Anthony Fitzpatrick, Ph.D.

Principal Investigator, Zuckerman Institute; Assistant Professor of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center; Member, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University


Anthony Fitzpatrick is an Assistant Professor of Biochemistry and Molecular Biophysics at the Zuckerman Institute, Columbia University, New York, USA. Previously, he was a Marie Curie International Outgoing Fellow at the Laboratory of Molecular Biology, University of Cambridge (2015-2017) and the California Institute of Technology (2012-2014). He has a biophysics background (Ph.D. with Professor Christopher M. Dobson University of Cambridge) and undertook postdoctoral training with Professors Helen Saibil in London, Robert G. Griffin at the Massachusetts Institute of Technology, Ahmed H. Zewail (Nobel Laureate) at the California Institute of Technology and Sjors Scheres and Michel Goedert at the Laboratory of Molecular Biology, Cambridge. The research focus of the Fitzpatrick lab is to determine the structure and behavior of patient-derived amyloid fibrils and, more generally, understanding the role of protein aggregation in vivo by identifying the cellular changes that occur in response to the formation, clearance and spread of fibrillar inclusions. The methods employed by his lab are largely experimental and include cryo-electron microscopy, mass spectrometry, transcriptomics, microfluidics, and optical super-resolution microscopy.

 

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Arakhamia, T., Lee, C. E., Carlomagno, Y., Duong, D. M., Kundinger, S. R., Wang, K., Williams, D., DeTure, M., Dickson, D. W., Cook, C. N., Seyfried, N. T., Petrucelli, L., & Fitzpatrick, A. W. P. Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains, Cell, February 20, 2020, Read More

Carlomagno, Y., Manne, S., DeTure, M., Prudencio, M., Zhang, Y. J., Hanna Al-Shaikh, R., Dunmore, J. A., Daughrity, L. M., Song, Y., Castanedes-Casey, M., Lewis-Tuffin, L. J., Nicholson, K. A., Wszolek, Z. K., Dickson, D. W., Fitzpatrick, A. W. P., Petrucelli, L., & Cook, C. N. The AD tau core spontaneously self-assembles and recruits full-length tau to filaments, Cell Reports, March 16, 2021, Read More