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Patrick Oeckl, Ph.D.

Research Group Leader, German Center for Neurodegenerative Diseases (DZNE), Ulm and Ulm University Hospital, Department of Neurology, Germany

Patrick Oeckl is a research group leader at the German Center for Neurodegenerative Diseases in Ulm (DZNE) and the Ulm University Hospital, Department of Neurology. His research interest is to uncover pathophysiological mechanisms of neurodegenerative diseases and the discovery, validation and implementation of biomarkers in cerebrospinal fluid (CSF) and blood to improve diagnosis, personalized medicine and drug development. He gained his many years of experience with mass spectrometric (MS) analyses of biomarkers in academia and industry and was among the first to successfully measure important biomarker candidates in CSF by MS such as synucleins and neurofilaments. With the development of a MS-based assay to measure the synaptic marker β-synuclein in blood, he could provide the first reliable synaptic blood marker to the scientific community thereby filling an important gap.

Links:

Oeckl Lab – DZNE

To learn more about the German Center for Neurodegenerative Diseases, visit www.dzne.de.

Related Research:

Characterization of the Longitudinal Trajectories of the Synaptic Blood Marker Beta-Synuclein During Alzheimer’s Disease Pathogenesis and Improvement of the Measurement Procedure Patrick Oeckl Markus Otto 2023-09-19

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Characterization of the Longitudinal Trajectories of the Synaptic Blood Marker Beta-Synuclein During Alzheimer’s Disease Pathogenesis and Improvement of the Measurement Procedure 2023, 2025

$290,605

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Oeckl, P., Abu-Rumeileh, S., Weise, C. M., Otto, M., & Alzheimer’s Disease Neuroimaging Initiative Longitudinal changes of blood β-synuclein in cognitively unimpaired, mild cognitive impairment and sporadic Alzheimer´s disease, Alzheimer's Research & Therapy, February 11, 2026, Read More

Barba, L., Bellomo, G., Alcolea, D., Wojdala, A. L., Gaetani, L., Fortea, J., Abu-Rumeileh, S., Lleó, A., Parnetti, L., Belbin, O., Otto, M., & Oeckl, P. Serum level changes of the synaptic marker beta-synuclein in Alzheimer’s disease continuum and other dementias, Journal of Neurology, Neurosurgery, and Psychiatry, June 26, 2025, Read More

Oeckl, P., Mayer, B., Bateman, R. J., Day, G. S., Fox, N. C., Huey, E. D., Ibanez, L., Ikeuchi, T., Jucker, M., Lee, J. H., Levin, J., Llibre-Guerra, J. J., Lopera, F., McDade, E., Morris, J. C., Niimi, Y., Roh, J. H., Sánchez-Valle, R., Schofield, P. R., Otto, M., & Dominantly Inherited Alzheimer Network Early increase of the synaptic blood marker β-synuclein in asymptomatic autosomal dominant Alzheimer’s disease, Alzheimer's & Dementia, April 10, 2025, Read More

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