Leah Cuddy, Ph.D.

Research Assistant Professor of Neurology, Northwestern University, Feinberg School of Medicine


Leah Cuddy’s research focuses on understanding the molecular mechanisms underlying neurodegeneration and cognitive dysfunction in Alzheimer’s disease and Parkinson’s disease. She is interested in understanding the physiological role of angiotensin I converting enzyme (ACE1) in the brain and how ACE genetic variants increase the risk of Alzheimer’s disease. FDA-approved medications that target ACE1 exist for the treatment of hypertension, and her work could provide insight as to whether these drugs could potentially prevent or treat Alzheimer’s disease. Dr. Cuddy is also interested in elucidating mechanisms that cause dysfunctional lysosomal trafficking in neurodegenerative diseases and lead to the aggregation of pathological proteins such as Ab42 and a-synuclein. Dr. Cuddy uses transgenic mouse models, cell lines and human iPSC derived neurons to investigate these questions.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Alia, A. O., Jeon, S., Popovic, J., Salvo, M. A., Sadleir, K. R., Vassar, R., & Cuddy, L. K. Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models, Scientific Reports, December 21, 2022, Read More

Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B. A., Hofmann, O., Hide, W., Procissi, D., Hanania, T., Leiser, S. C., Tanzi, R. E., & Vassar, R. Abeta-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice, Science Translational Medicine, September 30, 2020, Read More