These published papers resulted from Cure Alzheimer’s Fund support.
| Title | Researchers | Date |
|---|---|---|
| Exercise and Improved Cognition, Science | Rudy Tanzi, Se Hoon Choi | 2018-09-06 |
| Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzheimer’s mice, Neurobiology of Aging, 72 | Nina Fainstein, Nadav Dan-Goor, Tamir Ben-Hur | 2018-08-06 |
| The secret sulfate code that lets the bad Tau in, Science Daily | Marc Diamond | 2018-07-13 |
| 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes, ScienceDirect, Volume 180 | Marco Campisi, Yoojin Shin, Tatsuya Osaki, Cynthia Hajal, Valeria Chiono, Roger D.Kamm | 2018-07-14 |
| Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression, Cell, volume 24, Issue 3 | Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang | 2018-07-17 |
| N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer’s disease, Alzheimer's and Dementia | Erin J. Kodis, Sophie Choi, Eric Swanson, Gonzalo Ferreira, George S. Bloom | 2018-06-01 |
| A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience | Joseph Park, Isaac Wetzel, Ian Marriott, Didier Dréau, Carla D’Avanzo, Doo Yeon Kim, Rudolph E. Tanzi & Hansang Cho | 2018-06-27 |
| Alzheimer’s Disease-Associated b-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection, Neuron (Cell) | William A. Eimer,1,2 Deepak Kumar Vijaya Kumar,1,2 Nanda Kumar Navalpur Shanmugam,Alex S. Rodriguez, Teryn Mitchell, Kevin J. Washicosky, Bence Gyorgy, Xandra O. Breakefield, Rudolph E. Tanzi, and Robert D. Moir | 2018-07-11 |
| Alzheimer’s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia | Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph Tanzi, Marco Colonna | 2016-08-09 |
| Accelerating stem cell trials for Alzheimer’s disease, The Lancet Neurology | Joshua G Hunsberger, Ph.D., Mahendra Rao, M.D., Joanne Kurtzberg, M.D., Jeff W. M. Bulte, Ph.D., Anthony Atala, M.D., Frank M. LaFerla, Ph.D., Henry T. Greely, J.D., Akira Sawa, M.D., Sam Gandy, M.D., Lon S. Schneider, M.D., P. Murali Doraiswamy, M.B.B.S. | 2015-12-15 |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia | Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS | 2016-09-29 |
| Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology, Nature Communications, 8 | Tal Nuriel, Sergio L. Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y. Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S. Gross, S. Abid Hussaini, Herman Moreno, Scott A. Small, Karen E. Duff | 2017-11-13 |
| Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica, 134(5) | Jean-Vianney Haure-Mirande, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, William L. Klein, Charles Glabe, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Minghui Wang, Bin Zhang, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich | 2017-11-01 |
| CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5 | Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy | 2017-10-27 |
| Apolipoprotein E4 Impairs Neuronal Insulin Signaling, Neuron, 96(1) | Na Zhao, Chia-Chen Liu, Alexandra J. Van Ingelgom, Yuka A. Martens, Cynthia Linares, Joshua A. Knight, Meghan M. Painter, Patrick M. Sullivan, Guojun Bu | 2017-09-27 |
| Enhanced liver gene transfer and evasion of preexisting humoral immunity with exosome-enveloped AAV vectors, Blood Advances, 1(23) | Amine Meliani, Florence Boisgerault, Zachary Fitzpatrick, Solenne Marmier, Christian Leborgne, Fanny Collaud, Marcelo Simon Sola, Severine Charles, Giuseppe Ronzitti, Alban Vignaud, Laetitia van Wittenberghe, Beatrice Marolleau, Fabienne Jouen, Sisareuth Tan, Olivier Boyer, Olivier Christophe, Alain R. Brisson, Casey A. Maguire, Federico Mingozzi | 2017-10-24 |
| TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy, Proceedings of the National Academy of Sciences of the United States of America, 114(43) | Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, David M. Holtzman | 2017-10-24 |
| Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing, Nature, 550(7674) | Christina D. Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y. Nguyen, Allison Wing, Emily L. Goldberg, Yun-Hee Youm, Chester W. Brown, John Elsworth, Matthew S. Rodeheffer, Joachim L. Schultze, Vishwa Deep Dixit | 2017-10-05 |
| Regulating protein breakdown through proteasome phosphorylation, Biochemical Journal, 474(19) | Jordan J.S. VerPlank, Alfred L. Goldberg | 2017-10-01 |
| New Approaches to Difficult Drug Targets: The Phosphatase Story, SLAS DISCOVERY, 22(9) | John S. Lazo, Kelley E. McQueeney, Elizabeth R. Sharlow | 2017-10-01 |
| An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function, EMBO Molecular Medicine, 9(10) | Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass | 2017-10-01 |
| Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging, Nature Neuroscience, 20(10) | Petra Füger, Jasmin K. Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M. Wegenast-Braun, Jonas J. Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S. Sisodia, Angelos Skodras, Mathias Jucker | 2017-10-01 |
| Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology | George S.Bloom, John S.Lazo, Andrés Norambuena | 2017-09-29 |
| Toward Personalized Network Biomarkers in Alzheimer’s Disease: Computing Individualized Genomic and Protein Crosstalk Maps, Frontiers in Aging Neuroscience | Kanchana Padmanabhan, Katie Shpanskaya, Gonzalo Bello, P. Murali Doraiswamy, Nagiza F. Samatova | 2017-09-26 |
| ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy, Nature | Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T. Smith, Lingzhi Zhao, Wenjie Luo, Richard M. Tsai, Salvatore Spina, Lea T. Grinberg, Julio C. Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M. Sullivan, Caroline Baufeld, Michael W. Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L. Del-Aguila, John C. Morris, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Anne M. Fagan, Bruce L. Miller, Adam L. Boxer, William W. Seeley, Oleg Butovsky, Ben A. Barres, Steven M. Paul, David M. Holtzman | 2017-09-20 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases, Immunity, 47(3) | Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O’Loughlin, Yang Xu, Zain Fanek, David J. Greco, Scott T. Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D. Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L. Heppner, Vladimir Litvak, David M. Holtzman, Hans Lassmann, Howard L. Weiner, Jordi Ochando, Christian Haass, Oleg Butovsky | 2017-09-19 |
| MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts, Cell Stem Cell, 21(3) | Daniel G. Abernathy, Woo Kyung Kim, Matthew J. McCoy, Allison M. Lake, Rebecca Ouwenga, Seong Won Lee, Xiaoyun Xing, Daofeng Li, Hyung Joo Lee, Robert O. Heuckeroth, Joseph D. Dougherty, Ting Wang, Andrew S. Yoo | 2017-09-07 |
| Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(Delta E9) murine model of Alzheimer’s disease, Scientific Reports, 7 | Myles R. Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W. Musch, Xunuo Shen, Bana Jabri, Eugene B. Change, Rudolph E. Tanzi, Sangram Sisodia | 2017-09-05 |
| Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer’s disease, Current Opinion In Hematology, 24(5) | Hyung Jin Ahn, Zu-Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland | 2017-09-01 |
| Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer’s Disease: A New Computational Approach, Processes, 5(3) | Kanchana Padmanabhan, Kelly Nudelman, Steve Harenberg, Gonzalo Bello, Dongwha Sohn, Katie Shpanskaya, Priyanka Tiwari Dikshit, Pallavi S. Yerramsetty, Rudolph E. Tanzi, Andrew J. Saykin, Jeffrey R. Petrella, P. Murali Doraiswamy, Nagiza F. Samatova, Alzheimer’s Disease Neuroimaging Initiative | 2017-09-01 |
| Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain, Scientific Reports, 7 | Norelle C. Wildburger, Thomas J. Esparza, Richard D. LeDuc, Ryan T. Fellers, Paul M. Thomas, Nigel J. Cairns, Neil L. Kelleher, Randall J. Bateman, David L. Brody | 2017-08-25 |
| Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease, Alzheimers Research & Therapy, 9(1) | David L. Brody, Hao Jiang, Norelle Wildburger, Thomas J. Esparza | 2017-08-17 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease, Cell, 170(4) | Tyler K. Ulland, Wilbur M. Song, 7, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna | 2017-08-10 |
| Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease, Scientific Reports, 7 | Dragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, P. Murali Doraiswamy | 2017-07-28 |
| Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s diseaserelated oligomers by curcumin, Scientific Reports, 7 | Feng Liang, Yu Wan, Diane Schaak, Joseph Ward, Xunuo Shen, Rudolph E. Tanzi, Can Zhang, Qimin Quan | 2017-07-18 |
| APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics, 26(14) | Jing Zhao, Mary D. Davis, Yuka A. Martens, Mitsuru Shinohara, Neill R. Graff-Radford, Steven G. Younkin, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu | 2017-07-15 |
| Identification and characterization of Nanobodies targeting the EphA4 receptor, Journal Of Biological Chemistry, 292(27) | Lies Schoonaert, Laura Rue, Bart Roucourt, Mieke Timmers, Susan Little, Lucia Chavez-Gutierrez, Maarten Dewilde, Peter Joyce, Adam Curnock, Peter Weber, Jurgen Haustraete, Gholamreza Hassanzadeh-Ghassabeh, Bart De Strooper, Ludo Van den Bosch, Philip Van Damme, Robin Lemmens, Wim Robberecht | 2017-07-07 |
| The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, Embo Journal, 36(13) | Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez‐Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass | 2017-07-03 |
| Pharmacological and Toxicological Properties of the Potent Oral gamma-Secretase Modulator BPN-15606, Journal Of Pharmacology And Experimental Therapeutics, 362(1) | Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman, Rudolph E. Tanzi | 2017-07-01 |
| Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies, Journal Of Lipid Research, 58(7) | Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu | 2017-07-01 |
| TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers In Aging Neuroscience, 9 | Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Chen | 2017-06-21 |
| The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis, Journal Of Biological Chemistry, 292(23) | Hyoung Tae Kim, Alfred L. Goldberg | 2017-06-09 |
| Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue, Acta Neuropathologica Communications, 5 | Sarah K. Kaufman, Talitha L. Thomas, Kelly Del Tredici, Heiko Braak, Marc I. Diamond | 2017-06-07 |
| Disease-Modifying Effects of M-1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer’s Disease Mouse Model, Acs Chemical Neuroscience, 8(6) | Evan P. Lebois, Jason P. Schroeder, Thomas J. Esparza, Thomas M. Bridges, Craig W. Lindsley, P. Jeffrey Conn, David L. Brody, J. Scott Daniels, Allan I. Levey | 2017-06-01 |
| Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell, 169(6) | Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S. Boyden | 2017-06-01 |
| The Logic of the 26S Proteasome, Cell, 169(5) | Galen Andrew Collins, Alfred L. Goldberg | 2017-05-18 |
| TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports | Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass | 2017-05-08 |
| Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice, Blood, 129(18) | Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland | 2017-05-04 |
| Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging, 53 | Justin T. Rogers, Chia-Chen Liu, Na Zhao, Jian Wang, Travis Putzke, Longyu Yang, Mitsuru Shinohara, John D. Fryer, Takahisa Kanekiyo, Guojun Bu | 2017-05-01 |
| Elucidating the Role of TREM2 in Alzheimer’s Disease, Neuron, 94 | Jason D. Ulrich, Tyler K. Ulland, Marco Colonna, and David M. Holtzman | 2017-04-19 |
| The Retromer Supports AMPA Receptor Trafficking During LTP, Neuron, 94(1) | Paul Temkin, Wade Morishita, Debanjan Goswami, Kristin Arendt, Lu Chen, Robert Malenka | 2017-04-05 |
| In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology, 43 | L Ashley Watson, Li-Huei Tsai | 2017-04-01 |
| Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, 11 | Bevan S. Main, Myles R. Minter | 2017-03-23 |
| On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology, 41(4) | Heide Loehlein Fier, Dmitry Prokopenko, Julian Hecker, Michael H. Cho, Edwin K. Silverman, Scott T. Weiss, Rudolph E. Tanzi, Christoph Lange | 2017-03-20 |
| Altered sleep and EEG power in the P301S Tau transgenic mouse model, Ann Clin Transl Neurol, 4(3) | Jerrah K. Holth, Thomas E. Mahan, Grace O. Robinson, Andreia Rocha, David M. Holtzman | 2017-02-15 |
| Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage, PNAS, 114(6) | William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos | 2017-02-07 |
| Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?, Evol Med Public Health, 2017(1) | Randolph M. Nesse, Caleb E. Finch, and Charles L. Nunn | 2017-01-24 |
| Precise and efficient scarless genome editing in stem cells using CORRECT, Nature Protocols, 12 | Dylan Kwart, Dominik Paquet, Shaun Teo and Marc Tessier-Lavigne | 2017-01-19 |
| BIN1 localization is distinct from Tau tangles in Alzheimer’s disease, Matters | Pierre De Rossi, Virginie Buggia-Prevot, Robert J Andrew, Sofia V Krause, Elizabeth Woo, Peter T Nelson, Peter Pytel, Gopal Thinakaran | 2017-01-12 |
| The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer’s disease but not those of sTREM2, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 6 | Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo | 2016-12-22 |
| Chapter Three – Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins, Methods in Enzymology, 584 | S. Veugelen, M. Dewilde, B. De Strooper, L. Chávez-Gutiérrez | 2016-12-12 |
| The Alzheimer’s Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement, Alzheimer's & Dementia | Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, John C. Morris, Ronald C. Petersen, Jennifer Salazar, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski | 2016-12-05 |
| Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer’s disease, Alzheimer's & Dementia, 12(12) | Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monté, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo | 2016-12-01 |
| Chronic Progressive Neurodegeneration in a Transgenic Mouse Model of Prion Disease, Frontiers in Neuroscience, 10 | Nina Fainstein, Dvir Dori, Kati Frid, Alexa T. Fritz, Ilona Shapiro, Ruth Gabizon, and Tamir Ben-Hur | 2016-11-11 |
| The road to restoring neural circuits for the treatment of Alzheimer’s disease, Nature, 539(7628) | Rebecca G. Canter, Jay Penney, and Li-Huei Tsai | 2016-11-10 |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia, 13(2) | Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S. Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W. Mandell, George S. Bloom | 2017-02-01 |
| Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells, PLOS ONE, 11(9) | Han-Kyu Lee, Clara Velazquez Sanchez, Mei Chen, Peter J. Morin, John M. Wells, Eugene B. Hanlon, Weiming Xia | 2016-09-29 |
| Alzheimer’s disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide, Neurodegenerative Disease Management, 6(5) | Deepak Kumar Vijaya Kumar , William A Eimer , Rudolph E Tanzi and Robert D Moir | 2016-09-07 |
| TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine, 8(9) | Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass | 2016-09-01 |
| Alzheimer’s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 13(4) | Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph E. Tanzi, Marco Colonna | 2017-04-01 |
| Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia, 12(8) | Henry H. Ruiz, Tiffany Chi, Andrew C. Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettner | 2016-08-01 |
| Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes, Neurol Neuroimmunol Neuroinflamm, 3(3) | Elysse M. Knight, PhD, Soong Ho Kim, PhD, Jessica C. Kottwitz, BS, Asa Hatami, PhD, Ricardo Albay, BS, Akinobu Suzuki, PhD, Alex Lublin, PhD, Cristina M. Alberini, PhD, William L. Klein, PhD, Paul Szabo, PhD, Norman R. Relkin, MD, PhD, Michelle Ehrlich, MD, Charles G. Glabe, PhD, Sam Gandy, MD, PhD and John W. Steele, PhD | 2016-05-01 |
| Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature, 533(7601) | Dominik Paquet, Dylan Kwart, Antonia Chen, Andrew Sproul, Samson Jacob, Shaun Teo, Kimberly Moore Olsen, Andrew Gregg, Scott Noggle and Marc Tessier-Lavigne | 2016-05-01 |
| Interaction of tau with the RNA-binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Cell Reports | Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin | 2016-05-01 |
| A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer’s disease, Thrombosis Research, 141(2) | Daria Zamolodchikov, Sidney Strickland | 2016-05-01 |
| ABCA7 Deficiency Accelerates Amyloid- Generation and Alzheimer’s Neuronal Pathology, Neurobiology of Disease, 36(13) | Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M. Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D. Fryer, Michael L. Fitzgerald, Yasumasa Ohyagi, Steven G. Younkin, Guojun Bu, and Takahisa Kanekiyo | 2016-03-30 |
| Evidence That the “Lid” Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity, Journal of Biological Chemistry, 291(13) | Xulun Zhang, Eric Sullivan, Maggie Scimeca, Xianzhong Wu, Yue-ming Li and Sangram S. Sisodia | 2016-03-25 |
| APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations, Annals of Neurology, 79(5) | Mitsuru Shinohara, Takahisa Kanekiyo, Longyu Yang, Duane Linthicum, Motoko Shinohara, Yuan Fu, Laura Price, Jessica L. Frisch-Daiello, Xianlin Han, John D. Fryer, Guojun Bu | 2016-03-02 |
| sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer’s disease and associate with neuronal injury markers, EMBO Molecular Medicine, 8(3) | Marc Suárez‐Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez‐Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass | 2016-03-01 |
| Tau: The Center of a Signaling Nexus in Alzheimer’s Disease, Frontiers in Neuroscience | Shahzad S. Khan and George S. Bloom | 2016-02-01 |
| Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer’s disease with OSBPL6, PTPRG, and PDCL3, Molecular Psychiatry | C Herold, B V Hooli, K Mullin, T Liu, J T Roehr, M Mattheisen, A R Parrado, L Bertram, C Lange and R E Tanzi | 2016-02-01 |
| Chronic Traumatic Encephalopathy: Diagnosing the Repetitively Injured Brains of Athletes and Soldiers, Current Research: Concussion | Dara L. Dickstein, Effie M. Mitsis, Corey Fernandez, Mariel Pullman, Patrick R. Hof, Jennifer Short, Gregory Elder, Barry Jordan, Stephen Ahlers, Heidi Bender, Martin L. Goldstein, John F. Crary, Kristen Dams-O’Connor, Wayne Gordon, Robert Cantu, Karin Knesaurek, Mary Sano, James R. Stone6, Lale Kostakoglu, Steven T. DeKosky, and Sam Gandy | 2015-12-01 |
| Accelerating stem cell trials for Alzheimer’s disease, The Lancet Neurology, 15(2) | Joshua G Hunsberger, PhD, Mahendra Rao, MD, Joanne Kurtzberg, MD, Jeff W M Bulte, PhD, Anthony Atala, MD, Frank M LaFerla, PhD, Henry T Greely, JD, Akira Sawa,MD, Sam Gandy, MD, Lon S Schneider, MD, P Murali Doraiswamy, MBBS | 2016-02-01 |
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