheimer's & Dementia Weintraub, S., Karpouzian-Rogers, T., Peipert, J. D., Nowinski, C., Slotkin, J., Wortman, K., Ho, E., Rogalski, E., Carlsson, C., Giordani, B., Goldstein, F., Lucas, J., Manly, J. J., Rentz, D., Salmon, D., Snitz, B., Dodge, H. H., Riley, M., Eldes, F., Ustsinovich, V., & Gershon, R. 2021-11-17
Baseline characterization of the ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease) study cohorts, Alzheimer's & Dementia Karpouzian-Rogers, T., Ho, E., Novack, M., Chinkers, M., Bedjeti, K., Nowinski, C., Giordani, B., Gershon, R., & Weintraub, S. 2022-11-17
The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans, Alzheimer's & Dementia Haghani, A., Thorwald, M., Morgan, T. E., & Finch, C. E. 2020-11-20
Amyloid futures in the expanding pathology of brain aging and dementia, Alzheimer's & Dementia Thorwald, M. A., Silva, J., Head, E., & Finch, C. E. 2022-12-19
Does selection for short sleep duration explain huma vulnerability to Alzheimer’s disease?, Evolution, Medicine, and Public Health Nesse, R. M., Finch, C. E., & Nunn, C. L. 2017-01-24
Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts, Free Radical Biology and Medicine Cacciottolo, M., Morgan, T. E., Saffari, A. A., Shirmohammadi, F., Forman, H. J., Sioutas, C., & Finch, C. E. 2019-12-26
Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies, Frontiers in Aging Finch C. E. 2023-11-13
APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease, Frontiers in Aging Neuroscience Yassine, H. N., & Finch, C. E. 2020-06-10
Urban Air Pollution Nanoparticles from Los Angeles: Recently Decreased Neurotoxicity, Journal of Alzheimer's Disease Zhang, H., D'Agostino, C., Forman, H. J., Cacciottolo, M., Thorwald, M., Mack, W. J., Liu, Q., Shkirkova, K., Lamorie-Foote, K., Sioutas, C., Pirhadi, M., Mack, W. J., Morgan, T. E., & Finch, C. E. 2021-06-29
APOE4 Leads to Blood-Brain Barrier Dysfunction Predicting Cognitive Decline, Nature Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D'Orazio, L. M., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Reiman, E. M., Caselli, R. J., Chui, H. C., TCW, J., Chen, Y., Pa, J., Conti, P. S., Law, M., Toga, A.W., & Zlokovic, B. 2020-04-29
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β, Nature Aging Montagne, A., Nikolakopoulou, A. M., Huuskonen, M. T., Sagare, A. P., Lawson, E. J., Lazic, D., Rege, S. V., Grond, A., Zuniga, E., Barnes, S. R., Prince, J., Sagare, M., Hsu, C. J., LaDu, M. J., Jacobs, R. E., & Zlokovic, B. V. 2021-06-14
Blood–brain barrier link to human cognitive impairment and Alzheimer’s disease, Nature Cardiovascular Research Barisano, G., Montagne, A., Kisler, K., Schneider, J. A., Wardlaw, J. M., & Zlokovic, B. V. 2022-02-07
Microglia have a grip on brain microvasculature., Nature Communications Kisler, K., Nikolakopoulou, A. M., & Zlokovic, B. V. 2021-09-06
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction, Nature Medicine Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D'Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Chui, H. C., Law, M., Toga, A. W., & Zlokovic, B. V. 2019-01-01
The role of brain vasculature in neurodegenerative disorders, Nature Neuroscience Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. 2018-10-01
In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain, Nature Protocols Kisler, K., Lazic, D., Sweeney, M. D., Plunkett, S., El Khatib, M., Vinogradov, S. A., Boas, D. A., Sakadži, S., & Zlokovic, B. V. 2018-03-01
Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders, Nature Reviews Neurology Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. 2018-03-01
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice, Journal of Experimental Medicine Barisano, G., Kisler, K., Wilkinson, B., Nikolakopoulou, A. M., Sagare, A. P., Wang, Y., Gilliam, W., Huuskonen, M. T., Hung, S. T., Ichida, J. K., Gao, F., Coba, M. P., & Zlokovic, B. V. 2022-08-30
Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop, Alzheimer's & Dementia Zlokovic, B. V., Gottesman, R. F., Bernstein, K. E., Seshadri, S., McKee, A., Snyder, H., Greenberg, S. M., Yaffe, K., Schaffer, C. B., Yuan, C., Hughes, T. M., Daemen, M. J., Williamson, J. D., González, H. M., Schneider, J., Wellington, C. L., Katusic, Z. S., Stoeckel, L., Koenig, J. I., Corriveau, R. A., Fine, L., Galis, Z. G., Reis, J., Wright, J.D., & Chen, J. 2020-10-08
Immune Signaling in Neurodegeneration, Immunity Hammond, T. R., Marsh, S. E., & Stevens, B. 2019-04-16
New tricks for an ancient system: physiological and pathological roles of complement in the CNS, Molecular Immunology Tenner, A. J., Stevens, B., & Woodruff, T. M. 2018-10-01
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain, Nature Neuroscience Marsh, S. E., Walker, A. J., Kamath, T., Dissing-Olesen, L., Hammond, T. R., de Soysa, T. Y., Young, A. M. H., Murphy, S., Abdulraouf, A., Nadaf, N., Dufort, C., Walker, A. C., Lucca, L. E., Kozareva, V., Vanderburg, C., Hong, S., Bulstrode, H., Hutchinson, P. J., Gaffney, D. J., Hafler, D. A., Franklin, R. J. M., Macosko, E. Z., & Stevens, B. 2022-03-08
Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases, Seminars in Immunology Yvanka de Soysa, T., Therrien, M., Walker, A. C., & Stevens, B. 2022-09-22
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia, The EMBO Journal Scott-Hewitt, N., Perrucci, F., Morini, R., Erreni, M., Mahoney, M., Witkowska, A., Carey, A., Faggiani, E., Schuetz, L. T., Mason, S., Tamborini, M., Bizzotto, M., Passoni, L., Filipello, F., Jahn, R., Stevens, B., & Matteoli, M. 2020-07-13
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity, Cell Metabolism Wieder, N., Fried, J. C., Kim, C., Sidhom, E. H., Brown, M. R., Marshall, J. L., Arevalo, C., Dvela-Levitt, M., Kost-Alimova, M., Sieber, J., Gabriel, K. R., Pacheco, J., Clish, C., Abbasi, H. S., Singh, S., Rutter, J. C., Therrien, M., Yoon, H., Lai, Z. W., Baublis, A., Subramanian, R., Devkota, R., Small, J., Sreehanth, V., Han, My., Lim. D., Carprenter, A. E., Flannick, J., Finucane, H., Haigis, M.C., Claussnitzer, M., Sheu, E., Stevens, B., Wagner, B. K., Choudhary, A., Shaw, J. L., Pablo, J. L., & Greka, A. 2023-05-02
Microglia states and nomenclature: A field at its crossroads, Neuron Paolicelli, R. C., Sierra, A., Stevens, B., et al. 2022-11-02
Biologic targets of prescription medications and risk of neurodegenerative disease in United States Medicare beneficiaries, PLoS One Song, Y., Racette, B. A., Camacho-Soto, A., & Searles Nielsen, S. 2023-05-17
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau, Acta Neuropathologica Mate De Gerando, A., Welikovitch, L. A., Khasnavis, A., Commins, C., Glynn, C., Chun, J. E., Perbet, R., & Hyman, B. T. 2023-06-21
All the Tau We Cannot See, Annual Review of Medicine Hyman, B. 2023-01-27
Identification and in vivo characterization of a brain-penetrating nanobody, Fluids and Barriers of the CNS Wouters, Y., Jaspers, T., De Strooper, B., & Dewilde, M. 2020-10-14
Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics, Pharmaceutics Rué, L., Jaspers, T., Degors, I. M. S., Noppen, S., Schols, D., De Strooper, B., & Dewilde, M. 2023-06-16
RNA binding proteins co-localize with small tau inclusions in tauopathy, Acta Neuropathologica Maziuk, B. F., Apicco, D. J., Cruz, A. L., Jiang, L., Ash, P. E. A., da Rocha, E. L., Zhang, C., Yu, W. H., Leszyk, J., Abisambra, J. F., Li, H., & Wolozin, B. 2018-08-01
RNA Binding Proteins and the Genesis of Neurodegenerative Diseases, Advances in Experimental Medicine and Biology Wolozin, B., & Apicco, D. 2014-10-30
The Pathophysiology of Tau and Stress Granules in Disease, Advances in Experimental Medicine and Biology Cruz, A., Verma, M., & Wolozin, B. 2020-02-25
Disrupted in Dementia, Biological Psychiatry Wolozin, B. 2018-10-01
Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology, Cell Death & Differentiation Silva, J. M., Rodrigues, S., Sampaio-Marques, B., Gomes, P., Neves-Carvalho, A., Dioli, C., Soares-Cunha, C., Mazuik, B. F., Takashima, A., Ludovico, P., Wolozin, B., Sousa, N., & Sotiropoulos, I. 2018-11-15
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Cell Reports Vanderweyde, T., Apicco, D. J., Youmans-Kidder, K., Ash, P. E. A., Cook, C., Lummertz da Rocha, E., Jansen-West, K., Frame, A. A., Citro, A., Leszyk, J. D., Ivanov, P., Abisambra, J. F., Steffen, M., Li, H., Petrucelli, L., & Wolozin, B. 2016-05-17
Dysregulation of RNA Splicing in Tauopathies, Cell Reports Apicco, D. J., Zhang, C., Maziuk, B., Jiang, L., Ballance, H. I., Boudeau, S., Ung, C., Li, H., & Wolozin, B. 2019-12-24
Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders, Frontiers in Molecular Neuroscience Maziuk, B., Ballance, H. I., & Wolozin, B. 2017-04-04
Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes, Human Molecular Genetics Russo, A., Scardigli, R., La Regina, F., Murray, M. E., Romano, N., Dickson, D. W., Wolozin, B., Cattaneo, A., & Ceci, M. 2017-04-15
Directed evolution of a picomolar-affinity, high-specificity antibody targeting phosphorylated tau, Journal of Biological Chemistry Li, D., Wang, L., Maziuk, B. F., Yao, X., Wolozin, B., & Cho, Y. K. 2018-06-13
Dioxins and related environmental contaminants increase TDP-43 levels, Molecular Neurodegeneration Ash, P. E. A., Stanford, E. A., Al Abdulatif, A., Ramirez-Cardenas, A., Ballance, H. I., Boudeau, S., Jeh, A., Murithi, J. M., Tripodis, Y., Murphy, G. J., Sherr, D. H., & Wolozin, B. 2017-05-05
Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology, Toxicological Sciences Ash, P. E. A., Dhawan, U., Boudeau, S., Lei, S., Carlomagno, Y., Knobel, M., Al Mohanna, L. F. A., Boomhower, S. R., Newland, M. C., Sherr, D. H., & Wolozin, B. 2019-01-01
Beneficial Association of Angiotensin-Converting Enzyme Inhibitors and Statins on the Occurrence of Possible Alzheimer’s Disease After Traumatic Brain Injury, Alzheimer's Research & Therapy Li, M., Reisman, J., Morris-Eppolito, B., Qian, S. X., Kazis, L. E., Wolozin, B., Goldstein, L. E., & Xia, W. 2020-03-27
Bacillus Calmette–Guérin in Immuno-Regulation of Alzheimer’s Disease, Frontiers in Aging Neuroscience Klein, B. Y., Greenblatt, C. L., Gofrit, O. N., & Bercovier, H. 2022-06-27
The small HDL particle hypothesis of Alzheimer’s disease, Alzheimer's & Dementia Martinez, A. E., Weissberger, G., Kuklenyik, Z., He, X., Meuret, C., Parekh, T., Rees, J. C., Parks, B. A., Gardner, M. S., King, S. M., Collier, T. S., Harrington, M. G., Sweeney, M. D., Wang, X., Zlokovic, B. V., Joe, E., Nation, D. A., Schneider, L. S., Chui, H. C., Barr, J. R., Han, S.D., Krauss, R.M., & Yassine, H. N. 2022-04-13
On the intersection between systemic infection, brain vascular dysfunction and dementia, Brain Huuskonen, M. T., Kisler, K., Sagare, A. P., & Zlokovic, B. V. 2021-05-11
Editorial for “MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure”, Journal of Magnetic Resonance Imaging Huuskonen, M. T., Barisano, G., Chakhoyan, A., & Zlokovic, B. V. 2021-07-31
Intravenous delivery of targeted liposomes to amyloid-beta in APP/PSEN1 transgenic mice, PLoS One Tanifum, E. A., Dasgupta, I., Srivastava, M., Bhavane, R. C., Sun, L., Berridge, J., Pourgarzham, H., Kamath, R., Espinosa, G., Cook, S. C., Eriksen, J. L., & Annapragada, A. 2023-11-12
Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration, Science Advances Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., Leary, N. S., Pfenning, A. R., Kellis, M., & Tsai, L. H. 2022-09-28
Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration, Autophagy Oh, Y. M., Lee, S. W., & Yoo, A. S. 2023-02-08
LONGO: an R package for interactive gene length dependent analysis for neuronal identity, Bioinformatics McCoy, M. J., Paul, A. J., Victor, M. B., Richner, M., Gabel, H. W., Gong, H., Yoo, A. S., & Ahn, T. H. 2018-06-27
MicroRNAs induce a permissive chromatin environment that enabels neuronal subtype-specific reprogramming of adult human fibroblasts, Cell Stem Cell Abernathy, D. G., Kim, W. K., McCoy, M. J., Lake, A. M., Ouwenga, R., Lee, S. W., Xing, X., Li, D., Lee, H. J., Heuckeroth, R. O., Dougherty, J. D., Wang, T., & Yoo, A. S. 2017-09-07
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs, Cell Stem Cell Cates, K., McCoy, M. J., Kwon, J. S., Liu, Y., Abernathy, D. G., Zhang, B., Liu, S., Gontarz, P., Kim, W. K., Chen, S., Kong, W., Ho, J. N., Burbach, K. F., Gabel, H. W., Morris, S. A., & Yoo, A. S. 2021-01-07
MicroRNAs Overcome cell fate barrier by reducing EH2-controlled REST stability during neuronal conversion of human adult fibroblastrs, Developmental Cell Lee, S. W., Oh, Y. M., Lu, Y. L., Kim, W. K., & Yoo, A. S. 2018-07-02
Special Issue on Stem Cell and Tissue Engineering in Development, Disease, and Repair, Developmental Dynamics Shcheglovitov, A., Rao, M., & Yoo, A. 2019-01-01
Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts, eLife Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. 2016-09-20
Mechanistic insights into MicroRNA-induced Neuronal Reprogramming of Human Adult Fibroblasts, Frontiers in Neuroscience Lu, Y. L., & Yoo, A. S. 2018-08-02
Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1–TFEB pathway to Huntington’s disease neurodegeneration, Nature Aging Lee, S. W., Oh, Y. M., Victor, M. B., Yang, Y., Chen, S., Strunilin, I., Dahiya, S., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., & Yoo, A. S. 2023-12-08
Striatal Neurons directly converted from Huntington’s disease patient fibroblast recapitulate age-associated disease phenotypes, Nature Neuroscience Victor, M. B., Richner, M., Olsen, H. E., Lee, S. W., Monteys, A. M., Ma, C., Huh, C. J., Zhang, B., Davidson, B. L., Yang, X. W., & Yoo, A. S. 2018-02-05
Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy, Nature Neuroscience Oh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., Pak, S. C., Silverman, G. A., Perlmutter, D. H., & Yoo, A. S. 2022-10-27
Modeling Adult-Onset Neurodegenerative Disorders with Human Neurons through Direct Neuronal Reprogramming, The FASEB Journal Yoo, A. S. 2019-04-01
Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond, Annual Reviews Shaw, J. L., Pablo, J. L., & Greka, A. 2023-02-10
Lipid metabolism in sickness and in health:Emerging regulators of lipotoxicity, Molecular Cell Yoon, H., Shaw, J. L., Haigis, M. C., & Greka, A. 2021-09-16
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model, Nature Communications Suzzi, S., Croese, T., Ravid, A., Gold, O., Clark, A. R., Medina, S., Kitsberg, D., Adam, M., Vernon, K. A., Kohnert, E., Shapira, I., Malitsky, S., Itkin, M., Brandis, A., Mehlman, T., Salame, T. M., Colaiuta, S. P., Cahalon, L., Slyper, M., Greka, A., Habib, N., & Schwartz, M. 2023-03-09
The AD tau core spontaneously self-assembles and recruits full-length tau to filaments, Cell Reports Carlomagno, Y., Manne, S., DeTure, M., Prudencio, M., Zhang, Y. J., Hanna Al-Shaikh, R., Dunmore, J. A., Daughrity, L. M., Song, Y., Castanedes-Casey, M., Lewis-Tuffin, L. J., Nicholson, K. A., Wszolek, Z. K., Dickson, D. W., Fitzpatrick, A. W. P., Petrucelli, L., & Cook, C. N. 2021-03-16
Identification and characterization of nanobodies targeting the EphA4 receptor, Journal of Biological Chemistry Schoonaert, L., Rué, L., Roucourt, B., Timmers, M., Little, S., Chávez-Gutiérrez, L., Dewilde, M., Joyce, P., Curnock, A., Weber, P., Haustraete, J., Hassanzadeh-Ghassabeh, G., De Strooper, B., Van Den Bosch, L., Van Damme, P., Lemmens, R., & Robberecht, W. 2017-07-07
VHHs as tools for therapeutic protein delivery to the central nervous system, Fluids and Barriers of the CNS Wouters, Y., Jaspers, T., Rué, L., Serneels, L., De Strooper, B., & Dewilde, M. 2022-10-03
26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase, Proceedings of the National Academy of Sciences of the United States of America Lee, D., & Goldberg, A. L. 2022-06-21
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation, Proceedings of the National Academy of Sciences of the United States of America VerPlank, J. J. S., Lokireddy, S., Zhao, J., & Goldberg, A. L. 2019-03-05
Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation, Proceedings of the National Academy of Sciences of the United States of America Collins, G. A., & Goldberg, A. L. 2020-03-03
cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases, Proceedings of the National Academy of Sciences of the United States of America VerPlank, J. J. S., Tyrkalska, S. D., Fleming, A., Rubinsztein, D. C., & Goldberg, A. L. 2020-06-08
ZFand5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation, Proceedings of the National Academy of Sciences of the United States of America Lee, D., Takayama, S., & Goldberg, A. L. 2018-09-25
UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells (vol 115, pg E11642, 2018), Proceedings of the National Academy of Sciences of the United States of America Kim, H. T., & Goldberg, A. L. 2018-11-28
Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation, Biomolecules Goldberg, A. L., Kim, H. T., Lee, D., & Collins, G. A. 2021-05-22
Predictive value of ATN biomarker profiles in estimating disease progression in Alzheimer’s disease dementia, Alzheimer's & Dementia Ezzati, A., Abdulkadir, A., Jack, C. R., Jr, Thompson, P. M., Harvey, D. J., Truelove-Hill, M., Sreepada, L. P., Davatzikos, C., Alzheimer's Disease Neuroimaging Initiative, & Lipton, R. B. 2021-11-17
Impact of sex and APOE ε4 on the association of cognitionand hippocampal volume in clinically normal, amyloid positive adults, Alzheimer's & Dementia Petersen, K. K., Grober, E., Lipton, R. B., Sperling, R. A., Buckley, R. F., Aisen, P. S., & Ezzati, A. 2022-02-09
Application of predictive models in boosting power of Alzheimer’s disease clinical trials: A post hoc analysis of phase 3 solanezumab trials, Alzheimer's & Dementia Ezzati, A., Davatzikos, C., Wolk, D. A., Hall, C. B., Habeck, C., & Lipton, R. B. 2022-03-14
Tracking cognition with the T-MoCA in a racially/ethnically diverse older adult cohor, Alzheimer's & Dementia Wang, C., Nester, C. O., Chang, K., Rabin, L. A., Ezzati, A., Lipton, R. B., & Katz, M. J. 2023-03-08
Leveraging machine learning predictive biomarkers to augment the statistical power of clinical trials with baseline magnetic resonance imaging, Brain Communications Lou, C., Habes, M., Illenberger, N. A., Ezzati, A., Lipton, R. B., Shaw, P. A., Stephens-Shields, A. J., Akbari, H., Doshi, J., Davatzikos, C., & Shinohara, R. T. 2021-11-03
Associations of Stages of Objective Memory Impairment with Cerebrospinal Fluid and Neuroimaging Biomarkers of Alzheimer’s Disease, Journal of Prevention of Alzheimer's Disease Petersen, K. K., Ezzati, A., Lipton, R. B., Gordon, B. A., Hassenstab, J., Morris, J. C., & Grober, E. 2022-11-03
The maximum entropy principle for compositional data, BMC Bioinformatics Weistuch, C., Zhu, J., Deasy, J. O., & Tannenbaum, A. R. 2022-10-29
Geometric graph neural networks on multi-omics data to predict cancer survival outcomes, Computers in Biology and Medicine Zhu, J., Oh, J. H., Simhal, A. K., Elkin, R., Norton, L., Deasy, J. O., & Tannenbaum, A. 2023-06-09
Wasserstein HOG: Local Directionality Extraction via Optimal Transport, IEEE Transactions on Medical Imaging Zhu, J., Veeraraghavan, H., Jiang, J., Oh, J. H., Norton, L., Deasy, J. O., & Tannenbaum, A. 2023-10-24
Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain, Physiology Zhao, L., Tannenbaum, A., Bakker, E. N. T. P., & Benveniste, H. 2022-09-15
The role of innate immune genes in Alzheimer’s disease, Current Opinion in Neurology Griciuc, A., & Tanzi, R. E. 2021-04-01
Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta, Neuron Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. 2013-05-22
Cerebral vascular leak in a mouse model of amyloid neuropathology, Journal of Cerebral Blood Flow & Metabolism Tanifum, E. A., Starosolski, Z. A., Fowler, S. W., Jankowsky, J. L., & Annapragada, A. V. 2014-10-01
Controversies about the subcellular localization and mechanisms of action of the Alzhiemer’s disease-protective CD33 splice variant, Acta Neuropathologica Saha, S., Siddiqui, S. S., Khan, N., Verhagen, A., Jiang, W., Springer, S., Ghosh, P., & Varki, A. 2019-08-22
Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers, Molecular Biology and Evolution Saha, S., Khan, N., Comi, T., Verhagen, A., Sasmal, A., Diaz, S., Yu, H., Chen, X., Akey, J. M., Frank, M., Gagneux, P., & Varki, A. 2022-07-09
Amyloid precursor protein translation is regulated by a 3′ UTR Guanine Quadruplex, PLoS One Crenshaw, E., Leung, B. P., Kwok, C. K., Sharoni, M., Olson, K., Sebastian, N. P., Ansaloni, S., Schweitzer-Stenner, R., Akins, M. R., Bevilacqua, P. C., & Saunders, A. J. 2015-11-30
A predictive algorithm to identify ever smoking in medical claims-based epidemiologic studies, Annals of Epidemiology Faust, I., Warden, M., Camacho-Soto, A., Racette, B. A., & Nielsen, S. S. 2023-05-02
Protein kinase C: perfectly balanced, Critical Reviews in Biochemistry and Molecular Biology Newton A. C. 2018-03-07
Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?, Neuronal Signaling Lordén, C. & Newton A. C. 2021-10-08
Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation, Proceedings of the National Academy of Sciences of the United States of America Callender, J. A., Yang, Y., Lordén, G., Stephenson, N. L., Jones, A. C., Brognard, J., & Newton, A. C. 2018-05-29
Protein Kinase C alpha (PKC alpha) Gain-of-Function Variant in Alzheimer’s Disease Displays Enhanced Catalysis by a Mechanism that Evades Down-Regulation, Proceedings of the National Academy of Sciences of the United States of America Callender, J. A., Yang, Y., Lordén, G., Stephenson, N. L., Jones, A. C., Brognard, J., & Newton, A. C. 2018-05-29
Protein Kinase C as a tumor suppressor, Seminars in Cancer Biology Newton A. C. 2018-02-01
Rare Alzheimer’s Disease-Associated Protein Kinase C variant displays altered pharmacological profile in cellular environment, The FASEB Journal Yang Y., Callender, J., & Newton A. C. 2018-04-01
Amplified Protein Kinase C Signaling in Alzheimer’s Disease, The FASEB Journal Lorden, G., Wosniak, J. M., Dozier, L. E., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., & Newton, A. C. 2020-04-18
Gain of Function mutations in protein kinase c alpha (PKC alpha) may promote synaptic defects in Alzheimer’s disease, Science Signaling Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E., & Malinow, R. 2016-05-10
Editorial: Advances and perspectives in neuroplacentology, Frontiers in Endocrinology Vacher, C. M., Bonnin, A., Mir, I. N., & Penn, A. A. 2023-05-19
Regulating protein breakdown through proteasome phosphorylation, Biochemical Journal VerPlank, J. J. S., & Goldberg, A. L. 2017-09-24
Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy, Brain VerPlank, J. J. S., Gawron, J., Silvestri, N. J., Feltri, M. L., Wrabetz, L., & Goldberg, A. L. 2021-08-11
The Logic of the 26S Proteasome, Cell Collins, G. A., & Goldberg, A. L. 2017-05-18
The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis, Journal of Biological Chemistry Kim, H. T., & Goldberg, A. L. 2017-06-09
Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation, Journal of Biological Chemistry Collins, G. A., Sha, Z., Kuo, C. L., Erbil, B., & Goldberg, A. L. 2022-03-28
Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies, Journal of Biological Chemistry Sha, Z., Blyszcz, T., González-Prieto, R., Vertegaal, A. C. O., & Goldberg, A. L. 2019-07-08
Measurement of the Multiple Activities of 26S Proteasomes, Methods in Molecular Biology Kim, H. T., Collins, G. A., & Goldberg, A. L. 2018-09-22
Editorial: Understanding human biology with iPSC derived cell types in the era of CRISPR technology, Fronetiers in Cell and Developmental Biology Li, H., Przybyla, L., & Blanchard, J. W. 2023-12-22
Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human, Glia Prakash, P., Erdjument-Bromage, H., O'Dea, M. R., Munson, C. N., Labib, D., Fossati, V., Neubert, T. A., & Liddelow, S. A. 2023-11-30
Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics, Journal of Prevention of Alzheimer's Disease Riessland, M., & Orr, M. E. 2023-10-24
Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer’s disease and primary age-related tauopathy, Alzheimer's & Dementia Walker, J. M., Orr, M. E., Orr, T. C., ... Richardson, T. E. 2023-09-30
Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols, Nature Neuroscience Frazel, P. W., Labib, D., Fisher, T., Brosh, R., Pirianian, N., Marchildon, A., Boeke, J. D., Fossati, V., & Liddelow, S. A. 2023-09-11
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial, Nature Medicine Gonzales, M. M., Garbarino, V. R., Kautz, T. F., Palavicini, J. P., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J. J., Zare, H., Xu, P., Zhang, B., Franklin, C., Habes, M., Craft, S., Petersen, R. C., Tchkonia, T., Kirkland, J. L., Salardini, A., Seshadri, S., Musi, N., & Orr, M. E. 2023-09-07
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer’s disease, Alzheimer's & Dementia Castranio, E. L., Hasel, P., Haure-Mirande, J. V., Ramirez Jimenez, A. V., Hamilton, B. W., Kim, R. D., Glabe, C. G., Wang, M., Zhang, B., Gandy, S., Liddelow, S. A., & Ehrlich, M. E. 2022-11-30
Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis, Glia Titus, H. E., Xu, H., Robinson, A. P., Patel, P. A., Chen, Y., Fantini, D., Eaton, V., Karl, M., Garrison, E. D., Rose, I. V. L., Chiang, M. Y., Podojil, J. R., Balabanov, R., Liddelow, S. A., Miller, R. H., Popko, B., & Miller, S. D. 2022-07-09
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation, Cell Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M. H., Wood, J., … Liddelow, S. A., … Monje, M. 2022-06-13
Biological aging processes underlying cognitive decline and neurodegenerative disease, Journal of Clinical Investigation Gonzales, M. M., Garbarino, V. R., Pollet, E., Palavicini, J. P., Kellogg, D. L., Jr, Kraig, E., & Orr, M. E. 2022-05-16
Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models, Frontiers in Molecular Neuroscience Labib, D., Wang, Z., Prakash, P., Zimmer, M., Smith, M. D., Frazel, P. W., Barbar, L., Sapar, M. L., Calabresi, P. A., Peng, J., Liddelow, S. A., & Fossati, V. 2022-05-03
Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis, Cancer Discovery Kleffman, K., Levinson, G., Rose, I., Blumenberg, L. M., … Li, Y. M., … Liddelow, S.A., … Hernando, E. 2022-05-02
Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease., Neuron Sadick, J. S., O'Dea, M. R., Hasel, P., Dykstra, T., Faustin, A., & Liddelow, S. A. 2022-04-04
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling, Acta Neuropathologica Communications Walker, J. M., Kazempour Dehkordi, S., Fracassi, A., Vanschoiack, A., Pavenko, A., Taglialatela, G., Woltjer, R., Richardson, T. E., Zare, H., & Orr, M. E. 2022-02-14
Single-cell delineation of lineage and genetic identity in the mouse brain, Nature Bandler, R. C., Vitali, I., Delgado, R. N., Ho, M. C., Dvoretskova, E., Ibarra Molinas, J. S., Frazel, P. W., Mohammadkhani, M., Machold, R., Maedler, S., Liddelow, S. A., Nowakowski, T. J., Fishell, G., & Mayer, C. 2021-12-15
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology, Nature Aging Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., Andhey, P. S., Colonna, M., Sudmant, P. H., Xu, P., Wang, M., Zhang, B., Zare, H., & Orr, M. E. 2021-12-10
Neurotoxic reactive astrocytes induce cell death via saturated lipids., Nature Guttenplan, K. A., Weigel, M. K., Prakash, P., Wijewardhane, P. R., Hasel, P., Rufen-Blanchette, U., Münch, A. E., Blum, J. A., Fine, J., Neal, M. C., Bruce, K. D., Gitler, A. D., Chopra, G., Liddelow, S. A., & Barres, B. A. 2021-10-06
Neuroinflammatory astrocyte subtypes in the mouse brain, Nature Neuroscience Hasel, P., Rose, I. V. L., Sadick, J. S., Kim, R. D., & Liddelow, S. A. 2021-08-19
Monitoring phagocytic uptake of amyloid beta into glial cell lysosomes in real time, Chemical Science Prakash, P., Jethava, K. P., Korte, N., Izquierdo, P., Favuzzi, E., Rose, I. V. L., Guttenplan, K. A., Manchanda, P., Dutta, S., Rochet, J. C., Fishell, G., Liddelow, S. A., Attwell, D., & Chopra, G. 2021-07-21
The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration, Life Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Gillispie, G. J., Milligan, C., & Orr, M. E. 2021-03-11
Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells-Implications for Cancer and Neurodegeneration, Life Gillispie, G. J., Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Zhang, B., & Orr, M. E. 2021-02-17
An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse Models, Cells Spanos, F., & Liddelow, S. A. 2020-11-04
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency, Nature Zhang, J., Velmeshev, D., Hashimoto, K., Huang, Y. H., Hofmann, J. W., Shi, X., Chen, J., Leidal, A. M., Dishart, J. G., Cahill, M. K., Kelley, K. W., Liddelow, S. A., … Huang, E. J. 2020-08-31
Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?, Trends in Immunology Liddelow, S. A., Marsh, S. E., & Stevens, B. 2020-08-17
Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model, Nature Communications Guttenplan, K. A., Weigel, M. K., Adler, D. I., Couthouis, J., Liddelow, S. A., Gitler, A. D., & Barres, B. A. 2020-07-27
Neurotoxic Reactive Astrocytes Drive Neuronal Death After Retinal Injury, Cell Reports Guttenplan, K. A., Stafford, B. K., El-Danaf, R. N., Adler, D. I., Münch, A. E., Weigel, M. K., Huberman, A. D., & Liddelow, S. A. 2020-06-23
CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes, Neuron Barbar, L., Jain, T., Zimmer, M., Kruglikov, I., Sadick, J. S., Wang, M., Kalpana, K., Rose, I. V. L., Burstein, S. R., Rusielewicz, T., Nijsure, M., Guttenplan, K. A., di Domenico, A., Croft, G., Zhang, B., Nobuta, H., Hébert, J. M., Liddelow, S. A., & Fossati, V. 2020-06-01
Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues, Annals of Biomedical Engineering Sadick, J. S., Crawford, L. A., Cramer, H. C., 3rd, Franck, C., Liddelow, S. A., & Darling, E. M. 2020-04-17
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment, Cell Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., Woo, P. J., Barres, B. A., Liddelow, S., Vogel, H., & Monje, M. 2018-12-06
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy, Nature Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., Rojas, J. C., Gallardo, G., Wang, K., Roh, J., Robinson, G., Finn, M. B., Jiang, H., Sullivan, P. M., Baufeld, C., Wood, M. W., Sutphen, C., McCue, L., Xiong, C., Del-Aquila, J.L., Morris, J.C., Cruchage, C., Alzheimer's Disease Neuroimaging Initiative, Fagan, A.M., Miller, B.L., Boxer, A.L., Seeley, W.W., Butovsky, O., Barres, B.B., Paul, S.M., & Holtzman, D.M. 2017-09-28
Neurotoxic reactive astrocytes are induced by activated microglia, Nature Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V. L., Dawson, T. M., Stevens, B., Barres, B. A. 2017-01-18